tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHL7_LEIBR

TriTrypDb:

LbrM.29.2150 , LBRM2903_290028200

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHL7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006399	tRNA metabolic process	7	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008033	tRNA processing	8	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034470	ncRNA processing	7	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.326
CLV_C14_Caspase3-7	453	457	PF00656	0.492
CLV_C14_Caspase3-7	487	491	PF00656	0.449
CLV_MEL_PAP_1	396	402	PF00089	0.240
CLV_NRD_NRD_1	168	170	PF00675	0.410
CLV_NRD_NRD_1	313	315	PF00675	0.501
CLV_NRD_NRD_1	371	373	PF00675	0.492
CLV_NRD_NRD_1	415	417	PF00675	0.357
CLV_NRD_NRD_1	488	490	PF00675	0.500
CLV_NRD_NRD_1	493	495	PF00675	0.546
CLV_NRD_NRD_1	515	517	PF00675	0.669
CLV_NRD_NRD_1	575	577	PF00675	0.759
CLV_NRD_NRD_1	84	86	PF00675	0.616
CLV_NRD_NRD_1	91	93	PF00675	0.640
CLV_PCSK_FUR_1	311	315	PF00082	0.220
CLV_PCSK_FUR_1	486	490	PF00082	0.457
CLV_PCSK_FUR_1	573	577	PF00082	0.743
CLV_PCSK_KEX2_1	160	162	PF00082	0.449
CLV_PCSK_KEX2_1	168	170	PF00082	0.403
CLV_PCSK_KEX2_1	311	313	PF00082	0.309
CLV_PCSK_KEX2_1	417	419	PF00082	0.391
CLV_PCSK_KEX2_1	488	490	PF00082	0.494
CLV_PCSK_KEX2_1	493	495	PF00082	0.561
CLV_PCSK_KEX2_1	515	517	PF00082	0.669
CLV_PCSK_KEX2_1	575	577	PF00082	0.759
CLV_PCSK_KEX2_1	83	85	PF00082	0.619
CLV_PCSK_KEX2_1	91	93	PF00082	0.634
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.423
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.391
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.668
CLV_PCSK_PC7_1	489	495	PF00082	0.504
CLV_PCSK_SKI1_1	150	154	PF00082	0.501
CLV_PCSK_SKI1_1	391	395	PF00082	0.492
CLV_PCSK_SKI1_1	465	469	PF00082	0.438
CLV_PCSK_SKI1_1	583	587	PF00082	0.529
CLV_Separin_Metazoa	224	228	PF03568	0.391
DEG_APCC_DBOX_1	464	472	PF00400	0.301
DEG_APCC_DBOX_1	515	523	PF00400	0.599
DEG_APCC_DBOX_1	596	604	PF00400	0.514
DEG_COP1_1	563	571	PF00400	0.479
DEG_SPOP_SBC_1	105	109	PF00917	0.474
DEG_SPOP_SBC_1	18	22	PF00917	0.404
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.391
DOC_MAPK_DCC_7	132	141	PF00069	0.558
DOC_MAPK_gen_1	157	166	PF00069	0.512
DOC_MAPK_gen_1	168	174	PF00069	0.390
DOC_MAPK_gen_1	372	379	PF00069	0.391
DOC_MAPK_gen_1	83	89	PF00069	0.639
DOC_MAPK_MEF2A_6	132	141	PF00069	0.608
DOC_MAPK_MEF2A_6	395	404	PF00069	0.357
DOC_MAPK_MEF2A_6	500	508	PF00069	0.382
DOC_PP2B_LxvP_1	239	242	PF13499	0.391
DOC_PP2B_LxvP_1	517	520	PF13499	0.614
DOC_PP4_FxxP_1	571	574	PF00568	0.667
DOC_USP7_MATH_1	106	110	PF00917	0.724
DOC_USP7_MATH_1	111	115	PF00917	0.739
DOC_USP7_MATH_1	18	22	PF00917	0.604
DOC_USP7_MATH_1	398	402	PF00917	0.492
DOC_USP7_MATH_1	448	452	PF00917	0.474
DOC_USP7_MATH_1	588	592	PF00917	0.542
DOC_WW_Pin1_4	316	321	PF00397	0.492
DOC_WW_Pin1_4	356	361	PF00397	0.341
LIG_14-3-3_CanoR_1	161	167	PF00244	0.446
LIG_14-3-3_CanoR_1	168	173	PF00244	0.372
LIG_14-3-3_CanoR_1	202	206	PF00244	0.395
LIG_14-3-3_CanoR_1	340	344	PF00244	0.240
LIG_14-3-3_CanoR_1	399	403	PF00244	0.492
LIG_14-3-3_CanoR_1	50	54	PF00244	0.653
LIG_14-3-3_CanoR_1	545	555	PF00244	0.505
LIG_14-3-3_CanoR_1	56	64	PF00244	0.536
LIG_Actin_WH2_2	455	471	PF00022	0.438
LIG_APCC_ABBA_1	218	223	PF00400	0.357
LIG_CaM_NSCaTE_8	149	156	PF13499	0.307
LIG_Clathr_ClatBox_1	376	380	PF01394	0.391
LIG_deltaCOP1_diTrp_1	148	152	PF00928	0.455
LIG_EH1_1	31	39	PF00400	0.298
LIG_FHA_1	136	142	PF00498	0.531
LIG_FHA_1	215	221	PF00498	0.357
LIG_FHA_1	392	398	PF00498	0.492
LIG_FHA_1	512	518	PF00498	0.410
LIG_FHA_1	563	569	PF00498	0.431
LIG_FHA_1	584	590	PF00498	0.534
LIG_FHA_2	118	124	PF00498	0.682
LIG_FHA_2	194	200	PF00498	0.318
LIG_FHA_2	451	457	PF00498	0.492
LIG_FHA_2	547	553	PF00498	0.648
LIG_FHA_2	55	61	PF00498	0.595
LIG_HP1_1	398	402	PF01393	0.391
LIG_IBAR_NPY_1	28	30	PF08397	0.485
LIG_LIR_Apic_2	570	574	PF02991	0.667
LIG_LIR_Gen_1	138	147	PF02991	0.481
LIG_LIR_Gen_1	406	415	PF02991	0.360
LIG_LIR_Nem_3	138	143	PF02991	0.471
LIG_LIR_Nem_3	146	152	PF02991	0.370
LIG_LIR_Nem_3	406	411	PF02991	0.334
LIG_PTB_Apo_2	521	528	PF02174	0.504
LIG_PTB_Phospho_1	521	527	PF10480	0.510
LIG_SH2_CRK	291	295	PF00017	0.240
LIG_SH2_CRK	336	340	PF00017	0.240
LIG_SH2_SRC	291	294	PF00017	0.240
LIG_SH2_SRC	470	473	PF00017	0.523
LIG_SH2_STAP1	408	412	PF00017	0.357
LIG_SH2_STAP1	443	447	PF00017	0.438
LIG_SH2_STAT3	254	257	PF00017	0.492
LIG_SH2_STAT3	300	303	PF00017	0.337
LIG_SH2_STAT5	140	143	PF00017	0.498
LIG_SH2_STAT5	237	240	PF00017	0.438
LIG_SH2_STAT5	254	257	PF00017	0.391
LIG_SH2_STAT5	293	296	PF00017	0.466
LIG_SH2_STAT5	336	339	PF00017	0.326
LIG_SH2_STAT5	470	473	PF00017	0.324
LIG_SH2_STAT5	525	528	PF00017	0.427
LIG_SH3_3	354	360	PF00018	0.365
LIG_SH3_3	563	569	PF00018	0.582
LIG_SH3_3	582	588	PF00018	0.690
LIG_SUMO_SIM_par_1	375	382	PF11976	0.418
LIG_SUMO_SIM_par_1	563	570	PF11976	0.476
LIG_TRAF2_1	142	145	PF00917	0.624
LIG_TRAF2_1	269	272	PF00917	0.240
LIG_TRAF2_1	57	60	PF00917	0.639
LIG_UBA3_1	411	417	PF00899	0.357
MOD_CDK_SPK_2	316	321	PF00069	0.240
MOD_CK1_1	122	128	PF00069	0.773
MOD_CK1_1	228	234	PF00069	0.438
MOD_CK1_1	350	356	PF00069	0.448
MOD_CK1_1	49	55	PF00069	0.399
MOD_CK1_1	546	552	PF00069	0.623
MOD_CK1_1	560	566	PF00069	0.557
MOD_CK1_1	6	12	PF00069	0.739
MOD_CK2_1	139	145	PF00069	0.615
MOD_CK2_1	422	428	PF00069	0.357
MOD_CK2_1	54	60	PF00069	0.598
MOD_CK2_1	546	552	PF00069	0.650
MOD_CK2_1	588	594	PF00069	0.733
MOD_Cter_Amidation	578	581	PF01082	0.519
MOD_GlcNHglycan	123	127	PF01048	0.720
MOD_GlcNHglycan	129	132	PF01048	0.681
MOD_GlcNHglycan	154	157	PF01048	0.475
MOD_GlcNHglycan	230	233	PF01048	0.436
MOD_GlcNHglycan	478	481	PF01048	0.592
MOD_GlcNHglycan	559	562	PF01048	0.553
MOD_GlcNHglycan	8	11	PF01048	0.700
MOD_GSK3_1	122	129	PF00069	0.723
MOD_GSK3_1	135	142	PF00069	0.571
MOD_GSK3_1	2	9	PF00069	0.566
MOD_GSK3_1	277	284	PF00069	0.475
MOD_GSK3_1	339	346	PF00069	0.473
MOD_GSK3_1	423	430	PF00069	0.381
MOD_GSK3_1	45	52	PF00069	0.527
MOD_GSK3_1	507	514	PF00069	0.651
MOD_GSK3_1	553	560	PF00069	0.580
MOD_GSK3_1	583	590	PF00069	0.534
MOD_N-GLC_1	347	352	PF02516	0.356
MOD_N-GLC_2	524	526	PF02516	0.463
MOD_NEK2_1	152	157	PF00069	0.417
MOD_NEK2_1	19	24	PF00069	0.595
MOD_NEK2_1	225	230	PF00069	0.358
MOD_NEK2_1	299	304	PF00069	0.279
MOD_NEK2_1	334	339	PF00069	0.240
MOD_NEK2_1	378	383	PF00069	0.391
MOD_NEK2_1	427	432	PF00069	0.357
MOD_NEK2_1	461	466	PF00069	0.326
MOD_NEK2_1	543	548	PF00069	0.623
MOD_NEK2_2	277	282	PF00069	0.438
MOD_PIKK_1	299	305	PF00454	0.376
MOD_PIKK_1	602	608	PF00454	0.740
MOD_PK_1	168	174	PF00069	0.534
MOD_PKA_1	168	174	PF00069	0.418
MOD_PKA_1	416	422	PF00069	0.357
MOD_PKA_1	92	98	PF00069	0.569
MOD_PKA_2	168	174	PF00069	0.418
MOD_PKA_2	2	8	PF00069	0.532
MOD_PKA_2	201	207	PF00069	0.492
MOD_PKA_2	226	232	PF00069	0.357
MOD_PKA_2	339	345	PF00069	0.240
MOD_PKA_2	398	404	PF00069	0.492
MOD_PKA_2	49	55	PF00069	0.666
MOD_Plk_1	122	128	PF00069	0.518
MOD_Plk_1	143	149	PF00069	0.597
MOD_Plk_1	214	220	PF00069	0.374
MOD_Plk_1	379	385	PF00069	0.391
MOD_Plk_1	427	433	PF00069	0.357
MOD_Plk_1	581	587	PF00069	0.527
MOD_Plk_4	135	141	PF00069	0.573
MOD_Plk_4	162	168	PF00069	0.498
MOD_Plk_4	214	220	PF00069	0.351
MOD_Plk_4	272	278	PF00069	0.365
MOD_Plk_4	407	413	PF00069	0.357
MOD_ProDKin_1	316	322	PF00069	0.492
MOD_ProDKin_1	356	362	PF00069	0.341
MOD_SUMO_for_1	156	159	PF00179	0.343
MOD_SUMO_for_1	320	323	PF00179	0.386
MOD_SUMO_for_1	71	74	PF00179	0.439
MOD_SUMO_rev_2	142	152	PF00179	0.526
TRG_DiLeu_BaEn_1	215	220	PF01217	0.438
TRG_DiLeu_BaEn_2	147	153	PF01217	0.503
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.481
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.240
TRG_ENDOCYTIC_2	140	143	PF00928	0.560
TRG_ENDOCYTIC_2	291	294	PF00928	0.240
TRG_ENDOCYTIC_2	408	411	PF00928	0.332
TRG_ER_diArg_1	167	169	PF00400	0.436
TRG_ER_diArg_1	311	314	PF00400	0.239
TRG_ER_diArg_1	415	418	PF00400	0.391
TRG_ER_diArg_1	485	488	PF00400	0.367
TRG_ER_diArg_1	515	518	PF00400	0.614
TRG_ER_diArg_1	573	576	PF00400	0.738
TRG_ER_diArg_1	82	85	PF00400	0.584
TRG_NES_CRM1_1	208	224	PF08389	0.240
TRG_NLS_MonoExtC_3	415	420	PF00514	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V5	Leptomonas seymouri	55%	100%
A0A0S4JPN0	Bodo saltans	37%	100%
A0A3Q8IHF3	Leishmania donovani	75%	100%
A4I4S6	Leishmania infantum	75%	100%
C9ZLH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AE79	Leishmania major	75%	100%
E9ALK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%