LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HHM1_LEIBR

TriTrypDb:

LbrM.29.2190 , LBRM2903_290028600

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HHM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM1

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.504
CLV_MEL_PAP_1	372	378	PF00089	0.378
CLV_NRD_NRD_1	11	13	PF00675	0.201
CLV_NRD_NRD_1	358	360	PF00675	0.455
CLV_PCSK_KEX2_1	10	12	PF00082	0.201
CLV_PCSK_KEX2_1	254	256	PF00082	0.421
CLV_PCSK_KEX2_1	358	360	PF00082	0.434
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.421
CLV_PCSK_SKI1_1	254	258	PF00082	0.553
CLV_PCSK_SKI1_1	267	271	PF00082	0.439
CLV_PCSK_SKI1_1	63	67	PF00082	0.225
CLV_Separin_Metazoa	7	11	PF03568	0.457
DEG_APCC_DBOX_1	362	370	PF00400	0.521
DEG_APCC_DBOX_1	403	411	PF00400	0.667
DEG_SPOP_SBC_1	453	457	PF00917	0.443
DOC_CDC14_PxL_1	136	144	PF14671	0.491
DOC_CKS1_1	231	236	PF01111	0.526
DOC_CKS1_1	350	355	PF01111	0.305
DOC_CKS1_1	475	480	PF01111	0.526
DOC_CYCLIN_RxL_1	262	273	PF00134	0.437
DOC_MAPK_gen_1	262	270	PF00069	0.560
DOC_MAPK_gen_1	317	325	PF00069	0.318
DOC_MAPK_gen_1	63	73	PF00069	0.421
DOC_MAPK_MEF2A_6	271	278	PF00069	0.419
DOC_MAPK_MEF2A_6	317	325	PF00069	0.318
DOC_MAPK_MEF2A_6	66	75	PF00069	0.408
DOC_MAPK_MEF2A_6	92	99	PF00069	0.410
DOC_MAPK_NFAT4_5	92	100	PF00069	0.403
DOC_MAPK_RevD_3	345	359	PF00069	0.457
DOC_PP1_RVXF_1	61	68	PF00149	0.496
DOC_PP2B_LxvP_1	321	324	PF13499	0.383
DOC_USP7_MATH_1	229	233	PF00917	0.508
DOC_USP7_MATH_1	419	423	PF00917	0.661
DOC_USP7_MATH_1	453	457	PF00917	0.511
DOC_USP7_MATH_1	464	468	PF00917	0.621
DOC_USP7_MATH_1	481	485	PF00917	0.604
DOC_USP7_UBL2_3	197	201	PF12436	0.547
DOC_WW_Pin1_4	206	211	PF00397	0.393
DOC_WW_Pin1_4	230	235	PF00397	0.644
DOC_WW_Pin1_4	349	354	PF00397	0.331
DOC_WW_Pin1_4	415	420	PF00397	0.609
DOC_WW_Pin1_4	449	454	PF00397	0.552
DOC_WW_Pin1_4	474	479	PF00397	0.528
LIG_14-3-3_CanoR_1	3	7	PF00244	0.414
LIG_14-3-3_CanoR_1	338	347	PF00244	0.488
LIG_14-3-3_CanoR_1	404	408	PF00244	0.615
LIG_AP2alpha_2	192	194	PF02296	0.440
LIG_BIR_II_1	1	5	PF00653	0.389
LIG_Clathr_ClatBox_1	407	411	PF01394	0.671
LIG_EH_1	111	115	PF12763	0.496
LIG_FHA_1	298	304	PF00498	0.410
LIG_FHA_1	3	9	PF00498	0.401
LIG_FHA_1	340	346	PF00498	0.417
LIG_FHA_1	350	356	PF00498	0.387
LIG_FHA_1	426	432	PF00498	0.599
LIG_FHA_1	455	461	PF00498	0.563
LIG_FHA_1	464	470	PF00498	0.492
LIG_FHA_2	124	130	PF00498	0.462
LIG_FHA_2	207	213	PF00498	0.379
LIG_FHA_2	255	261	PF00498	0.452
LIG_FHA_2	404	410	PF00498	0.698
LIG_FHA_2	77	83	PF00498	0.414
LIG_LIR_Nem_3	129	134	PF02991	0.414
LIG_LRP6_Inhibitor_1	51	57	PF00058	0.149
LIG_SH2_GRB2like	70	73	PF00017	0.401
LIG_SH2_PTP2	55	58	PF00017	0.349
LIG_SH2_SRC	134	137	PF00017	0.457
LIG_SH2_STAT5	134	137	PF00017	0.414
LIG_SH2_STAT5	351	354	PF00017	0.317
LIG_SH2_STAT5	50	53	PF00017	0.401
LIG_SH2_STAT5	55	58	PF00017	0.401
LIG_SH2_STAT5	70	73	PF00017	0.401
LIG_SH3_1	271	277	PF00018	0.421
LIG_SH3_2	274	279	PF14604	0.382
LIG_SH3_3	190	196	PF00018	0.407
LIG_SH3_3	228	234	PF00018	0.468
LIG_SH3_3	271	277	PF00018	0.421
LIG_SH3_3	344	350	PF00018	0.363
LIG_SH3_3	420	426	PF00018	0.549
LIG_SH3_3	447	453	PF00018	0.443
LIG_SH3_3	465	471	PF00018	0.441
LIG_SH3_3	472	478	PF00018	0.536
LIG_SUMO_SIM_anti_2	308	313	PF11976	0.368
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.401
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.416
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.414
LIG_SUMO_SIM_par_1	286	293	PF11976	0.430
LIG_SUMO_SIM_par_1	405	412	PF11976	0.667
LIG_TRAF2_1	168	171	PF00917	0.491
LIG_TRAF2_1	209	212	PF00917	0.377
LIG_TRAF2_1	257	260	PF00917	0.443
LIG_TYR_ITIM	68	73	PF00017	0.235
LIG_WW_1	195	198	PF00397	0.454
MOD_CDK_SPxxK_3	206	213	PF00069	0.384
MOD_CK1_1	105	111	PF00069	0.332
MOD_CK1_1	339	345	PF00069	0.429
MOD_CK1_1	377	383	PF00069	0.562
MOD_CK1_1	417	423	PF00069	0.599
MOD_CK1_1	435	441	PF00069	0.580
MOD_CK1_1	452	458	PF00069	0.450
MOD_CK1_1	484	490	PF00069	0.445
MOD_CK2_1	123	129	PF00069	0.300
MOD_CK2_1	206	212	PF00069	0.405
MOD_CK2_1	254	260	PF00069	0.456
MOD_CK2_1	403	409	PF00069	0.594
MOD_CK2_1	430	436	PF00069	0.474
MOD_GlcNHglycan	359	362	PF01048	0.484
MOD_GlcNHglycan	377	380	PF01048	0.683
MOD_GlcNHglycan	382	385	PF01048	0.584
MOD_GlcNHglycan	390	393	PF01048	0.653
MOD_GlcNHglycan	432	435	PF01048	0.719
MOD_GSK3_1	101	108	PF00069	0.335
MOD_GSK3_1	114	121	PF00069	0.270
MOD_GSK3_1	250	257	PF00069	0.629
MOD_GSK3_1	297	304	PF00069	0.515
MOD_GSK3_1	345	352	PF00069	0.362
MOD_GSK3_1	415	422	PF00069	0.604
MOD_GSK3_1	435	442	PF00069	0.574
MOD_GSK3_1	449	456	PF00069	0.638
MOD_GSK3_1	470	477	PF00069	0.696
MOD_N-GLC_1	76	81	PF02516	0.254
MOD_NEK2_1	114	119	PF00069	0.277
MOD_NEK2_1	297	302	PF00069	0.386
MOD_NEK2_1	345	350	PF00069	0.361
MOD_NEK2_1	402	407	PF00069	0.549
MOD_NEK2_1	414	419	PF00069	0.609
MOD_NEK2_1	439	444	PF00069	0.491
MOD_NEK2_1	93	98	PF00069	0.259
MOD_PIKK_1	331	337	PF00454	0.454
MOD_PKA_1	254	260	PF00069	0.439
MOD_PKA_2	2	8	PF00069	0.254
MOD_PKA_2	254	260	PF00069	0.499
MOD_PKA_2	337	343	PF00069	0.529
MOD_PKA_2	357	363	PF00069	0.306
MOD_PKA_2	374	380	PF00069	0.461
MOD_PKA_2	403	409	PF00069	0.629
MOD_Plk_1	331	337	PF00069	0.406
MOD_Plk_1	435	441	PF00069	0.459
MOD_Plk_1	484	490	PF00069	0.440
MOD_Plk_1	76	82	PF00069	0.254
MOD_Plk_1	93	99	PF00069	0.259
MOD_Plk_4	105	111	PF00069	0.367
MOD_Plk_4	298	304	PF00069	0.403
MOD_Plk_4	403	409	PF00069	0.594
MOD_Plk_4	440	446	PF00069	0.463
MOD_Plk_4	454	460	PF00069	0.450
MOD_Plk_4	464	470	PF00069	0.438
MOD_Plk_4	484	490	PF00069	0.440
MOD_ProDKin_1	206	212	PF00069	0.387
MOD_ProDKin_1	230	236	PF00069	0.649
MOD_ProDKin_1	349	355	PF00069	0.328
MOD_ProDKin_1	415	421	PF00069	0.611
MOD_ProDKin_1	449	455	PF00069	0.552
MOD_ProDKin_1	474	480	PF00069	0.528
MOD_SUMO_for_1	151	154	PF00179	0.254
MOD_SUMO_for_1	182	185	PF00179	0.378
MOD_SUMO_for_1	200	203	PF00179	0.433
TRG_DiLeu_BaEn_1	34	39	PF01217	0.314
TRG_DiLeu_BaEn_2	292	298	PF01217	0.454
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.425
TRG_ENDOCYTIC_2	55	58	PF00928	0.311
TRG_ENDOCYTIC_2	70	73	PF00928	0.217
TRG_ER_diArg_1	174	177	PF00400	0.382
TRG_ER_diArg_1	362	365	PF00400	0.458
TRG_ER_diArg_1	9	12	PF00400	0.235
TRG_NES_CRM1_1	141	154	PF08389	0.162
TRG_NES_CRM1_1	449	463	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R7	Leptomonas seymouri	73%	100%
A0A0S4IYI1	Bodo saltans	60%	100%
A0A1L8G016	Xenopus laevis	35%	100%
A0A1X0P946	Trypanosomatidae	63%	100%
A0A3Q8IBL9	Leishmania donovani	83%	100%
A0A3R7LV56	Trypanosoma rangeli	64%	100%
A4I4T0	Leishmania infantum	82%	100%
B3DH20	Danio rerio	36%	100%
C9ZLH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AE83	Leishmania major	84%	100%
E9ALK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O88978	Mus musculus	35%	100%
Q1RMR5	Bos taurus	36%	100%
Q28FY0	Xenopus tropicalis	35%	100%
Q4R3F0	Macaca fascicularis	35%	100%
Q86X45	Homo sapiens	33%	100%
Q9NJE9	Trypanosoma brucei brucei	61%	100%
Q9VR52	Drosophila melanogaster	36%	100%