Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHK4_LEIBR

TriTrypDb:

LbrM.29.2020 , LBRM2903_290026700

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.556
CLV_NRD_NRD_1	486	488	PF00675	0.551
CLV_NRD_NRD_1	646	648	PF00675	0.636
CLV_NRD_NRD_1	706	708	PF00675	0.791
CLV_NRD_NRD_1	716	718	PF00675	0.586
CLV_PCSK_KEX2_1	485	487	PF00082	0.558
CLV_PCSK_KEX2_1	646	648	PF00082	0.635
CLV_PCSK_KEX2_1	706	708	PF00082	0.619
CLV_PCSK_KEX2_1	722	724	PF00082	0.513
CLV_PCSK_PC1ET2_1	722	724	PF00082	0.645
CLV_PCSK_SKI1_1	149	153	PF00082	0.515
CLV_PCSK_SKI1_1	16	20	PF00082	0.528
CLV_PCSK_SKI1_1	210	214	PF00082	0.517
CLV_PCSK_SKI1_1	322	326	PF00082	0.527
CLV_PCSK_SKI1_1	722	726	PF00082	0.523
CLV_PCSK_SKI1_1	729	733	PF00082	0.543
DEG_SCF_FBW7_1	511	517	PF00400	0.486
DEG_SPOP_SBC_1	604	608	PF00917	0.687
DEG_SPOP_SBC_1	63	67	PF00917	0.548
DOC_CDC14_PxL_1	169	177	PF14671	0.558
DOC_CKS1_1	19	24	PF01111	0.528
DOC_CKS1_1	224	229	PF01111	0.530
DOC_CKS1_1	440	445	PF01111	0.550
DOC_CKS1_1	511	516	PF01111	0.541
DOC_CKS1_1	562	567	PF01111	0.560
DOC_CYCLIN_RxL_1	489	503	PF00134	0.561
DOC_CYCLIN_yClb1_LxF_4	727	732	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	686	689	PF00134	0.585
DOC_MAPK_DCC_7	659	667	PF00069	0.527
DOC_MAPK_gen_1	643	654	PF00069	0.558
DOC_PP1_RVXF_1	727	733	PF00149	0.526
DOC_PP2B_LxvP_1	164	167	PF13499	0.695
DOC_PP2B_LxvP_1	686	689	PF13499	0.534
DOC_PP4_FxxP_1	19	22	PF00568	0.530
DOC_USP7_MATH_1	10	14	PF00917	0.638
DOC_USP7_MATH_1	182	186	PF00917	0.639
DOC_USP7_MATH_1	282	286	PF00917	0.506
DOC_USP7_MATH_1	335	339	PF00917	0.526
DOC_USP7_MATH_1	341	345	PF00917	0.742
DOC_USP7_MATH_1	350	354	PF00917	0.636
DOC_USP7_MATH_1	532	536	PF00917	0.623
DOC_USP7_MATH_1	572	576	PF00917	0.582
DOC_USP7_MATH_1	604	608	PF00917	0.642
DOC_USP7_MATH_1	68	72	PF00917	0.594
DOC_USP7_UBL2_3	659	663	PF12436	0.518
DOC_USP7_UBL2_3	718	722	PF12436	0.576
DOC_WW_Pin1_4	111	116	PF00397	0.659
DOC_WW_Pin1_4	123	128	PF00397	0.523
DOC_WW_Pin1_4	133	138	PF00397	0.530
DOC_WW_Pin1_4	18	23	PF00397	0.564
DOC_WW_Pin1_4	223	228	PF00397	0.655
DOC_WW_Pin1_4	251	256	PF00397	0.629
DOC_WW_Pin1_4	333	338	PF00397	0.535
DOC_WW_Pin1_4	428	433	PF00397	0.535
DOC_WW_Pin1_4	439	444	PF00397	0.514
DOC_WW_Pin1_4	448	453	PF00397	0.718
DOC_WW_Pin1_4	510	515	PF00397	0.671
DOC_WW_Pin1_4	561	566	PF00397	0.576
DOC_WW_Pin1_4	568	573	PF00397	0.594
DOC_WW_Pin1_4	581	586	PF00397	0.581
DOC_WW_Pin1_4	674	679	PF00397	0.539
LIG_14-3-3_CanoR_1	149	155	PF00244	0.559
LIG_14-3-3_CanoR_1	181	191	PF00244	0.559
LIG_14-3-3_CanoR_1	27	33	PF00244	0.564
LIG_14-3-3_CanoR_1	40	49	PF00244	0.627
LIG_14-3-3_CanoR_1	479	485	PF00244	0.578
LIG_14-3-3_CanoR_1	486	496	PF00244	0.607
LIG_14-3-3_CanoR_1	557	563	PF00244	0.530
LIG_14-3-3_CanoR_1	646	656	PF00244	0.574
LIG_14-3-3_CanoR_1	699	708	PF00244	0.585
LIG_14-3-3_CanoR_1	737	742	PF00244	0.602
LIG_14-3-3_CterR_2	739	742	PF00244	0.515
LIG_Actin_WH2_2	494	509	PF00022	0.496
LIG_BRCT_BRCA1_1	388	392	PF00533	0.446
LIG_BRCT_BRCA1_1	535	539	PF00533	0.530
LIG_BRCT_BRCA1_1	650	654	PF00533	0.545
LIG_EVH1_1	164	168	PF00568	0.698
LIG_FHA_1	252	258	PF00498	0.626
LIG_FHA_1	366	372	PF00498	0.530
LIG_FHA_1	49	55	PF00498	0.615
LIG_FHA_1	506	512	PF00498	0.552
LIG_FHA_1	546	552	PF00498	0.614
LIG_FHA_1	562	568	PF00498	0.628
LIG_FHA_1	593	599	PF00498	0.639
LIG_FHA_1	67	73	PF00498	0.494
LIG_FHA_1	677	683	PF00498	0.679
LIG_FHA_2	185	191	PF00498	0.543
LIG_FHA_2	302	308	PF00498	0.539
LIG_FHA_2	440	446	PF00498	0.569
LIG_FHA_2	462	468	PF00498	0.537
LIG_FHA_2	515	521	PF00498	0.524
LIG_IRF3_LxIS_1	478	483	PF10401	0.463
LIG_LIR_Gen_1	303	312	PF02991	0.413
LIG_LIR_Gen_1	377	386	PF02991	0.475
LIG_LIR_Nem_3	150	155	PF02991	0.672
LIG_LIR_Nem_3	303	308	PF02991	0.483
LIG_LIR_Nem_3	377	381	PF02991	0.485
LIG_LIR_Nem_3	578	582	PF02991	0.534
LIG_MYND_1	167	171	PF01753	0.553
LIG_SH2_STAT3	716	719	PF00017	0.466
LIG_SH2_STAT5	62	65	PF00017	0.548
LIG_SH3_1	221	227	PF00018	0.531
LIG_SH3_3	162	168	PF00018	0.621
LIG_SH3_3	221	227	PF00018	0.586
LIG_SH3_3	361	367	PF00018	0.589
LIG_SH3_3	437	443	PF00018	0.555
LIG_SH3_3	508	514	PF00018	0.501
LIG_SH3_3	51	57	PF00018	0.623
LIG_SH3_3	559	565	PF00018	0.700
LIG_SH3_3	658	664	PF00018	0.663
LIG_SUMO_SIM_par_1	284	291	PF11976	0.596
LIG_SUMO_SIM_par_1	50	55	PF11976	0.541
LIG_TRAF2_1	36	39	PF00917	0.535
MOD_CDC14_SPxK_1	126	129	PF00782	0.543
MOD_CDK_SPK_2	676	681	PF00069	0.539
MOD_CDK_SPxK_1	123	129	PF00069	0.548
MOD_CDK_SPxxK_3	674	681	PF00069	0.540
MOD_CK1_1	104	110	PF00069	0.737
MOD_CK1_1	111	117	PF00069	0.678
MOD_CK1_1	144	150	PF00069	0.594
MOD_CK1_1	153	159	PF00069	0.703
MOD_CK1_1	200	206	PF00069	0.568
MOD_CK1_1	211	217	PF00069	0.515
MOD_CK1_1	291	297	PF00069	0.624
MOD_CK1_1	300	306	PF00069	0.574
MOD_CK1_1	353	359	PF00069	0.667
MOD_CK1_1	374	380	PF00069	0.547
MOD_CK1_1	382	388	PF00069	0.547
MOD_CK1_1	428	434	PF00069	0.642
MOD_CK1_1	510	516	PF00069	0.507
MOD_CK1_1	560	566	PF00069	0.663
MOD_CK1_1	575	581	PF00069	0.550
MOD_CK1_1	616	622	PF00069	0.614
MOD_CK1_1	648	654	PF00069	0.536
MOD_CK1_1	66	72	PF00069	0.564
MOD_CK1_1	83	89	PF00069	0.668
MOD_CK2_1	184	190	PF00069	0.547
MOD_CK2_1	301	307	PF00069	0.547
MOD_CK2_1	348	354	PF00069	0.546
MOD_CK2_1	399	405	PF00069	0.445
MOD_Cter_Amidation	644	647	PF01082	0.533
MOD_Cter_Amidation	704	707	PF01082	0.704
MOD_DYRK1A_RPxSP_1	133	137	PF00069	0.548
MOD_GlcNHglycan	133	136	PF01048	0.578
MOD_GlcNHglycan	155	158	PF01048	0.623
MOD_GlcNHglycan	184	187	PF01048	0.652
MOD_GlcNHglycan	199	202	PF01048	0.578
MOD_GlcNHglycan	23	26	PF01048	0.629
MOD_GlcNHglycan	258	261	PF01048	0.585
MOD_GlcNHglycan	284	287	PF01048	0.646
MOD_GlcNHglycan	337	340	PF01048	0.721
MOD_GlcNHglycan	432	435	PF01048	0.640
MOD_GlcNHglycan	44	47	PF01048	0.667
MOD_GlcNHglycan	461	464	PF01048	0.698
MOD_GlcNHglycan	574	577	PF01048	0.562
MOD_GlcNHglycan	607	610	PF01048	0.631
MOD_GlcNHglycan	615	618	PF01048	0.559
MOD_GlcNHglycan	647	650	PF01048	0.519
MOD_GlcNHglycan	66	69	PF01048	0.598
MOD_GlcNHglycan	683	686	PF01048	0.621
MOD_GlcNHglycan	703	706	PF01048	0.677
MOD_GlcNHglycan	711	714	PF01048	0.703
MOD_GlcNHglycan	83	86	PF01048	0.689
MOD_GSK3_1	100	107	PF00069	0.740
MOD_GSK3_1	109	116	PF00069	0.625
MOD_GSK3_1	140	147	PF00069	0.779
MOD_GSK3_1	182	189	PF00069	0.696
MOD_GSK3_1	243	250	PF00069	0.661
MOD_GSK3_1	265	272	PF00069	0.663
MOD_GSK3_1	297	304	PF00069	0.454
MOD_GSK3_1	333	340	PF00069	0.688
MOD_GSK3_1	341	348	PF00069	0.671
MOD_GSK3_1	353	360	PF00069	0.571
MOD_GSK3_1	370	377	PF00069	0.754
MOD_GSK3_1	38	45	PF00069	0.560
MOD_GSK3_1	382	389	PF00069	0.462
MOD_GSK3_1	426	433	PF00069	0.776
MOD_GSK3_1	441	448	PF00069	0.728
MOD_GSK3_1	457	464	PF00069	0.548
MOD_GSK3_1	48	55	PF00069	0.513
MOD_GSK3_1	501	508	PF00069	0.581
MOD_GSK3_1	510	517	PF00069	0.510
MOD_GSK3_1	557	564	PF00069	0.714
MOD_GSK3_1	568	575	PF00069	0.565
MOD_GSK3_1	577	584	PF00069	0.553
MOD_GSK3_1	605	612	PF00069	0.624
MOD_GSK3_1	619	626	PF00069	0.620
MOD_GSK3_1	62	69	PF00069	0.563
MOD_GSK3_1	635	642	PF00069	0.708
MOD_GSK3_1	648	655	PF00069	0.707
MOD_GSK3_1	668	675	PF00069	0.502
MOD_GSK3_1	71	78	PF00069	0.621
MOD_GSK3_1	733	740	PF00069	0.629
MOD_N-GLC_1	192	197	PF02516	0.603
MOD_N-GLC_1	237	242	PF02516	0.618
MOD_N-GLC_1	393	398	PF02516	0.439
MOD_N-GLC_1	598	603	PF02516	0.600
MOD_N-GLC_1	623	628	PF02516	0.502
MOD_N-GLC_2	243	245	PF02516	0.562
MOD_NEK2_1	100	105	PF00069	0.611
MOD_NEK2_1	141	146	PF00069	0.628
MOD_NEK2_1	208	213	PF00069	0.618
MOD_NEK2_1	370	375	PF00069	0.509
MOD_NEK2_1	399	404	PF00069	0.434
MOD_NEK2_1	461	466	PF00069	0.790
MOD_NEK2_1	480	485	PF00069	0.493
MOD_NEK2_1	52	57	PF00069	0.626
MOD_NEK2_1	598	603	PF00069	0.721
MOD_NEK2_1	605	610	PF00069	0.618
MOD_NEK2_2	68	73	PF00069	0.549
MOD_NMyristoyl	1	7	PF02799	0.664
MOD_OFUCOSY	488	493	PF10250	0.471
MOD_PIKK_1	109	115	PF00454	0.653
MOD_PIKK_1	345	351	PF00454	0.697
MOD_PIKK_1	371	377	PF00454	0.495
MOD_PIKK_1	38	44	PF00454	0.550
MOD_PIKK_1	461	467	PF00454	0.584
MOD_PIKK_1	52	58	PF00454	0.488
MOD_PIKK_1	598	604	PF00454	0.533
MOD_PK_1	507	513	PF00069	0.501
MOD_PK_1	635	641	PF00069	0.593
MOD_PKA_2	26	32	PF00069	0.522
MOD_PKA_2	488	494	PF00069	0.628
MOD_PKA_2	501	507	PF00069	0.649
MOD_PKA_2	645	651	PF00069	0.632
MOD_PKA_2	698	704	PF00069	0.626
MOD_PKA_2	81	87	PF00069	0.573
MOD_PKB_1	485	493	PF00069	0.617
MOD_Plk_1	141	147	PF00069	0.685
MOD_Plk_1	288	294	PF00069	0.633
MOD_Plk_1	300	306	PF00069	0.520
MOD_Plk_1	341	347	PF00069	0.621
MOD_Plk_1	38	44	PF00069	0.587
MOD_Plk_1	592	598	PF00069	0.565
MOD_Plk_1	623	629	PF00069	0.500
MOD_Plk_1	75	81	PF00069	0.583
MOD_Plk_2-3	158	164	PF00069	0.523
MOD_Plk_2-3	301	307	PF00069	0.426
MOD_Plk_4	101	107	PF00069	0.581
MOD_Plk_4	208	214	PF00069	0.579
MOD_Plk_4	341	347	PF00069	0.563
MOD_Plk_4	382	388	PF00069	0.466
MOD_Plk_4	507	513	PF00069	0.501
MOD_Plk_4	563	569	PF00069	0.628
MOD_Plk_4	635	641	PF00069	0.593
MOD_ProDKin_1	111	117	PF00069	0.662
MOD_ProDKin_1	123	129	PF00069	0.524
MOD_ProDKin_1	133	139	PF00069	0.526
MOD_ProDKin_1	18	24	PF00069	0.562
MOD_ProDKin_1	223	229	PF00069	0.656
MOD_ProDKin_1	251	257	PF00069	0.629
MOD_ProDKin_1	333	339	PF00069	0.536
MOD_ProDKin_1	428	434	PF00069	0.537
MOD_ProDKin_1	439	445	PF00069	0.516
MOD_ProDKin_1	448	454	PF00069	0.715
MOD_ProDKin_1	510	516	PF00069	0.664
MOD_ProDKin_1	561	567	PF00069	0.576
MOD_ProDKin_1	568	574	PF00069	0.595
MOD_ProDKin_1	581	587	PF00069	0.579
MOD_ProDKin_1	674	680	PF00069	0.535
MOD_SUMO_rev_2	726	731	PF00179	0.523
TRG_DiLeu_BaEn_2	394	400	PF01217	0.506
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.498
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.599
TRG_ER_diArg_1	484	487	PF00400	0.535
TRG_ER_diArg_1	706	708	PF00400	0.622
TRG_NLS_MonoExtC_3	642	647	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	495	500	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW90	Leptomonas seymouri	27%	88%
A0A3S7X2M1	Leishmania donovani	50%	100%
A4I4R6	Leishmania infantum	51%	100%
E9AE67	Leishmania major	50%	99%
E9ALL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	99%