Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHK6_LEIBR

TriTrypDb:

LbrM.29.2040 , LBRM2903_290027000

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.564
CLV_NRD_NRD_1	13	15	PF00675	0.553
CLV_NRD_NRD_1	195	197	PF00675	0.728
CLV_NRD_NRD_1	209	211	PF00675	0.648
CLV_NRD_NRD_1	268	270	PF00675	0.814
CLV_NRD_NRD_1	271	273	PF00675	0.785
CLV_PCSK_FUR_1	269	273	PF00082	0.678
CLV_PCSK_KEX2_1	15	17	PF00082	0.557
CLV_PCSK_KEX2_1	195	197	PF00082	0.732
CLV_PCSK_KEX2_1	209	211	PF00082	0.662
CLV_PCSK_KEX2_1	268	270	PF00082	0.804
CLV_PCSK_KEX2_1	271	273	PF00082	0.832
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.557
CLV_PCSK_SKI1_1	224	228	PF00082	0.602
CLV_PCSK_SKI1_1	248	252	PF00082	0.570
CLV_PCSK_SKI1_1	405	409	PF00082	0.650
DEG_APCC_DBOX_1	209	217	PF00400	0.459
DEG_SCF_TRCP1_1	261	266	PF00400	0.596
DEG_SPOP_SBC_1	100	104	PF00917	0.544
DOC_CDC14_PxL_1	1	9	PF14671	0.625
DOC_CKS1_1	106	111	PF01111	0.558
DOC_MAPK_DCC_7	209	218	PF00069	0.454
DOC_MAPK_DCC_7	37	46	PF00069	0.747
DOC_MAPK_HePTP_8	206	218	PF00069	0.469
DOC_MAPK_MEF2A_6	209	218	PF00069	0.523
DOC_MAPK_MEF2A_6	224	231	PF00069	0.529
DOC_MAPK_MEF2A_6	37	46	PF00069	0.747
DOC_MAPK_NFAT4_5	224	232	PF00069	0.535
DOC_USP7_MATH_1	303	307	PF00917	0.815
DOC_USP7_MATH_1	321	325	PF00917	0.755
DOC_USP7_MATH_1	35	39	PF00917	0.641
DOC_USP7_MATH_1	352	356	PF00917	0.732
DOC_USP7_MATH_1	375	379	PF00917	0.687
DOC_USP7_MATH_1	6	10	PF00917	0.533
DOC_USP7_MATH_1	99	103	PF00917	0.669
DOC_WW_Pin1_4	105	110	PF00397	0.641
DOC_WW_Pin1_4	185	190	PF00397	0.780
DOC_WW_Pin1_4	198	203	PF00397	0.538
DOC_WW_Pin1_4	20	25	PF00397	0.532
DOC_WW_Pin1_4	301	306	PF00397	0.823
DOC_WW_Pin1_4	348	353	PF00397	0.642
DOC_WW_Pin1_4	395	400	PF00397	0.669
DOC_WW_Pin1_4	414	419	PF00397	0.658
DOC_WW_Pin1_4	72	77	PF00397	0.565
LIG_14-3-3_CanoR_1	195	199	PF00244	0.703
LIG_14-3-3_CanoR_1	209	213	PF00244	0.698
LIG_14-3-3_CanoR_1	248	253	PF00244	0.675
LIG_14-3-3_CanoR_1	269	277	PF00244	0.747
LIG_14-3-3_CanoR_1	288	298	PF00244	0.743
LIG_14-3-3_CanoR_1	346	352	PF00244	0.591
LIG_14-3-3_CanoR_1	368	373	PF00244	0.644
LIG_14-3-3_CanoR_1	37	41	PF00244	0.706
LIG_14-3-3_CanoR_1	381	391	PF00244	0.509
LIG_14-3-3_CanoR_1	405	410	PF00244	0.651
LIG_14-3-3_CanoR_1	56	62	PF00244	0.548
LIG_14-3-3_CanoR_1	79	83	PF00244	0.609
LIG_14-3-3_CanoR_1	95	99	PF00244	0.718
LIG_AP2alpha_2	390	392	PF02296	0.529
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BIR_III_4	341	345	PF00653	0.572
LIG_FHA_1	21	27	PF00498	0.682
LIG_FHA_1	289	295	PF00498	0.771
LIG_FHA_2	106	112	PF00498	0.724
LIG_IRF3_LxIS_1	90	97	PF10401	0.515
LIG_LIR_Gen_1	128	138	PF02991	0.430
LIG_LIR_Nem_3	128	134	PF02991	0.444
LIG_LIR_Nem_3	388	392	PF02991	0.573
LIG_MYND_1	332	336	PF01753	0.543
LIG_NRBOX	89	95	PF00104	0.662
LIG_PDZ_Class_1	414	419	PF00595	0.508
LIG_PTB_Apo_2	230	237	PF02174	0.546
LIG_SH2_CRK	404	408	PF00017	0.507
LIG_SH2_STAT5	212	215	PF00017	0.452
LIG_SH3_3	103	109	PF00018	0.584
LIG_SH3_3	299	305	PF00018	0.813
LIG_SH3_3	388	394	PF00018	0.670
LIG_SH3_3	62	68	PF00018	0.645
LIG_SH3_3	80	86	PF00018	0.617
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.445
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.509
LIG_TRAF2_1	108	111	PF00917	0.773
MOD_CDK_SPK_2	348	353	PF00069	0.598
MOD_CDK_SPxxK_3	20	27	PF00069	0.572
MOD_CDK_SPxxK_3	72	79	PF00069	0.568
MOD_CK1_1	140	146	PF00069	0.490
MOD_CK1_1	208	214	PF00069	0.595
MOD_CK1_1	240	246	PF00069	0.656
MOD_CK1_1	30	36	PF00069	0.635
MOD_CK1_1	322	328	PF00069	0.730
MOD_CK1_1	348	354	PF00069	0.727
MOD_CK1_1	382	388	PF00069	0.610
MOD_CK1_1	45	51	PF00069	0.744
MOD_CK1_1	72	78	PF00069	0.749
MOD_CK2_1	105	111	PF00069	0.681
MOD_CK2_1	259	265	PF00069	0.602
MOD_CK2_1	303	309	PF00069	0.819
MOD_GlcNHglycan	239	242	PF01048	0.647
MOD_GlcNHglycan	261	264	PF01048	0.681
MOD_GlcNHglycan	29	32	PF01048	0.534
MOD_GlcNHglycan	298	301	PF01048	0.647
MOD_GlcNHglycan	347	350	PF01048	0.796
MOD_GlcNHglycan	362	365	PF01048	0.523
MOD_GlcNHglycan	382	385	PF01048	0.692
MOD_GlcNHglycan	71	74	PF01048	0.649
MOD_GSK3_1	101	108	PF00069	0.615
MOD_GSK3_1	137	144	PF00069	0.481
MOD_GSK3_1	194	201	PF00069	0.645
MOD_GSK3_1	259	266	PF00069	0.678
MOD_GSK3_1	27	34	PF00069	0.641
MOD_GSK3_1	348	355	PF00069	0.716
MOD_GSK3_1	375	382	PF00069	0.693
MOD_GSK3_1	44	51	PF00069	0.606
MOD_GSK3_1	6	13	PF00069	0.673
MOD_N-GLC_1	140	145	PF02516	0.490
MOD_NEK2_1	137	142	PF00069	0.537
MOD_NEK2_1	327	332	PF00069	0.534
MOD_NEK2_1	44	49	PF00069	0.632
MOD_NEK2_1	94	99	PF00069	0.742
MOD_PIKK_1	263	269	PF00454	0.693
MOD_PIKK_1	352	358	PF00454	0.790
MOD_PIKK_1	88	94	PF00454	0.644
MOD_PKA_1	259	265	PF00069	0.593
MOD_PKA_1	271	277	PF00069	0.633
MOD_PKA_2	194	200	PF00069	0.721
MOD_PKA_2	208	214	PF00069	0.643
MOD_PKA_2	270	276	PF00069	0.767
MOD_PKA_2	287	293	PF00069	0.546
MOD_PKA_2	345	351	PF00069	0.838
MOD_PKA_2	36	42	PF00069	0.798
MOD_PKA_2	367	373	PF00069	0.734
MOD_PKA_2	380	386	PF00069	0.611
MOD_PKA_2	78	84	PF00069	0.554
MOD_PKA_2	94	100	PF00069	0.779
MOD_PKB_1	269	277	PF00069	0.628
MOD_PKB_1	366	374	PF00069	0.564
MOD_Plk_1	110	116	PF00069	0.780
MOD_Plk_2-3	110	116	PF00069	0.780
MOD_Plk_4	101	107	PF00069	0.549
MOD_Plk_4	330	336	PF00069	0.594
MOD_Plk_4	36	42	PF00069	0.769
MOD_ProDKin_1	105	111	PF00069	0.640
MOD_ProDKin_1	185	191	PF00069	0.780
MOD_ProDKin_1	198	204	PF00069	0.536
MOD_ProDKin_1	20	26	PF00069	0.533
MOD_ProDKin_1	301	307	PF00069	0.825
MOD_ProDKin_1	348	354	PF00069	0.644
MOD_ProDKin_1	395	401	PF00069	0.672
MOD_ProDKin_1	72	78	PF00069	0.565
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.687
TRG_ENDOCYTIC_2	404	407	PF00928	0.658
TRG_ER_diArg_1	268	271	PF00400	0.762
TRG_ER_diArg_1	365	368	PF00400	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW7	Leptomonas seymouri	28%	100%
A0A3Q8IRH8	Leishmania donovani	54%	95%
A4I4R7	Leishmania infantum	54%	95%
E9AE69	Leishmania major	53%	99%
E9ALL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	94%