LeishMANIAdb
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Putative serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine protein kinase
Gene product:
5'-AMP-activated protein kinase catalytic subunit alpha, putative
Species:
Leishmania braziliensis
UniProt:
A4HHK1_LEIBR
TriTrypDb:
LbrM.29.1990 , LBRM2903_290026400 *
Length:
812

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHK1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 9
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 329 331 PF00675 0.551
CLV_NRD_NRD_1 353 355 PF00675 0.483
CLV_NRD_NRD_1 503 505 PF00675 0.771
CLV_NRD_NRD_1 533 535 PF00675 0.737
CLV_NRD_NRD_1 670 672 PF00675 0.756
CLV_NRD_NRD_1 78 80 PF00675 0.303
CLV_NRD_NRD_1 808 810 PF00675 0.672
CLV_PCSK_FUR_1 351 355 PF00082 0.538
CLV_PCSK_KEX2_1 320 322 PF00082 0.494
CLV_PCSK_KEX2_1 351 353 PF00082 0.483
CLV_PCSK_KEX2_1 503 505 PF00082 0.746
CLV_PCSK_KEX2_1 670 672 PF00082 0.756
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.484
CLV_PCSK_SKI1_1 137 141 PF00082 0.353
CLV_PCSK_SKI1_1 158 162 PF00082 0.323
CLV_PCSK_SKI1_1 423 427 PF00082 0.508
DEG_MDM2_SWIB_1 578 585 PF02201 0.559
DEG_SPOP_SBC_1 748 752 PF00917 0.766
DOC_CKS1_1 103 108 PF01111 0.355
DOC_MAPK_gen_1 158 167 PF00069 0.335
DOC_MAPK_gen_1 306 315 PF00069 0.570
DOC_MAPK_gen_1 778 787 PF00069 0.593
DOC_MAPK_gen_1 79 90 PF00069 0.335
DOC_MAPK_HePTP_8 205 217 PF00069 0.355
DOC_MAPK_MEF2A_6 208 217 PF00069 0.355
DOC_MAPK_MEF2A_6 306 315 PF00069 0.570
DOC_MAPK_MEF2A_6 391 399 PF00069 0.565
DOC_MAPK_MEF2A_6 657 666 PF00069 0.535
DOC_PP1_RVXF_1 172 179 PF00149 0.335
DOC_PP1_RVXF_1 206 212 PF00149 0.355
DOC_PP2B_LxvP_1 277 280 PF13499 0.355
DOC_PP2B_LxvP_1 483 486 PF13499 0.511
DOC_PP4_FxxP_1 425 428 PF00568 0.504
DOC_PP4_FxxP_1 91 94 PF00568 0.335
DOC_USP7_MATH_1 252 256 PF00917 0.411
DOC_USP7_MATH_1 458 462 PF00917 0.728
DOC_USP7_MATH_1 479 483 PF00917 0.539
DOC_USP7_MATH_1 564 568 PF00917 0.399
DOC_USP7_MATH_1 609 613 PF00917 0.649
DOC_USP7_MATH_1 622 626 PF00917 0.621
DOC_USP7_MATH_1 639 643 PF00917 0.568
DOC_USP7_MATH_1 675 679 PF00917 0.700
DOC_USP7_MATH_1 733 737 PF00917 0.762
DOC_USP7_MATH_1 748 752 PF00917 0.735
DOC_USP7_UBL2_3 383 387 PF12436 0.658
DOC_WW_Pin1_4 102 107 PF00397 0.355
DOC_WW_Pin1_4 193 198 PF00397 0.335
DOC_WW_Pin1_4 399 404 PF00397 0.563
DOC_WW_Pin1_4 583 588 PF00397 0.546
DOC_WW_Pin1_4 605 610 PF00397 0.586
DOC_WW_Pin1_4 731 736 PF00397 0.778
DOC_WW_Pin1_4 757 762 PF00397 0.698
LIG_14-3-3_CanoR_1 276 280 PF00244 0.383
LIG_14-3-3_CanoR_1 295 305 PF00244 0.477
LIG_14-3-3_CanoR_1 309 314 PF00244 0.412
LIG_14-3-3_CanoR_1 593 601 PF00244 0.631
LIG_14-3-3_CanoR_1 677 683 PF00244 0.714
LIG_14-3-3_CanoR_1 716 725 PF00244 0.665
LIG_Actin_RPEL_3 147 166 PF02755 0.447
LIG_Actin_WH2_2 59 75 PF00022 0.378
LIG_BIR_II_1 1 5 PF00653 0.705
LIG_BRCT_BRCA1_1 735 739 PF00533 0.542
LIG_BRCT_BRCA1_1 768 772 PF00533 0.715
LIG_FHA_1 463 469 PF00498 0.587
LIG_FHA_1 503 509 PF00498 0.732
LIG_FHA_1 596 602 PF00498 0.643
LIG_FHA_1 689 695 PF00498 0.522
LIG_FHA_1 716 722 PF00498 0.529
LIG_FHA_1 750 756 PF00498 0.749
LIG_FHA_1 758 764 PF00498 0.698
LIG_FHA_2 103 109 PF00498 0.335
LIG_FHA_2 431 437 PF00498 0.710
LIG_FHA_2 538 544 PF00498 0.541
LIG_FHA_2 726 732 PF00498 0.538
LIG_GBD_Chelix_1 799 807 PF00786 0.539
LIG_LIR_Apic_2 196 202 PF02991 0.335
LIG_LIR_Gen_1 107 116 PF02991 0.335
LIG_LIR_Gen_1 120 126 PF02991 0.335
LIG_LIR_Gen_1 569 580 PF02991 0.529
LIG_LIR_Gen_1 58 67 PF02991 0.447
LIG_LIR_Gen_1 597 603 PF02991 0.547
LIG_LIR_Nem_3 120 125 PF02991 0.335
LIG_LIR_Nem_3 24 28 PF02991 0.606
LIG_LIR_Nem_3 46 50 PF02991 0.354
LIG_LIR_Nem_3 569 575 PF02991 0.509
LIG_LIR_Nem_3 58 64 PF02991 0.335
LIG_LIR_Nem_3 586 591 PF02991 0.372
LIG_LIR_Nem_3 597 602 PF02991 0.563
LIG_LIR_Nem_3 769 775 PF02991 0.677
LIG_LYPXL_yS_3 25 28 PF13949 0.467
LIG_MAD2 154 162 PF02301 0.447
LIG_MLH1_MIPbox_1 768 772 PF16413 0.715
LIG_MYND_1 761 765 PF01753 0.480
LIG_NRBOX 223 229 PF00104 0.355
LIG_NRBOX 798 804 PF00104 0.708
LIG_OCRL_FandH_1 771 783 PF00620 0.683
LIG_PCNA_yPIPBox_3 764 778 PF02747 0.666
LIG_Pex14_1 10 14 PF04695 0.524
LIG_Pex14_2 578 582 PF04695 0.509
LIG_REV1ctd_RIR_1 770 778 PF16727 0.684
LIG_SH2_CRK 122 126 PF00017 0.408
LIG_SH2_CRK 225 229 PF00017 0.335
LIG_SH2_CRK 251 255 PF00017 0.355
LIG_SH2_CRK 344 348 PF00017 0.372
LIG_SH2_CRK 572 576 PF00017 0.482
LIG_SH2_NCK_1 100 104 PF00017 0.335
LIG_SH2_NCK_1 199 203 PF00017 0.335
LIG_SH2_NCK_1 251 255 PF00017 0.447
LIG_SH2_PTP2 61 64 PF00017 0.447
LIG_SH2_SRC 115 118 PF00017 0.355
LIG_SH2_SRC 122 125 PF00017 0.355
LIG_SH2_STAP1 122 126 PF00017 0.355
LIG_SH2_STAP1 298 302 PF00017 0.622
LIG_SH2_STAT3 124 127 PF00017 0.402
LIG_SH2_STAT3 138 141 PF00017 0.249
LIG_SH2_STAT5 110 113 PF00017 0.341
LIG_SH2_STAT5 115 118 PF00017 0.342
LIG_SH2_STAT5 124 127 PF00017 0.355
LIG_SH2_STAT5 138 141 PF00017 0.267
LIG_SH2_STAT5 149 152 PF00017 0.303
LIG_SH2_STAT5 210 213 PF00017 0.335
LIG_SH2_STAT5 341 344 PF00017 0.330
LIG_SH2_STAT5 36 39 PF00017 0.342
LIG_SH2_STAT5 539 542 PF00017 0.552
LIG_SH2_STAT5 61 64 PF00017 0.447
LIG_SH2_STAT5 699 702 PF00017 0.749
LIG_SH2_STAT5 771 774 PF00017 0.565
LIG_SH2_STAT5 783 786 PF00017 0.525
LIG_SH3_3 20 26 PF00018 0.700
LIG_SH3_3 267 273 PF00018 0.335
LIG_SH3_3 450 456 PF00018 0.683
LIG_SH3_3 581 587 PF00018 0.539
LIG_SH3_3 677 683 PF00018 0.745
LIG_SH3_3 732 738 PF00018 0.807
LIG_SH3_3 759 765 PF00018 0.729
LIG_SUMO_SIM_anti_2 798 805 PF11976 0.678
LIG_SUMO_SIM_anti_2 84 89 PF11976 0.447
LIG_SUMO_SIM_par_1 267 272 PF11976 0.323
LIG_SUMO_SIM_par_1 404 413 PF11976 0.648
LIG_SUMO_SIM_par_1 764 769 PF11976 0.692
LIG_SUMO_SIM_par_1 798 805 PF11976 0.596
LIG_TRAF2_1 540 543 PF00917 0.568
LIG_TYR_ITIM 223 228 PF00017 0.335
LIG_TYR_ITIM 342 347 PF00017 0.370
LIG_UBA3_1 242 250 PF00899 0.335
LIG_WRC_WIRS_1 459 464 PF05994 0.756
LIG_WRC_WIRS_1 575 580 PF05994 0.534
LIG_WW_1 22 25 PF00397 0.483
MOD_CDC14_SPxK_1 586 589 PF00782 0.607
MOD_CDK_SPK_2 605 610 PF00069 0.688
MOD_CDK_SPxK_1 583 589 PF00069 0.601
MOD_CK1_1 104 110 PF00069 0.378
MOD_CK1_1 181 187 PF00069 0.408
MOD_CK1_1 193 199 PF00069 0.258
MOD_CK1_1 301 307 PF00069 0.561
MOD_CK1_1 430 436 PF00069 0.682
MOD_CK1_1 440 446 PF00069 0.615
MOD_CK1_1 478 484 PF00069 0.654
MOD_CK1_1 605 611 PF00069 0.658
MOD_CK1_1 640 646 PF00069 0.788
MOD_CK1_1 678 684 PF00069 0.719
MOD_CK1_1 734 740 PF00069 0.781
MOD_CK1_1 746 752 PF00069 0.619
MOD_CK1_1 9 15 PF00069 0.692
MOD_CK2_1 294 300 PF00069 0.464
MOD_CK2_1 301 307 PF00069 0.513
MOD_CK2_1 363 369 PF00069 0.681
MOD_CK2_1 537 543 PF00069 0.550
MOD_CK2_1 591 597 PF00069 0.564
MOD_CK2_1 725 731 PF00069 0.754
MOD_GlcNHglycan 18 21 PF01048 0.734
MOD_GlcNHglycan 205 208 PF01048 0.344
MOD_GlcNHglycan 336 339 PF01048 0.357
MOD_GlcNHglycan 365 368 PF01048 0.655
MOD_GlcNHglycan 446 450 PF01048 0.790
MOD_GlcNHglycan 475 478 PF01048 0.636
MOD_GlcNHglycan 508 511 PF01048 0.560
MOD_GlcNHglycan 568 571 PF01048 0.601
MOD_GlcNHglycan 624 628 PF01048 0.706
MOD_GlcNHglycan 634 637 PF01048 0.721
MOD_GlcNHglycan 639 642 PF01048 0.666
MOD_GlcNHglycan 680 683 PF01048 0.782
MOD_GlcNHglycan 73 76 PF01048 0.417
MOD_GlcNHglycan 731 734 PF01048 0.742
MOD_GlcNHglycan 752 755 PF01048 0.740
MOD_GSK3_1 189 196 PF00069 0.335
MOD_GSK3_1 294 301 PF00069 0.490
MOD_GSK3_1 309 316 PF00069 0.467
MOD_GSK3_1 363 370 PF00069 0.656
MOD_GSK3_1 430 437 PF00069 0.535
MOD_GSK3_1 458 465 PF00069 0.697
MOD_GSK3_1 469 476 PF00069 0.599
MOD_GSK3_1 493 500 PF00069 0.786
MOD_GSK3_1 502 509 PF00069 0.709
MOD_GSK3_1 591 598 PF00069 0.524
MOD_GSK3_1 6 13 PF00069 0.666
MOD_GSK3_1 605 612 PF00069 0.567
MOD_GSK3_1 717 724 PF00069 0.729
MOD_GSK3_1 725 732 PF00069 0.768
MOD_GSK3_1 742 749 PF00069 0.607
MOD_N-GLC_1 181 186 PF02516 0.480
MOD_N-GLC_1 689 694 PF02516 0.783
MOD_N-GLC_2 95 97 PF02516 0.335
MOD_NEK2_1 166 171 PF00069 0.415
MOD_NEK2_1 178 183 PF00069 0.292
MOD_NEK2_1 189 194 PF00069 0.301
MOD_NEK2_1 241 246 PF00069 0.403
MOD_NEK2_1 294 299 PF00069 0.476
MOD_NEK2_1 32 37 PF00069 0.467
MOD_NEK2_1 397 402 PF00069 0.564
MOD_NEK2_1 434 439 PF00069 0.531
MOD_NEK2_1 462 467 PF00069 0.646
MOD_NEK2_1 473 478 PF00069 0.586
MOD_NEK2_1 508 513 PF00069 0.686
MOD_NEK2_1 591 596 PF00069 0.524
MOD_NEK2_1 747 752 PF00069 0.663
MOD_NEK2_2 298 303 PF00069 0.512
MOD_NEK2_2 458 463 PF00069 0.759
MOD_NEK2_2 479 484 PF00069 0.668
MOD_PIKK_1 376 382 PF00454 0.512
MOD_PIKK_1 397 403 PF00454 0.567
MOD_PIKK_1 603 609 PF00454 0.712
MOD_PIKK_1 689 695 PF00454 0.770
MOD_PK_1 309 315 PF00069 0.537
MOD_PK_1 528 534 PF00069 0.653
MOD_PKA_2 131 137 PF00069 0.447
MOD_PKA_2 275 281 PF00069 0.335
MOD_PKA_2 294 300 PF00069 0.440
MOD_PKA_2 38 44 PF00069 0.447
MOD_PKA_2 462 468 PF00069 0.741
MOD_PKA_2 502 508 PF00069 0.572
MOD_PKA_2 592 598 PF00069 0.579
MOD_PKA_2 715 721 PF00069 0.666
MOD_Plk_1 10 16 PF00069 0.518
MOD_Plk_1 235 241 PF00069 0.355
MOD_Plk_1 440 446 PF00069 0.793
MOD_Plk_1 564 570 PF00069 0.507
MOD_Plk_1 658 664 PF00069 0.532
MOD_Plk_1 689 695 PF00069 0.522
MOD_Plk_1 742 748 PF00069 0.552
MOD_Plk_4 298 304 PF00069 0.487
MOD_Plk_4 309 315 PF00069 0.409
MOD_Plk_4 32 38 PF00069 0.475
MOD_Plk_4 469 475 PF00069 0.743
MOD_Plk_4 651 657 PF00069 0.539
MOD_Plk_4 717 723 PF00069 0.727
MOD_Plk_4 766 772 PF00069 0.662
MOD_ProDKin_1 102 108 PF00069 0.355
MOD_ProDKin_1 193 199 PF00069 0.335
MOD_ProDKin_1 399 405 PF00069 0.559
MOD_ProDKin_1 583 589 PF00069 0.547
MOD_ProDKin_1 605 611 PF00069 0.586
MOD_ProDKin_1 731 737 PF00069 0.780
MOD_ProDKin_1 757 763 PF00069 0.696
MOD_SUMO_for_1 160 163 PF00179 0.335
MOD_SUMO_rev_2 430 440 PF00179 0.551
MOD_SUMO_rev_2 74 81 PF00179 0.385
MOD_SUMO_rev_2 780 790 PF00179 0.669
TRG_DiLeu_BaEn_2 541 547 PF01217 0.561
TRG_DiLeu_BaEn_3 542 548 PF01217 0.560
TRG_DiLeu_BaEn_4 659 665 PF01217 0.537
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.447
TRG_DiLeu_BaLyEn_6 586 591 PF01217 0.548
TRG_ENDOCYTIC_2 100 103 PF00928 0.373
TRG_ENDOCYTIC_2 110 113 PF00928 0.335
TRG_ENDOCYTIC_2 122 125 PF00928 0.355
TRG_ENDOCYTIC_2 225 228 PF00928 0.319
TRG_ENDOCYTIC_2 25 28 PF00928 0.467
TRG_ENDOCYTIC_2 344 347 PF00928 0.370
TRG_ENDOCYTIC_2 572 575 PF00928 0.461
TRG_ENDOCYTIC_2 61 64 PF00928 0.447
TRG_ER_diArg_1 351 354 PF00400 0.532
TRG_ER_diArg_1 670 672 PF00400 0.757
TRG_NES_CRM1_1 355 369 PF08389 0.604
TRG_NLS_MonoExtN_4 245 251 PF00514 0.408
TRG_NLS_MonoExtN_4 49 55 PF00514 0.408
TRG_Pf-PMV_PEXEL_1 137 141 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 158 163 PF00026 0.335
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I379 Leptomonas seymouri 69% 99%
A0A1X0P022 Trypanosomatidae 59% 100%
A0A3R7MPF2 Trypanosoma rangeli 60% 100%
A0A3S7X2Q3 Leishmania donovani 86% 100%
A4I4Q9 Leishmania infantum 86% 100%
C9ZLF2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AE64 Leishmania major 87% 100%
E9ALM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
V5BL06 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS