DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania braziliensis

UniProt:

A4HHL8_LEIBR

TriTrypDb:

LbrM.29.2160 , LBRM2903_290028300

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.607
CLV_C14_Caspase3-7	203	207	PF00656	0.673
CLV_C14_Caspase3-7	236	240	PF00656	0.620
CLV_NRD_NRD_1	126	128	PF00675	0.662
CLV_NRD_NRD_1	195	197	PF00675	0.541
CLV_NRD_NRD_1	21	23	PF00675	0.541
CLV_NRD_NRD_1	221	223	PF00675	0.664
CLV_NRD_NRD_1	225	227	PF00675	0.529
CLV_NRD_NRD_1	470	472	PF00675	0.360
CLV_NRD_NRD_1	59	61	PF00675	0.698
CLV_PCSK_FUR_1	124	128	PF00082	0.528
CLV_PCSK_FUR_1	222	226	PF00082	0.656
CLV_PCSK_KEX2_1	126	128	PF00082	0.637
CLV_PCSK_KEX2_1	195	197	PF00082	0.587
CLV_PCSK_KEX2_1	21	23	PF00082	0.541
CLV_PCSK_KEX2_1	221	223	PF00082	0.654
CLV_PCSK_KEX2_1	224	226	PF00082	0.539
CLV_PCSK_KEX2_1	472	474	PF00082	0.365
CLV_PCSK_KEX2_1	59	61	PF00082	0.698
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.241
CLV_PCSK_PC7_1	221	227	PF00082	0.587
CLV_PCSK_SKI1_1	226	230	PF00082	0.588
CLV_PCSK_SKI1_1	323	327	PF00082	0.247
CLV_PCSK_SKI1_1	482	486	PF00082	0.567
CLV_PCSK_SKI1_1	52	56	PF00082	0.565
DEG_APCC_DBOX_1	126	134	PF00400	0.645
DEG_APCC_DBOX_1	344	352	PF00400	0.304
DEG_SPOP_SBC_1	53	57	PF00917	0.570
DOC_CYCLIN_RxL_1	266	277	PF00134	0.486
DOC_MAPK_gen_1	343	351	PF00069	0.412
DOC_MAPK_JIP1_4	345	351	PF00069	0.304
DOC_PP1_RVXF_1	443	449	PF00149	0.304
DOC_PP4_FxxP_1	165	168	PF00568	0.682
DOC_PP4_FxxP_1	360	363	PF00568	0.304
DOC_USP7_MATH_1	102	106	PF00917	0.725
DOC_USP7_MATH_1	119	123	PF00917	0.606
DOC_USP7_MATH_1	367	371	PF00917	0.259
DOC_USP7_MATH_1	53	57	PF00917	0.746
DOC_USP7_MATH_1	68	72	PF00917	0.552
DOC_WW_Pin1_4	117	122	PF00397	0.617
DOC_WW_Pin1_4	245	250	PF00397	0.569
DOC_WW_Pin1_4	289	294	PF00397	0.369
DOC_WW_Pin1_4	435	440	PF00397	0.369
LIG_14-3-3_CanoR_1	126	131	PF00244	0.620
LIG_14-3-3_CanoR_1	224	229	PF00244	0.512
LIG_14-3-3_CanoR_1	308	316	PF00244	0.303
LIG_14-3-3_CanoR_1	337	342	PF00244	0.414
LIG_14-3-3_CanoR_1	398	405	PF00244	0.316
LIG_14-3-3_CanoR_1	406	413	PF00244	0.478
LIG_14-3-3_CanoR_1	471	476	PF00244	0.341
LIG_14-3-3_CanoR_1	69	75	PF00244	0.694
LIG_14-3-3_CanoR_1	76	80	PF00244	0.713
LIG_BRCT_BRCA1_1	13	17	PF00533	0.524
LIG_BRCT_BRCA1_1	161	165	PF00533	0.699
LIG_BRCT_BRCA1_1	317	321	PF00533	0.369
LIG_CtBP_PxDLS_1	63	67	PF00389	0.541
LIG_EH_1	357	361	PF12763	0.304
LIG_FHA_1	13	19	PF00498	0.566
LIG_FHA_1	218	224	PF00498	0.510
LIG_FHA_1	289	295	PF00498	0.326
LIG_FHA_1	336	342	PF00498	0.484
LIG_FHA_1	483	489	PF00498	0.586
LIG_FHA_2	175	181	PF00498	0.641
LIG_FHA_2	201	207	PF00498	0.674
LIG_LIR_Apic_2	162	168	PF02991	0.689
LIG_LIR_Apic_2	373	379	PF02991	0.304
LIG_LIR_Nem_3	423	427	PF02991	0.335
LIG_MYND_1	359	363	PF01753	0.304
LIG_REV1ctd_RIR_1	89	98	PF16727	0.586
LIG_SH2_NCK_1	282	286	PF00017	0.304
LIG_SH2_STAP1	385	389	PF00017	0.304
LIG_SH2_STAT5	270	273	PF00017	0.504
LIG_TRAF2_1	414	417	PF00917	0.565
MOD_CDK_SPxxK_3	117	124	PF00069	0.525
MOD_CK1_1	244	250	PF00069	0.544
MOD_CK1_1	370	376	PF00069	0.298
MOD_CK1_1	415	421	PF00069	0.484
MOD_CK1_1	78	84	PF00069	0.592
MOD_CK2_1	107	113	PF00069	0.801
MOD_CK2_1	206	212	PF00069	0.669
MOD_CK2_1	245	251	PF00069	0.648
MOD_CK2_1	406	412	PF00069	0.432
MOD_CK2_1	95	101	PF00069	0.672
MOD_GlcNHglycan	121	124	PF01048	0.636
MOD_GlcNHglycan	230	233	PF01048	0.663
MOD_GlcNHglycan	24	27	PF01048	0.610
MOD_GlcNHglycan	258	261	PF01048	0.544
MOD_GlcNHglycan	300	303	PF01048	0.333
MOD_GlcNHglycan	317	320	PF01048	0.369
MOD_GlcNHglycan	408	411	PF01048	0.501
MOD_GlcNHglycan	45	48	PF01048	0.629
MOD_GlcNHglycan	66	69	PF01048	0.667
MOD_GSK3_1	107	114	PF00069	0.559
MOD_GSK3_1	159	166	PF00069	0.763
MOD_GSK3_1	194	201	PF00069	0.690
MOD_GSK3_1	224	231	PF00069	0.514
MOD_GSK3_1	240	247	PF00069	0.611
MOD_GSK3_1	288	295	PF00069	0.227
MOD_GSK3_1	435	442	PF00069	0.440
MOD_GSK3_1	64	71	PF00069	0.637
MOD_GSK3_1	7	14	PF00069	0.639
MOD_GSK3_1	74	81	PF00069	0.616
MOD_LATS_1	480	486	PF00433	0.702
MOD_N-GLC_1	289	294	PF02516	0.222
MOD_N-GLC_1	335	340	PF02516	0.501
MOD_N-GLC_2	328	330	PF02516	0.300
MOD_NEK2_1	228	233	PF00069	0.582
MOD_NEK2_1	298	303	PF00069	0.369
MOD_NEK2_1	404	409	PF00069	0.492
MOD_NEK2_1	74	79	PF00069	0.707
MOD_PIKK_1	2	8	PF00454	0.522
MOD_PIKK_1	206	212	PF00454	0.667
MOD_PIKK_1	404	410	PF00454	0.545
MOD_PKA_1	126	132	PF00069	0.609
MOD_PKA_1	198	204	PF00069	0.570
MOD_PKA_1	224	230	PF00069	0.513
MOD_PKA_1	471	477	PF00069	0.227
MOD_PKA_2	126	132	PF00069	0.613
MOD_PKA_2	135	141	PF00069	0.617
MOD_PKA_2	194	200	PF00069	0.619
MOD_PKA_2	2	8	PF00069	0.518
MOD_PKA_2	224	230	PF00069	0.513
MOD_PKA_2	307	313	PF00069	0.227
MOD_PKA_2	33	39	PF00069	0.608
MOD_PKA_2	336	342	PF00069	0.419
MOD_PKA_2	381	387	PF00069	0.353
MOD_PKA_2	397	403	PF00069	0.227
MOD_PKA_2	463	469	PF00069	0.279
MOD_PKA_2	68	74	PF00069	0.615
MOD_PKA_2	75	81	PF00069	0.650
MOD_PKA_2	93	99	PF00069	0.672
MOD_PKB_1	124	132	PF00069	0.528
MOD_PKB_1	196	204	PF00069	0.534
MOD_PKB_1	222	230	PF00069	0.539
MOD_PKB_1	469	477	PF00069	0.227
MOD_Plk_1	415	421	PF00069	0.539
MOD_Plk_1	457	463	PF00069	0.304
MOD_Plk_2-3	107	113	PF00069	0.556
MOD_Plk_2-3	167	173	PF00069	0.663
MOD_Plk_2-3	412	418	PF00069	0.416
MOD_Plk_4	370	376	PF00069	0.304
MOD_Plk_4	4	10	PF00069	0.548
MOD_Plk_4	415	421	PF00069	0.667
MOD_Plk_4	70	76	PF00069	0.627
MOD_ProDKin_1	117	123	PF00069	0.614
MOD_ProDKin_1	245	251	PF00069	0.566
MOD_ProDKin_1	289	295	PF00069	0.369
MOD_ProDKin_1	435	441	PF00069	0.369
MOD_SUMO_for_1	361	364	PF00179	0.294
MOD_SUMO_rev_2	364	373	PF00179	0.316
TRG_DiLeu_BaEn_4	416	422	PF01217	0.536
TRG_ENDOCYTIC_2	270	273	PF00928	0.464
TRG_ER_diArg_1	125	127	PF00400	0.617
TRG_ER_diArg_1	133	136	PF00400	0.668
TRG_ER_diArg_1	195	198	PF00400	0.540
TRG_ER_diArg_1	21	23	PF00400	0.517
TRG_ER_diArg_1	221	224	PF00400	0.656
TRG_ER_diArg_1	467	470	PF00400	0.359
TRG_NLS_MonoExtN_4	469	475	PF00514	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX8	Leptomonas seymouri	52%	100%
A0A3Q8IEK2	Leishmania donovani	73%	100%
A4I4S7	Leishmania infantum	73%	100%
E9AE80	Leishmania major	73%	100%
E9ALK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%