Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HHM8_LEIBR

TriTrypDb:

LbrM.29.2260 , LBRM2903_290029400

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.805
CLV_NRD_NRD_1	8	10	PF00675	0.679
CLV_PCSK_KEX2_1	8	10	PF00082	0.679
CLV_PCSK_SKI1_1	186	190	PF00082	0.834
DEG_APCC_DBOX_1	183	191	PF00400	0.831
DEG_Nend_Nbox_1	1	3	PF02207	0.757
DEG_SCF_FBW7_1	55	62	PF00400	0.829
DEG_SPOP_SBC_1	194	198	PF00917	0.567
DOC_CKS1_1	145	150	PF01111	0.775
DOC_CKS1_1	46	51	PF01111	0.812
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.807
DOC_PP4_FxxP_1	142	145	PF00568	0.765
DOC_USP7_MATH_1	14	18	PF00917	0.768
DOC_USP7_MATH_1	195	199	PF00917	0.704
DOC_USP7_MATH_1	216	220	PF00917	0.826
DOC_USP7_MATH_1	24	28	PF00917	0.733
DOC_USP7_MATH_1	273	277	PF00917	0.568
DOC_USP7_MATH_1	35	39	PF00917	0.675
DOC_USP7_MATH_1	50	54	PF00917	0.711
DOC_USP7_MATH_1	59	63	PF00917	0.733
DOC_USP7_MATH_1	98	102	PF00917	0.787
DOC_WW_Pin1_4	110	115	PF00397	0.587
DOC_WW_Pin1_4	144	149	PF00397	0.758
DOC_WW_Pin1_4	164	169	PF00397	0.483
DOC_WW_Pin1_4	177	182	PF00397	0.593
DOC_WW_Pin1_4	197	202	PF00397	0.470
DOC_WW_Pin1_4	231	236	PF00397	0.778
DOC_WW_Pin1_4	237	242	PF00397	0.712
DOC_WW_Pin1_4	257	262	PF00397	0.445
DOC_WW_Pin1_4	294	299	PF00397	0.754
DOC_WW_Pin1_4	45	50	PF00397	0.812
DOC_WW_Pin1_4	55	60	PF00397	0.632
LIG_BRCT_BRCA1_1	168	172	PF00533	0.824
LIG_BRCT_BRCA1_1	19	23	PF00533	0.790
LIG_BRCT_BRCA1_1	248	252	PF00533	0.751
LIG_FHA_1	152	158	PF00498	0.699
LIG_FHA_1	227	233	PF00498	0.808
LIG_IBAR_NPY_1	3	5	PF08397	0.754
LIG_LIR_Apic_2	140	145	PF02991	0.650
LIG_LIR_Gen_1	249	256	PF02991	0.742
LIG_LIR_Nem_3	129	135	PF02991	0.795
LIG_LIR_Nem_3	200	205	PF02991	0.736
LIG_LIR_Nem_3	249	255	PF02991	0.783
LIG_SH2_CRK	267	271	PF00017	0.533
LIG_SH2_NCK_1	25	29	PF00017	0.674
LIG_SH2_NCK_1	267	271	PF00017	0.533
LIG_SH2_PTP2	11	14	PF00017	0.515
LIG_SH2_PTP2	46	49	PF00017	0.694
LIG_SH2_SRC	11	14	PF00017	0.515
LIG_SH2_SRC	119	122	PF00017	0.800
LIG_SH2_STAT3	203	206	PF00017	0.810
LIG_SH2_STAT5	11	14	PF00017	0.599
LIG_SH2_STAT5	25	28	PF00017	0.544
LIG_SH2_STAT5	254	257	PF00017	0.671
LIG_SH2_STAT5	46	49	PF00017	0.704
LIG_SH3_1	267	273	PF00018	0.530
LIG_SH3_1	46	52	PF00018	0.770
LIG_SH3_2	4	9	PF14604	0.715
LIG_SH3_3	1	7	PF00018	0.709
LIG_SH3_3	142	148	PF00018	0.716
LIG_SH3_3	198	204	PF00018	0.720
LIG_SH3_3	266	272	PF00018	0.768
LIG_SH3_3	44	50	PF00018	0.800
LIG_SUMO_SIM_anti_2	100	106	PF11976	0.795
MOD_CDK_SPxxK_3	177	184	PF00069	0.780
MOD_CK1_1	100	106	PF00069	0.765
MOD_CK1_1	115	121	PF00069	0.713
MOD_CK1_1	122	128	PF00069	0.731
MOD_CK1_1	17	23	PF00069	0.725
MOD_CK1_1	219	225	PF00069	0.818
MOD_CK1_1	227	233	PF00069	0.677
MOD_CK1_1	240	246	PF00069	0.585
MOD_CK1_1	276	282	PF00069	0.716
MOD_CK1_1	292	298	PF00069	0.732
MOD_CK1_1	53	59	PF00069	0.767
MOD_CK1_1	62	68	PF00069	0.675
MOD_CK1_1	80	86	PF00069	0.654
MOD_CK2_1	290	296	PF00069	0.546
MOD_CK2_1	35	41	PF00069	0.586
MOD_CK2_1	61	67	PF00069	0.805
MOD_GlcNHglycan	17	20	PF01048	0.690
MOD_GlcNHglycan	190	193	PF01048	0.751
MOD_GlcNHglycan	218	221	PF01048	0.833
MOD_GlcNHglycan	226	229	PF01048	0.681
MOD_GlcNHglycan	248	251	PF01048	0.739
MOD_GlcNHglycan	257	260	PF01048	0.612
MOD_GlcNHglycan	26	29	PF01048	0.762
MOD_GlcNHglycan	292	295	PF01048	0.817
MOD_GlcNHglycan	55	58	PF01048	0.808
MOD_GlcNHglycan	59	62	PF01048	0.784
MOD_GlcNHglycan	77	80	PF01048	0.787
MOD_GSK3_1	108	115	PF00069	0.613
MOD_GSK3_1	119	126	PF00069	0.708
MOD_GSK3_1	140	147	PF00069	0.730
MOD_GSK3_1	15	22	PF00069	0.716
MOD_GSK3_1	166	173	PF00069	0.819
MOD_GSK3_1	193	200	PF00069	0.626
MOD_GSK3_1	204	211	PF00069	0.670
MOD_GSK3_1	227	234	PF00069	0.809
MOD_GSK3_1	236	243	PF00069	0.662
MOD_GSK3_1	24	31	PF00069	0.710
MOD_GSK3_1	286	293	PF00069	0.732
MOD_GSK3_1	53	60	PF00069	0.739
MOD_GSK3_1	73	80	PF00069	0.622
MOD_GSK3_1	84	91	PF00069	0.838
MOD_GSK3_1	94	101	PF00069	0.588
MOD_N-GLC_1	115	120	PF02516	0.809
MOD_N-GLC_1	126	131	PF02516	0.685
MOD_N-GLC_1	62	67	PF02516	0.676
MOD_NEK2_1	149	154	PF00069	0.752
MOD_NEK2_1	188	193	PF00069	0.611
MOD_NEK2_1	236	241	PF00069	0.690
MOD_NEK2_1	265	270	PF00069	0.744
MOD_NEK2_1	290	295	PF00069	0.804
MOD_NEK2_1	68	73	PF00069	0.817
MOD_NEK2_2	137	142	PF00069	0.543
MOD_PIKK_1	108	114	PF00454	0.540
MOD_PIKK_1	140	146	PF00454	0.694
MOD_PIKK_1	149	155	PF00454	0.682
MOD_PIKK_1	166	172	PF00454	0.720
MOD_PIKK_1	227	233	PF00454	0.808
MOD_PIKK_1	240	246	PF00454	0.585
MOD_PIKK_1	276	282	PF00454	0.736
MOD_PIKK_1	29	35	PF00454	0.586
MOD_PIKK_1	50	56	PF00454	0.703
MOD_PIKK_1	68	74	PF00454	0.818
MOD_PKA_2	122	128	PF00069	0.757
MOD_Plk_1	115	121	PF00069	0.809
MOD_Plk_1	29	35	PF00069	0.586
MOD_Plk_4	100	106	PF00069	0.775
MOD_Plk_4	137	143	PF00069	0.543
MOD_Plk_4	286	292	PF00069	0.585
MOD_ProDKin_1	110	116	PF00069	0.590
MOD_ProDKin_1	144	150	PF00069	0.758
MOD_ProDKin_1	164	170	PF00069	0.484
MOD_ProDKin_1	177	183	PF00069	0.591
MOD_ProDKin_1	197	203	PF00069	0.475
MOD_ProDKin_1	231	237	PF00069	0.781
MOD_ProDKin_1	257	263	PF00069	0.773
MOD_ProDKin_1	294	300	PF00069	0.756
MOD_ProDKin_1	45	51	PF00069	0.813
MOD_ProDKin_1	55	61	PF00069	0.632
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.780
TRG_ER_diArg_1	184	187	PF00400	0.841
TRG_ER_diArg_1	7	9	PF00400	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C9	Leptomonas seymouri	31%	73%
A0A3S7X2N6	Leishmania donovani	81%	74%
A4I4U3	Leishmania infantum	82%	74%
E9AE91	Leishmania major	81%	100%
E9ALJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	74%