Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HHN7_LEIBR

TriTrypDb:

LbrM.29.2350 , LBRM2903_290030200

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.471
CLV_C14_Caspase3-7	343	347	PF00656	0.385
CLV_NRD_NRD_1	101	103	PF00675	0.399
CLV_NRD_NRD_1	123	125	PF00675	0.400
CLV_NRD_NRD_1	192	194	PF00675	0.457
CLV_NRD_NRD_1	211	213	PF00675	0.347
CLV_PCSK_KEX2_1	101	103	PF00082	0.399
CLV_PCSK_SKI1_1	345	349	PF00082	0.567
CLV_PCSK_SKI1_1	45	49	PF00082	0.488
CLV_PCSK_SKI1_1	453	457	PF00082	0.514
CLV_PCSK_SKI1_1	78	82	PF00082	0.366
CLV_Separin_Metazoa	121	125	PF03568	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.210
DEG_SCF_FBW7_1	454	460	PF00400	0.470
DOC_CKS1_1	454	459	PF01111	0.485
DOC_CYCLIN_RxL_1	42	50	PF00134	0.490
DOC_CYCLIN_yClb5_NLxxxL_5	405	414	PF00134	0.580
DOC_MAPK_gen_1	212	219	PF00069	0.406
DOC_MAPK_HePTP_8	359	371	PF00069	0.397
DOC_MAPK_MEF2A_6	143	152	PF00069	0.341
DOC_MAPK_MEF2A_6	212	221	PF00069	0.256
DOC_MAPK_MEF2A_6	362	371	PF00069	0.384
DOC_PP2B_LxvP_1	392	395	PF13499	0.482
DOC_PP2B_LxvP_1	80	83	PF13499	0.366
DOC_USP7_MATH_1	205	209	PF00917	0.352
DOC_USP7_MATH_1	347	351	PF00917	0.580
DOC_USP7_MATH_1	383	387	PF00917	0.505
DOC_USP7_UBL2_3	467	471	PF12436	0.453
DOC_WW_Pin1_4	244	249	PF00397	0.356
DOC_WW_Pin1_4	453	458	PF00397	0.459
LIG_14-3-3_CanoR_1	106	111	PF00244	0.490
LIG_14-3-3_CanoR_1	130	137	PF00244	0.484
LIG_14-3-3_CanoR_1	204	210	PF00244	0.352
LIG_14-3-3_CanoR_1	485	494	PF00244	0.506
LIG_Actin_WH2_2	346	364	PF00022	0.414
LIG_APCC_ABBA_1	70	75	PF00400	0.366
LIG_APCC_ABBA_1	93	98	PF00400	0.366
LIG_BRCT_BRCA1_1	152	156	PF00533	0.490
LIG_BRCT_BRCA1_1	214	218	PF00533	0.437
LIG_BRCT_BRCA1_1	230	234	PF00533	0.263
LIG_BRCT_BRCA1_1	278	282	PF00533	0.370
LIG_BRCT_BRCA1_1	442	446	PF00533	0.515
LIG_EH1_1	386	394	PF00400	0.539
LIG_eIF4E_1	387	393	PF01652	0.544
LIG_FHA_1	22	28	PF00498	0.357
LIG_FHA_1	225	231	PF00498	0.352
LIG_FHA_1	238	244	PF00498	0.352
LIG_FHA_1	252	258	PF00498	0.352
LIG_FHA_1	300	306	PF00498	0.421
LIG_FHA_1	310	316	PF00498	0.429
LIG_FHA_1	389	395	PF00498	0.419
LIG_FHA_1	415	421	PF00498	0.535
LIG_FHA_1	435	441	PF00498	0.529
LIG_FHA_1	454	460	PF00498	0.490
LIG_FHA_1	478	484	PF00498	0.457
LIG_FHA_1	60	66	PF00498	0.490
LIG_FHA_2	178	184	PF00498	0.455
LIG_FHA_2	326	332	PF00498	0.454
LIG_LIR_Gen_1	153	164	PF02991	0.448
LIG_LIR_Gen_1	215	226	PF02991	0.355
LIG_LIR_Gen_1	24	31	PF02991	0.448
LIG_LIR_Gen_1	281	290	PF02991	0.542
LIG_LIR_Gen_1	490	499	PF02991	0.468
LIG_LIR_LC3C_4	391	394	PF02991	0.529
LIG_LIR_Nem_3	153	159	PF02991	0.381
LIG_LIR_Nem_3	215	221	PF02991	0.355
LIG_LIR_Nem_3	24	28	PF02991	0.371
LIG_LIR_Nem_3	281	287	PF02991	0.568
LIG_LIR_Nem_3	3	9	PF02991	0.373
LIG_LIR_Nem_3	490	496	PF02991	0.482
LIG_MAD2	453	461	PF02301	0.331
LIG_NRBOX	225	231	PF00104	0.381
LIG_PTB_Apo_2	462	469	PF02174	0.534
LIG_Rb_pABgroove_1	391	399	PF01858	0.464
LIG_Rb_pABgroove_1	42	50	PF01858	0.490
LIG_SH2_CRK	25	29	PF00017	0.490
LIG_SH2_CRK	397	401	PF00017	0.567
LIG_SH2_NCK_1	397	401	PF00017	0.612
LIG_SH2_SRC	293	296	PF00017	0.391
LIG_SH2_STAP1	262	266	PF00017	0.352
LIG_SH2_STAP1	284	288	PF00017	0.465
LIG_SH2_STAT3	308	311	PF00017	0.488
LIG_SH2_STAT5	104	107	PF00017	0.366
LIG_SH2_STAT5	293	296	PF00017	0.473
LIG_SH2_STAT5	308	311	PF00017	0.348
LIG_SH2_STAT5	474	477	PF00017	0.455
LIG_SH2_STAT5	493	496	PF00017	0.410
LIG_SH3_3	397	403	PF00018	0.603
LIG_SH3_3	451	457	PF00018	0.514
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.515
LIG_SUMO_SIM_par_1	165	172	PF11976	0.381
LIG_SUMO_SIM_par_1	325	332	PF11976	0.589
LIG_SUMO_SIM_par_1	419	425	PF11976	0.516
LIG_TYR_ITIM	491	496	PF00017	0.487
LIG_UBA3_1	119	125	PF00899	0.381
LIG_UBA3_1	287	292	PF00899	0.497
LIG_WRC_WIRS_1	206	211	PF05994	0.352
MOD_CK1_1	129	135	PF00069	0.397
MOD_CK1_1	141	147	PF00069	0.337
MOD_CK1_1	21	27	PF00069	0.399
MOD_CK1_1	224	230	PF00069	0.352
MOD_CK1_1	256	262	PF00069	0.464
MOD_CK1_1	378	384	PF00069	0.469
MOD_CK2_1	177	183	PF00069	0.342
MOD_CK2_1	205	211	PF00069	0.315
MOD_CK2_1	217	223	PF00069	0.429
MOD_CK2_1	300	306	PF00069	0.499
MOD_CK2_1	329	335	PF00069	0.561
MOD_CK2_1	498	504	PF00069	0.542
MOD_CK2_1	65	71	PF00069	0.366
MOD_DYRK1A_RPxSP_1	453	457	PF00069	0.462
MOD_GlcNHglycan	114	117	PF01048	0.490
MOD_GlcNHglycan	183	187	PF01048	0.455
MOD_GlcNHglycan	20	23	PF01048	0.385
MOD_GlcNHglycan	295	299	PF01048	0.499
MOD_GlcNHglycan	487	490	PF01048	0.598
MOD_GSK3_1	137	144	PF00069	0.352
MOD_GSK3_1	173	180	PF00069	0.331
MOD_GSK3_1	217	224	PF00069	0.348
MOD_GSK3_1	242	249	PF00069	0.355
MOD_GSK3_1	251	258	PF00069	0.339
MOD_GSK3_1	300	307	PF00069	0.533
MOD_GSK3_1	325	332	PF00069	0.553
MOD_GSK3_1	347	354	PF00069	0.586
MOD_GSK3_1	371	378	PF00069	0.448
MOD_GSK3_1	449	456	PF00069	0.469
MOD_GSK3_1	59	66	PF00069	0.433
MOD_N-GLC_1	126	131	PF02516	0.376
MOD_N-GLC_1	137	142	PF02516	0.339
MOD_N-GLC_1	195	200	PF02516	0.352
MOD_N-GLC_1	251	256	PF02516	0.352
MOD_N-GLC_1	275	280	PF02516	0.493
MOD_N-GLC_1	329	334	PF02516	0.623
MOD_N-GLC_2	10	12	PF02516	0.359
MOD_NEK2_1	137	142	PF00069	0.352
MOD_NEK2_1	221	226	PF00069	0.352
MOD_NEK2_1	230	235	PF00069	0.352
MOD_NEK2_1	242	247	PF00069	0.352
MOD_NEK2_1	253	258	PF00069	0.352
MOD_NEK2_1	267	272	PF00069	0.492
MOD_NEK2_1	294	299	PF00069	0.463
MOD_NEK2_1	329	334	PF00069	0.531
MOD_NEK2_1	371	376	PF00069	0.472
MOD_NEK2_2	59	64	PF00069	0.490
MOD_OFUCOSY	370	375	PF10250	0.472
MOD_PIKK_1	150	156	PF00454	0.352
MOD_PIKK_1	300	306	PF00454	0.610
MOD_PIKK_1	329	335	PF00454	0.636
MOD_PK_1	106	112	PF00069	0.490
MOD_PKA_1	212	218	PF00069	0.477
MOD_PKA_2	129	135	PF00069	0.370
MOD_PKA_2	177	183	PF00069	0.342
MOD_PKA_2	221	227	PF00069	0.348
MOD_PKA_2	299	305	PF00069	0.546
MOD_PKA_2	440	446	PF00069	0.517
MOD_Plk_1	195	201	PF00069	0.352
MOD_Plk_1	300	306	PF00069	0.360
MOD_Plk_1	329	335	PF00069	0.600
MOD_Plk_1	59	65	PF00069	0.490
MOD_Plk_2-3	155	161	PF00069	0.256
MOD_Plk_2-3	30	36	PF00069	0.256
MOD_Plk_2-3	325	331	PF00069	0.452
MOD_Plk_2-3	340	346	PF00069	0.389
MOD_Plk_2-3	89	95	PF00069	0.399
MOD_Plk_4	166	172	PF00069	0.385
MOD_Plk_4	195	201	PF00069	0.352
MOD_Plk_4	23	29	PF00069	0.366
MOD_Plk_4	237	243	PF00069	0.352
MOD_Plk_4	304	310	PF00069	0.574
MOD_Plk_4	388	394	PF00069	0.424
MOD_Plk_4	440	446	PF00069	0.460
MOD_Plk_4	65	71	PF00069	0.366
MOD_ProDKin_1	244	250	PF00069	0.356
MOD_ProDKin_1	453	459	PF00069	0.457
MOD_SUMO_for_1	315	318	PF00179	0.628
MOD_SUMO_rev_2	155	164	PF00179	0.291
MOD_SUMO_rev_2	208	215	PF00179	0.479
MOD_SUMO_rev_2	220	227	PF00179	0.487
TRG_DiLeu_BaEn_1	283	288	PF01217	0.608
TRG_DiLeu_BaEn_1	344	349	PF01217	0.532
TRG_DiLeu_BaEn_1	388	393	PF01217	0.537
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.381
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.455
TRG_ENDOCYTIC_2	25	28	PF00928	0.448
TRG_ENDOCYTIC_2	284	287	PF00928	0.583
TRG_ENDOCYTIC_2	293	296	PF00928	0.562
TRG_ENDOCYTIC_2	397	400	PF00928	0.533
TRG_ENDOCYTIC_2	493	496	PF00928	0.488
TRG_ENDOCYTIC_2	6	9	PF00928	0.437
TRG_ER_diArg_1	101	103	PF00400	0.366
TRG_ER_diArg_1	83	86	PF00400	0.356
TRG_NES_CRM1_1	163	177	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY56	Leptomonas seymouri	28%	76%
A0A0N1IH46	Leptomonas seymouri	33%	73%
A0A0S4J1I2	Bodo saltans	32%	78%
A0A0S4J3A4	Bodo saltans	29%	85%
A0A0S4JJ54	Bodo saltans	31%	74%
A0A0S4KL43	Bodo saltans	28%	100%
A0A1X0P9E3	Trypanosomatidae	63%	87%
A0A1X0PAG9	Trypanosomatidae	51%	87%
A0A3Q8IEL2	Leishmania donovani	67%	88%
A0A3Q8IHG6	Leishmania donovani	88%	88%
A0A3R7KHX7	Trypanosoma rangeli	34%	70%
A0A3R7MDH9	Trypanosoma rangeli	29%	73%
A0A3R7R330	Trypanosoma rangeli	64%	99%
A0A3S7X2P9	Leishmania donovani	88%	88%
A0A422NXU3	Trypanosoma rangeli	44%	100%
A4I4V2	Leishmania infantum	88%	88%
A4I4V3	Leishmania infantum	67%	88%
B9G2X9	Oryza sativa subsp. japonica	33%	86%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	88%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	90%
E9AEA0	Leishmania major	87%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	88%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	85%
Q10E64	Oryza sativa subsp. japonica	36%	70%
Q4Q7S4	Leishmania major	32%	85%
Q5E913	Arabidopsis thaliana	28%	82%
Q6S001	Dictyostelium discoideum	32%	76%
Q8J1G1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	76%
Q965T6	Caenorhabditis elegans	38%	80%
Q9D2Z8	Mus musculus	33%	81%
Q9V877	Drosophila melanogaster	29%	82%
V5B8M1	Trypanosoma cruzi	35%	84%
V5BK25	Trypanosoma cruzi	30%	72%
V5BMP0	Trypanosoma cruzi	34%	67%
V5DMS2	Trypanosoma cruzi	34%	97%
V5DTU1	Trypanosoma cruzi	48%	90%