Nucleosome assembly protein 1-like 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein (NAP), putative

Species:

Leishmania braziliensis

UniProt:

A4HHN3_LEIBR

TriTrypDb:

LbrM.29.2310 , LBRM2903_290029900

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000785	chromatin	2	1

Expansion

Sequence features

A4HHN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN3

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006334	nucleosome assembly	7	10
GO:0006338	chromatin remodeling	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0034728	nucleosome organization	6	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0065004	protein-DNA complex assembly	6	10
GO:0071824	protein-DNA complex subunit organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	47	49	PF00675	0.724
CLV_PCSK_KEX2_1	47	49	PF00082	0.603
CLV_PCSK_SKI1_1	48	52	PF00082	0.658
CLV_PCSK_SKI1_1	83	87	PF00082	0.582
DEG_APCC_DBOX_1	47	55	PF00400	0.718
DEG_Nend_UBRbox_2	1	3	PF02207	0.588
DEG_SCF_FBW7_2	65	71	PF00400	0.448
DOC_CKS1_1	65	70	PF01111	0.658
DOC_PP1_RVXF_1	99	106	PF00149	0.598
DOC_WW_Pin1_4	61	66	PF00397	0.549
LIG_14-3-3_CanoR_1	142	151	PF00244	0.606
LIG_14-3-3_CanoR_1	83	91	PF00244	0.573
LIG_APCC_ABBAyCdc20_2	108	114	PF00400	0.550
LIG_CaM_IQ_9	85	100	PF13499	0.648
LIG_Clathr_ClatBox_1	18	22	PF01394	0.576
LIG_EH_1	175	179	PF12763	0.551
LIG_FHA_1	126	132	PF00498	0.574
LIG_FHA_1	13	19	PF00498	0.564
LIG_FHA_1	5	11	PF00498	0.550
LIG_LIR_Apic_2	171	177	PF02991	0.516
LIG_LIR_Gen_1	146	157	PF02991	0.644
LIG_LIR_Nem_3	145	151	PF02991	0.521
LIG_LIR_Nem_3	86	91	PF02991	0.610
LIG_LIR_Nem_3	97	103	PF02991	0.429
LIG_Pex14_2	148	152	PF04695	0.645
LIG_PTB_Apo_2	99	106	PF02174	0.441
LIG_SH2_CRK	100	104	PF00017	0.600
LIG_SH2_CRK	174	178	PF00017	0.610
LIG_SH2_GRB2like	174	177	PF00017	0.611
LIG_SH2_SRC	174	177	PF00017	0.643
LIG_SH2_STAT3	36	39	PF00017	0.454
LIG_SH3_3	62	68	PF00018	0.575
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.529
LIG_WRC_WIRS_1	104	109	PF05994	0.665
MOD_CK1_1	12	18	PF00069	0.536
MOD_CK1_1	4	10	PF00069	0.571
MOD_CK1_1	64	70	PF00069	0.651
MOD_CK2_1	155	161	PF00069	0.630
MOD_CK2_1	35	41	PF00069	0.527
MOD_CK2_1	60	66	PF00069	0.595
MOD_GlcNHglycan	58	61	PF01048	0.549
MOD_GlcNHglycan	94	97	PF01048	0.429
MOD_GSK3_1	121	128	PF00069	0.600
MOD_GSK3_1	56	63	PF00069	0.602
MOD_N-GLC_1	73	78	PF02516	0.535
MOD_NEK2_1	1	6	PF00069	0.573
MOD_PIKK_1	1	7	PF00454	0.540
MOD_PIKK_1	35	41	PF00454	0.420
MOD_PKA_2	92	98	PF00069	0.645
MOD_PKB_1	142	150	PF00069	0.603
MOD_Plk_1	27	33	PF00069	0.624
MOD_Plk_4	144	150	PF00069	0.525
MOD_ProDKin_1	61	67	PF00069	0.552
MOD_SUMO_rev_2	119	129	PF00179	0.593
TRG_DiLeu_BaEn_1	46	51	PF01217	0.601
TRG_DiLeu_BaEn_4	27	33	PF01217	0.650
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.630
TRG_ENDOCYTIC_2	100	103	PF00928	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I131	Leptomonas seymouri	73%	100%
A0A0S4JW42	Bodo saltans	32%	92%
A0A1X0P944	Trypanosomatidae	43%	99%
A0A3S7X2Q8	Leishmania donovani	84%	100%
A0A422MX53	Trypanosoma rangeli	48%	99%
A4I4U8	Leishmania infantum	84%	100%
C9ZLJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AE96	Leishmania major	82%	100%
E9ALJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q8LC68	Arabidopsis thaliana	26%	72%
Q9CA59	Arabidopsis thaliana	26%	72%