Helo_like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHN2_LEIBR

TriTrypDb:

LbrM.29.2300 , LBRM2903_290029800

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.491
CLV_NRD_NRD_1	229	231	PF00675	0.602
CLV_NRD_NRD_1	301	303	PF00675	0.570
CLV_NRD_NRD_1	372	374	PF00675	0.545
CLV_NRD_NRD_1	70	72	PF00675	0.466
CLV_PCSK_KEX2_1	187	189	PF00082	0.504
CLV_PCSK_KEX2_1	300	302	PF00082	0.545
CLV_PCSK_KEX2_1	372	374	PF00082	0.545
CLV_PCSK_KEX2_1	61	63	PF00082	0.507
CLV_PCSK_KEX2_1	70	72	PF00082	0.405
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.573
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.559
CLV_PCSK_SKI1_1	301	305	PF00082	0.608
CLV_PCSK_SKI1_1	323	327	PF00082	0.519
CLV_PCSK_SKI1_1	71	75	PF00082	0.485
DEG_APCC_DBOX_1	40	48	PF00400	0.418
DEG_APCC_DBOX_1	69	77	PF00400	0.468
DEG_APCC_KENBOX_2	192	196	PF00400	0.596
DEG_COP1_1	342	350	PF00400	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.489
DOC_CYCLIN_RxL_1	68	78	PF00134	0.546
DOC_MAPK_gen_1	203	213	PF00069	0.539
DOC_MAPK_gen_1	70	76	PF00069	0.517
DOC_MAPK_MEF2A_6	206	213	PF00069	0.494
DOC_USP7_MATH_1	333	337	PF00917	0.706
DOC_USP7_MATH_1	352	356	PF00917	0.766
DOC_USP7_MATH_1	9	13	PF00917	0.419
DOC_USP7_UBL2_3	287	291	PF12436	0.565
DOC_WW_Pin1_4	329	334	PF00397	0.711
DOC_WW_Pin1_4	346	351	PF00397	0.572
DOC_WW_Pin1_4	362	367	PF00397	0.664
LIG_14-3-3_CanoR_1	308	315	PF00244	0.624
LIG_14-3-3_CanoR_1	41	45	PF00244	0.572
LIG_14-3-3_CanoR_1	96	102	PF00244	0.312
LIG_Actin_WH2_2	126	143	PF00022	0.420
LIG_BRCT_BRCA1_1	257	261	PF00533	0.449
LIG_BRCT_BRCA1_1	63	67	PF00533	0.473
LIG_Clathr_ClatBox_1	98	102	PF01394	0.518
LIG_FHA_1	1	7	PF00498	0.648
LIG_FHA_1	147	153	PF00498	0.488
LIG_FHA_1	156	162	PF00498	0.464
LIG_FHA_1	241	247	PF00498	0.332
LIG_FHA_1	310	316	PF00498	0.589
LIG_FHA_1	37	43	PF00498	0.625
LIG_FHA_1	85	91	PF00498	0.496
LIG_FHA_2	151	157	PF00498	0.495
LIG_FHA_2	179	185	PF00498	0.457
LIG_FHA_2	20	26	PF00498	0.639
LIG_FHA_2	202	208	PF00498	0.640
LIG_FHA_2	52	58	PF00498	0.601
LIG_FXI_DFP_1	180	184	PF00024	0.567
LIG_LIR_Gen_1	127	136	PF02991	0.461
LIG_LIR_Nem_3	127	133	PF02991	0.398
LIG_LIR_Nem_3	46	51	PF02991	0.600
LIG_LIR_Nem_3	78	83	PF02991	0.414
LIG_SH2_SRC	232	235	PF00017	0.546
LIG_SH2_STAT5	18	21	PF00017	0.589
LIG_SH2_STAT5	218	221	PF00017	0.522
LIG_SH2_STAT5	232	235	PF00017	0.546
LIG_SH3_3	344	350	PF00018	0.765
LIG_SUMO_SIM_par_1	97	102	PF11976	0.523
LIG_UBA3_1	268	277	PF00899	0.558
LIG_UBA3_1	283	291	PF00899	0.490
MOD_CK1_1	150	156	PF00069	0.549
MOD_CK1_1	202	208	PF00069	0.534
MOD_CK1_1	250	256	PF00069	0.421
MOD_CK1_1	270	276	PF00069	0.226
MOD_CK1_1	337	343	PF00069	0.690
MOD_CK1_1	43	49	PF00069	0.540
MOD_CK2_1	201	207	PF00069	0.652
MOD_CK2_1	357	363	PF00069	0.768
MOD_CK2_1	51	57	PF00069	0.540
MOD_CK2_1	9	15	PF00069	0.544
MOD_Cter_Amidation	228	231	PF01082	0.561
MOD_GlcNHglycan	119	123	PF01048	0.627
MOD_GlcNHglycan	271	275	PF01048	0.512
MOD_GlcNHglycan	329	332	PF01048	0.718
MOD_GlcNHglycan	359	362	PF01048	0.813
MOD_GlcNHglycan	63	66	PF01048	0.491
MOD_GSK3_1	146	153	PF00069	0.442
MOD_GSK3_1	16	23	PF00069	0.653
MOD_GSK3_1	250	257	PF00069	0.439
MOD_GSK3_1	286	293	PF00069	0.558
MOD_GSK3_1	315	322	PF00069	0.667
MOD_GSK3_1	323	330	PF00069	0.448
MOD_GSK3_1	333	340	PF00069	0.633
MOD_GSK3_1	342	349	PF00069	0.608
MOD_GSK3_1	36	43	PF00069	0.323
MOD_N-GLC_1	342	347	PF02516	0.637
MOD_NEK2_1	147	152	PF00069	0.473
MOD_NEK2_1	16	21	PF00069	0.574
MOD_NEK2_1	201	206	PF00069	0.523
MOD_NEK2_1	240	245	PF00069	0.476
MOD_NEK2_1	247	252	PF00069	0.413
MOD_NEK2_1	272	277	PF00069	0.450
MOD_NEK2_1	36	41	PF00069	0.317
MOD_NEK2_2	9	14	PF00069	0.417
MOD_PIKK_1	286	292	PF00454	0.575
MOD_PIKK_1	352	358	PF00454	0.623
MOD_PKA_1	61	67	PF00069	0.426
MOD_PKA_2	202	208	PF00069	0.633
MOD_PKA_2	307	313	PF00069	0.572
MOD_PKA_2	40	46	PF00069	0.412
MOD_PKA_2	61	67	PF00069	0.410
MOD_Plk_1	118	124	PF00069	0.407
MOD_Plk_1	247	253	PF00069	0.477
MOD_Plk_1	342	348	PF00069	0.671
MOD_Plk_4	342	348	PF00069	0.714
MOD_Plk_4	40	46	PF00069	0.539
MOD_ProDKin_1	329	335	PF00069	0.711
MOD_ProDKin_1	346	352	PF00069	0.570
MOD_ProDKin_1	362	368	PF00069	0.664
TRG_DiLeu_BaEn_3	298	304	PF01217	0.661
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.449
TRG_ER_diArg_1	187	189	PF00400	0.556
TRG_ER_diArg_1	301	303	PF00400	0.553
TRG_ER_diArg_1	372	374	PF00400	0.545
TRG_NES_CRM1_1	88	102	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR2	Leptomonas seymouri	51%	98%
A0A0S4K0W0	Bodo saltans	24%	82%
A0A1X0P9E6	Trypanosomatidae	29%	100%
A0A3R7JW64	Trypanosoma rangeli	31%	100%
A0A3S7X2T0	Leishmania donovani	70%	100%
A4I4U7	Leishmania infantum	70%	100%
E9AE95	Leishmania major	71%	100%
E9ALJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
V5BSJ0	Trypanosoma cruzi	28%	100%