Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHM5_LEIBR

TriTrypDb:

LbrM.29.2230 , LBRM2903_290029100

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.511
CLV_C14_Caspase3-7	325	329	PF00656	0.484
CLV_C14_Caspase3-7	531	535	PF00656	0.574
CLV_NRD_NRD_1	215	217	PF00675	0.628
CLV_NRD_NRD_1	67	69	PF00675	0.515
CLV_PCSK_KEX2_1	214	216	PF00082	0.492
CLV_PCSK_SKI1_1	206	210	PF00082	0.660
CLV_PCSK_SKI1_1	258	262	PF00082	0.625
CLV_PCSK_SKI1_1	271	275	PF00082	0.505
CLV_PCSK_SKI1_1	471	475	PF00082	0.709
CLV_PCSK_SKI1_1	533	537	PF00082	0.465
CLV_PCSK_SKI1_1	668	672	PF00082	0.497
CLV_PCSK_SKI1_1	68	72	PF00082	0.575
CLV_PCSK_SKI1_1	681	685	PF00082	0.490
CLV_Separin_Metazoa	357	361	PF03568	0.293
DEG_APCC_DBOX_1	369	377	PF00400	0.431
DEG_APCC_DBOX_1	532	540	PF00400	0.463
DEG_ODPH_VHL_1	465	476	PF01847	0.519
DEG_SPOP_SBC_1	466	470	PF00917	0.507
DOC_CYCLIN_RxL_1	268	278	PF00134	0.529
DOC_MAPK_gen_1	25	31	PF00069	0.498
DOC_MAPK_gen_1	316	323	PF00069	0.447
DOC_MAPK_MEF2A_6	370	377	PF00069	0.549
DOC_MAPK_NFAT4_5	370	378	PF00069	0.553
DOC_PP4_FxxP_1	476	479	PF00568	0.529
DOC_USP7_MATH_1	152	156	PF00917	0.555
DOC_USP7_MATH_1	395	399	PF00917	0.752
DOC_USP7_MATH_1	467	471	PF00917	0.610
DOC_USP7_MATH_1	547	551	PF00917	0.645
DOC_USP7_MATH_1	578	582	PF00917	0.692
DOC_USP7_MATH_1	601	605	PF00917	0.642
DOC_USP7_MATH_1	634	638	PF00917	0.660
DOC_USP7_MATH_1	683	687	PF00917	0.594
DOC_USP7_MATH_1	699	703	PF00917	0.651
DOC_USP7_MATH_1	704	708	PF00917	0.504
DOC_USP7_UBL2_3	158	162	PF12436	0.657
DOC_WW_Pin1_4	444	449	PF00397	0.623
DOC_WW_Pin1_4	475	480	PF00397	0.792
DOC_WW_Pin1_4	569	574	PF00397	0.754
DOC_WW_Pin1_4	581	586	PF00397	0.689
LIG_14-3-3_CanoR_1	140	146	PF00244	0.577
LIG_14-3-3_CanoR_1	178	182	PF00244	0.677
LIG_14-3-3_CanoR_1	258	264	PF00244	0.547
LIG_14-3-3_CanoR_1	275	280	PF00244	0.458
LIG_14-3-3_CanoR_1	293	297	PF00244	0.366
LIG_14-3-3_CanoR_1	305	309	PF00244	0.360
LIG_14-3-3_CanoR_1	360	369	PF00244	0.433
LIG_14-3-3_CanoR_1	507	516	PF00244	0.482
LIG_14-3-3_CanoR_1	579	585	PF00244	0.554
LIG_14-3-3_CanoR_1	61	67	PF00244	0.610
LIG_14-3-3_CanoR_1	633	639	PF00244	0.632
LIG_14-3-3_CanoR_1	668	675	PF00244	0.425
LIG_14-3-3_CanoR_1	68	74	PF00244	0.603
LIG_Actin_WH2_2	163	180	PF00022	0.612
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_CSL_BTD_1	231	234	PF09270	0.514
LIG_CtBP_PxDLS_1	486	490	PF00389	0.626
LIG_FHA_1	158	164	PF00498	0.614
LIG_FHA_1	226	232	PF00498	0.722
LIG_FHA_1	475	481	PF00498	0.771
LIG_FHA_1	51	57	PF00498	0.596
LIG_FHA_1	543	549	PF00498	0.479
LIG_FHA_1	670	676	PF00498	0.397
LIG_FHA_1	691	697	PF00498	0.617
LIG_FHA_2	145	151	PF00498	0.575
LIG_FHA_2	225	231	PF00498	0.756
LIG_FHA_2	293	299	PF00498	0.506
LIG_FHA_2	467	473	PF00498	0.765
LIG_FHA_2	656	662	PF00498	0.576
LIG_GBD_Chelix_1	280	288	PF00786	0.581
LIG_HCF-1_HBM_1	387	390	PF13415	0.365
LIG_LIR_Gen_1	425	433	PF02991	0.350
LIG_LIR_Gen_1	508	516	PF02991	0.506
LIG_LIR_Gen_1	619	628	PF02991	0.611
LIG_LIR_Gen_1	637	646	PF02991	0.614
LIG_LIR_Nem_3	363	368	PF02991	0.454
LIG_LIR_Nem_3	425	430	PF02991	0.347
LIG_LIR_Nem_3	508	513	PF02991	0.505
LIG_LIR_Nem_3	619	624	PF02991	0.636
LIG_MYND_1	238	242	PF01753	0.520
LIG_MYND_1	603	607	PF01753	0.519
LIG_NRBOX	319	325	PF00104	0.501
LIG_NRBOX	488	494	PF00104	0.631
LIG_Pex14_2	204	208	PF04695	0.521
LIG_SH2_CRK	427	431	PF00017	0.575
LIG_SH2_CRK	510	514	PF00017	0.348
LIG_SH2_STAP1	427	431	PF00017	0.575
LIG_SH2_STAP1	621	625	PF00017	0.582
LIG_SH2_STAP1	646	650	PF00017	0.406
LIG_SH2_STAT3	638	641	PF00017	0.551
LIG_SH2_STAT5	143	146	PF00017	0.566
LIG_SH2_STAT5	195	198	PF00017	0.607
LIG_SH2_STAT5	390	393	PF00017	0.598
LIG_SH2_STAT5	510	513	PF00017	0.343
LIG_SH2_STAT5	639	642	PF00017	0.581
LIG_SH3_1	214	220	PF00018	0.496
LIG_SH3_3	214	220	PF00018	0.679
LIG_SH3_3	228	234	PF00018	0.743
LIG_SH3_3	236	242	PF00018	0.706
LIG_SH3_3	572	578	PF00018	0.693
LIG_SUMO_SIM_anti_2	686	693	PF11976	0.582
LIG_SUMO_SIM_par_1	27	32	PF11976	0.495
LIG_SUMO_SIM_par_1	373	379	PF11976	0.456
LIG_SUMO_SIM_par_1	485	491	PF11976	0.483
LIG_SUMO_SIM_par_1	518	525	PF11976	0.510
LIG_SUMO_SIM_par_1	622	629	PF11976	0.670
LIG_TRAF2_1	3	6	PF00917	0.581
LIG_TRAF2_1	337	340	PF00917	0.734
LIG_TRAF2_1	494	497	PF00917	0.370
LIG_TRAF2_1	549	552	PF00917	0.674
MOD_CK1_1	102	108	PF00069	0.724
MOD_CK1_1	379	385	PF00069	0.409
MOD_CK1_1	389	395	PF00069	0.564
MOD_CK1_1	398	404	PF00069	0.783
MOD_CK1_1	50	56	PF00069	0.639
MOD_CK1_1	505	511	PF00069	0.585
MOD_CK1_1	581	587	PF00069	0.745
MOD_CK1_1	591	597	PF00069	0.717
MOD_CK1_1	637	643	PF00069	0.669
MOD_CK1_1	686	692	PF00069	0.603
MOD_CK1_1	82	88	PF00069	0.580
MOD_CK2_1	144	150	PF00069	0.501
MOD_CK2_1	224	230	PF00069	0.757
MOD_CK2_1	466	472	PF00069	0.750
MOD_CK2_1	475	481	PF00069	0.684
MOD_CK2_1	655	661	PF00069	0.550
MOD_GlcNHglycan	154	157	PF01048	0.624
MOD_GlcNHglycan	221	224	PF01048	0.499
MOD_GlcNHglycan	264	267	PF01048	0.519
MOD_GlcNHglycan	331	334	PF01048	0.590
MOD_GlcNHglycan	346	349	PF01048	0.589
MOD_GlcNHglycan	396	400	PF01048	0.773
MOD_GlcNHglycan	424	427	PF01048	0.386
MOD_GlcNHglycan	456	459	PF01048	0.742
MOD_GlcNHglycan	517	520	PF01048	0.502
MOD_GlcNHglycan	560	563	PF01048	0.631
MOD_GlcNHglycan	580	583	PF01048	0.532
MOD_GlcNHglycan	628	631	PF01048	0.557
MOD_GlcNHglycan	82	85	PF01048	0.641
MOD_GSK3_1	180	187	PF00069	0.494
MOD_GSK3_1	243	250	PF00069	0.734
MOD_GSK3_1	262	269	PF00069	0.426
MOD_GSK3_1	391	398	PF00069	0.637
MOD_GSK3_1	422	429	PF00069	0.480
MOD_GSK3_1	505	512	PF00069	0.575
MOD_GSK3_1	554	561	PF00069	0.561
MOD_GSK3_1	569	576	PF00069	0.518
MOD_GSK3_1	583	590	PF00069	0.757
MOD_GSK3_1	686	693	PF00069	0.606
MOD_GSK3_1	99	106	PF00069	0.670
MOD_N-GLC_1	474	479	PF02516	0.779
MOD_N-GLC_1	527	532	PF02516	0.544
MOD_N-GLC_1	553	558	PF02516	0.707
MOD_N-GLC_1	587	592	PF02516	0.712
MOD_N-GLC_1	62	67	PF02516	0.440
MOD_NEK2_1	209	214	PF00069	0.672
MOD_NEK2_1	224	229	PF00069	0.693
MOD_NEK2_1	243	248	PF00069	0.731
MOD_NEK2_1	376	381	PF00069	0.498
MOD_NEK2_1	474	479	PF00069	0.745
MOD_NEK2_1	480	485	PF00069	0.689
MOD_NEK2_1	49	54	PF00069	0.517
MOD_NEK2_1	509	514	PF00069	0.508
MOD_NEK2_1	690	695	PF00069	0.557
MOD_NEK2_2	266	271	PF00069	0.559
MOD_NEK2_2	502	507	PF00069	0.551
MOD_PIKK_1	121	127	PF00454	0.553
MOD_PIKK_1	480	486	PF00454	0.750
MOD_PIKK_1	50	56	PF00454	0.627
MOD_PIKK_1	637	643	PF00454	0.525
MOD_PIKK_1	683	689	PF00454	0.496
MOD_PIKK_1	690	696	PF00454	0.490
MOD_PK_1	275	281	PF00069	0.522
MOD_PKA_1	19	25	PF00069	0.599
MOD_PKA_2	139	145	PF00069	0.591
MOD_PKA_2	177	183	PF00069	0.418
MOD_PKA_2	187	193	PF00069	0.402
MOD_PKA_2	292	298	PF00069	0.559
MOD_PKA_2	304	310	PF00069	0.365
MOD_PKA_2	578	584	PF00069	0.530
MOD_PKA_2	612	618	PF00069	0.596
MOD_PKA_2	80	86	PF00069	0.637
MOD_Plk_1	386	392	PF00069	0.453
MOD_Plk_1	487	493	PF00069	0.598
MOD_Plk_1	587	593	PF00069	0.779
MOD_Plk_1	62	68	PF00069	0.422
MOD_Plk_1	699	705	PF00069	0.562
MOD_Plk_2-3	292	298	PF00069	0.633
MOD_Plk_4	269	275	PF00069	0.434
MOD_Plk_4	304	310	PF00069	0.429
MOD_Plk_4	379	385	PF00069	0.448
MOD_Plk_4	386	392	PF00069	0.564
MOD_Plk_4	433	439	PF00069	0.502
MOD_Plk_4	488	494	PF00069	0.593
MOD_Plk_4	601	607	PF00069	0.628
MOD_Plk_4	634	640	PF00069	0.593
MOD_Plk_4	94	100	PF00069	0.580
MOD_ProDKin_1	444	450	PF00069	0.624
MOD_ProDKin_1	475	481	PF00069	0.788
MOD_ProDKin_1	569	575	PF00069	0.758
MOD_ProDKin_1	581	587	PF00069	0.686
MOD_SUMO_for_1	315	318	PF00179	0.324
MOD_SUMO_rev_2	13	22	PF00179	0.539
MOD_SUMO_rev_2	673	680	PF00179	0.651
TRG_DiLeu_BaEn_1	357	362	PF01217	0.444
TRG_DiLeu_BaEn_1	364	369	PF01217	0.411
TRG_DiLeu_BaEn_1	6	11	PF01217	0.576
TRG_DiLeu_BaEn_2	413	419	PF01217	0.519
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.630
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.493
TRG_DiLeu_BaLyEn_6	665	670	PF01217	0.380
TRG_ENDOCYTIC_2	427	430	PF00928	0.572
TRG_ENDOCYTIC_2	510	513	PF00928	0.343
TRG_ENDOCYTIC_2	621	624	PF00928	0.616
TRG_ENDOCYTIC_2	639	642	PF00928	0.581
TRG_ENDOCYTIC_2	646	649	PF00928	0.538
TRG_ER_diArg_1	213	216	PF00400	0.490
TRG_ER_FFAT_2	470	481	PF00635	0.522
TRG_NES_CRM1_1	356	372	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM6	Leptomonas seymouri	52%	95%
A0A1X0P953	Trypanosomatidae	31%	100%
A0A3R7K9I4	Trypanosoma rangeli	32%	100%
A0A3S7X2P1	Leishmania donovani	75%	100%
A4I4T4	Leishmania infantum	75%	100%
C9ZLI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AE87	Leishmania major	76%	100%
E9ALJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BC22	Trypanosoma cruzi	32%	100%