Homologous to fungal ERG2 sterol isomerase and the mammalian sigma receptor 1. A lipid modifying enzyme family. Related to fungal C-8 sterol isomerases, but the catalytic activity of animal orthologs is unclear. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 1, no: 8 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | 5 | 10 |
| GO:0016020 | membrane | 2 | 10 |
| GO:0043226 | organelle | 2 | 10 |
| GO:0043227 | membrane-bounded organelle | 3 | 10 |
| GO:0043229 | intracellular organelle | 3 | 10 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 10 |
| GO:0110165 | cellular anatomical entity | 1 | 10 |
Related structures:
AlphaFold database: A4HHL4
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 10 |
| GO:0016853 | isomerase activity | 2 | 10 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_SKI1_1 | 216 | 220 | PF00082 | 0.391 |
| CLV_PCSK_SKI1_1 | 60 | 64 | PF00082 | 0.542 |
| DOC_MAPK_MEF2A_6 | 5 | 14 | PF00069 | 0.478 |
| DOC_USP7_MATH_1 | 42 | 46 | PF00917 | 0.354 |
| DOC_USP7_MATH_1 | 92 | 96 | PF00917 | 0.257 |
| LIG_14-3-3_CanoR_1 | 56 | 62 | PF00244 | 0.177 |
| LIG_14-3-3_CanoR_1 | 68 | 72 | PF00244 | 0.144 |
| LIG_Actin_WH2_2 | 200 | 218 | PF00022 | 0.177 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.640 |
| LIG_BRCT_BRCA1_1 | 183 | 187 | PF00533 | 0.243 |
| LIG_FHA_1 | 195 | 201 | PF00498 | 0.270 |
| LIG_FHA_1 | 64 | 70 | PF00498 | 0.307 |
| LIG_FHA_2 | 204 | 210 | PF00498 | 0.275 |
| LIG_LIR_Gen_1 | 104 | 114 | PF02991 | 0.256 |
| LIG_LIR_Gen_1 | 127 | 134 | PF02991 | 0.248 |
| LIG_LIR_Gen_1 | 136 | 145 | PF02991 | 0.252 |
| LIG_LIR_Nem_3 | 102 | 106 | PF02991 | 0.259 |
| LIG_LIR_Nem_3 | 127 | 133 | PF02991 | 0.248 |
| LIG_LIR_Nem_3 | 136 | 141 | PF02991 | 0.252 |
| LIG_LIR_Nem_3 | 184 | 190 | PF02991 | 0.257 |
| LIG_LIR_Nem_3 | 20 | 25 | PF02991 | 0.193 |
| LIG_LIR_Nem_3 | 3 | 7 | PF02991 | 0.517 |
| LIG_PCNA_PIPBox_1 | 15 | 24 | PF02747 | 0.200 |
| LIG_Pex14_1 | 125 | 129 | PF04695 | 0.275 |
| LIG_Pex14_1 | 173 | 177 | PF04695 | 0.275 |
| LIG_REV1ctd_RIR_1 | 19 | 27 | PF16727 | 0.200 |
| LIG_SH2_SRC | 106 | 109 | PF00017 | 0.257 |
| LIG_SH2_SRC | 33 | 36 | PF00017 | 0.328 |
| LIG_SH2_STAT3 | 24 | 27 | PF00017 | 0.411 |
| LIG_SH2_STAT5 | 106 | 109 | PF00017 | 0.256 |
| LIG_SH2_STAT5 | 123 | 126 | PF00017 | 0.202 |
| LIG_SH2_STAT5 | 24 | 27 | PF00017 | 0.411 |
| LIG_SH2_STAT5 | 80 | 83 | PF00017 | 0.328 |
| LIG_SH3_3 | 146 | 152 | PF00018 | 0.297 |
| LIG_SH3_3 | 22 | 28 | PF00018 | 0.299 |
| LIG_SH3_3 | 29 | 35 | PF00018 | 0.238 |
| LIG_SUMO_SIM_par_1 | 195 | 202 | PF11976 | 0.262 |
| LIG_SUMO_SIM_par_1 | 8 | 13 | PF11976 | 0.368 |
| LIG_UBA3_1 | 214 | 222 | PF00899 | 0.267 |
| LIG_WRC_WIRS_1 | 1 | 6 | PF05994 | 0.643 |
| LIG_WRC_WIRS_1 | 18 | 23 | PF05994 | 0.165 |
| MOD_CK1_1 | 113 | 119 | PF00069 | 0.344 |
| MOD_CK1_1 | 3 | 9 | PF00069 | 0.377 |
| MOD_CK2_1 | 203 | 209 | PF00069 | 0.275 |
| MOD_CK2_1 | 99 | 105 | PF00069 | 0.257 |
| MOD_GlcNHglycan | 209 | 212 | PF01048 | 0.490 |
| MOD_GSK3_1 | 109 | 116 | PF00069 | 0.290 |
| MOD_GSK3_1 | 194 | 201 | PF00069 | 0.260 |
| MOD_GSK3_1 | 203 | 210 | PF00069 | 0.252 |
| MOD_GSK3_1 | 63 | 70 | PF00069 | 0.312 |
| MOD_GSK3_1 | 74 | 81 | PF00069 | 0.291 |
| MOD_NEK2_1 | 110 | 115 | PF00069 | 0.257 |
| MOD_NEK2_1 | 193 | 198 | PF00069 | 0.265 |
| MOD_NEK2_1 | 203 | 208 | PF00069 | 0.243 |
| MOD_NEK2_1 | 99 | 104 | PF00069 | 0.257 |
| MOD_PKA_2 | 159 | 165 | PF00069 | 0.286 |
| MOD_PKA_2 | 55 | 61 | PF00069 | 0.177 |
| MOD_PKA_2 | 67 | 73 | PF00069 | 0.296 |
| MOD_Plk_1 | 198 | 204 | PF00069 | 0.267 |
| MOD_Plk_1 | 63 | 69 | PF00069 | 0.306 |
| MOD_Plk_4 | 10 | 16 | PF00069 | 0.315 |
| MOD_Plk_4 | 17 | 23 | PF00069 | 0.276 |
| MOD_Plk_4 | 203 | 209 | PF00069 | 0.244 |
| MOD_Plk_4 | 94 | 100 | PF00069 | 0.257 |
| TRG_DiLeu_BaEn_4 | 170 | 176 | PF01217 | 0.288 |
| TRG_ENDOCYTIC_2 | 106 | 109 | PF00928 | 0.257 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I584 | Leptomonas seymouri | 81% | 100% |
| A0A1D8PCB9 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 46% | 100% |
| A0A1X0P040 | Trypanosomatidae | 63% | 100% |
| A0A3Q8IDV8 | Leishmania donovani | 85% | 100% |
| A0A3R7RKQ2 | Trypanosoma rangeli | 69% | 100% |
| A4I4S3 | Leishmania infantum | 84% | 100% |
| C9ZLG7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 58% | 100% |
| E9AE76 | Leishmania major | 82% | 100% |
| E9ALK9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 84% | 100% |
| I1RT23 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 48% | 95% |
| P32352 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 44% | 100% |
| P32360 | Ustilago maydis (strain 521 / FGSC 9021) | 48% | 93% |
| P33281 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 50% | 100% |
| P87113 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 46% | 100% |
| Q4WJU9 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 43% | 93% |
| Q55BU8 | Dictyostelium discoideum | 33% | 96% |
| Q7ZWG9 | Danio rerio | 33% | 100% |
| Q92254 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 50% | 87% |