Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynamin-1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HHM0_LEIBR

TriTrypDb:

LbrM.29.2180 , LBRM2903_290028500

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005874	microtubule	6	1
GO:0016020	membrane	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHM0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.476
CLV_NRD_NRD_1	242	244	PF00675	0.471
CLV_NRD_NRD_1	305	307	PF00675	0.292
CLV_NRD_NRD_1	375	377	PF00675	0.385
CLV_NRD_NRD_1	658	660	PF00675	0.390
CLV_PCSK_KEX2_1	102	104	PF00082	0.476
CLV_PCSK_KEX2_1	295	297	PF00082	0.417
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.417
CLV_PCSK_SKI1_1	152	156	PF00082	0.356
CLV_PCSK_SKI1_1	186	190	PF00082	0.413
CLV_PCSK_SKI1_1	350	354	PF00082	0.390
CLV_PCSK_SKI1_1	377	381	PF00082	0.413
CLV_PCSK_SKI1_1	49	53	PF00082	0.356
CLV_PCSK_SKI1_1	578	582	PF00082	0.684
CLV_PCSK_SKI1_1	617	621	PF00082	0.356
CLV_PCSK_SKI1_1	643	647	PF00082	0.476
CLV_PCSK_SKI1_1	660	664	PF00082	0.358
CLV_PCSK_SKI1_1	88	92	PF00082	0.270
DEG_Nend_UBRbox_2	1	3	PF02207	0.510
DEG_SPOP_SBC_1	688	692	PF00917	0.560
DOC_ANK_TNKS_1	596	603	PF00023	0.356
DOC_CDC14_PxL_1	132	140	PF14671	0.356
DOC_CKS1_1	501	506	PF01111	0.747
DOC_MAPK_DCC_7	23	31	PF00069	0.437
DOC_MAPK_gen_1	277	284	PF00069	0.390
DOC_MAPK_HePTP_8	118	130	PF00069	0.250
DOC_MAPK_JIP1_4	116	122	PF00069	0.356
DOC_MAPK_MEF2A_6	121	130	PF00069	0.374
DOC_MAPK_MEF2A_6	165	172	PF00069	0.476
DOC_MAPK_MEF2A_6	19	26	PF00069	0.513
DOC_MAPK_MEF2A_6	61	68	PF00069	0.356
DOC_MAPK_NFAT4_5	165	173	PF00069	0.476
DOC_MAPK_NFAT4_5	19	27	PF00069	0.503
DOC_PP1_RVXF_1	420	427	PF00149	0.356
DOC_PP2B_LxvP_1	24	27	PF13499	0.453
DOC_PP2B_LxvP_1	83	86	PF13499	0.441
DOC_PP2B_PxIxI_1	26	32	PF00149	0.356
DOC_USP7_MATH_1	249	253	PF00917	0.507
DOC_USP7_MATH_1	53	57	PF00917	0.370
DOC_USP7_MATH_1	644	648	PF00917	0.250
DOC_USP7_MATH_1	675	679	PF00917	0.390
DOC_USP7_UBL2_3	19	23	PF12436	0.543
DOC_USP7_UBL2_3	307	311	PF12436	0.402
DOC_USP7_UBL2_3	531	535	PF12436	0.801
DOC_USP7_UBL2_3	538	542	PF12436	0.655
DOC_USP7_UBL2_3	546	550	PF12436	0.682
DOC_WW_Pin1_4	160	165	PF00397	0.342
DOC_WW_Pin1_4	170	175	PF00397	0.343
DOC_WW_Pin1_4	257	262	PF00397	0.476
DOC_WW_Pin1_4	462	467	PF00397	0.419
DOC_WW_Pin1_4	500	505	PF00397	0.643
LIG_14-3-3_CanoR_1	243	247	PF00244	0.471
LIG_14-3-3_CanoR_1	250	257	PF00244	0.482
LIG_14-3-3_CanoR_1	464	474	PF00244	0.422
LIG_Actin_WH2_2	211	228	PF00022	0.390
LIG_APCC_ABBA_1	330	335	PF00400	0.390
LIG_CORNRBOX	283	291	PF00104	0.356
LIG_deltaCOP1_diTrp_1	77	82	PF00928	0.355
LIG_FHA_1	102	108	PF00498	0.301
LIG_FHA_1	157	163	PF00498	0.356
LIG_FHA_1	165	171	PF00498	0.356
LIG_FHA_1	194	200	PF00498	0.358
LIG_FHA_1	270	276	PF00498	0.356
LIG_FHA_1	347	353	PF00498	0.402
LIG_FHA_1	644	650	PF00498	0.437
LIG_FHA_2	129	135	PF00498	0.356
LIG_FHA_2	201	207	PF00498	0.356
LIG_FHA_2	584	590	PF00498	0.679
LIG_IRF3_LxIS_1	168	173	PF10401	0.356
LIG_IRF3_LxIS_1	619	625	PF10401	0.250
LIG_LIR_Apic_2	159	164	PF02991	0.356
LIG_LIR_Apic_2	462	466	PF02991	0.345
LIG_LIR_Apic_2	498	504	PF02991	0.445
LIG_LIR_Gen_1	212	223	PF02991	0.380
LIG_LIR_Gen_1	252	261	PF02991	0.466
LIG_LIR_Gen_1	380	391	PF02991	0.356
LIG_LIR_Gen_1	402	413	PF02991	0.352
LIG_LIR_Gen_1	425	435	PF02991	0.397
LIG_LIR_Gen_1	478	489	PF02991	0.356
LIG_LIR_Gen_1	601	612	PF02991	0.390
LIG_LIR_Gen_1	629	640	PF02991	0.371
LIG_LIR_Gen_1	81	90	PF02991	0.476
LIG_LIR_Gen_1	92	100	PF02991	0.371
LIG_LIR_Nem_3	13	18	PF02991	0.479
LIG_LIR_Nem_3	212	218	PF02991	0.380
LIG_LIR_Nem_3	252	257	PF02991	0.452
LIG_LIR_Nem_3	260	266	PF02991	0.357
LIG_LIR_Nem_3	364	369	PF02991	0.356
LIG_LIR_Nem_3	380	386	PF02991	0.342
LIG_LIR_Nem_3	402	408	PF02991	0.349
LIG_LIR_Nem_3	425	431	PF02991	0.394
LIG_LIR_Nem_3	443	448	PF02991	0.172
LIG_LIR_Nem_3	478	484	PF02991	0.356
LIG_LIR_Nem_3	601	607	PF02991	0.356
LIG_LIR_Nem_3	629	635	PF02991	0.343
LIG_LIR_Nem_3	76	82	PF02991	0.357
LIG_LIR_Nem_3	92	96	PF02991	0.371
LIG_LYPXL_yS_3	445	448	PF13949	0.441
LIG_NRBOX	278	284	PF00104	0.356
LIG_PCNA_yPIPBox_3	591	600	PF02747	0.389
LIG_Pex14_2	362	366	PF04695	0.356
LIG_PTB_Apo_2	84	91	PF02174	0.443
LIG_SH2_CRK	263	267	PF00017	0.351
LIG_SH2_CRK	463	467	PF00017	0.390
LIG_SH2_CRK	501	505	PF00017	0.624
LIG_SH2_CRK	632	636	PF00017	0.356
LIG_SH2_GRB2like	123	126	PF00017	0.366
LIG_SH2_NCK_1	263	267	PF00017	0.351
LIG_SH2_PTP2	161	164	PF00017	0.346
LIG_SH2_PTP2	383	386	PF00017	0.356
LIG_SH2_STAP1	123	127	PF00017	0.413
LIG_SH2_STAP1	254	258	PF00017	0.449
LIG_SH2_STAP1	428	432	PF00017	0.255
LIG_SH2_STAP1	632	636	PF00017	0.371
LIG_SH2_STAP1	640	644	PF00017	0.250
LIG_SH2_STAT5	161	164	PF00017	0.346
LIG_SH2_STAT5	274	277	PF00017	0.371
LIG_SH2_STAT5	360	363	PF00017	0.356
LIG_SH2_STAT5	369	372	PF00017	0.356
LIG_SH2_STAT5	383	386	PF00017	0.356
LIG_SH2_STAT5	603	606	PF00017	0.358
LIG_SH3_2	509	514	PF14604	0.578
LIG_SH3_3	104	110	PF00018	0.366
LIG_SH3_3	130	136	PF00018	0.364
LIG_SH3_3	481	487	PF00018	0.356
LIG_SH3_3	506	512	PF00018	0.748
LIG_SH3_3	66	72	PF00018	0.371
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.443
LIG_SUMO_SIM_par_1	167	173	PF11976	0.356
LIG_SUMO_SIM_par_1	620	625	PF11976	0.344
LIG_TRAF2_1	95	98	PF00917	0.250
LIG_UBA3_1	283	288	PF00899	0.356
LIG_UBA3_1	665	671	PF00899	0.356
MOD_CDK_SPK_2	160	165	PF00069	0.460
MOD_CK1_1	465	471	PF00069	0.250
MOD_CK1_1	510	516	PF00069	0.769
MOD_CK1_1	518	524	PF00069	0.636
MOD_CK1_1	647	653	PF00069	0.387
MOD_CK2_1	38	44	PF00069	0.356
MOD_CK2_1	583	589	PF00069	0.545
MOD_CK2_1	71	77	PF00069	0.391
MOD_GlcNHglycan	15	18	PF01048	0.381
MOD_GlcNHglycan	321	325	PF01048	0.292
MOD_GlcNHglycan	373	376	PF01048	0.374
MOD_GlcNHglycan	467	470	PF01048	0.385
MOD_GlcNHglycan	475	478	PF01048	0.385
MOD_GlcNHglycan	509	512	PF01048	0.766
MOD_GlcNHglycan	55	58	PF01048	0.470
MOD_GSK3_1	156	163	PF00069	0.346
MOD_GSK3_1	170	177	PF00069	0.384
MOD_GSK3_1	257	264	PF00069	0.432
MOD_GSK3_1	269	276	PF00069	0.328
MOD_GSK3_1	33	40	PF00069	0.353
MOD_GSK3_1	333	340	PF00069	0.363
MOD_GSK3_1	365	372	PF00069	0.476
MOD_GSK3_1	394	401	PF00069	0.382
MOD_GSK3_1	515	522	PF00069	0.715
MOD_GSK3_1	53	60	PF00069	0.172
MOD_GSK3_1	570	577	PF00069	0.528
MOD_GSK3_1	643	650	PF00069	0.250
MOD_N-GLC_1	128	133	PF02516	0.356
MOD_N-GLC_1	317	322	PF02516	0.482
MOD_N-GLC_1	337	342	PF02516	0.351
MOD_N-GLC_2	436	438	PF02516	0.250
MOD_NEK2_1	128	133	PF00069	0.343
MOD_NEK2_1	179	184	PF00069	0.356
MOD_NEK2_1	302	307	PF00069	0.368
MOD_NEK2_1	333	338	PF00069	0.410
MOD_NEK2_1	394	399	PF00069	0.390
MOD_NEK2_1	581	586	PF00069	0.644
MOD_NEK2_1	622	627	PF00069	0.342
MOD_NEK2_2	675	680	PF00069	0.390
MOD_PIKK_1	179	185	PF00454	0.476
MOD_PIKK_1	233	239	PF00454	0.348
MOD_PIKK_1	31	37	PF00454	0.352
MOD_PKA_2	101	107	PF00069	0.415
MOD_PKA_2	242	248	PF00069	0.471
MOD_PKA_2	249	255	PF00069	0.482
MOD_PKA_2	53	59	PF00069	0.356
MOD_Plk_1	128	134	PF00069	0.353
MOD_Plk_1	337	343	PF00069	0.390
MOD_Plk_2-3	242	248	PF00069	0.476
MOD_Plk_4	128	134	PF00069	0.335
MOD_Plk_4	164	170	PF00069	0.356
MOD_Plk_4	269	275	PF00069	0.359
MOD_Plk_4	286	292	PF00069	0.374
MOD_Plk_4	325	331	PF00069	0.247
MOD_Plk_4	365	371	PF00069	0.362
MOD_Plk_4	38	44	PF00069	0.347
MOD_Plk_4	394	400	PF00069	0.379
MOD_Plk_4	422	428	PF00069	0.476
MOD_Plk_4	644	650	PF00069	0.443
MOD_ProDKin_1	160	166	PF00069	0.342
MOD_ProDKin_1	170	176	PF00069	0.343
MOD_ProDKin_1	257	263	PF00069	0.476
MOD_ProDKin_1	462	468	PF00069	0.419
MOD_ProDKin_1	500	506	PF00069	0.653
MOD_SUMO_rev_2	236	246	PF00179	0.370
MOD_SUMO_rev_2	541	551	PF00179	0.811
TRG_DiLeu_BaEn_3	429	435	PF01217	0.356
TRG_DiLeu_BaEn_3	77	83	PF01217	0.390
TRG_ENDOCYTIC_2	123	126	PF00928	0.250
TRG_ENDOCYTIC_2	254	257	PF00928	0.410
TRG_ENDOCYTIC_2	263	266	PF00928	0.266
TRG_ENDOCYTIC_2	383	386	PF00928	0.353
TRG_ENDOCYTIC_2	428	431	PF00928	0.356
TRG_ENDOCYTIC_2	445	448	PF00928	0.342
TRG_ENDOCYTIC_2	603	606	PF00928	0.356
TRG_ENDOCYTIC_2	632	635	PF00928	0.342
TRG_NES_CRM1_1	450	462	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	637	642	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD95	Leptomonas seymouri	83%	100%
A0A1X0P9B2	Trypanosomatidae	70%	100%
A0A3Q8IRJ0	Leishmania donovani	85%	99%
A0A422NEK1	Trypanosoma rangeli	67%	100%
A0MWD1	Bubalus bubalis	32%	97%
A4I4S9	Leishmania infantum	85%	99%
A6H7I5	Bos taurus	44%	80%
C9ZLH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZLI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AE82	Leishmania major	84%	100%
E9ALK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O00429	Homo sapiens	36%	94%
O35303	Rattus norvegicus	36%	92%
P20592	Homo sapiens	30%	97%
P21575	Rattus norvegicus	44%	80%
P21576	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	98%
P27594	Sus scrofa	33%	100%
P27619	Drosophila melanogaster	45%	79%
P33237	Ovis aries	34%	100%
P39052	Rattus norvegicus	44%	80%
P39053	Mus musculus	44%	80%
P39054	Mus musculus	44%	80%
P39055	Caenorhabditis elegans	42%	83%
P42697	Arabidopsis thaliana	37%	100%
P50570	Homo sapiens	44%	80%
P54861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	91%
P79135	Bos taurus	33%	100%
Q000A9	Larimichthys crocea	27%	100%
Q05193	Homo sapiens	44%	80%
Q08877	Rattus norvegicus	44%	80%
Q08DF4	Bos taurus	45%	81%
Q09748	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	89%
Q2KIA5	Bos taurus	36%	92%
Q2KTC2	Dicentrarchus labrax	32%	100%
Q39821	Glycine max	37%	100%
Q39828	Glycine max	37%	100%
Q4ADG6	Phoca vitulina	32%	100%
Q5I2P5	Ovis aries	32%	97%
Q5U752	Solea senegalensis	32%	100%
Q7SXN5	Danio rerio	39%	100%
Q84XF3	Arabidopsis thaliana	36%	100%
Q8BZ98	Mus musculus	44%	80%
Q8JH68	Danio rerio	32%	100%
Q8K1M6	Mus musculus	37%	93%
Q8LF21	Arabidopsis thaliana	38%	100%
Q8LFT2	Arabidopsis thaliana	35%	89%
Q8S3C9	Arabidopsis thaliana	36%	100%
Q8S944	Arabidopsis thaliana	34%	86%
Q94464	Dictyostelium discoideum	48%	81%
Q9BDI7	Bos taurus	32%	97%
Q9FNX5	Arabidopsis thaliana	36%	100%
Q9LQ55	Arabidopsis thaliana	23%	75%
Q9N0Y3	Canis lupus familiaris	32%	100%
Q9SE83	Arabidopsis thaliana	24%	76%
Q9U1M9	Dictyostelium discoideum	40%	75%
Q9UQ16	Homo sapiens	44%	80%
Q9URZ5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q9ZP55	Arabidopsis thaliana	27%	100%
V5DTS8	Trypanosoma cruzi	69%	100%