SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHJ9_LEIBR

TriTrypDb:

LbrM.29.1970 , LBRM2903_290026100 , LBRM2903_290026200

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ9

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009451	RNA modification	5	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0032259	methylation	2	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043414	macromolecule methylation	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008168	methyltransferase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.520
CLV_C14_Caspase3-7	608	612	PF00656	0.573
CLV_C14_Caspase3-7	737	741	PF00656	0.464
CLV_NRD_NRD_1	240	242	PF00675	0.496
CLV_NRD_NRD_1	366	368	PF00675	0.426
CLV_NRD_NRD_1	384	386	PF00675	0.459
CLV_NRD_NRD_1	594	596	PF00675	0.229
CLV_NRD_NRD_1	623	625	PF00675	0.450
CLV_NRD_NRD_1	90	92	PF00675	0.421
CLV_PCSK_KEX2_1	365	367	PF00082	0.470
CLV_PCSK_KEX2_1	383	385	PF00082	0.641
CLV_PCSK_KEX2_1	594	596	PF00082	0.346
CLV_PCSK_KEX2_1	623	625	PF00082	0.450
CLV_PCSK_KEX2_1	89	91	PF00082	0.436
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.620
CLV_PCSK_PC7_1	380	386	PF00082	0.445
CLV_PCSK_SKI1_1	389	393	PF00082	0.769
CLV_PCSK_SKI1_1	415	419	PF00082	0.411
CLV_PCSK_SKI1_1	594	598	PF00082	0.229
CLV_PCSK_SKI1_1	81	85	PF00082	0.509
DEG_APCC_DBOX_1	179	187	PF00400	0.384
DEG_SIAH_1	189	197	PF03145	0.274
DEG_SPOP_SBC_1	146	150	PF00917	0.436
DEG_SPOP_SBC_1	549	553	PF00917	0.503
DOC_CYCLIN_RxL_1	412	420	PF00134	0.272
DOC_CYCLIN_yCln2_LP_2	629	635	PF00134	0.429
DOC_MAPK_gen_1	241	249	PF00069	0.446
DOC_MAPK_gen_1	623	630	PF00069	0.410
DOC_MAPK_gen_1	715	724	PF00069	0.532
DOC_MAPK_gen_1	726	736	PF00069	0.433
DOC_MAPK_gen_1	89	95	PF00069	0.414
DOC_MAPK_MEF2A_6	175	183	PF00069	0.450
DOC_MAPK_MEF2A_6	505	513	PF00069	0.528
DOC_MAPK_MEF2A_6	623	630	PF00069	0.298
DOC_MAPK_MEF2A_6	729	738	PF00069	0.475
DOC_PP1_RVXF_1	482	489	PF00149	0.491
DOC_PP4_FxxP_1	205	208	PF00568	0.424
DOC_PP4_MxPP_1	1	4	PF00568	0.461
DOC_USP7_MATH_1	117	121	PF00917	0.466
DOC_USP7_MATH_1	190	194	PF00917	0.395
DOC_USP7_MATH_1	453	457	PF00917	0.412
DOC_USP7_MATH_1	526	530	PF00917	0.780
DOC_USP7_MATH_1	532	536	PF00917	0.789
DOC_USP7_MATH_1	538	542	PF00917	0.755
DOC_USP7_MATH_1	550	554	PF00917	0.502
DOC_USP7_MATH_1	558	562	PF00917	0.525
DOC_USP7_MATH_1	580	584	PF00917	0.484
DOC_USP7_MATH_1	707	711	PF00917	0.388
DOC_USP7_MATH_2	396	402	PF00917	0.488
DOC_USP7_UBL2_3	726	730	PF12436	0.300
DOC_WW_Pin1_4	11	16	PF00397	0.611
DOC_WW_Pin1_4	148	153	PF00397	0.632
DOC_WW_Pin1_4	213	218	PF00397	0.340
DOC_WW_Pin1_4	271	276	PF00397	0.565
DOC_WW_Pin1_4	277	282	PF00397	0.546
DOC_WW_Pin1_4	399	404	PF00397	0.667
DOC_WW_Pin1_4	48	53	PF00397	0.551
LIG_14-3-3_CanoR_1	302	306	PF00244	0.448
LIG_14-3-3_CanoR_1	337	341	PF00244	0.341
LIG_14-3-3_CanoR_1	383	389	PF00244	0.460
LIG_14-3-3_CanoR_1	57	64	PF00244	0.461
LIG_14-3-3_CanoR_1	688	693	PF00244	0.384
LIG_14-3-3_CanoR_1	697	706	PF00244	0.644
LIG_14-3-3_CanoR_1	715	724	PF00244	0.358
LIG_Actin_WH2_2	556	574	PF00022	0.441
LIG_BIR_III_2	49	53	PF00653	0.435
LIG_BRCT_BRCA1_1	215	219	PF00533	0.342
LIG_Clathr_ClatBox_1	224	228	PF01394	0.376
LIG_CSL_BTD_1	198	201	PF09270	0.421
LIG_DLG_GKlike_1	688	695	PF00625	0.381
LIG_EH1_1	665	673	PF00400	0.369
LIG_EVH1_2	73	77	PF00568	0.382
LIG_FHA_1	348	354	PF00498	0.526
LIG_FHA_1	372	378	PF00498	0.441
LIG_FHA_1	433	439	PF00498	0.482
LIG_FHA_1	472	478	PF00498	0.519
LIG_FHA_2	359	365	PF00498	0.393
LIG_FHA_2	385	391	PF00498	0.711
LIG_FHA_2	615	621	PF00498	0.740
LIG_LIR_Apic_2	125	131	PF02991	0.410
LIG_LIR_Gen_1	581	592	PF02991	0.480
LIG_LIR_Gen_1	719	727	PF02991	0.314
LIG_LIR_Nem_3	565	571	PF02991	0.512
LIG_LIR_Nem_3	581	587	PF02991	0.480
LIG_LIR_Nem_3	678	682	PF02991	0.431
LIG_LIR_Nem_3	710	716	PF02991	0.386
LIG_LIR_Nem_3	719	724	PF02991	0.326
LIG_MAD2	245	253	PF02301	0.423
LIG_PCNA_PIPBox_1	20	29	PF02747	0.453
LIG_PCNA_yPIPBox_3	20	28	PF02747	0.455
LIG_Pex14_1	713	717	PF04695	0.379
LIG_Pex14_2	205	209	PF04695	0.381
LIG_Pex14_2	717	721	PF04695	0.363
LIG_SH2_CRK	568	572	PF00017	0.435
LIG_SH2_CRK	584	588	PF00017	0.480
LIG_SH2_CRK	679	683	PF00017	0.453
LIG_SH2_PTP2	689	692	PF00017	0.377
LIG_SH2_PTP2	92	95	PF00017	0.358
LIG_SH2_SRC	409	412	PF00017	0.444
LIG_SH2_STAP1	413	417	PF00017	0.263
LIG_SH2_STAT5	406	409	PF00017	0.279
LIG_SH2_STAT5	586	589	PF00017	0.479
LIG_SH2_STAT5	591	594	PF00017	0.491
LIG_SH2_STAT5	689	692	PF00017	0.565
LIG_SH2_STAT5	723	726	PF00017	0.410
LIG_SH2_STAT5	92	95	PF00017	0.372
LIG_SH3_3	108	114	PF00018	0.433
LIG_SH3_3	276	282	PF00018	0.700
LIG_SH3_3	321	327	PF00018	0.446
LIG_SH3_3	405	411	PF00018	0.533
LIG_SH3_3	625	631	PF00018	0.498
LIG_TRAF2_1	361	364	PF00917	0.349
LIG_TRAF2_1	636	639	PF00917	0.342
LIG_TYR_ITAM	565	587	PF00017	0.380
LIG_WRC_WIRS_1	533	538	PF05994	0.506
LIG_WW_1	403	406	PF00397	0.357
MOD_CDK_SPxK_1	148	154	PF00069	0.449
MOD_CK1_1	274	280	PF00069	0.673
MOD_CK1_1	339	345	PF00069	0.562
MOD_CK1_1	489	495	PF00069	0.596
MOD_CK1_1	541	547	PF00069	0.749
MOD_CK1_1	552	558	PF00069	0.387
MOD_CK1_1	614	620	PF00069	0.681
MOD_CK1_1	698	704	PF00069	0.479
MOD_CK2_1	26	32	PF00069	0.437
MOD_CK2_1	358	364	PF00069	0.385
MOD_CK2_1	384	390	PF00069	0.461
MOD_CK2_1	517	523	PF00069	0.720
MOD_CK2_1	541	547	PF00069	0.594
MOD_CK2_1	698	704	PF00069	0.533
MOD_GlcNHglycan	119	122	PF01048	0.392
MOD_GlcNHglycan	276	279	PF01048	0.668
MOD_GlcNHglycan	28	31	PF01048	0.430
MOD_GlcNHglycan	341	344	PF01048	0.526
MOD_GlcNHglycan	392	395	PF01048	0.681
MOD_GlcNHglycan	479	482	PF01048	0.694
MOD_GlcNHglycan	488	491	PF01048	0.646
MOD_GlcNHglycan	552	555	PF01048	0.641
MOD_GlcNHglycan	560	563	PF01048	0.287
MOD_GlcNHglycan	59	62	PF01048	0.548
MOD_GlcNHglycan	700	703	PF01048	0.608
MOD_GlcNHglycan	740	744	PF01048	0.470
MOD_GSK3_1	113	120	PF00069	0.545
MOD_GSK3_1	146	153	PF00069	0.601
MOD_GSK3_1	262	269	PF00069	0.377
MOD_GSK3_1	315	322	PF00069	0.765
MOD_GSK3_1	355	362	PF00069	0.518
MOD_GSK3_1	371	378	PF00069	0.417
MOD_GSK3_1	409	416	PF00069	0.559
MOD_GSK3_1	428	435	PF00069	0.530
MOD_GSK3_1	453	460	PF00069	0.404
MOD_GSK3_1	486	493	PF00069	0.704
MOD_GSK3_1	527	534	PF00069	0.723
MOD_GSK3_1	537	544	PF00069	0.731
MOD_GSK3_1	548	555	PF00069	0.577
MOD_GSK3_1	578	585	PF00069	0.460
MOD_LATS_1	686	692	PF00433	0.385
MOD_N-GLC_1	293	298	PF02516	0.351
MOD_N-GLC_1	347	352	PF02516	0.336
MOD_N-GLC_1	477	482	PF02516	0.530
MOD_NEK2_1	122	127	PF00069	0.539
MOD_NEK2_1	26	31	PF00069	0.436
MOD_NEK2_1	300	305	PF00069	0.486
MOD_NEK2_1	347	352	PF00069	0.548
MOD_NEK2_1	417	422	PF00069	0.270
MOD_NEK2_1	527	532	PF00069	0.770
MOD_NEK2_1	578	583	PF00069	0.485
MOD_NEK2_1	695	700	PF00069	0.418
MOD_NEK2_1	717	722	PF00069	0.352
MOD_NEK2_2	301	306	PF00069	0.294
MOD_NEK2_2	532	537	PF00069	0.504
MOD_OFUCOSY	33	39	PF10250	0.434
MOD_PIKK_1	159	165	PF00454	0.654
MOD_PIKK_1	319	325	PF00454	0.608
MOD_PIKK_1	527	533	PF00454	0.750
MOD_PKA_1	383	389	PF00069	0.453
MOD_PKA_2	301	307	PF00069	0.491
MOD_PKA_2	336	342	PF00069	0.337
MOD_PKA_2	383	389	PF00069	0.461
MOD_PKA_2	717	723	PF00069	0.335
MOD_Plk_1	123	129	PF00069	0.412
MOD_Plk_1	293	299	PF00069	0.472
MOD_Plk_1	372	378	PF00069	0.392
MOD_Plk_1	640	646	PF00069	0.483
MOD_Plk_1	695	701	PF00069	0.530
MOD_Plk_4	124	130	PF00069	0.549
MOD_Plk_4	220	226	PF00069	0.406
MOD_Plk_4	349	355	PF00069	0.478
MOD_Plk_4	417	423	PF00069	0.295
MOD_Plk_4	552	558	PF00069	0.338
MOD_Plk_4	573	579	PF00069	0.459
MOD_Plk_4	582	588	PF00069	0.449
MOD_Plk_4	717	723	PF00069	0.463
MOD_ProDKin_1	11	17	PF00069	0.611
MOD_ProDKin_1	148	154	PF00069	0.637
MOD_ProDKin_1	213	219	PF00069	0.337
MOD_ProDKin_1	271	277	PF00069	0.564
MOD_ProDKin_1	399	405	PF00069	0.647
MOD_ProDKin_1	48	54	PF00069	0.543
MOD_SUMO_rev_2	132	137	PF00179	0.365
MOD_SUMO_rev_2	634	644	PF00179	0.450
TRG_DiLeu_BaEn_4	363	369	PF01217	0.347
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.412
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.526
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.502
TRG_ENDOCYTIC_2	568	571	PF00928	0.435
TRG_ENDOCYTIC_2	584	587	PF00928	0.480
TRG_ENDOCYTIC_2	679	682	PF00928	0.425
TRG_ENDOCYTIC_2	689	692	PF00928	0.455
TRG_ENDOCYTIC_2	92	95	PF00928	0.358
TRG_ER_diArg_1	366	368	PF00400	0.471
TRG_ER_diArg_1	383	385	PF00400	0.558
TRG_ER_diArg_1	593	595	PF00400	0.432
TRG_ER_diArg_1	622	624	PF00400	0.423
TRG_ER_diArg_1	89	91	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B6	Leptomonas seymouri	43%	100%
A0A1X0P1I1	Trypanosomatidae	32%	100%
A0A3S7X2L4	Leishmania donovani	69%	100%
A0A422NNK7	Trypanosoma rangeli	33%	100%
E9AE62	Leishmania major	68%	100%
E9ALM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
V5DCM2	Trypanosoma cruzi	31%	100%