Aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aminopeptidase

Gene product:

Aminopeptidase M1, putative

Species:

Leishmania braziliensis

UniProt:

A4HHM4_LEIBR

TriTrypDb:

LbrM.29.2220 , LBRM2903_290029000

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006518	peptide metabolic process	4	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043171	peptide catabolic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004177	aminopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0008238	exopeptidase activity	4	12
GO:0008270	zinc ion binding	6	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008235	metalloexopeptidase activity	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0070006	metalloaminopeptidase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.385
CLV_C14_Caspase3-7	489	493	PF00656	0.510
CLV_C14_Caspase3-7	791	795	PF00656	0.249
CLV_NRD_NRD_1	556	558	PF00675	0.359
CLV_NRD_NRD_1	645	647	PF00675	0.440
CLV_NRD_NRD_1	71	73	PF00675	0.476
CLV_PCSK_KEX2_1	291	293	PF00082	0.415
CLV_PCSK_KEX2_1	556	558	PF00082	0.357
CLV_PCSK_KEX2_1	645	647	PF00082	0.440
CLV_PCSK_KEX2_1	71	73	PF00082	0.476
CLV_PCSK_KEX2_1	751	753	PF00082	0.325
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.415
CLV_PCSK_PC1ET2_1	751	753	PF00082	0.325
CLV_PCSK_SKI1_1	470	474	PF00082	0.504
CLV_PCSK_SKI1_1	5	9	PF00082	0.594
CLV_PCSK_SKI1_1	557	561	PF00082	0.419
CLV_PCSK_SKI1_1	579	583	PF00082	0.421
CLV_PCSK_SKI1_1	619	623	PF00082	0.431
CLV_PCSK_SKI1_1	65	69	PF00082	0.452
CLV_PCSK_SKI1_1	680	684	PF00082	0.369
DEG_APCC_DBOX_1	247	255	PF00400	0.249
DEG_APCC_DBOX_1	618	626	PF00400	0.249
DOC_CDC14_PxL_1	571	579	PF14671	0.502
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.442
DOC_MAPK_DCC_7	248	256	PF00069	0.374
DOC_MAPK_gen_1	105	115	PF00069	0.476
DOC_MAPK_gen_1	477	486	PF00069	0.540
DOC_MAPK_gen_1	503	512	PF00069	0.531
DOC_MAPK_MEF2A_6	147	156	PF00069	0.355
DOC_MAPK_MEF2A_6	248	256	PF00069	0.360
DOC_MAPK_MEF2A_6	479	488	PF00069	0.524
DOC_MAPK_MEF2A_6	503	512	PF00069	0.568
DOC_PP2B_PxIxI_1	449	455	PF00149	0.438
DOC_PP2B_PxIxI_1	56	62	PF00149	0.502
DOC_PP4_FxxP_1	624	627	PF00568	0.476
DOC_USP7_MATH_1	439	443	PF00917	0.359
DOC_USP7_MATH_1	55	59	PF00917	0.486
DOC_USP7_MATH_1	736	740	PF00917	0.473
DOC_USP7_UBL2_3	116	120	PF12436	0.502
DOC_WW_Pin1_4	549	554	PF00397	0.476
LIG_14-3-3_CanoR_1	123	132	PF00244	0.364
LIG_14-3-3_CanoR_1	456	464	PF00244	0.334
LIG_14-3-3_CanoR_1	497	502	PF00244	0.596
LIG_14-3-3_CanoR_1	556	560	PF00244	0.415
LIG_14-3-3_CanoR_1	579	585	PF00244	0.420
LIG_14-3-3_CanoR_1	702	710	PF00244	0.422
LIG_Actin_WH2_2	306	324	PF00022	0.355
LIG_AP2alpha_1	560	564	PF02296	0.249
LIG_APCC_ABBAyCdc20_2	556	562	PF00400	0.476
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BRCT_BRCA1_1	125	129	PF00533	0.440
LIG_BRCT_BRCA1_1	517	521	PF00533	0.337
LIG_BRCT_BRCA1_1	560	564	PF00533	0.385
LIG_BRCT_BRCA1_1	628	632	PF00533	0.249
LIG_BRCT_BRCA1_1	741	745	PF00533	0.502
LIG_deltaCOP1_diTrp_1	317	325	PF00928	0.357
LIG_deltaCOP1_diTrp_1	781	790	PF00928	0.428
LIG_deltaCOP1_diTrp_1	794	802	PF00928	0.292
LIG_EH1_1	363	371	PF00400	0.249
LIG_EH1_1	801	809	PF00400	0.355
LIG_FHA_1	149	155	PF00498	0.373
LIG_FHA_1	194	200	PF00498	0.462
LIG_FHA_1	2	8	PF00498	0.611
LIG_FHA_1	21	27	PF00498	0.247
LIG_FHA_1	32	38	PF00498	0.365
LIG_FHA_1	417	423	PF00498	0.356
LIG_FHA_1	435	441	PF00498	0.310
LIG_FHA_1	479	485	PF00498	0.496
LIG_FHA_1	48	54	PF00498	0.341
LIG_FHA_1	497	503	PF00498	0.316
LIG_FHA_1	509	515	PF00498	0.505
LIG_FHA_1	612	618	PF00498	0.506
LIG_FHA_1	639	645	PF00498	0.311
LIG_FHA_1	692	698	PF00498	0.293
LIG_FHA_1	76	82	PF00498	0.434
LIG_FHA_1	828	834	PF00498	0.440
LIG_FHA_1	842	848	PF00498	0.440
LIG_FHA_1	85	91	PF00498	0.368
LIG_FHA_2	125	131	PF00498	0.366
LIG_FHA_2	272	278	PF00498	0.468
LIG_FHA_2	471	477	PF00498	0.515
LIG_FHA_2	629	635	PF00498	0.291
LIG_FXI_DFP_1	259	263	PF00024	0.405
LIG_GBD_Chelix_1	351	359	PF00786	0.325
LIG_GBD_Chelix_1	391	399	PF00786	0.355
LIG_GBD_Chelix_1	807	815	PF00786	0.502
LIG_IBAR_NPY_1	11	13	PF08397	0.514
LIG_Integrin_RGD_1	177	179	PF01839	0.249
LIG_Integrin_RGD_1	503	505	PF01839	0.498
LIG_LIR_Apic_2	481	485	PF02991	0.399
LIG_LIR_Gen_1	160	170	PF02991	0.392
LIG_LIR_Gen_1	184	193	PF02991	0.348
LIG_LIR_Gen_1	216	224	PF02991	0.515
LIG_LIR_Gen_1	377	385	PF02991	0.355
LIG_LIR_Gen_1	518	526	PF02991	0.249
LIG_LIR_Gen_1	561	571	PF02991	0.362
LIG_LIR_Gen_1	607	613	PF02991	0.344
LIG_LIR_Gen_1	629	637	PF02991	0.457
LIG_LIR_Gen_1	714	723	PF02991	0.377
LIG_LIR_Gen_1	788	795	PF02991	0.483
LIG_LIR_Gen_1	822	832	PF02991	0.374
LIG_LIR_LC3C_4	732	735	PF02991	0.347
LIG_LIR_Nem_3	126	132	PF02991	0.440
LIG_LIR_Nem_3	160	166	PF02991	0.373
LIG_LIR_Nem_3	184	188	PF02991	0.348
LIG_LIR_Nem_3	216	221	PF02991	0.503
LIG_LIR_Nem_3	268	273	PF02991	0.347
LIG_LIR_Nem_3	327	331	PF02991	0.374
LIG_LIR_Nem_3	377	383	PF02991	0.355
LIG_LIR_Nem_3	518	524	PF02991	0.249
LIG_LIR_Nem_3	561	567	PF02991	0.327
LIG_LIR_Nem_3	607	611	PF02991	0.353
LIG_LIR_Nem_3	629	635	PF02991	0.501
LIG_LIR_Nem_3	714	720	PF02991	0.377
LIG_LIR_Nem_3	781	786	PF02991	0.473
LIG_LIR_Nem_3	788	793	PF02991	0.478
LIG_LIR_Nem_3	822	827	PF02991	0.374
LIG_LYPXL_SIV_4	12	20	PF13949	0.249
LIG_LYPXL_yS_3	449	452	PF13949	0.425
LIG_PALB2_WD40_1	302	310	PF16756	0.355
LIG_PCNA_yPIPBox_3	100	111	PF02747	0.473
LIG_Pex14_1	328	332	PF04695	0.360
LIG_Pex14_1	544	548	PF04695	0.476
LIG_Pex14_2	241	245	PF04695	0.337
LIG_Pex14_2	560	564	PF04695	0.249
LIG_Pex14_2	604	608	PF04695	0.476
LIG_Pex14_2	786	790	PF04695	0.371
LIG_Pex14_2	824	828	PF04695	0.355
LIG_PTB_Apo_2	535	542	PF02174	0.476
LIG_PTB_Apo_2	771	778	PF02174	0.385
LIG_Rb_LxCxE_1	268	289	PF01857	0.371
LIG_REV1ctd_RIR_1	242	249	PF16727	0.357
LIG_SH2_CRK	218	222	PF00017	0.414
LIG_SH2_CRK	548	552	PF00017	0.365
LIG_SH2_CRK	717	721	PF00017	0.399
LIG_SH2_GRB2like	410	413	PF00017	0.347
LIG_SH2_GRB2like	536	539	PF00017	0.476
LIG_SH2_NCK_1	571	575	PF00017	0.440
LIG_SH2_PTP2	163	166	PF00017	0.478
LIG_SH2_SRC	13	16	PF00017	0.519
LIG_SH2_SRC	536	539	PF00017	0.476
LIG_SH2_SRC	571	574	PF00017	0.440
LIG_SH2_SRC	649	652	PF00017	0.412
LIG_SH2_STAP1	332	336	PF00017	0.417
LIG_SH2_STAT5	13	16	PF00017	0.485
LIG_SH2_STAT5	138	141	PF00017	0.390
LIG_SH2_STAT5	163	166	PF00017	0.372
LIG_SH2_STAT5	194	197	PF00017	0.372
LIG_SH2_STAT5	240	243	PF00017	0.244
LIG_SH2_STAT5	410	413	PF00017	0.354
LIG_SH2_STAT5	592	595	PF00017	0.476
LIG_SH2_STAT5	597	600	PF00017	0.476
LIG_SH2_STAT5	649	652	PF00017	0.412
LIG_SH3_3	151	157	PF00018	0.367
LIG_SH3_3	186	192	PF00018	0.371
LIG_SH3_3	254	260	PF00018	0.355
LIG_SH3_3	333	339	PF00018	0.403
LIG_SH3_3	507	513	PF00018	0.430
LIG_SH3_3	9	15	PF00018	0.442
LIG_SUMO_SIM_par_1	149	155	PF11976	0.502
LIG_SUMO_SIM_par_1	21	28	PF11976	0.286
LIG_SUMO_SIM_par_1	255	261	PF11976	0.355
LIG_SUMO_SIM_par_1	484	489	PF11976	0.447
LIG_SUMO_SIM_par_1	86	92	PF11976	0.249
LIG_TRAF2_1	427	430	PF00917	0.371
LIG_TRAF2_2	144	149	PF00917	0.476
LIG_UBA3_1	379	387	PF00899	0.371
LIG_WRC_WIRS_1	182	187	PF05994	0.460
LIG_WRC_WIRS_1	440	445	PF05994	0.411
LIG_WRC_WIRS_1	605	610	PF05994	0.452
MOD_CDK_SPxxK_3	549	556	PF00069	0.476
MOD_CK1_1	27	33	PF00069	0.476
MOD_CK1_1	283	289	PF00069	0.308
MOD_CK1_1	442	448	PF00069	0.407
MOD_CK1_1	475	481	PF00069	0.584
MOD_CK1_1	558	564	PF00069	0.401
MOD_CK1_1	681	687	PF00069	0.304
MOD_CK1_1	739	745	PF00069	0.490
MOD_CK2_1	124	130	PF00069	0.355
MOD_CK2_1	271	277	PF00069	0.461
MOD_CK2_1	470	476	PF00069	0.483
MOD_CK2_1	628	634	PF00069	0.280
MOD_CK2_1	681	687	PF00069	0.249
MOD_CK2_1	702	708	PF00069	0.385
MOD_CK2_1	775	781	PF00069	0.502
MOD_GlcNHglycan	132	135	PF01048	0.396
MOD_GlcNHglycan	459	462	PF01048	0.499
MOD_GlcNHglycan	517	520	PF01048	0.396
MOD_GlcNHglycan	601	604	PF01048	0.476
MOD_GlcNHglycan	683	686	PF01048	0.345
MOD_GlcNHglycan	704	707	PF01048	0.308
MOD_GlcNHglycan	738	741	PF01048	0.479
MOD_GlcNHglycan	777	780	PF01048	0.488
MOD_GSK3_1	148	155	PF00069	0.389
MOD_GSK3_1	177	184	PF00069	0.418
MOD_GSK3_1	20	27	PF00069	0.411
MOD_GSK3_1	213	220	PF00069	0.465
MOD_GSK3_1	271	278	PF00069	0.295
MOD_GSK3_1	280	287	PF00069	0.234
MOD_GSK3_1	434	441	PF00069	0.443
MOD_GSK3_1	55	62	PF00069	0.431
MOD_GSK3_1	609	616	PF00069	0.459
MOD_GSK3_1	653	660	PF00069	0.477
MOD_GSK3_1	735	742	PF00069	0.502
MOD_GSK3_1	857	864	PF00069	0.450
MOD_N-GLC_1	537	542	PF02516	0.367
MOD_NEK2_1	1	6	PF00069	0.740
MOD_NEK2_1	124	129	PF00069	0.344
MOD_NEK2_1	150	155	PF00069	0.378
MOD_NEK2_1	231	236	PF00069	0.406
MOD_NEK2_1	280	285	PF00069	0.408
MOD_NEK2_1	416	421	PF00069	0.484
MOD_NEK2_1	428	433	PF00069	0.348
MOD_NEK2_1	508	513	PF00069	0.510
MOD_NEK2_1	560	565	PF00069	0.445
MOD_NEK2_1	613	618	PF00069	0.456
MOD_NEK2_1	729	734	PF00069	0.468
MOD_NEK2_1	827	832	PF00069	0.440
MOD_NEK2_1	861	866	PF00069	0.360
MOD_NEK2_2	33	38	PF00069	0.509
MOD_PIKK_1	374	380	PF00454	0.355
MOD_PIKK_1	442	448	PF00454	0.392
MOD_PIKK_1	758	764	PF00454	0.390
MOD_PIKK_1	859	865	PF00454	0.338
MOD_PK_1	284	290	PF00069	0.385
MOD_PKA_2	170	176	PF00069	0.500
MOD_PKA_2	416	422	PF00069	0.417
MOD_PKA_2	455	461	PF00069	0.487
MOD_PKA_2	496	502	PF00069	0.468
MOD_PKA_2	555	561	PF00069	0.440
MOD_PKA_2	841	847	PF00069	0.413
MOD_Plk_1	148	154	PF00069	0.365
MOD_Plk_1	231	237	PF00069	0.249
MOD_Plk_1	24	30	PF00069	0.461
MOD_Plk_1	374	380	PF00069	0.355
MOD_Plk_1	508	514	PF00069	0.557
MOD_Plk_1	536	542	PF00069	0.450
MOD_Plk_1	59	65	PF00069	0.447
MOD_Plk_1	609	615	PF00069	0.458
MOD_Plk_2-3	537	543	PF00069	0.288
MOD_Plk_4	177	183	PF00069	0.464
MOD_Plk_4	205	211	PF00069	0.533
MOD_Plk_4	213	219	PF00069	0.507
MOD_Plk_4	275	281	PF00069	0.269
MOD_Plk_4	497	503	PF00069	0.599
MOD_Plk_4	628	634	PF00069	0.476
MOD_Plk_4	65	71	PF00069	0.409
MOD_Plk_4	653	659	PF00069	0.476
MOD_Plk_4	75	81	PF00069	0.460
MOD_ProDKin_1	549	555	PF00069	0.476
MOD_SUMO_for_1	157	160	PF00179	0.476
MOD_SUMO_for_1	7	10	PF00179	0.599
MOD_SUMO_rev_2	277	286	PF00179	0.385
MOD_SUMO_rev_2	92	102	PF00179	0.249
TRG_DiLeu_BaEn_2	466	472	PF01217	0.438
TRG_DiLeu_BaEn_2	619	625	PF01217	0.476
TRG_DiLeu_BaEn_4	429	435	PF01217	0.440
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.417
TRG_ENDOCYTIC_2	163	166	PF00928	0.372
TRG_ENDOCYTIC_2	218	221	PF00928	0.420
TRG_ENDOCYTIC_2	449	452	PF00928	0.425
TRG_ENDOCYTIC_2	548	551	PF00928	0.358
TRG_ENDOCYTIC_2	571	574	PF00928	0.440
TRG_ENDOCYTIC_2	717	720	PF00928	0.502
TRG_ER_diArg_1	532	535	PF00400	0.353
TRG_ER_diArg_1	644	646	PF00400	0.437
TRG_ER_diArg_1	70	72	PF00400	0.422
TRG_ER_diArg_1	847	850	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	557	562	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R5	Leptomonas seymouri	72%	100%
A0A0S4IPD6	Bodo saltans	40%	97%
A0A0S4JBK9	Bodo saltans	32%	100%
A0A1X0NMW3	Trypanosomatidae	30%	100%
A0A1X0P9F6	Trypanosomatidae	51%	100%
A0A3R7K1R9	Trypanosoma rangeli	28%	100%
A0A3S7X2P7	Leishmania donovani	83%	100%
A0A422NEK9	Trypanosoma rangeli	52%	100%
A4I4T3	Leishmania infantum	83%	100%
A6QPT7	Bos taurus	26%	91%
C9ZLI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A6I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D3UW23	Bitis rhinoceros	30%	91%
E9AE86	Leishmania major	82%	100%
E9AIS1	Leishmania braziliensis	28%	99%
E9ALJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O57579	Gallus gallus	25%	89%
O93654	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	27%	100%
O93655	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	31%	100%
P15145	Sus scrofa	26%	90%
P15684	Rattus norvegicus	26%	90%
P16406	Mus musculus	31%	92%
P37898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P40462	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	92%
P50123	Rattus norvegicus	30%	92%
P55786	Homo sapiens	29%	94%
P79098	Bos taurus	25%	90%
P79143	Canis lupus familiaris	27%	89%
P79171	Felis catus	26%	90%
P97629	Rattus norvegicus	31%	85%
Q0J5V5	Oryza sativa subsp. japonica	29%	99%
Q11000	Heliothis virescens	26%	86%
Q11001	Manduca sexta	25%	88%
Q11011	Mus musculus	29%	94%
Q48656	Lactococcus lactis subsp. lactis	27%	100%
Q4TT88	Caenorhabditis elegans	29%	92%
Q5RFP3	Pongo abelii	26%	90%
Q6K4E7	Oryza sativa subsp. japonica	33%	99%
Q6P179	Homo sapiens	26%	90%
Q6Z6L4	Oryza sativa subsp. japonica	30%	99%
Q8C129	Mus musculus	27%	85%
Q8K093	Mus musculus	28%	85%
Q8VZH2	Arabidopsis thaliana	29%	99%
Q96ZT9	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	27%	100%
Q978U3	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	27%	100%
Q9EQH2	Mus musculus	28%	93%
Q9JJ22	Rattus norvegicus	25%	93%
Q9NZ08	Homo sapiens	23%	92%
Q9UIQ6	Homo sapiens	30%	85%
Q9UKU6	Homo sapiens	28%	85%
Q9USX1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	98%
V5BSI2	Trypanosoma cruzi	51%	100%
V5D7P4	Trypanosoma cruzi	29%	100%