LeishMANIAdb
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PlsC domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PlsC domain-containing protein
Gene product:
acyltransferase, putative
Species:
Leishmania braziliensis
UniProt:
A4HHM7_LEIBR
TriTrypDb:
LbrM.29.2250 , LBRM2903_290029300
Length:
306

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 28
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 23
GO:0110165 cellular anatomical entity 1 23

Expansion

Sequence features

A4HHM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM7

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 4
GO:0006644 phospholipid metabolic process 4 4
GO:0006650 glycerophospholipid metabolic process 5 4
GO:0006654 phosphatidic acid biosynthetic process 6 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0008152 metabolic process 1 4
GO:0008610 lipid biosynthetic process 4 4
GO:0008654 phospholipid biosynthetic process 5 4
GO:0009058 biosynthetic process 2 4
GO:0009987 cellular process 1 4
GO:0019637 organophosphate metabolic process 3 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044255 cellular lipid metabolic process 3 4
GO:0045017 glycerolipid biosynthetic process 4 4
GO:0046473 phosphatidic acid metabolic process 6 4
GO:0046474 glycerophospholipid biosynthetic process 5 4
GO:0046486 glycerolipid metabolic process 4 4
GO:0071704 organic substance metabolic process 2 4
GO:0090407 organophosphate biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 29
GO:0016740 transferase activity 2 29
GO:0016746 acyltransferase activity 3 29
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 4
GO:0008374 O-acyltransferase activity 5 4
GO:0016411 acylglycerol O-acyltransferase activity 6 4
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 4
GO:0042171 lysophosphatidic acid acyltransferase activity 6 4
GO:0071617 lysophospholipid acyltransferase activity 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 265 269 PF00656 0.286
CLV_NRD_NRD_1 22 24 PF00675 0.304
CLV_PCSK_FUR_1 291 295 PF00082 0.624
CLV_PCSK_KEX2_1 293 295 PF00082 0.567
CLV_PCSK_PC1ET2_1 293 295 PF00082 0.580
CLV_PCSK_SKI1_1 286 290 PF00082 0.515
DEG_Nend_UBRbox_4 1 3 PF02207 0.262
DOC_MAPK_DCC_7 21 30 PF00069 0.544
DOC_MAPK_gen_1 18 27 PF00069 0.361
DOC_MAPK_MEF2A_6 139 147 PF00069 0.313
DOC_MAPK_MEF2A_6 21 30 PF00069 0.498
DOC_MAPK_MEF2A_6 83 91 PF00069 0.306
DOC_MAPK_RevD_3 10 24 PF00069 0.205
DOC_PP2B_LxvP_1 143 146 PF13499 0.328
DOC_PP2B_PxIxI_1 86 92 PF00149 0.261
DOC_PP4_FxxP_1 84 87 PF00568 0.249
DOC_USP7_MATH_1 138 142 PF00917 0.201
DOC_USP7_UBL2_3 135 139 PF12436 0.226
DOC_USP7_UBL2_3 282 286 PF12436 0.448
DOC_USP7_UBL2_3 293 297 PF12436 0.268
DOC_WW_Pin1_4 202 207 PF00397 0.280
DOC_WW_Pin1_4 237 242 PF00397 0.290
DOC_WW_Pin1_4 83 88 PF00397 0.243
LIG_14-3-3_CanoR_1 31 37 PF00244 0.461
LIG_APCC_ABBA_1 194 199 PF00400 0.284
LIG_APCC_ABBA_1 301 306 PF00400 0.300
LIG_CSL_BTD_1 238 241 PF09270 0.359
LIG_FHA_1 203 209 PF00498 0.316
LIG_FHA_1 33 39 PF00498 0.307
LIG_FHA_1 68 74 PF00498 0.281
LIG_GBD_Chelix_1 272 280 PF00786 0.547
LIG_LIR_Gen_1 114 123 PF02991 0.263
LIG_LIR_Gen_1 216 225 PF02991 0.266
LIG_LIR_Gen_1 252 262 PF02991 0.350
LIG_LIR_Gen_1 35 44 PF02991 0.405
LIG_LIR_Gen_1 5 13 PF02991 0.435
LIG_LIR_Nem_3 114 120 PF02991 0.284
LIG_LIR_Nem_3 216 220 PF02991 0.280
LIG_LIR_Nem_3 252 257 PF02991 0.332
LIG_LIR_Nem_3 35 39 PF02991 0.399
LIG_LIR_Nem_3 5 9 PF02991 0.454
LIG_Pex14_1 124 128 PF04695 0.329
LIG_Pex14_2 158 162 PF04695 0.290
LIG_SH2_PTP2 254 257 PF00017 0.378
LIG_SH2_SRC 254 257 PF00017 0.326
LIG_SH2_STAP1 260 264 PF00017 0.247
LIG_SH2_STAT5 130 133 PF00017 0.271
LIG_SH2_STAT5 229 232 PF00017 0.285
LIG_SH2_STAT5 254 257 PF00017 0.299
LIG_SH3_1 244 250 PF00018 0.331
LIG_SH3_3 235 241 PF00018 0.287
LIG_SH3_3 244 250 PF00018 0.306
LIG_SUMO_SIM_par_1 59 65 PF11976 0.226
LIG_UBA3_1 287 293 PF00899 0.379
LIG_WRC_WIRS_1 214 219 PF05994 0.283
LIG_WRC_WIRS_1 75 80 PF05994 0.302
LIG_WRPW_2 296 299 PF00400 0.365
MOD_CDK_SPxxK_3 237 244 PF00069 0.303
MOD_CDK_SPxxK_3 83 90 PF00069 0.290
MOD_CK1_1 101 107 PF00069 0.307
MOD_CK1_1 216 222 PF00069 0.303
MOD_CK1_1 271 277 PF00069 0.383
MOD_GlcNHglycan 273 276 PF01048 0.581
MOD_GSK3_1 112 119 PF00069 0.271
MOD_GSK3_1 161 168 PF00069 0.254
MOD_GSK3_1 186 193 PF00069 0.376
MOD_GSK3_1 94 101 PF00069 0.348
MOD_N-GLC_1 202 207 PF02516 0.466
MOD_NEK2_1 111 116 PF00069 0.258
MOD_NEK2_1 147 152 PF00069 0.292
MOD_NEK2_1 98 103 PF00069 0.400
MOD_NEK2_2 112 117 PF00069 0.266
MOD_Plk_1 165 171 PF00069 0.206
MOD_Plk_4 112 118 PF00069 0.273
MOD_Plk_4 138 144 PF00069 0.235
MOD_Plk_4 147 153 PF00069 0.261
MOD_Plk_4 2 8 PF00069 0.475
MOD_Plk_4 216 222 PF00069 0.320
MOD_Plk_4 42 48 PF00069 0.336
MOD_Plk_4 94 100 PF00069 0.392
MOD_ProDKin_1 202 208 PF00069 0.280
MOD_ProDKin_1 237 243 PF00069 0.293
MOD_ProDKin_1 83 89 PF00069 0.240
TRG_DiLeu_BaEn_1 56 61 PF01217 0.224
TRG_DiLeu_BaLyEn_6 15 20 PF01217 0.215
TRG_DiLeu_BaLyEn_6 23 28 PF01217 0.453
TRG_ENDOCYTIC_2 13 16 PF00928 0.368
TRG_ENDOCYTIC_2 228 231 PF00928 0.274
TRG_ENDOCYTIC_2 254 257 PF00928 0.310
TRG_NES_CRM1_1 278 292 PF08389 0.343
TRG_Pf-PMV_PEXEL_1 18 22 PF00026 0.314

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P455 Leptomonas seymouri 33% 90%
A0A0N1HTP4 Leptomonas seymouri 33% 100%
A0A0N1I6V1 Leptomonas seymouri 52% 100%
A0A0N1IKX5 Leptomonas seymouri 69% 100%
A0A0S4IQ05 Bodo saltans 43% 90%
A0A0S4IR22 Bodo saltans 36% 100%
A0A0S4JRB2 Bodo saltans 37% 96%
A0A1X0P9F0 Trypanosomatidae 45% 100%
A0A3R7NKA0 Trypanosoma rangeli 44% 100%
A0A3S5H5E4 Leishmania donovani 32% 71%
A0A3S5H7L8 Leishmania donovani 71% 94%
A0A3S7WNW6 Leishmania donovani 33% 86%
A4H418 Leishmania braziliensis 40% 100%
A4H419 Leishmania braziliensis 35% 100%
A4H420 Leishmania braziliensis 34% 100%
A4HSA1 Leishmania infantum 32% 99%
A4HSA2 Leishmania infantum 33% 86%
A4I4U1 Leishmania infantum 48% 94%
A4I4U2 Leishmania infantum 75% 100%
C9ZLI8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AE89 Leishmania major 50% 100%
E9AE90 Leishmania major 74% 100%
E9AK86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9ALJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 99%
Q9NF90 Leishmania major 33% 100%
Q9NF91 Leishmania major 33% 100%
V5C201 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS