Pentatricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHK0_LEIBR

TriTrypDb:

LbrM.29.1980 , LBRM2903_290026300

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.538
CLV_NRD_NRD_1	182	184	PF00675	0.379
CLV_NRD_NRD_1	2	4	PF00675	0.687
CLV_NRD_NRD_1	25	27	PF00675	0.633
CLV_NRD_NRD_1	444	446	PF00675	0.412
CLV_NRD_NRD_1	463	465	PF00675	0.531
CLV_NRD_NRD_1	81	83	PF00675	0.465
CLV_PCSK_KEX2_1	10	12	PF00082	0.448
CLV_PCSK_KEX2_1	182	184	PF00082	0.379
CLV_PCSK_KEX2_1	2	4	PF00082	0.693
CLV_PCSK_KEX2_1	25	27	PF00082	0.582
CLV_PCSK_KEX2_1	444	446	PF00082	0.412
CLV_PCSK_KEX2_1	463	465	PF00082	0.424
CLV_PCSK_KEX2_1	470	472	PF00082	0.452
CLV_PCSK_KEX2_1	81	83	PF00082	0.502
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.613
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.554
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.479
CLV_PCSK_PC7_1	440	446	PF00082	0.396
CLV_PCSK_SKI1_1	119	123	PF00082	0.481
CLV_PCSK_SKI1_1	260	264	PF00082	0.288
CLV_PCSK_SKI1_1	314	318	PF00082	0.340
CLV_PCSK_SKI1_1	440	444	PF00082	0.372
CLV_PCSK_SKI1_1	456	460	PF00082	0.276
CLV_PCSK_SKI1_1	57	61	PF00082	0.556
CLV_PCSK_SKI1_1	94	98	PF00082	0.556
CLV_Separin_Metazoa	211	215	PF03568	0.331
DEG_APCC_DBOX_1	313	321	PF00400	0.351
DEG_Nend_UBRbox_1	1	4	PF02207	0.640
DEG_SCF_FBW7_2	541	546	PF00400	0.634
DEG_SPOP_SBC_1	635	639	PF00917	0.407
DOC_CKS1_1	497	502	PF01111	0.548
DOC_CYCLIN_RxL_1	116	127	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	670	676	PF00134	0.638
DOC_MAPK_gen_1	116	124	PF00069	0.529
DOC_MAPK_gen_1	463	469	PF00069	0.492
DOC_MAPK_gen_1	81	90	PF00069	0.401
DOC_MAPK_MEF2A_6	203	212	PF00069	0.531
DOC_MAPK_MEF2A_6	653	661	PF00069	0.519
DOC_PP1_RVXF_1	118	125	PF00149	0.531
DOC_PP2B_LxvP_1	304	307	PF13499	0.424
DOC_PP2B_LxvP_1	670	673	PF13499	0.497
DOC_USP7_MATH_1	36	40	PF00917	0.539
DOC_USP7_MATH_1	548	552	PF00917	0.587
DOC_USP7_MATH_1	584	588	PF00917	0.640
DOC_USP7_MATH_1	677	681	PF00917	0.515
DOC_USP7_MATH_1	99	103	PF00917	0.526
DOC_USP7_UBL2_3	528	532	PF12436	0.461
DOC_WW_Pin1_4	44	49	PF00397	0.506
DOC_WW_Pin1_4	496	501	PF00397	0.608
DOC_WW_Pin1_4	516	521	PF00397	0.431
DOC_WW_Pin1_4	539	544	PF00397	0.718
LIG_14-3-3_CanoR_1	2	6	PF00244	0.697
LIG_14-3-3_CanoR_1	224	228	PF00244	0.427
LIG_14-3-3_CanoR_1	606	614	PF00244	0.476
LIG_14-3-3_CanoR_1	616	624	PF00244	0.384
LIG_APCC_ABBA_1	191	196	PF00400	0.445
LIG_BRCT_BRCA1_1	418	422	PF00533	0.484
LIG_FHA_1	2	8	PF00498	0.629
LIG_FHA_1	224	230	PF00498	0.419
LIG_FHA_1	275	281	PF00498	0.504
LIG_FHA_1	347	353	PF00498	0.565
LIG_FHA_1	388	394	PF00498	0.482
LIG_FHA_1	39	45	PF00498	0.522
LIG_FHA_1	47	53	PF00498	0.505
LIG_FHA_1	84	90	PF00498	0.508
LIG_FHA_2	418	424	PF00498	0.464
LIG_FHA_2	45	51	PF00498	0.580
LIG_FHA_2	565	571	PF00498	0.590
LIG_FHA_2	610	616	PF00498	0.435
LIG_LIR_Gen_1	102	112	PF02991	0.376
LIG_LIR_Gen_1	419	429	PF02991	0.412
LIG_LIR_Nem_3	102	108	PF02991	0.382
LIG_LIR_Nem_3	310	316	PF02991	0.342
LIG_LIR_Nem_3	419	425	PF02991	0.411
LIG_LIR_Nem_3	426	432	PF02991	0.357
LIG_LIR_Nem_3	472	477	PF02991	0.500
LIG_LIR_Nem_3	598	604	PF02991	0.552
LIG_PCNA_yPIPBox_3	379	391	PF02747	0.550
LIG_SH2_CRK	105	109	PF00017	0.371
LIG_SH2_CRK	246	250	PF00017	0.475
LIG_SH2_CRK	313	317	PF00017	0.343
LIG_SH2_CRK	429	433	PF00017	0.354
LIG_SH2_NCK_1	429	433	PF00017	0.480
LIG_SH2_STAP1	429	433	PF00017	0.338
LIG_SH2_STAP1	482	486	PF00017	0.456
LIG_SH2_STAT3	482	485	PF00017	0.457
LIG_SH2_STAT3	663	666	PF00017	0.540
LIG_SH2_STAT5	105	108	PF00017	0.373
LIG_SH2_STAT5	209	212	PF00017	0.322
LIG_SH2_STAT5	491	494	PF00017	0.458
LIG_SH3_3	165	171	PF00018	0.476
LIG_SH3_3	429	435	PF00018	0.446
LIG_SH3_3	494	500	PF00018	0.550
LIG_SH3_3	514	520	PF00018	0.421
LIG_SH3_3	596	602	PF00018	0.591
LIG_SH3_3	658	664	PF00018	0.408
LIG_SH3_3	669	675	PF00018	0.517
LIG_SH3_3	688	694	PF00018	0.543
LIG_SUMO_SIM_par_1	349	355	PF11976	0.523
LIG_TYR_ITIM	207	212	PF00017	0.424
LIG_TYR_ITSM	309	316	PF00017	0.487
LIG_UBA3_1	212	220	PF00899	0.477
LIG_WRC_WIRS_1	375	380	PF05994	0.436
MOD_CDK_SPxxK_3	44	51	PF00069	0.513
MOD_CK1_1	276	282	PF00069	0.410
MOD_CK1_1	587	593	PF00069	0.681
MOD_CK2_1	264	270	PF00069	0.488
MOD_CK2_1	417	423	PF00069	0.458
MOD_CK2_1	44	50	PF00069	0.522
MOD_CK2_1	609	615	PF00069	0.414
MOD_Cter_Amidation	23	26	PF01082	0.551
MOD_GlcNHglycan	395	398	PF01048	0.615
MOD_GlcNHglycan	551	554	PF01048	0.746
MOD_GlcNHglycan	638	641	PF01048	0.334
MOD_GlcNHglycan	679	682	PF01048	0.599
MOD_GSK3_1	235	242	PF00069	0.543
MOD_GSK3_1	348	355	PF00069	0.409
MOD_GSK3_1	417	424	PF00069	0.481
MOD_GSK3_1	580	587	PF00069	0.660
MOD_GSK3_1	591	598	PF00069	0.560
MOD_GSK3_1	600	607	PF00069	0.491
MOD_GSK3_1	634	641	PF00069	0.576
MOD_N-GLC_2	179	181	PF02516	0.332
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	142	147	PF00069	0.421
MOD_NEK2_1	239	244	PF00069	0.356
MOD_NEK2_1	264	269	PF00069	0.452
MOD_NEK2_1	348	353	PF00069	0.452
MOD_NEK2_1	393	398	PF00069	0.605
MOD_NEK2_1	417	422	PF00069	0.525
MOD_NEK2_1	487	492	PF00069	0.535
MOD_NEK2_1	605	610	PF00069	0.462
MOD_NEK2_1	623	628	PF00069	0.410
MOD_NEK2_1	636	641	PF00069	0.413
MOD_PIKK_1	327	333	PF00454	0.527
MOD_PIKK_1	587	593	PF00454	0.685
MOD_PIKK_1	638	644	PF00454	0.480
MOD_PIKK_1	99	105	PF00454	0.498
MOD_PK_1	610	616	PF00069	0.542
MOD_PKA_1	10	16	PF00069	0.648
MOD_PKA_2	1	7	PF00069	0.623
MOD_PKA_2	10	16	PF00069	0.406
MOD_PKA_2	115	121	PF00069	0.487
MOD_PKA_2	223	229	PF00069	0.341
MOD_PKA_2	561	567	PF00069	0.700
MOD_PKA_2	605	611	PF00069	0.480
MOD_PKA_2	615	621	PF00069	0.384
MOD_PKA_2	677	683	PF00069	0.660
MOD_Plk_1	235	241	PF00069	0.474
MOD_Plk_1	327	333	PF00069	0.516
MOD_Plk_4	158	164	PF00069	0.456
MOD_Plk_4	308	314	PF00069	0.426
MOD_Plk_4	428	434	PF00069	0.393
MOD_Plk_4	487	493	PF00069	0.445
MOD_Plk_4	600	606	PF00069	0.533
MOD_Plk_4	69	75	PF00069	0.427
MOD_ProDKin_1	44	50	PF00069	0.511
MOD_ProDKin_1	496	502	PF00069	0.606
MOD_ProDKin_1	516	522	PF00069	0.434
MOD_ProDKin_1	539	545	PF00069	0.718
MOD_SUMO_for_1	469	472	PF00179	0.547
MOD_SUMO_rev_2	127	134	PF00179	0.433
MOD_SUMO_rev_2	334	339	PF00179	0.512
MOD_SUMO_rev_2	34	39	PF00179	0.661
TRG_DiLeu_BaEn_1	211	216	PF01217	0.456
TRG_DiLeu_BaEn_1	511	516	PF01217	0.647
TRG_DiLeu_BaEn_4	472	478	PF01217	0.536
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.611
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.390
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.663
TRG_DiLeu_LyEn_5	211	216	PF01217	0.400
TRG_ENDOCYTIC_2	105	108	PF00928	0.373
TRG_ENDOCYTIC_2	209	212	PF00928	0.322
TRG_ENDOCYTIC_2	246	249	PF00928	0.476
TRG_ENDOCYTIC_2	313	316	PF00928	0.329
TRG_ENDOCYTIC_2	375	378	PF00928	0.553
TRG_ENDOCYTIC_2	429	432	PF00928	0.344
TRG_ER_diArg_1	1	3	PF00400	0.663
TRG_ER_diArg_1	182	184	PF00400	0.505
TRG_ER_diArg_1	444	447	PF00400	0.427
TRG_ER_diArg_1	462	464	PF00400	0.427
TRG_ER_diArg_1	80	82	PF00400	0.527
TRG_NES_CRM1_1	50	64	PF08389	0.559
TRG_NLS_Bipartite_1	9	29	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.431
TRG_PTS1	695	698	PF00515	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R0	Leptomonas seymouri	71%	97%
A0A0S4IQD8	Bodo saltans	36%	94%
A0A1X0P086	Trypanosomatidae	45%	100%
A0A3S7X2T2	Leishmania donovani	87%	100%
A0A422NKV6	Trypanosoma rangeli	43%	100%
A4I4Q8	Leishmania infantum	87%	100%
C9ZLE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AE63	Leishmania major	85%	100%
E9ALM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BGI2	Trypanosoma cruzi	45%	95%