DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 37

Species:

Leishmania braziliensis

UniProt:

A4HHL0_LEIBR

TriTrypDb:

LbrM.29.2080 , LBRM2903_290027300

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HHL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.720
CLV_C14_Caspase3-7	239	243	PF00656	0.646
CLV_NRD_NRD_1	210	212	PF00675	0.517
CLV_NRD_NRD_1	235	237	PF00675	0.442
CLV_NRD_NRD_1	335	337	PF00675	0.389
CLV_NRD_NRD_1	40	42	PF00675	0.500
CLV_NRD_NRD_1	597	599	PF00675	0.345
CLV_NRD_NRD_1	613	615	PF00675	0.283
CLV_PCSK_KEX2_1	210	212	PF00082	0.532
CLV_PCSK_KEX2_1	217	219	PF00082	0.511
CLV_PCSK_KEX2_1	335	337	PF00082	0.389
CLV_PCSK_KEX2_1	40	42	PF00082	0.500
CLV_PCSK_KEX2_1	507	509	PF00082	0.326
CLV_PCSK_KEX2_1	543	545	PF00082	0.369
CLV_PCSK_KEX2_1	613	615	PF00082	0.418
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.502
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.319
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.355
CLV_PCSK_SKI1_1	148	152	PF00082	0.472
CLV_PCSK_SKI1_1	153	157	PF00082	0.439
CLV_PCSK_SKI1_1	218	222	PF00082	0.549
CLV_PCSK_SKI1_1	267	271	PF00082	0.479
CLV_PCSK_SKI1_1	395	399	PF00082	0.201
CLV_PCSK_SKI1_1	507	511	PF00082	0.311
CLV_PCSK_SKI1_1	531	535	PF00082	0.341
CLV_PCSK_SKI1_1	543	547	PF00082	0.433
CLV_PCSK_SKI1_1	86	90	PF00082	0.560
CLV_Separin_Metazoa	219	223	PF03568	0.628
DEG_APCC_DBOX_1	426	434	PF00400	0.355
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DOC_CDC14_PxL_1	355	363	PF14671	0.201
DOC_CYCLIN_RxL_1	148	158	PF00134	0.454
DOC_CYCLIN_RxL_1	231	242	PF00134	0.355
DOC_CYCLIN_RxL_1	505	514	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.437
DOC_MAPK_gen_1	148	156	PF00069	0.527
DOC_MAPK_gen_1	40	47	PF00069	0.548
DOC_MAPK_gen_1	613	623	PF00069	0.463
DOC_MAPK_MEF2A_6	103	112	PF00069	0.436
DOC_MAPK_MEF2A_6	616	625	PF00069	0.389
DOC_MAPK_MEF2A_6	72	79	PF00069	0.532
DOC_PP2B_LxvP_1	433	436	PF13499	0.420
DOC_PP2B_LxvP_1	464	467	PF13499	0.437
DOC_PP4_FxxP_1	411	414	PF00568	0.355
DOC_PP4_FxxP_1	47	50	PF00568	0.667
DOC_USP7_MATH_1	119	123	PF00917	0.765
DOC_USP7_MATH_1	205	209	PF00917	0.476
DOC_USP7_MATH_1	445	449	PF00917	0.406
DOC_USP7_MATH_1	500	504	PF00917	0.287
DOC_USP7_MATH_1	545	549	PF00917	0.492
DOC_USP7_MATH_1	617	621	PF00917	0.382
DOC_USP7_MATH_1	632	636	PF00917	0.401
DOC_USP7_UBL2_3	527	531	PF12436	0.413
DOC_WW_Pin1_4	13	18	PF00397	0.754
DOC_WW_Pin1_4	21	26	PF00397	0.634
DOC_WW_Pin1_4	572	577	PF00397	0.413
LIG_14-3-3_CanoR_1	222	228	PF00244	0.535
LIG_14-3-3_CanoR_1	427	436	PF00244	0.272
LIG_Actin_WH2_2	256	272	PF00022	0.613
LIG_APCC_ABBA_1	23	28	PF00400	0.622
LIG_APCC_ABBA_1	470	475	PF00400	0.389
LIG_APCC_ABBA_1	577	582	PF00400	0.445
LIG_APCC_ABBA_1	583	588	PF00400	0.429
LIG_BIR_III_4	125	129	PF00653	0.611
LIG_FHA_1	105	111	PF00498	0.663
LIG_FHA_1	18	24	PF00498	0.681
LIG_FHA_1	256	262	PF00498	0.531
LIG_FHA_1	263	269	PF00498	0.641
LIG_FHA_1	301	307	PF00498	0.389
LIG_FHA_1	341	347	PF00498	0.334
LIG_FHA_1	403	409	PF00498	0.350
LIG_FHA_1	423	429	PF00498	0.391
LIG_FHA_1	532	538	PF00498	0.344
LIG_FHA_2	214	220	PF00498	0.436
LIG_FHA_2	255	261	PF00498	0.562
LIG_FHA_2	299	305	PF00498	0.201
LIG_FHA_2	396	402	PF00498	0.201
LIG_FHA_2	561	567	PF00498	0.408
LIG_LIR_Apic_2	283	287	PF02991	0.328
LIG_LIR_Apic_2	46	50	PF02991	0.671
LIG_LIR_Gen_1	288	299	PF02991	0.419
LIG_LIR_Gen_1	438	449	PF02991	0.307
LIG_LIR_Gen_1	460	471	PF02991	0.375
LIG_LIR_Nem_3	288	294	PF02991	0.346
LIG_LIR_Nem_3	438	444	PF02991	0.307
LIG_LIR_Nem_3	460	466	PF02991	0.375
LIG_PDZ_Class_2	635	640	PF00595	0.486
LIG_Pex14_1	291	295	PF04695	0.339
LIG_Pex14_2	79	83	PF04695	0.534
LIG_PTB_Apo_2	517	524	PF02174	0.201
LIG_SH2_GRB2like	309	312	PF00017	0.328
LIG_SH2_GRB2like	33	36	PF00017	0.507
LIG_SH2_NCK_1	580	584	PF00017	0.201
LIG_SH2_PTP2	284	287	PF00017	0.201
LIG_SH2_PTP2	441	444	PF00017	0.306
LIG_SH2_SRC	580	583	PF00017	0.201
LIG_SH2_STAP1	170	174	PF00017	0.534
LIG_SH2_STAP1	295	299	PF00017	0.353
LIG_SH2_STAP1	580	584	PF00017	0.288
LIG_SH2_STAT5	281	284	PF00017	0.305
LIG_SH2_STAT5	441	444	PF00017	0.326
LIG_SH2_STAT5	478	481	PF00017	0.420
LIG_SH2_STAT5	497	500	PF00017	0.420
LIG_SH2_STAT5	522	525	PF00017	0.360
LIG_SH2_STAT5	584	587	PF00017	0.398
LIG_SH3_1	270	276	PF00018	0.469
LIG_SH3_1	353	359	PF00018	0.201
LIG_SH3_3	270	276	PF00018	0.577
LIG_SH3_3	353	359	PF00018	0.389
LIG_SH3_3	439	445	PF00018	0.378
LIG_SH3_3	53	59	PF00018	0.625
LIG_SH3_3	573	579	PF00018	0.383
LIG_SH3_3	626	632	PF00018	0.364
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.546
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.437
LIG_SUMO_SIM_par_1	324	331	PF11976	0.201
LIG_SUMO_SIM_par_1	606	612	PF11976	0.454
LIG_TRAF2_1	564	567	PF00917	0.376
LIG_TRFH_1	463	467	PF08558	0.437
LIG_TYR_ITIM	439	444	PF00017	0.311
LIG_WRC_WIRS_1	530	535	PF05994	0.201
MOD_CDC14_SPxK_1	575	578	PF00782	0.437
MOD_CDK_SPxK_1	572	578	PF00069	0.437
MOD_CK1_1	104	110	PF00069	0.558
MOD_CK1_1	246	252	PF00069	0.728
MOD_CK1_1	440	446	PF00069	0.368
MOD_CK1_1	633	639	PF00069	0.571
MOD_CK2_1	213	219	PF00069	0.439
MOD_CK2_1	395	401	PF00069	0.415
MOD_CK2_1	440	446	PF00069	0.398
MOD_CK2_1	560	566	PF00069	0.363
MOD_GlcNHglycan	119	122	PF01048	0.770
MOD_GlcNHglycan	135	138	PF01048	0.512
MOD_GlcNHglycan	207	210	PF01048	0.486
MOD_GlcNHglycan	248	251	PF01048	0.586
MOD_GlcNHglycan	287	290	PF01048	0.411
MOD_GlcNHglycan	291	294	PF01048	0.402
MOD_GlcNHglycan	317	320	PF01048	0.418
MOD_GlcNHglycan	330	333	PF01048	0.324
MOD_GlcNHglycan	47	50	PF01048	0.539
MOD_GlcNHglycan	547	550	PF01048	0.419
MOD_GSK3_1	1	8	PF00069	0.705
MOD_GSK3_1	117	124	PF00069	0.703
MOD_GSK3_1	13	20	PF00069	0.643
MOD_GSK3_1	142	149	PF00069	0.383
MOD_GSK3_1	285	292	PF00069	0.343
MOD_GSK3_1	45	52	PF00069	0.553
MOD_GSK3_1	525	532	PF00069	0.361
MOD_N-GLC_1	34	39	PF02516	0.497
MOD_N-GLC_1	458	463	PF02516	0.331
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	327	332	PF00069	0.353
MOD_NEK2_1	45	50	PF00069	0.660
MOD_NEK2_1	511	516	PF00069	0.331
MOD_NEK2_1	523	528	PF00069	0.333
MOD_NEK2_1	597	602	PF00069	0.220
MOD_NEK2_2	262	267	PF00069	0.496
MOD_NEK2_2	535	540	PF00069	0.331
MOD_PIKK_1	142	148	PF00454	0.458
MOD_PIKK_1	5	11	PF00454	0.529
MOD_PKA_1	543	549	PF00069	0.328
MOD_PKA_2	246	252	PF00069	0.696
MOD_PKA_2	28	34	PF00069	0.547
MOD_PKA_2	289	295	PF00069	0.448
MOD_PKA_2	368	374	PF00069	0.326
MOD_PKA_2	511	517	PF00069	0.471
MOD_PKA_2	543	549	PF00069	0.378
MOD_PKA_2	597	603	PF00069	0.431
MOD_PKA_2	71	77	PF00069	0.567
MOD_Plk_1	168	174	PF00069	0.521
MOD_Plk_1	34	40	PF00069	0.583
MOD_Plk_1	437	443	PF00069	0.277
MOD_Plk_1	445	451	PF00069	0.476
MOD_Plk_1	633	639	PF00069	0.545
MOD_Plk_2-3	163	169	PF00069	0.317
MOD_Plk_4	163	169	PF00069	0.613
MOD_Plk_4	28	34	PF00069	0.502
MOD_Plk_4	280	286	PF00069	0.279
MOD_Plk_4	415	421	PF00069	0.439
MOD_Plk_4	518	524	PF00069	0.453
MOD_Plk_4	633	639	PF00069	0.582
MOD_ProDKin_1	13	19	PF00069	0.751
MOD_ProDKin_1	21	27	PF00069	0.622
MOD_ProDKin_1	572	578	PF00069	0.413
MOD_SUMO_rev_2	104	113	PF00179	0.436
MOD_SUMO_rev_2	230	238	PF00179	0.492
MOD_SUMO_rev_2	318	325	PF00179	0.317
MOD_SUMO_rev_2	501	509	PF00179	0.367
MOD_SUMO_rev_2	78	88	PF00179	0.643
TRG_DiLeu_BaEn_2	468	474	PF01217	0.328
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.328
TRG_ENDOCYTIC_2	441	444	PF00928	0.304
TRG_ENDOCYTIC_2	580	583	PF00928	0.201
TRG_ER_diArg_1	334	336	PF00400	0.396
TRG_ER_diArg_1	481	484	PF00400	0.201
TRG_ER_diArg_1	613	616	PF00400	0.442
TRG_NES_CRM1_1	146	158	PF08389	0.509
TRG_NES_CRM1_1	434	446	PF08389	0.201
TRG_NLS_MonoExtN_4	540	546	PF00514	0.419
TRG_Pf-PMV_PEXEL_1	508	513	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W3	Leptomonas seymouri	61%	100%
A0A0S4JNB4	Bodo saltans	23%	100%
A0A0S4KK03	Bodo saltans	26%	100%
A0A3Q8IFG9	Leishmania donovani	78%	100%
A0A3Q8IHT6	Leishmania donovani	26%	100%
A0A3R7LIT5	Trypanosoma rangeli	31%	100%
A4HI48	Leishmania braziliensis	25%	100%
A4I4S0	Leishmania infantum	78%	100%
A4I5C4	Leishmania infantum	26%	100%
C9ZQQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZUB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
E9AE72	Leishmania major	76%	100%
E9ALL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B0M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q7L0	Leishmania major	25%	100%
V5DQS5	Trypanosoma cruzi	23%	100%