DNA replication complex GINS protein SLD5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication complex GINS protein SLD5, putative

Species:

Leishmania braziliensis

UniProt:

A4HHM6_LEIBR

TriTrypDb:

LbrM.29.2240 , LBRM2903_290029200

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HHM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006261	DNA-templated DNA replication	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.326
CLV_PCSK_SKI1_1	129	133	PF00082	0.561
CLV_PCSK_SKI1_1	164	168	PF00082	0.374
CLV_Separin_Metazoa	153	157	PF03568	0.293
DEG_APCC_DBOX_1	155	163	PF00400	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_SCF_FBW7_1	54	61	PF00400	0.566
DOC_CKS1_1	301	306	PF01111	0.517
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.368
DOC_MAPK_MEF2A_6	135	144	PF00069	0.392
DOC_PP1_RVXF_1	144	150	PF00149	0.405
DOC_PP4_FxxP_1	301	304	PF00568	0.414
DOC_USP7_MATH_1	127	131	PF00917	0.512
DOC_USP7_MATH_1	176	180	PF00917	0.550
DOC_USP7_MATH_1	251	255	PF00917	0.489
DOC_USP7_MATH_1	58	62	PF00917	0.481
DOC_WW_Pin1_4	213	218	PF00397	0.385
DOC_WW_Pin1_4	300	305	PF00397	0.517
DOC_WW_Pin1_4	36	41	PF00397	0.464
DOC_WW_Pin1_4	54	59	PF00397	0.418
DOC_WW_Pin1_4	87	92	PF00397	0.476
LIG_14-3-3_CanoR_1	164	171	PF00244	0.477
LIG_14-3-3_CanoR_1	225	235	PF00244	0.435
LIG_Actin_WH2_2	144	162	PF00022	0.326
LIG_Actin_WH2_2	277	295	PF00022	0.356
LIG_FHA_1	190	196	PF00498	0.438
LIG_FHA_1	199	205	PF00498	0.356
LIG_FHA_1	46	52	PF00498	0.601
LIG_FHA_1	55	61	PF00498	0.715
LIG_FHA_2	82	88	PF00498	0.370
LIG_FHA_2	9	15	PF00498	0.518
LIG_LIR_Apic_2	299	304	PF02991	0.414
LIG_LIR_Nem_3	10	16	PF02991	0.616
LIG_LIR_Nem_3	168	174	PF02991	0.372
LIG_LIR_Nem_3	303	308	PF02991	0.480
LIG_NRBOX	150	156	PF00104	0.314
LIG_PCNA_yPIPBox_3	110	119	PF02747	0.440
LIG_SH2_STAT5	270	273	PF00017	0.443
LIG_SH2_STAT5	311	314	PF00017	0.448
LIG_SH3_3	130	136	PF00018	0.410
LIG_SH3_3	204	210	PF00018	0.471
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.457
LIG_TYR_ITIM	169	174	PF00017	0.376
LIG_WRPW_2	308	311	PF00400	0.425
MOD_CDK_SPK_2	213	218	PF00069	0.385
MOD_CDK_SPxK_1	300	306	PF00069	0.356
MOD_CK1_1	196	202	PF00069	0.683
MOD_CK1_1	28	34	PF00069	0.721
MOD_CK1_1	36	42	PF00069	0.719
MOD_CK2_1	213	219	PF00069	0.349
MOD_CK2_1	251	257	PF00069	0.504
MOD_CK2_1	8	14	PF00069	0.453
MOD_CK2_1	81	87	PF00069	0.390
MOD_GlcNHglycan	196	199	PF01048	0.673
MOD_GlcNHglycan	228	231	PF01048	0.463
MOD_GlcNHglycan	236	239	PF01048	0.396
MOD_GlcNHglycan	313	316	PF01048	0.317
MOD_GlcNHglycan	36	39	PF01048	0.671
MOD_GlcNHglycan	60	63	PF01048	0.573
MOD_GlcNHglycan	70	73	PF01048	0.452
MOD_GlcNHglycan	98	101	PF01048	0.316
MOD_GSK3_1	189	196	PF00069	0.619
MOD_GSK3_1	226	233	PF00069	0.492
MOD_GSK3_1	234	241	PF00069	0.502
MOD_GSK3_1	34	41	PF00069	0.638
MOD_GSK3_1	52	59	PF00069	0.570
MOD_GSK3_1	66	73	PF00069	0.486
MOD_GSK3_1	96	103	PF00069	0.492
MOD_N-GLC_1	213	218	PF02516	0.499
MOD_N-GLC_1	45	50	PF02516	0.453
MOD_N-GLC_1	7	12	PF02516	0.601
MOD_NEK2_1	165	170	PF00069	0.323
MOD_NEK2_1	226	231	PF00069	0.413
MOD_NEK2_1	234	239	PF00069	0.347
MOD_NEK2_1	81	86	PF00069	0.264
MOD_PIKK_1	25	31	PF00454	0.694
MOD_PIKK_1	66	72	PF00454	0.591
MOD_Plk_1	45	51	PF00069	0.693
MOD_Plk_4	100	106	PF00069	0.406
MOD_Plk_4	114	120	PF00069	0.476
MOD_Plk_4	165	171	PF00069	0.356
MOD_Plk_4	230	236	PF00069	0.393
MOD_ProDKin_1	213	219	PF00069	0.378
MOD_ProDKin_1	300	306	PF00069	0.517
MOD_ProDKin_1	36	42	PF00069	0.465
MOD_ProDKin_1	54	60	PF00069	0.415
MOD_ProDKin_1	87	93	PF00069	0.473
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.465
TRG_ENDOCYTIC_2	13	16	PF00928	0.624
TRG_ENDOCYTIC_2	171	174	PF00928	0.380
TRG_ENDOCYTIC_2	305	308	PF00928	0.414
TRG_ER_diArg_1	155	158	PF00400	0.293
TRG_NES_CRM1_1	266	278	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I580	Leptomonas seymouri	62%	100%
A0A0S4IV76	Bodo saltans	36%	100%
A0A1X0PA08	Trypanosomatidae	40%	100%
A0A3R7MDL7	Trypanosoma rangeli	46%	100%
A0A3S7X2T6	Leishmania donovani	80%	100%
A2VE40	Bos taurus	23%	100%
A4I4U0	Leishmania infantum	79%	100%
C9ZLI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AE88	Leishmania major	81%	100%
E9ALJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q753I0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
V5DTT2	Trypanosoma cruzi	46%	100%