Putative aspartyl aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartyl aminopeptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHN5_LEIBR

TriTrypDb:

LbrM.29.2330 , LBRM2903_290030100

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HHN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004177	aminopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0008238	exopeptidase activity	4	11
GO:0008270	zinc ion binding	6	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.600
CLV_C14_Caspase3-7	390	394	PF00656	0.433
CLV_PCSK_SKI1_1	11	15	PF00082	0.453
CLV_PCSK_SKI1_1	128	132	PF00082	0.310
CLV_PCSK_SKI1_1	146	150	PF00082	0.310
CLV_PCSK_SKI1_1	170	174	PF00082	0.320
CLV_PCSK_SKI1_1	347	351	PF00082	0.334
CLV_PCSK_SKI1_1	363	367	PF00082	0.253
DEG_SCF_FBW7_1	24	29	PF00400	0.433
DOC_CDC14_PxL_1	154	162	PF14671	0.510
DOC_CYCLIN_yClb5_NLxxxL_5	155	164	PF00134	0.585
DOC_MAPK_DCC_7	152	162	PF00069	0.510
DOC_MAPK_gen_1	11	19	PF00069	0.441
DOC_MAPK_gen_1	149	157	PF00069	0.542
DOC_MAPK_gen_1	379	385	PF00069	0.541
DOC_MAPK_MEF2A_6	156	164	PF00069	0.510
DOC_USP7_MATH_1	213	217	PF00917	0.614
DOC_USP7_MATH_1	297	301	PF00917	0.555
DOC_USP7_MATH_1	395	399	PF00917	0.541
DOC_USP7_UBL2_3	375	379	PF12436	0.510
DOC_WW_Pin1_4	171	176	PF00397	0.623
DOC_WW_Pin1_4	22	27	PF00397	0.510
DOC_WW_Pin1_4	247	252	PF00397	0.598
DOC_WW_Pin1_4	391	396	PF00397	0.534
DOC_WW_Pin1_4	90	95	PF00397	0.510
LIG_14-3-3_CanoR_1	101	109	PF00244	0.614
LIG_14-3-3_CanoR_1	316	320	PF00244	0.541
LIG_Actin_WH2_2	23	40	PF00022	0.581
LIG_Actin_WH2_2	302	318	PF00022	0.524
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	92	96	PF00533	0.562
LIG_Clathr_ClatBox_1	325	329	PF01394	0.510
LIG_EH1_1	434	442	PF00400	0.574
LIG_eIF4E_1	435	441	PF01652	0.590
LIG_FHA_1	364	370	PF00498	0.518
LIG_FHA_1	410	416	PF00498	0.510
LIG_FHA_1	429	435	PF00498	0.510
LIG_FHA_1	436	442	PF00498	0.510
LIG_FHA_1	65	71	PF00498	0.590
LIG_FHA_2	103	109	PF00498	0.549
LIG_FHA_2	122	128	PF00498	0.440
LIG_FHA_2	164	170	PF00498	0.477
LIG_FHA_2	388	394	PF00498	0.433
LIG_FHA_2	41	47	PF00498	0.483
LIG_FXI_DFP_1	225	229	PF00024	0.390
LIG_LIR_Gen_1	106	117	PF02991	0.587
LIG_LIR_Gen_1	15	24	PF02991	0.363
LIG_LIR_Gen_1	25	35	PF02991	0.510
LIG_LIR_Gen_1	258	267	PF02991	0.590
LIG_LIR_Gen_1	39	48	PF02991	0.510
LIG_LIR_Nem_3	106	112	PF02991	0.498
LIG_LIR_Nem_3	15	19	PF02991	0.405
LIG_LIR_Nem_3	25	30	PF02991	0.510
LIG_LIR_Nem_3	258	263	PF02991	0.523
LIG_LIR_Nem_3	39	45	PF02991	0.510
LIG_LIR_Nem_3	442	448	PF02991	0.510
LIG_LIR_Nem_3	48	54	PF02991	0.510
LIG_PCNA_PIPBox_1	277	286	PF02747	0.510
LIG_Pex14_1	122	126	PF04695	0.510
LIG_Rb_pABgroove_1	278	286	PF01858	0.510
LIG_SH2_CRK	109	113	PF00017	0.489
LIG_SH2_CRK	260	264	PF00017	0.590
LIG_SH2_GRB2like	448	451	PF00017	0.556
LIG_SH2_SRC	448	451	PF00017	0.556
LIG_SH2_STAT5	260	263	PF00017	0.579
LIG_SH2_STAT5	42	45	PF00017	0.614
LIG_SH2_STAT5	61	64	PF00017	0.513
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.510
LIG_SUMO_SIM_par_1	323	329	PF11976	0.524
LIG_TRAF2_1	384	387	PF00917	0.510
LIG_TRFH_1	96	100	PF08558	0.556
LIG_UBA3_1	147	152	PF00899	0.590
LIG_UBA3_1	403	411	PF00899	0.590
LIG_WRC_WIRS_1	16	21	PF05994	0.293
LIG_WRC_WIRS_1	441	446	PF05994	0.590
MOD_CDC14_SPxK_1	174	177	PF00782	0.586
MOD_CDK_SPK_2	247	252	PF00069	0.614
MOD_CDK_SPxK_1	171	177	PF00069	0.586
MOD_CK1_1	104	110	PF00069	0.520
MOD_CK1_1	291	297	PF00069	0.541
MOD_CK1_1	311	317	PF00069	0.378
MOD_CK1_1	405	411	PF00069	0.524
MOD_CK1_1	421	427	PF00069	0.510
MOD_CK2_1	421	427	PF00069	0.510
MOD_CMANNOS	122	125	PF00535	0.310
MOD_GlcNHglycan	343	346	PF01048	0.233
MOD_GlcNHglycan	404	407	PF01048	0.328
MOD_GlcNHglycan	81	84	PF01048	0.233
MOD_GSK3_1	22	29	PF00069	0.554
MOD_GSK3_1	228	235	PF00069	0.510
MOD_GSK3_1	311	318	PF00069	0.533
MOD_GSK3_1	320	327	PF00069	0.489
MOD_GSK3_1	363	370	PF00069	0.510
MOD_GSK3_1	387	394	PF00069	0.516
MOD_GSK3_1	405	412	PF00069	0.517
MOD_GSK3_1	60	67	PF00069	0.449
MOD_GSK3_1	99	106	PF00069	0.538
MOD_N-GLC_1	273	278	PF02516	0.390
MOD_N-GLC_1	311	316	PF02516	0.390
MOD_N-GLC_1	391	396	PF02516	0.303
MOD_N-GLC_1	64	69	PF02516	0.310
MOD_N-GLC_2	205	207	PF02516	0.390
MOD_NEK2_1	121	126	PF00069	0.510
MOD_NEK2_1	228	233	PF00069	0.581
MOD_NEK2_1	315	320	PF00069	0.524
MOD_NEK2_1	440	445	PF00069	0.550
MOD_NEK2_2	418	423	PF00069	0.510
MOD_PIKK_1	184	190	PF00454	0.587
MOD_PIKK_1	232	238	PF00454	0.510
MOD_PIKK_1	291	297	PF00454	0.524
MOD_PIKK_1	40	46	PF00454	0.614
MOD_PKA_2	102	108	PF00069	0.433
MOD_PKA_2	315	321	PF00069	0.524
MOD_PKB_1	101	109	PF00069	0.433
MOD_Plk_1	128	134	PF00069	0.510
MOD_Plk_1	228	234	PF00069	0.510
MOD_Plk_1	273	279	PF00069	0.536
MOD_Plk_1	311	317	PF00069	0.590
MOD_Plk_4	121	127	PF00069	0.504
MOD_Plk_4	15	21	PF00069	0.443
MOD_Plk_4	228	234	PF00069	0.510
MOD_Plk_4	273	279	PF00069	0.590
MOD_Plk_4	297	303	PF00069	0.510
MOD_Plk_4	315	321	PF00069	0.510
MOD_Plk_4	440	446	PF00069	0.590
MOD_Plk_4	65	71	PF00069	0.541
MOD_ProDKin_1	171	177	PF00069	0.623
MOD_ProDKin_1	22	28	PF00069	0.510
MOD_ProDKin_1	247	253	PF00069	0.598
MOD_ProDKin_1	391	397	PF00069	0.534
MOD_ProDKin_1	90	96	PF00069	0.510
MOD_SUMO_rev_2	141	148	PF00179	0.591
TRG_DiLeu_BaEn_2	14	20	PF01217	0.409
TRG_ENDOCYTIC_2	109	112	PF00928	0.510
TRG_ENDOCYTIC_2	260	263	PF00928	0.619
TRG_ENDOCYTIC_2	42	45	PF00928	0.524
TRG_ER_diArg_1	100	103	PF00400	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTZ6	Leptomonas seymouri	78%	100%
A0A1X0P949	Trypanosomatidae	64%	100%
A0A3Q8IEG8	Leishmania donovani	89%	100%
A0A3R7K726	Trypanosoma rangeli	62%	100%
A0PYH7	Clostridium novyi (strain NT)	39%	100%
A1KGT3	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	35%	100%
A4I4V0	Leishmania infantum	89%	100%
A4VJG1	Pseudomonas stutzeri (strain A1501)	40%	100%
A4XRN0	Pseudomonas mendocina (strain ymp)	41%	100%
A5U0I9	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	35%	100%
A5W7K3	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	40%	100%
A6V2H4	Pseudomonas aeruginosa (strain PA7)	41%	100%
B0KTU0	Pseudomonas putida (strain GB-1)	41%	100%
B1J1S3	Pseudomonas putida (strain W619)	40%	100%
B7J1T9	Borreliella burgdorferi (strain ZS7)	23%	99%
B7V7X2	Pseudomonas aeruginosa (strain LESB58)	40%	100%
B9RAJ0	Ricinus communis	46%	92%
C1ALD5	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)	35%	100%
C1DQM8	Azotobacter vinelandii (strain DJ / ATCC BAA-1303)	39%	100%
C3K0D7	Pseudomonas fluorescens (strain SBW25)	39%	100%
C9ZL10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AE98	Leishmania major	88%	100%
E9ALI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O36014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	97%
O51572	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	35%	100%
O86957	Thermotoga neapolitana	23%	100%
P0C925	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	23%	99%
P14904	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	88%
P38821	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	92%
P59951	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	35%	100%
P9WHT0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	100%
P9WHT1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	100%
Q02Q78	Pseudomonas aeruginosa (strain UCBPP-PA14)	41%	100%
Q0SNE8	Borreliella afzelii (strain PKo)	24%	99%
Q19087	Caenorhabditis elegans	45%	96%
Q1IDE6	Pseudomonas entomophila (strain L48)	40%	100%
Q2HJH1	Bos taurus	44%	96%
Q2UPZ7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	44%	91%
Q3KFM3	Pseudomonas fluorescens (strain Pf0-1)	39%	100%
Q48L80	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	39%	100%
Q4ZW15	Pseudomonas syringae pv. syringae (strain B728a)	39%	100%
Q50022	Mycobacterium leprae (strain TN)	37%	100%
Q54M70	Dictyostelium discoideum	46%	94%
Q5RBT2	Pongo abelii	45%	96%
Q661Q3	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	25%	99%
Q82F74	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	36%	100%
Q87YC5	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	39%	100%
Q88M44	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	40%	100%
Q97K30	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	22%	97%
Q97LF4	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	37%	100%
Q9HYZ3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	40%	100%
Q9ULA0	Homo sapiens	45%	93%
Q9WYJ9	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	24%	100%
Q9XA76	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	38%	100%
Q9Z2W0	Mus musculus	45%	96%
V5BC31	Trypanosoma cruzi	64%	100%