5-demethoxyubiquinone hydroxylase, mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquinone biosynthesis protein COQ7, putative

Species:

Leishmania braziliensis

UniProt:

A4HHN4_LEIBR

TriTrypDb:

LbrM.29.2320 , LBRM2903_290030000

Length:

206

Annotations

LeishMANIAdb annotations

Very conserved, homologous to animal COQ7 proteins. Probably perimembrane protein.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0019898	extrinsic component of membrane	2	10
GO:0031090	organelle membrane	3	1
GO:0031312	extrinsic component of organelle membrane	3	10
GO:0031314	extrinsic component of mitochondrial inner membrane	4	10
GO:0031966	mitochondrial membrane	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4HHN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	10
GO:0006744	ubiquinone biosynthetic process	6	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0042181	ketone biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044281	small molecule metabolic process	2	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	10
GO:0005488	binding	1	10
GO:0008682	3-demethoxyubiquinol 3-hydroxylase activity	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	10
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	204	206	PF00082	0.456
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.456
CLV_PCSK_SKI1_1	154	158	PF00082	0.267
CLV_PCSK_SKI1_1	2	6	PF00082	0.549
DEG_APCC_DBOX_1	43	51	PF00400	0.359
DEG_Nend_UBRbox_1	1	4	PF02207	0.506
DEG_SPOP_SBC_1	83	87	PF00917	0.307
DOC_MAPK_gen_1	154	163	PF00069	0.238
DOC_MAPK_gen_1	21	31	PF00069	0.327
DOC_MAPK_MEF2A_6	193	202	PF00069	0.223

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB42	Leptomonas seymouri	81%	100%
A0A1X0P9Z6	Trypanosomatidae	64%	100%
A0A3R7LIB4	Trypanosoma rangeli	64%	100%
A0A3S7X2Q6	Leishmania donovani	86%	100%
A4I4U9	Leishmania infantum	86%	100%
C9ZLJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AE97	Leishmania major	87%	100%
E9ALI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O74826	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	95%
P41735	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	88%

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