Rab GDP dissociation inhibitor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rab-GDP dissociation inhibitor, putative

Species:

Leishmania braziliensis

UniProt:

A4HHL6_LEIBR

TriTrypDb:

LbrM.29.2140 , LBRM2903_290028100

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHL6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0007165	signal transduction	2	12
GO:0007264	small GTPase mediated signal transduction	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0035556	intracellular signal transduction	3	12
GO:0045184	establishment of protein localization	3	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0065007	biological regulation	1	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0016192	vesicle-mediated transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005092	GDP-dissociation inhibitor activity	3	12
GO:0005093	Rab GDP-dissociation inhibitor activity	4	12
GO:0030234	enzyme regulator activity	2	12
GO:0030695	GTPase regulator activity	4	12
GO:0060589	nucleoside-triphosphatase regulator activity	3	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.273
CLV_PCSK_KEX2_1	136	138	PF00082	0.287
CLV_PCSK_KEX2_1	437	439	PF00082	0.623
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.287
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.623
CLV_PCSK_SKI1_1	114	118	PF00082	0.287
CLV_PCSK_SKI1_1	140	144	PF00082	0.293
CLV_PCSK_SKI1_1	163	167	PF00082	0.274
CLV_PCSK_SKI1_1	199	203	PF00082	0.241
CLV_PCSK_SKI1_1	278	282	PF00082	0.322
DEG_APCC_DBOX_1	139	147	PF00400	0.512
DEG_APCC_DBOX_1	65	73	PF00400	0.460
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DOC_CKS1_1	250	255	PF01111	0.491
DOC_PP1_RVXF_1	254	260	PF00149	0.460
DOC_USP7_MATH_2	391	397	PF00917	0.533
DOC_USP7_UBL2_3	274	278	PF12436	0.493
DOC_USP7_UBL2_3	292	296	PF12436	0.524
DOC_WW_Pin1_4	125	130	PF00397	0.404
DOC_WW_Pin1_4	218	223	PF00397	0.479
DOC_WW_Pin1_4	249	254	PF00397	0.491
LIG_14-3-3_CanoR_1	137	143	PF00244	0.403
LIG_14-3-3_CanoR_1	163	168	PF00244	0.423
LIG_14-3-3_CanoR_1	90	94	PF00244	0.460
LIG_Actin_WH2_2	297	314	PF00022	0.563
LIG_APCC_ABBAyCdc20_2	207	213	PF00400	0.423
LIG_BRCT_BRCA1_1	397	401	PF00533	0.471
LIG_FHA_1	10	16	PF00498	0.467
LIG_FHA_1	245	251	PF00498	0.460
LIG_FHA_1	259	265	PF00498	0.460
LIG_FHA_2	119	125	PF00498	0.460
LIG_FHA_2	250	256	PF00498	0.554
LIG_FHA_2	354	360	PF00498	0.460
LIG_FHA_2	408	414	PF00498	0.471
LIG_FHA_2	437	443	PF00498	0.472
LIG_FHA_2	90	96	PF00498	0.460
LIG_IBAR_NPY_1	36	38	PF08397	0.423
LIG_LIR_Apic_2	221	226	PF02991	0.462
LIG_LIR_Gen_1	100	109	PF02991	0.461
LIG_LIR_Gen_1	2	9	PF02991	0.460
LIG_LIR_Gen_1	347	358	PF02991	0.471
LIG_LIR_Gen_1	380	389	PF02991	0.471
LIG_LIR_Gen_1	421	431	PF02991	0.457
LIG_LIR_Gen_1	49	60	PF02991	0.501
LIG_LIR_Nem_3	100	104	PF02991	0.461
LIG_LIR_Nem_3	141	145	PF02991	0.583
LIG_LIR_Nem_3	154	160	PF02991	0.543
LIG_LIR_Nem_3	2	8	PF02991	0.460
LIG_LIR_Nem_3	212	218	PF02991	0.467
LIG_LIR_Nem_3	380	385	PF02991	0.463
LIG_LIR_Nem_3	386	392	PF02991	0.456
LIG_LIR_Nem_3	421	426	PF02991	0.447
LIG_LIR_Nem_3	432	436	PF02991	0.498
LIG_LIR_Nem_3	49	55	PF02991	0.472
LIG_MAD2	29	37	PF02301	0.423
LIG_NRBOX	18	24	PF00104	0.460
LIG_PDZ_Class_2	440	445	PF00595	0.625
LIG_PTB_Apo_2	33	40	PF02174	0.423
LIG_PTB_Phospho_1	33	39	PF10480	0.423
LIG_REV1ctd_RIR_1	131	142	PF16727	0.460
LIG_SH2_CRK	28	32	PF00017	0.460
LIG_SH2_CRK	5	9	PF00017	0.460
LIG_SH2_NCK_1	406	410	PF00017	0.483
LIG_SH2_PTP2	223	226	PF00017	0.460
LIG_SH2_SRC	211	214	PF00017	0.491
LIG_SH2_SRC	223	226	PF00017	0.425
LIG_SH2_STAP1	211	215	PF00017	0.471
LIG_SH2_STAP1	431	435	PF00017	0.512
LIG_SH2_STAP1	5	9	PF00017	0.460
LIG_SH2_STAT3	248	251	PF00017	0.460
LIG_SH2_STAT3	334	337	PF00017	0.460
LIG_SH2_STAT5	145	148	PF00017	0.579
LIG_SH2_STAT5	196	199	PF00017	0.508
LIG_SH2_STAT5	218	221	PF00017	0.490
LIG_SH2_STAT5	223	226	PF00017	0.471
LIG_SH2_STAT5	286	289	PF00017	0.460
LIG_SH2_STAT5	334	337	PF00017	0.460
LIG_SH2_STAT5	350	353	PF00017	0.460
LIG_SH3_3	355	361	PF00018	0.600
LIG_SUMO_SIM_par_1	350	356	PF11976	0.527
LIG_SUMO_SIM_par_1	418	424	PF11976	0.403
LIG_TRAF2_1	439	442	PF00917	0.593
LIG_UBA3_1	335	343	PF00899	0.460
LIG_UBA3_1	422	429	PF00899	0.490
LIG_WRC_WIRS_1	139	144	PF05994	0.403
LIG_WRC_WIRS_1	379	384	PF05994	0.471
MOD_CDK_SPxxK_3	249	256	PF00069	0.460
MOD_CK1_1	238	244	PF00069	0.563
MOD_CK1_1	267	273	PF00069	0.460
MOD_CK2_1	118	124	PF00069	0.460
MOD_CK2_1	353	359	PF00069	0.460
MOD_CK2_1	381	387	PF00069	0.509
MOD_CK2_1	407	413	PF00069	0.482
MOD_CK2_1	436	442	PF00069	0.460
MOD_GlcNHglycan	19	22	PF01048	0.260
MOD_GlcNHglycan	229	232	PF01048	0.271
MOD_GlcNHglycan	240	243	PF01048	0.271
MOD_GlcNHglycan	269	272	PF01048	0.327
MOD_GlcNHglycan	42	45	PF01048	0.313
MOD_GSK3_1	145	152	PF00069	0.403
MOD_GSK3_1	17	24	PF00069	0.460
MOD_GSK3_1	175	182	PF00069	0.537
MOD_GSK3_1	60	67	PF00069	0.465
MOD_LATS_1	427	433	PF00433	0.512
MOD_N-GLC_2	316	318	PF02516	0.271
MOD_NEK2_1	104	109	PF00069	0.460
MOD_NEK2_1	311	316	PF00069	0.420
MOD_NEK2_1	353	358	PF00069	0.609
MOD_NEK2_1	64	69	PF00069	0.471
MOD_NEK2_1	89	94	PF00069	0.460
MOD_NEK2_2	211	216	PF00069	0.481
MOD_PKA_2	238	244	PF00069	0.563
MOD_PKA_2	89	95	PF00069	0.460
MOD_Plk_1	104	110	PF00069	0.460
MOD_Plk_1	211	217	PF00069	0.480
MOD_Plk_4	104	110	PF00069	0.460
MOD_Plk_4	201	207	PF00069	0.480
MOD_Plk_4	244	250	PF00069	0.460
MOD_Plk_4	282	288	PF00069	0.460
MOD_Plk_4	353	359	PF00069	0.503
MOD_Plk_4	378	384	PF00069	0.471
MOD_Plk_4	89	95	PF00069	0.460
MOD_ProDKin_1	125	131	PF00069	0.404
MOD_ProDKin_1	218	224	PF00069	0.479
MOD_ProDKin_1	249	255	PF00069	0.491
MOD_SUMO_rev_2	107	116	PF00179	0.516
MOD_SUMO_rev_2	340	344	PF00179	0.563
TRG_ENDOCYTIC_2	28	31	PF00928	0.460
TRG_ENDOCYTIC_2	350	353	PF00928	0.399
TRG_ENDOCYTIC_2	389	392	PF00928	0.460
TRG_ENDOCYTIC_2	5	8	PF00928	0.460
TRG_ENDOCYTIC_2	52	55	PF00928	0.502
TRG_ER_diArg_1	137	140	PF00400	0.567
TRG_NES_CRM1_1	179	194	PF08389	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R8	Leptomonas seymouri	85%	100%
A0A0S4JSB4	Bodo saltans	71%	100%
A0A1X0P0G2	Trypanosomatidae	77%	100%
A0A3Q8IEG2	Leishmania donovani	91%	100%
A0A3R7MJZ3	Trypanosoma rangeli	73%	100%
A4I4S5	Leishmania infantum	91%	100%
C9ZLH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AE78	Leishmania major	91%	100%
E9ALK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
G4MT60	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	45%	96%
O24653	Arabidopsis thaliana	48%	100%
O93831	Candida albicans	25%	70%
O97555	Canis lupus familiaris	50%	100%
O97556	Canis lupus familiaris	49%	100%
P21856	Bos taurus	50%	100%
P24386	Homo sapiens	27%	68%
P26374	Homo sapiens	26%	68%
P31150	Homo sapiens	51%	100%
P32864	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	74%
P37727	Rattus norvegicus	26%	68%
P39958	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	99%
P50395	Homo sapiens	49%	100%
P50396	Mus musculus	51%	100%
P50397	Bos taurus	50%	100%
P50398	Rattus norvegicus	51%	100%
P50399	Rattus norvegicus	49%	100%
P60028	Pan troglodytes	51%	100%
Q10305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	100%
Q5RCE1	Pongo abelii	49%	100%
Q61598	Mus musculus	49%	100%
Q6Q7J2	Sus scrofa	50%	100%
Q7YQM0	Pongo pygmaeus	50%	100%
Q8HXX7	Macaca fascicularis	50%	100%
Q8LLD4	Arabidopsis thaliana	25%	79%
Q96254	Arabidopsis thaliana	50%	100%
Q9BKQ5	Caenorhabditis elegans	26%	87%
Q9LXC0	Arabidopsis thaliana	50%	100%
Q9QXG2	Mus musculus	25%	67%
Q9QZD5	Mus musculus	26%	72%
Q9V8W3	Drosophila melanogaster	27%	87%
V5BGJ6	Trypanosoma cruzi	76%	100%