Contig, possible fusion of chromosomes 20 and 34

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHM3_LEIBR

TriTrypDb:

LbrM.29.2210 , LBRM2903_290028900

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A4HHM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM3

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0046168	glycerol-3-phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0052646	alditol phosphate metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0036094	small molecule binding	2	2
GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	5	1
GO:0051287	NAD binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.350
CLV_C14_Caspase3-7	327	331	PF00656	0.564
CLV_NRD_NRD_1	280	282	PF00675	0.468
CLV_NRD_NRD_1	414	416	PF00675	0.506
CLV_NRD_NRD_1	421	423	PF00675	0.541
CLV_PCSK_KEX2_1	280	282	PF00082	0.468
CLV_PCSK_SKI1_1	2	6	PF00082	0.520
CLV_PCSK_SKI1_1	315	319	PF00082	0.511
CLV_PCSK_SKI1_1	489	493	PF00082	0.481
CLV_PCSK_SKI1_1	501	505	PF00082	0.463
CLV_PCSK_SKI1_1	508	512	PF00082	0.596
CLV_Separin_Metazoa	498	502	PF03568	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.472
DEG_SCF_FBW7_1	114	121	PF00400	0.521
DEG_SCF_FBW7_1	229	236	PF00400	0.649
DEG_SPOP_SBC_1	254	258	PF00917	0.712
DEG_SPOP_SBC_1	273	277	PF00917	0.532
DOC_CKS1_1	115	120	PF01111	0.505
DOC_CKS1_1	230	235	PF01111	0.473
DOC_PP1_RVXF_1	313	319	PF00149	0.552
DOC_PP1_RVXF_1	413	420	PF00149	0.574
DOC_PP2B_LxvP_1	326	329	PF13499	0.567
DOC_PP2B_LxvP_1	391	394	PF13499	0.544
DOC_SPAK_OSR1_1	168	172	PF12202	0.288
DOC_USP7_MATH_1	118	122	PF00917	0.474
DOC_USP7_MATH_1	155	159	PF00917	0.684
DOC_USP7_MATH_1	204	208	PF00917	0.666
DOC_USP7_MATH_1	22	26	PF00917	0.554
DOC_USP7_MATH_1	228	232	PF00917	0.468
DOC_USP7_MATH_1	233	237	PF00917	0.574
DOC_USP7_MATH_1	273	277	PF00917	0.751
DOC_USP7_MATH_1	319	323	PF00917	0.550
DOC_USP7_MATH_1	343	347	PF00917	0.433
DOC_USP7_MATH_1	394	398	PF00917	0.474
DOC_USP7_MATH_1	402	406	PF00917	0.465
DOC_USP7_MATH_1	528	532	PF00917	0.542
DOC_WW_Pin1_4	114	119	PF00397	0.470
DOC_WW_Pin1_4	210	215	PF00397	0.615
DOC_WW_Pin1_4	229	234	PF00397	0.347
DOC_WW_Pin1_4	294	299	PF00397	0.508
DOC_WW_Pin1_4	386	391	PF00397	0.457
DOC_WW_Pin1_4	454	459	PF00397	0.439
LIG_14-3-3_CanoR_1	131	135	PF00244	0.618
LIG_14-3-3_CanoR_1	150	159	PF00244	0.616
LIG_14-3-3_CanoR_1	472	480	PF00244	0.488
LIG_14-3-3_CanoR_1	501	510	PF00244	0.432
LIG_BRCT_BRCA1_1	165	169	PF00533	0.592
LIG_BRCT_BRCA1_1	407	411	PF00533	0.472
LIG_BRCT_BRCA1_1	530	534	PF00533	0.443
LIG_CSL_BTD_1	295	298	PF09270	0.474
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.589
LIG_FHA_1	115	121	PF00498	0.439
LIG_FHA_1	140	146	PF00498	0.469
LIG_FHA_1	165	171	PF00498	0.526
LIG_FHA_1	211	217	PF00498	0.572
LIG_FHA_1	295	301	PF00498	0.476
LIG_FHA_1	31	37	PF00498	0.491
LIG_FHA_1	373	379	PF00498	0.384
LIG_FHA_1	402	408	PF00498	0.529
LIG_FHA_1	45	51	PF00498	0.669
LIG_FHA_1	7	13	PF00498	0.511
LIG_FHA_2	325	331	PF00498	0.519
LIG_FHA_2	502	508	PF00498	0.558
LIG_LIR_Apic_2	70	76	PF02991	0.525
LIG_LIR_Gen_1	166	177	PF02991	0.439
LIG_LIR_Gen_1	457	467	PF02991	0.405
LIG_LIR_Nem_3	166	172	PF02991	0.542
LIG_LIR_Nem_3	456	462	PF02991	0.401
LIG_LIR_Nem_3	483	488	PF02991	0.568
LIG_LIR_Nem_3	58	62	PF02991	0.672
LIG_LIR_Nem_3	82	87	PF02991	0.564
LIG_PAM2_1	75	87	PF00658	0.435
LIG_PDZ_Class_1	529	534	PF00595	0.629
LIG_Pex14_2	169	173	PF04695	0.468
LIG_SH2_CRK	73	77	PF00017	0.515
LIG_SH2_NCK_1	73	77	PF00017	0.515
LIG_SH2_STAP1	367	371	PF00017	0.500
LIG_SH2_STAP1	460	464	PF00017	0.382
LIG_SH2_STAT5	122	125	PF00017	0.506
LIG_SH2_STAT5	325	328	PF00017	0.476
LIG_SH2_STAT5	356	359	PF00017	0.607
LIG_SH2_STAT5	420	423	PF00017	0.588
LIG_SH3_3	106	112	PF00018	0.443
LIG_SH3_3	245	251	PF00018	0.706
LIG_SH3_3	452	458	PF00018	0.547
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.530
LIG_SUMO_SIM_par_1	111	117	PF11976	0.287
LIG_SUMO_SIM_par_1	212	219	PF11976	0.484
LIG_SxIP_EBH_1	240	250	PF03271	0.709
LIG_WRC_WIRS_1	344	349	PF05994	0.497
LIG_WRC_WIRS_1	56	61	PF05994	0.684
MOD_CK1_1	121	127	PF00069	0.460
MOD_CK1_1	151	157	PF00069	0.647
MOD_CK1_1	158	164	PF00069	0.706
MOD_CK1_1	202	208	PF00069	0.517
MOD_CK1_1	236	242	PF00069	0.670
MOD_CK1_1	25	31	PF00069	0.545
MOD_CK1_1	253	259	PF00069	0.752
MOD_CK1_1	354	360	PF00069	0.536
MOD_CK1_1	405	411	PF00069	0.459
MOD_CK1_1	454	460	PF00069	0.363
MOD_CK1_1	48	54	PF00069	0.720
MOD_CK2_1	204	210	PF00069	0.751
MOD_CK2_1	509	515	PF00069	0.576
MOD_Cter_Amidation	278	281	PF01082	0.487
MOD_Cter_Amidation	413	416	PF01082	0.512
MOD_GlcNHglycan	101	104	PF01048	0.680
MOD_GlcNHglycan	123	126	PF01048	0.540
MOD_GlcNHglycan	162	165	PF01048	0.627
MOD_GlcNHglycan	201	204	PF01048	0.701
MOD_GlcNHglycan	206	209	PF01048	0.659
MOD_GlcNHglycan	218	221	PF01048	0.291
MOD_GlcNHglycan	238	242	PF01048	0.421
MOD_GlcNHglycan	252	255	PF01048	0.599
MOD_GlcNHglycan	267	270	PF01048	0.539
MOD_GlcNHglycan	286	289	PF01048	0.450
MOD_GlcNHglycan	511	514	PF01048	0.493
MOD_GlcNHglycan	531	534	PF01048	0.363
MOD_GSK3_1	114	121	PF00069	0.477
MOD_GSK3_1	144	151	PF00069	0.601
MOD_GSK3_1	160	167	PF00069	0.511
MOD_GSK3_1	198	205	PF00069	0.656
MOD_GSK3_1	2	9	PF00069	0.351
MOD_GSK3_1	206	213	PF00069	0.629
MOD_GSK3_1	229	236	PF00069	0.559
MOD_GSK3_1	237	244	PF00069	0.623
MOD_GSK3_1	246	253	PF00069	0.580
MOD_GSK3_1	265	272	PF00069	0.728
MOD_GSK3_1	350	357	PF00069	0.443
MOD_GSK3_1	401	408	PF00069	0.435
MOD_GSK3_1	42	49	PF00069	0.729
MOD_GSK3_1	51	58	PF00069	0.728
MOD_GSK3_1	63	70	PF00069	0.762
MOD_GSK3_1	79	86	PF00069	0.501
MOD_GSK3_1	95	102	PF00069	0.563
MOD_N-GLC_1	104	109	PF02516	0.622
MOD_N-GLC_1	192	197	PF02516	0.405
MOD_N-GLC_1	22	27	PF02516	0.581
MOD_N-GLC_1	236	241	PF02516	0.574
MOD_N-GLC_2	339	341	PF02516	0.372
MOD_NEK2_1	187	192	PF00069	0.494
MOD_NEK2_1	216	221	PF00069	0.531
MOD_NEK2_1	255	260	PF00069	0.585
MOD_NEK2_1	351	356	PF00069	0.468
MOD_NEK2_1	463	468	PF00069	0.417
MOD_NEK2_1	529	534	PF00069	0.609
MOD_PIKK_1	144	150	PF00454	0.336
MOD_PIKK_1	471	477	PF00454	0.338
MOD_PKA_2	130	136	PF00069	0.365
MOD_PKA_2	149	155	PF00069	0.526
MOD_PKA_2	319	325	PF00069	0.445
MOD_PKA_2	384	390	PF00069	0.473
MOD_PKA_2	471	477	PF00069	0.509
MOD_Plk_1	104	110	PF00069	0.601
MOD_Plk_1	22	28	PF00069	0.566
MOD_Plk_1	45	51	PF00069	0.700
MOD_Plk_4	118	124	PF00069	0.478
MOD_Plk_4	187	193	PF00069	0.370
MOD_Plk_4	2	8	PF00069	0.477
MOD_Plk_4	242	248	PF00069	0.677
MOD_Plk_4	27	33	PF00069	0.480
MOD_Plk_4	321	327	PF00069	0.472
MOD_Plk_4	351	357	PF00069	0.469
MOD_Plk_4	395	401	PF00069	0.482
MOD_Plk_4	402	408	PF00069	0.483
MOD_Plk_4	466	472	PF00069	0.463
MOD_Plk_4	79	85	PF00069	0.573
MOD_ProDKin_1	114	120	PF00069	0.470
MOD_ProDKin_1	210	216	PF00069	0.603
MOD_ProDKin_1	229	235	PF00069	0.355
MOD_ProDKin_1	294	300	PF00069	0.507
MOD_ProDKin_1	386	392	PF00069	0.450
MOD_ProDKin_1	454	460	PF00069	0.432
MOD_SUMO_rev_2	86	96	PF00179	0.566
TRG_DiLeu_BaEn_1	212	217	PF01217	0.554
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.308
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.338
TRG_ENDOCYTIC_2	460	463	PF00928	0.378
TRG_ENDOCYTIC_2	467	470	PF00928	0.447
TRG_ER_diArg_1	280	282	PF00400	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P658	Leptomonas seymouri	53%	100%
A0A0S4ITH1	Bodo saltans	23%	100%
A0A1X0P970	Trypanosomatidae	40%	100%
A0A3Q8IFB4	Leishmania donovani	79%	100%
A0A422NEK6	Trypanosoma rangeli	33%	100%
A4I4T2	Leishmania infantum	80%	92%
C9ZLH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AE85	Leishmania major	79%	100%
E9ALK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%