Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHL3_LEIBR

TriTrypDb:

LbrM.29.2110 , LBRM2903_290027800

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4HHL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	142	144	PF00082	0.584
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.584
CLV_PCSK_SKI1_1	139	143	PF00082	0.505
CLV_PCSK_SKI1_1	261	265	PF00082	0.517
CLV_PCSK_SKI1_1	443	447	PF00082	0.242
CLV_Separin_Metazoa	391	395	PF03568	0.372
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DEG_SPOP_SBC_1	213	217	PF00917	0.580
DOC_CYCLIN_RxL_1	388	402	PF00134	0.482
DOC_CYCLIN_yClb5_NLxxxL_5	333	342	PF00134	0.253
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.256
DOC_MAPK_MEF2A_6	80	89	PF00069	0.301
DOC_PP1_RVXF_1	28	35	PF00149	0.409
DOC_PP1_RVXF_1	392	399	PF00149	0.289
DOC_USP7_UBL2_3	261	265	PF12436	0.275
DOC_WW_Pin1_4	214	219	PF00397	0.630
DOC_WW_Pin1_4	307	312	PF00397	0.626
LIG_14-3-3_CanoR_1	111	116	PF00244	0.284
LIG_14-3-3_CanoR_1	143	151	PF00244	0.475
LIG_14-3-3_CanoR_1	24	29	PF00244	0.654
LIG_14-3-3_CanoR_1	243	249	PF00244	0.571
LIG_14-3-3_CanoR_1	273	279	PF00244	0.230
LIG_14-3-3_CanoR_1	289	298	PF00244	0.346
LIG_14-3-3_CanoR_1	68	73	PF00244	0.489
LIG_14-3-3_CanoR_1	97	104	PF00244	0.512
LIG_14-3-3_CterR_2	478	482	PF00244	0.501
LIG_Actin_WH2_2	274	291	PF00022	0.240
LIG_FHA_1	114	120	PF00498	0.559
LIG_FHA_1	233	239	PF00498	0.471
LIG_FHA_1	251	257	PF00498	0.243
LIG_FHA_1	337	343	PF00498	0.539
LIG_FHA_1	35	41	PF00498	0.590
LIG_FHA_1	387	393	PF00498	0.479
LIG_FHA_1	405	411	PF00498	0.412
LIG_FHA_1	428	434	PF00498	0.335
LIG_FHA_2	168	174	PF00498	0.570
LIG_FHA_2	257	263	PF00498	0.570
LIG_IRF3_LxIS_1	270	277	PF10401	0.531
LIG_LIR_Apic_2	476	480	PF02991	0.676
LIG_LIR_Gen_1	284	291	PF02991	0.339
LIG_LIR_Gen_1	395	406	PF02991	0.275
LIG_LIR_Nem_3	131	137	PF02991	0.522
LIG_LIR_Nem_3	277	281	PF02991	0.417
LIG_LIR_Nem_3	284	288	PF02991	0.397
LIG_LIR_Nem_3	395	401	PF02991	0.400
LIG_LIR_Nem_3	420	424	PF02991	0.286
LIG_SH2_CRK	477	481	PF00017	0.407
LIG_SH2_PTP2	444	447	PF00017	0.260
LIG_SH2_PTP2	467	470	PF00017	0.260
LIG_SH2_STAP1	246	250	PF00017	0.466
LIG_SH2_STAT5	332	335	PF00017	0.548
LIG_SH2_STAT5	421	424	PF00017	0.533
LIG_SH2_STAT5	444	447	PF00017	0.243
LIG_SH2_STAT5	467	470	PF00017	0.409
LIG_SH3_3	305	311	PF00018	0.649
LIG_SUMO_SIM_par_1	152	159	PF11976	0.587
LIG_SUMO_SIM_par_1	224	229	PF11976	0.506
LIG_SUMO_SIM_par_1	234	240	PF11976	0.527
LIG_SUMO_SIM_par_1	296	301	PF11976	0.407
LIG_SUMO_SIM_par_1	310	315	PF11976	0.511
LIG_SUMO_SIM_par_1	352	357	PF11976	0.330
LIG_TRAF2_1	118	121	PF00917	0.581
LIG_TYR_ITIM	419	424	PF00017	0.538
LIG_TYR_ITIM	442	447	PF00017	0.263
LIG_TYR_ITIM	465	470	PF00017	0.261
LIG_UBA3_1	1	6	PF00899	0.455
LIG_UBA3_1	341	350	PF00899	0.263
MOD_CK1_1	149	155	PF00069	0.443
MOD_CK1_1	310	316	PF00069	0.499
MOD_CK2_1	167	173	PF00069	0.565
MOD_CK2_1	256	262	PF00069	0.580
MOD_CK2_1	46	52	PF00069	0.583
MOD_GlcNHglycan	106	109	PF01048	0.259
MOD_GlcNHglycan	228	231	PF01048	0.543
MOD_GlcNHglycan	299	303	PF01048	0.409
MOD_GlcNHglycan	304	307	PF01048	0.441
MOD_GlcNHglycan	400	404	PF01048	0.406
MOD_GlcNHglycan	47	51	PF01048	0.460
MOD_GlcNHglycan	92	95	PF01048	0.552
MOD_GSK3_1	128	135	PF00069	0.455
MOD_GSK3_1	182	189	PF00069	0.555
MOD_GSK3_1	244	251	PF00069	0.516
MOD_GSK3_1	298	305	PF00069	0.452
MOD_GSK3_1	30	37	PF00069	0.532
MOD_GSK3_1	332	339	PF00069	0.379
MOD_LATS_1	22	28	PF00433	0.439
MOD_N-GLC_1	128	133	PF02516	0.375
MOD_N-GLC_1	232	237	PF02516	0.338
MOD_N-GLC_1	274	279	PF02516	0.475
MOD_N-GLC_1	336	341	PF02516	0.423
MOD_N-GLC_1	410	415	PF02516	0.324
MOD_N-GLC_1	433	438	PF02516	0.483
MOD_N-GLC_1	450	455	PF02516	0.264
MOD_N-GLC_2	204	206	PF02516	0.261
MOD_NEK2_1	1	6	PF00069	0.455
MOD_NEK2_1	104	109	PF00069	0.560
MOD_NEK2_1	155	160	PF00069	0.500
MOD_NEK2_1	167	172	PF00069	0.450
MOD_NEK2_1	226	231	PF00069	0.448
MOD_NEK2_1	248	253	PF00069	0.548
MOD_NEK2_1	274	279	PF00069	0.268
MOD_NEK2_1	290	295	PF00069	0.368
MOD_NEK2_1	298	303	PF00069	0.438
MOD_NEK2_1	312	317	PF00069	0.494
MOD_NEK2_1	331	336	PF00069	0.239
MOD_NEK2_1	34	39	PF00069	0.410
MOD_NEK2_1	372	377	PF00069	0.366
MOD_NEK2_1	383	388	PF00069	0.290
MOD_NEK2_1	399	404	PF00069	0.213
MOD_NEK2_1	422	427	PF00069	0.308
MOD_PIKK_1	149	155	PF00454	0.286
MOD_PIKK_1	250	256	PF00454	0.545
MOD_PIKK_1	290	296	PF00454	0.440
MOD_PIKK_1	312	318	PF00454	0.591
MOD_PIKK_1	386	392	PF00454	0.444
MOD_PIKK_1	433	439	PF00454	0.498
MOD_PK_1	111	117	PF00069	0.314
MOD_PK_1	68	74	PF00069	0.605
MOD_PKA_2	144	150	PF00069	0.579
MOD_PKA_2	23	29	PF00069	0.689
MOD_PKA_2	427	433	PF00069	0.264
MOD_PKA_2	96	102	PF00069	0.505
MOD_Plk_1	232	238	PF00069	0.317
MOD_Plk_1	274	280	PF00069	0.472
MOD_Plk_1	433	439	PF00069	0.475
MOD_Plk_1	46	52	PF00069	0.553
MOD_Plk_4	175	181	PF00069	0.616
MOD_ProDKin_1	214	220	PF00069	0.620
MOD_ProDKin_1	307	313	PF00069	0.620
MOD_SUMO_for_1	209	212	PF00179	0.633
MOD_SUMO_rev_2	301	311	PF00179	0.324
TRG_DiLeu_BaEn_2	51	57	PF01217	0.338
TRG_ENDOCYTIC_2	421	424	PF00928	0.483
TRG_ENDOCYTIC_2	444	447	PF00928	0.403
TRG_ENDOCYTIC_2	467	470	PF00928	0.531
TRG_ER_diArg_1	143	146	PF00400	0.572
TRG_NES_CRM1_1	240	254	PF08389	0.546
TRG_NES_CRM1_1	391	405	PF08389	0.555
TRG_NLS_MonoExtN_4	139	146	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P012	Trypanosomatidae	30%	100%
A0A3R7KGL7	Trypanosoma rangeli	29%	100%
A0A3S5H7L7	Leishmania donovani	70%	100%
A4I4S2	Leishmania infantum	69%	100%
E9AE75	Leishmania major	70%	100%
E9ALL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
V5BBX4	Trypanosoma cruzi	30%	100%