LeishMANIAdb
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NAD(P)-binding protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
NAD(P)-binding protein
Gene product:
short chain dehydrogenase, putative
Species:
Leishmania braziliensis
UniProt:
A4HHK7_LEIBR
TriTrypDb:
LbrM.29.2050 , LBRM2903_290027100 *
Length:
449

Annotations

LeishMANIAdb annotations

The closest related human enzyme is a retinol dehydrogenase. Anchored to the membrane from the inner side.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HHK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHK7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 181 185 PF00656 0.430
CLV_C14_Caspase3-7 439 443 PF00656 0.595
CLV_NRD_NRD_1 234 236 PF00675 0.226
CLV_NRD_NRD_1 370 372 PF00675 0.422
CLV_NRD_NRD_1 88 90 PF00675 0.380
CLV_PCSK_KEX2_1 234 236 PF00082 0.226
CLV_PCSK_KEX2_1 370 372 PF00082 0.334
CLV_PCSK_KEX2_1 46 48 PF00082 0.387
CLV_PCSK_KEX2_1 88 90 PF00082 0.380
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.425
CLV_PCSK_PC7_1 230 236 PF00082 0.215
CLV_PCSK_SKI1_1 142 146 PF00082 0.386
CLV_PCSK_SKI1_1 23 27 PF00082 0.396
CLV_PCSK_SKI1_1 75 79 PF00082 0.437
DEG_Nend_Nbox_1 1 3 PF02207 0.474
DOC_CYCLIN_RxL_1 137 147 PF00134 0.609
DOC_MAPK_gen_1 88 94 PF00069 0.514
DOC_PP1_RVXF_1 8 14 PF00149 0.458
DOC_PP4_FxxP_1 446 449 PF00568 0.473
DOC_PP4_MxPP_1 246 249 PF00568 0.451
DOC_SPAK_OSR1_1 251 255 PF12202 0.421
DOC_USP7_MATH_1 293 297 PF00917 0.580
DOC_USP7_MATH_1 327 331 PF00917 0.577
DOC_USP7_MATH_1 415 419 PF00917 0.608
DOC_USP7_MATH_1 67 71 PF00917 0.615
DOC_WW_Pin1_4 201 206 PF00397 0.522
DOC_WW_Pin1_4 63 68 PF00397 0.606
LIG_14-3-3_CanoR_1 207 213 PF00244 0.606
LIG_14-3-3_CanoR_1 234 244 PF00244 0.645
LIG_14-3-3_CanoR_1 444 449 PF00244 0.591
LIG_Actin_WH2_2 179 195 PF00022 0.546
LIG_Actin_WH2_2 7 25 PF00022 0.263
LIG_APCC_ABBA_1 153 158 PF00400 0.627
LIG_BRCT_BRCA1_1 405 409 PF00533 0.588
LIG_eIF4E_1 116 122 PF01652 0.477
LIG_EVH1_2 248 252 PF00568 0.419
LIG_FHA_1 174 180 PF00498 0.497
LIG_FHA_1 217 223 PF00498 0.505
LIG_FHA_1 315 321 PF00498 0.504
LIG_FHA_1 37 43 PF00498 0.660
LIG_FHA_1 427 433 PF00498 0.575
LIG_FHA_1 74 80 PF00498 0.672
LIG_FHA_2 268 274 PF00498 0.557
LIG_FHA_2 434 440 PF00498 0.426
LIG_Integrin_RGD_1 55 57 PF01839 0.439
LIG_LIR_Gen_1 16 26 PF02991 0.359
LIG_LIR_Gen_1 281 290 PF02991 0.612
LIG_LIR_Gen_1 76 86 PF02991 0.653
LIG_LIR_Nem_3 109 113 PF02991 0.525
LIG_LIR_Nem_3 16 21 PF02991 0.359
LIG_LIR_Nem_3 281 287 PF02991 0.563
LIG_LIR_Nem_3 31 36 PF02991 0.232
LIG_LIR_Nem_3 406 412 PF02991 0.634
LIG_LIR_Nem_3 76 81 PF02991 0.657
LIG_NRBOX 118 124 PF00104 0.554
LIG_PCNA_PIPBox_1 277 286 PF02747 0.553
LIG_PCNA_yPIPBox_3 286 299 PF02747 0.561
LIG_Pex14_1 13 17 PF04695 0.334
LIG_REV1ctd_RIR_1 377 385 PF16727 0.544
LIG_SH2_CRK 110 114 PF00017 0.500
LIG_SH2_CRK 116 120 PF00017 0.478
LIG_SH2_STAT5 116 119 PF00017 0.477
LIG_SH2_STAT5 143 146 PF00017 0.616
LIG_SH2_STAT5 33 36 PF00017 0.439
LIG_SH2_STAT5 362 365 PF00017 0.489
LIG_SH2_STAT5 434 437 PF00017 0.499
LIG_SH3_3 319 325 PF00018 0.483
LIG_SH3_3 407 413 PF00018 0.601
LIG_TRAF2_1 276 279 PF00917 0.578
LIG_TYR_ITIM 108 113 PF00017 0.373
LIG_WRC_WIRS_1 268 273 PF05994 0.371
LIG_WW_3 204 208 PF00397 0.468
MOD_CDC14_SPxK_1 204 207 PF00782 0.491
MOD_CDK_SPxK_1 201 207 PF00069 0.463
MOD_CK1_1 259 265 PF00069 0.430
MOD_CK1_1 70 76 PF00069 0.398
MOD_CK2_1 267 273 PF00069 0.547
MOD_CK2_1 433 439 PF00069 0.273
MOD_GlcNHglycan 101 104 PF01048 0.395
MOD_GlcNHglycan 123 126 PF01048 0.458
MOD_GlcNHglycan 146 149 PF01048 0.514
MOD_GlcNHglycan 158 162 PF01048 0.553
MOD_GlcNHglycan 256 259 PF01048 0.475
MOD_GlcNHglycan 295 298 PF01048 0.375
MOD_GlcNHglycan 69 72 PF01048 0.462
MOD_GSK3_1 167 174 PF00069 0.304
MOD_GSK3_1 236 243 PF00069 0.539
MOD_GSK3_1 259 266 PF00069 0.457
MOD_GSK3_1 63 70 PF00069 0.520
MOD_GSK3_1 99 106 PF00069 0.343
MOD_N-GLC_1 327 332 PF02516 0.369
MOD_N-GLC_1 384 389 PF02516 0.319
MOD_N-GLC_1 404 409 PF02516 0.629
MOD_N-GLC_1 81 86 PF02516 0.455
MOD_NEK2_1 121 126 PF00069 0.443
MOD_NEK2_1 144 149 PF00069 0.442
MOD_NEK2_1 173 178 PF00069 0.330
MOD_NEK2_1 236 241 PF00069 0.546
MOD_NEK2_1 300 305 PF00069 0.475
MOD_NEK2_1 314 319 PF00069 0.332
MOD_NEK2_1 366 371 PF00069 0.445
MOD_NEK2_1 403 408 PF00069 0.587
MOD_NEK2_1 62 67 PF00069 0.594
MOD_NEK2_1 81 86 PF00069 0.281
MOD_NEK2_2 267 272 PF00069 0.590
MOD_PIKK_1 206 212 PF00454 0.503
MOD_PIKK_1 273 279 PF00454 0.523
MOD_PIKK_1 333 339 PF00454 0.574
MOD_PKA_2 206 212 PF00069 0.527
MOD_Plk_1 327 333 PF00069 0.597
MOD_Plk_1 384 390 PF00069 0.484
MOD_Plk_1 404 410 PF00069 0.591
MOD_Plk_1 73 79 PF00069 0.532
MOD_Plk_1 81 87 PF00069 0.399
MOD_Plk_4 222 228 PF00069 0.362
MOD_Plk_4 357 363 PF00069 0.457
MOD_Plk_4 384 390 PF00069 0.484
MOD_Plk_4 404 410 PF00069 0.558
MOD_Plk_4 49 55 PF00069 0.589
MOD_Plk_4 73 79 PF00069 0.532
MOD_Plk_4 81 87 PF00069 0.399
MOD_ProDKin_1 201 207 PF00069 0.407
MOD_ProDKin_1 63 69 PF00069 0.513
TRG_DiLeu_BaEn_2 15 21 PF01217 0.410
TRG_DiLeu_BaEn_2 73 79 PF01217 0.567
TRG_DiLeu_BaLyEn_6 227 232 PF01217 0.344
TRG_ENDOCYTIC_2 110 113 PF00928 0.377
TRG_ENDOCYTIC_2 116 119 PF00928 0.336
TRG_ENDOCYTIC_2 390 393 PF00928 0.566
TRG_ER_diArg_1 140 143 PF00400 0.548
TRG_ER_diArg_1 234 236 PF00400 0.472
TRG_ER_diArg_1 88 90 PF00400 0.481

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKI4 Leptomonas seymouri 69% 100%
A0A1X0P177 Trypanosomatidae 47% 100%
A0A3Q8IBK9 Leishmania donovani 84% 100%
A0A3R7NQF7 Trypanosoma rangeli 48% 100%
A4I4R8 Leishmania infantum 84% 100%
E9AE70 Leishmania major 82% 100%
E9ALL5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
O74959 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
Q17QW3 Bos taurus 27% 100%
Q9ERI6 Mus musculus 27% 100%
Q9HBH5 Homo sapiens 27% 100%
V5BBW8 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS