Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHM9_LEIBR

TriTrypDb:

LbrM.29.2270 , LBRM2903_290029500

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0008270	zinc ion binding	6	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	685	689	PF00656	0.365
CLV_NRD_NRD_1	547	549	PF00675	0.341
CLV_NRD_NRD_1	748	750	PF00675	0.407
CLV_PCSK_KEX2_1	547	549	PF00082	0.341
CLV_PCSK_SKI1_1	266	270	PF00082	0.475
CLV_PCSK_SKI1_1	329	333	PF00082	0.321
CLV_PCSK_SKI1_1	381	385	PF00082	0.315
CLV_PCSK_SKI1_1	508	512	PF00082	0.216
CLV_PCSK_SKI1_1	63	67	PF00082	0.216
CLV_PCSK_SKI1_1	631	635	PF00082	0.314
CLV_PCSK_SKI1_1	675	679	PF00082	0.445
CLV_PCSK_SKI1_1	684	688	PF00082	0.409
CLV_PCSK_SKI1_1	722	726	PF00082	0.327
DOC_CDC14_PxL_1	115	123	PF14671	0.528
DOC_CKS1_1	670	675	PF01111	0.216
DOC_CYCLIN_RxL_1	716	729	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.296
DOC_MAPK_FxFP_2	330	333	PF00069	0.281
DOC_MAPK_gen_1	462	470	PF00069	0.322
DOC_MAPK_gen_1	559	567	PF00069	0.300
DOC_MAPK_MEF2A_6	462	470	PF00069	0.382
DOC_MAPK_MEF2A_6	559	567	PF00069	0.233
DOC_PP1_RVXF_1	720	727	PF00149	0.327
DOC_PP2B_LxvP_1	466	469	PF13499	0.296
DOC_PP4_FxxP_1	330	333	PF00568	0.281
DOC_PP4_FxxP_1	649	652	PF00568	0.387
DOC_USP7_MATH_1	137	141	PF00917	0.629
DOC_USP7_MATH_1	290	294	PF00917	0.534
DOC_USP7_MATH_1	333	337	PF00917	0.405
DOC_USP7_MATH_1	482	486	PF00917	0.469
DOC_USP7_MATH_1	499	503	PF00917	0.220
DOC_USP7_MATH_1	589	593	PF00917	0.416
DOC_USP7_MATH_1	616	620	PF00917	0.508
DOC_USP7_MATH_1	663	667	PF00917	0.275
DOC_USP7_UBL2_3	265	269	PF12436	0.503
DOC_USP7_UBL2_3	385	389	PF12436	0.322
DOC_WW_Pin1_4	162	167	PF00397	0.413
DOC_WW_Pin1_4	18	23	PF00397	0.540
DOC_WW_Pin1_4	292	297	PF00397	0.445
DOC_WW_Pin1_4	334	339	PF00397	0.451
DOC_WW_Pin1_4	669	674	PF00397	0.291
LIG_14-3-3_CanoR_1	455	461	PF00244	0.364
LIG_14-3-3_CanoR_1	498	504	PF00244	0.301
LIG_14-3-3_CanoR_1	508	513	PF00244	0.293
LIG_14-3-3_CanoR_1	534	539	PF00244	0.353
LIG_14-3-3_CanoR_1	547	551	PF00244	0.438
LIG_14-3-3_CanoR_1	675	683	PF00244	0.376
LIG_14-3-3_CterR_2	749	751	PF00244	0.413
LIG_APCC_ABBA_1	26	31	PF00400	0.216
LIG_APCC_ABBA_1	561	566	PF00400	0.227
LIG_APCC_ABBAyCdc20_2	560	566	PF00400	0.217
LIG_APCC_ABBAyCdc20_2	722	728	PF00400	0.327
LIG_BRCT_BRCA1_1	278	282	PF00533	0.495
LIG_BRCT_BRCA1_1	363	367	PF00533	0.308
LIG_Clathr_ClatBox_1	157	161	PF01394	0.411
LIG_FHA_1	353	359	PF00498	0.361
LIG_FHA_1	373	379	PF00498	0.394
LIG_FHA_1	694	700	PF00498	0.412
LIG_FHA_1	83	89	PF00498	0.671
LIG_FHA_2	171	177	PF00498	0.566
LIG_FHA_2	268	274	PF00498	0.480
LIG_FHA_2	547	553	PF00498	0.412
LIG_FHA_2	592	598	PF00498	0.349
LIG_FHA_2	64	70	PF00498	0.503
LIG_FHA_2	74	80	PF00498	0.420
LIG_KLC1_Yacidic_2	562	566	PF13176	0.216
LIG_LIR_Apic_2	646	652	PF02991	0.387
LIG_LIR_Gen_1	283	292	PF02991	0.441
LIG_LIR_Gen_1	44	51	PF02991	0.387
LIG_LIR_Gen_1	526	536	PF02991	0.216
LIG_LIR_Gen_1	562	571	PF02991	0.327
LIG_LIR_Gen_1	720	731	PF02991	0.339
LIG_LIR_Nem_3	235	239	PF02991	0.503
LIG_LIR_Nem_3	283	287	PF02991	0.410
LIG_LIR_Nem_3	404	408	PF02991	0.293
LIG_LIR_Nem_3	526	532	PF02991	0.361
LIG_LIR_Nem_3	537	541	PF02991	0.239
LIG_LIR_Nem_3	549	553	PF02991	0.233
LIG_LIR_Nem_3	562	567	PF02991	0.327
LIG_LIR_Nem_3	574	579	PF02991	0.327
LIG_LIR_Nem_3	720	726	PF02991	0.339
LIG_LIR_Nem_3	90	96	PF02991	0.727
LIG_NRBOX	405	411	PF00104	0.387
LIG_Pex14_2	327	331	PF04695	0.293
LIG_Pex14_2	383	387	PF04695	0.217
LIG_PTB_Apo_2	307	314	PF02174	0.293
LIG_PTB_Apo_2	733	740	PF02174	0.387
LIG_PTB_Phospho_1	307	313	PF10480	0.293
LIG_REV1ctd_RIR_1	744	751	PF16727	0.492
LIG_SH2_CRK	529	533	PF00017	0.216
LIG_SH2_CRK	576	580	PF00017	0.216
LIG_SH2_CRK	632	636	PF00017	0.352
LIG_SH2_CRK	74	78	PF00017	0.498
LIG_SH2_NCK_1	529	533	PF00017	0.438
LIG_SH2_NCK_1	632	636	PF00017	0.216
LIG_SH2_PTP2	416	419	PF00017	0.227
LIG_SH2_PTP2	564	567	PF00017	0.438
LIG_SH2_SRC	276	279	PF00017	0.547
LIG_SH2_SRC	564	567	PF00017	0.438
LIG_SH2_STAP1	102	106	PF00017	0.358
LIG_SH2_STAP1	278	282	PF00017	0.495
LIG_SH2_STAP1	693	697	PF00017	0.358
LIG_SH2_STAT3	278	281	PF00017	0.487
LIG_SH2_STAT3	745	748	PF00017	0.470
LIG_SH2_STAT5	237	240	PF00017	0.458
LIG_SH2_STAT5	313	316	PF00017	0.412
LIG_SH2_STAT5	348	351	PF00017	0.265
LIG_SH2_STAT5	35	38	PF00017	0.294
LIG_SH2_STAT5	405	408	PF00017	0.310
LIG_SH2_STAT5	416	419	PF00017	0.303
LIG_SH2_STAT5	458	461	PF00017	0.327
LIG_SH2_STAT5	47	50	PF00017	0.293
LIG_SH2_STAT5	550	553	PF00017	0.403
LIG_SH2_STAT5	564	567	PF00017	0.391
LIG_SH2_STAT5	647	650	PF00017	0.308
LIG_SH2_STAT5	711	714	PF00017	0.293
LIG_SH2_STAT5	74	77	PF00017	0.422
LIG_SH2_STAT5	745	748	PF00017	0.325
LIG_SH2_STAT5	93	96	PF00017	0.726
LIG_SH3_3	149	155	PF00018	0.475
LIG_SH3_3	166	172	PF00018	0.506
LIG_SH3_3	430	436	PF00018	0.394
LIG_SH3_3	468	474	PF00018	0.312
LIG_SH3_3	562	568	PF00018	0.327
LIG_SH3_3	583	589	PF00018	0.308
LIG_SH3_3	602	608	PF00018	0.406
LIG_SH3_3	677	683	PF00018	0.398
LIG_SH3_3	93	99	PF00018	0.604
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.387
LIG_SUMO_SIM_par_1	488	493	PF11976	0.216
LIG_SUMO_SIM_par_1	616	622	PF11976	0.438
LIG_TRAF2_1	608	611	PF00917	0.438
LIG_TRAF2_2	608	613	PF00917	0.358
LIG_TYR_ITIM	527	532	PF00017	0.259
LIG_TYR_ITIM	72	77	PF00017	0.289
LIG_TYR_ITIM	91	96	PF00017	0.713
MOD_CDK_SPxK_1	669	675	PF00069	0.347
MOD_CK1_1	530	536	PF00069	0.273
MOD_CK1_1	591	597	PF00069	0.384
MOD_CK1_1	619	625	PF00069	0.465
MOD_CK1_1	705	711	PF00069	0.308
MOD_CK2_1	267	273	PF00069	0.481
MOD_CK2_1	482	488	PF00069	0.316
MOD_CK2_1	591	597	PF00069	0.346
MOD_CK2_1	63	69	PF00069	0.503
MOD_CK2_1	73	79	PF00069	0.372
MOD_GlcNHglycan	126	129	PF01048	0.503
MOD_GlcNHglycan	16	19	PF01048	0.498
MOD_GlcNHglycan	178	181	PF01048	0.427
MOD_GlcNHglycan	363	366	PF01048	0.295
MOD_GlcNHglycan	423	426	PF01048	0.440
MOD_GlcNHglycan	591	594	PF01048	0.415
MOD_GlcNHglycan	684	687	PF01048	0.269
MOD_GlcNHglycan	704	707	PF01048	0.326
MOD_GSK3_1	14	21	PF00069	0.575
MOD_GSK3_1	260	267	PF00069	0.455
MOD_GSK3_1	290	297	PF00069	0.611
MOD_GSK3_1	361	368	PF00069	0.335
MOD_GSK3_1	508	515	PF00069	0.261
MOD_GSK3_1	523	530	PF00069	0.313
MOD_GSK3_1	588	595	PF00069	0.308
MOD_GSK3_1	63	70	PF00069	0.267
MOD_GSK3_1	671	678	PF00069	0.405
MOD_GSK3_1	689	696	PF00069	0.235
MOD_N-GLC_1	14	19	PF02516	0.514
MOD_N-GLC_1	421	426	PF02516	0.343
MOD_N-GLC_2	310	312	PF02516	0.293
MOD_NEK2_1	191	196	PF00069	0.464
MOD_NEK2_1	374	379	PF00069	0.265
MOD_NEK2_1	634	639	PF00069	0.294
MOD_NEK2_1	702	707	PF00069	0.352
MOD_NEK2_1	73	78	PF00069	0.544
MOD_NEK2_2	24	29	PF00069	0.428
MOD_OFUCOSY	33	40	PF10250	0.308
MOD_OFUCOSY	343	350	PF10250	0.216
MOD_PIKK_1	277	283	PF00454	0.449
MOD_PIKK_1	731	737	PF00454	0.438
MOD_PKA_2	456	462	PF00069	0.347
MOD_PKA_2	499	505	PF00069	0.352
MOD_PKA_2	546	552	PF00069	0.438
MOD_Plk_1	14	20	PF00069	0.413
MOD_Plk_1	693	699	PF00069	0.289
MOD_Plk_4	313	319	PF00069	0.308
MOD_Plk_4	616	622	PF00069	0.358
MOD_ProDKin_1	162	168	PF00069	0.425
MOD_ProDKin_1	18	24	PF00069	0.551
MOD_ProDKin_1	292	298	PF00069	0.441
MOD_ProDKin_1	334	340	PF00069	0.451
MOD_ProDKin_1	669	675	PF00069	0.291
MOD_SUMO_rev_2	656	661	PF00179	0.358
MOD_SUMO_rev_2	84	91	PF00179	0.655
TRG_ENDOCYTIC_2	47	50	PF00928	0.438
TRG_ENDOCYTIC_2	529	532	PF00928	0.500
TRG_ENDOCYTIC_2	550	553	PF00928	0.438
TRG_ENDOCYTIC_2	564	567	PF00928	0.438
TRG_ENDOCYTIC_2	576	579	PF00928	0.438
TRG_ENDOCYTIC_2	632	635	PF00928	0.327
TRG_ENDOCYTIC_2	74	77	PF00928	0.373
TRG_ENDOCYTIC_2	93	96	PF00928	0.726
TRG_ER_diArg_1	455	458	PF00400	0.462
TRG_ER_diArg_1	497	500	PF00400	0.414
TRG_ER_diArg_1	546	548	PF00400	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C0	Leptomonas seymouri	72%	100%
A0A0S4IPD1	Bodo saltans	46%	100%
A0A1X0PA40	Trypanosomatidae	54%	100%
A0A3Q8IDW9	Leishmania donovani	84%	100%
A0A422NEJ9	Trypanosoma rangeli	57%	100%
A4I4U4	Leishmania infantum	84%	100%
C9ZLJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E1BMF7	Bos taurus	29%	87%
E1BY77	Gallus gallus	28%	87%
E9AE92	Leishmania major	83%	99%
E9ALJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
F1QFS9	Danio rerio	29%	87%
F6V6I0	Xenopus tropicalis	28%	89%
P0C8Z3	Bos taurus	23%	100%
P38237	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	96%
P45974	Homo sapiens	31%	88%
P54201	Dictyostelium discoideum	29%	90%
P56399	Mus musculus	31%	88%
Q11119	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	97%
Q5BKP2	Mus musculus	29%	88%
Q5R407	Pongo abelii	31%	88%
Q8L6Y1	Arabidopsis thaliana	30%	94%
Q92995	Homo sapiens	28%	87%
V5BC27	Trypanosoma cruzi	56%	100%