Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHJ8_LEIBR

TriTrypDb:

LbrM.29.1950 , LBRM2903_290025900

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.698
CLV_NRD_NRD_1	97	99	PF00675	0.599
CLV_PCSK_KEX2_1	120	122	PF00082	0.686
CLV_PCSK_KEX2_1	97	99	PF00082	0.599
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.547
DEG_SPOP_SBC_1	409	413	PF00917	0.611
DOC_ANK_TNKS_1	451	458	PF00023	0.607
DOC_CDC14_PxL_1	165	173	PF14671	0.600
DOC_CKS1_1	6	11	PF01111	0.681
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	155	158	PF00134	0.576
DOC_PP1_RVXF_1	210	217	PF00149	0.422
DOC_PP2B_LxvP_1	155	158	PF13499	0.511
DOC_PP4_FxxP_1	150	153	PF00568	0.671
DOC_PP4_FxxP_1	273	276	PF00568	0.434
DOC_PP4_FxxP_1	6	9	PF00568	0.711
DOC_SPAK_OSR1_1	238	242	PF12202	0.615
DOC_USP7_MATH_1	161	165	PF00917	0.680
DOC_USP7_MATH_1	198	202	PF00917	0.605
DOC_USP7_MATH_1	362	366	PF00917	0.628
DOC_USP7_MATH_1	409	413	PF00917	0.672
DOC_USP7_MATH_1	438	442	PF00917	0.728
DOC_USP7_MATH_2	125	131	PF00917	0.522
DOC_USP7_MATH_2	5	11	PF00917	0.525
DOC_WW_Pin1_4	172	177	PF00397	0.607
DOC_WW_Pin1_4	255	260	PF00397	0.553
DOC_WW_Pin1_4	405	410	PF00397	0.555
DOC_WW_Pin1_4	434	439	PF00397	0.678
DOC_WW_Pin1_4	5	10	PF00397	0.757
DOC_WW_Pin1_4	517	522	PF00397	0.494
LIG_14-3-3_CanoR_1	190	194	PF00244	0.489
LIG_14-3-3_CanoR_1	30	39	PF00244	0.549
LIG_14-3-3_CanoR_1	314	320	PF00244	0.437
LIG_14-3-3_CanoR_1	370	377	PF00244	0.576
LIG_14-3-3_CanoR_1	97	106	PF00244	0.606
LIG_Actin_WH2_2	176	192	PF00022	0.431
LIG_APCC_ABBA_1	90	95	PF00400	0.635
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_CtBP_PxDLS_1	157	161	PF00389	0.516
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.605
LIG_EVH1_1	445	449	PF00568	0.506
LIG_FHA_1	261	267	PF00498	0.452
LIG_FHA_1	328	334	PF00498	0.495
LIG_FHA_1	339	345	PF00498	0.534
LIG_FHA_1	34	40	PF00498	0.661
LIG_FHA_1	386	392	PF00498	0.478
LIG_FHA_1	397	403	PF00498	0.573
LIG_FHA_1	448	454	PF00498	0.630
LIG_FHA_2	414	420	PF00498	0.662
LIG_FHA_2	494	500	PF00498	0.491
LIG_FHA_2	60	66	PF00498	0.542
LIG_FHA_2	78	84	PF00498	0.471
LIG_LIR_Gen_1	180	189	PF02991	0.412
LIG_LIR_Gen_1	520	530	PF02991	0.543
LIG_LIR_Nem_3	126	131	PF02991	0.621
LIG_LIR_Nem_3	13	18	PF02991	0.656
LIG_LIR_Nem_3	140	145	PF02991	0.584
LIG_LIR_Nem_3	180	185	PF02991	0.411
LIG_LIR_Nem_3	520	526	PF02991	0.596
LIG_LYPXL_yS_3	128	131	PF13949	0.514
LIG_MYND_1	129	133	PF01753	0.506
LIG_MYND_1	153	157	PF01753	0.515
LIG_MYND_1	517	521	PF01753	0.565
LIG_SH2_CRK	134	138	PF00017	0.618
LIG_SH2_STAP1	134	138	PF00017	0.618
LIG_SH2_STAP1	202	206	PF00017	0.429
LIG_SH2_STAT3	324	327	PF00017	0.553
LIG_SH2_STAT5	181	184	PF00017	0.491
LIG_SH2_STAT5	270	273	PF00017	0.493
LIG_SH3_3	126	132	PF00018	0.517
LIG_SH3_3	146	152	PF00018	0.684
LIG_SH3_3	295	301	PF00018	0.652
LIG_SH3_3	432	438	PF00018	0.608
LIG_SH3_3	443	449	PF00018	0.631
LIG_SUMO_SIM_par_1	172	180	PF11976	0.460
LIG_TRAF2_1	275	278	PF00917	0.450
LIG_TRAF2_1	496	499	PF00917	0.489
LIG_UBA3_1	464	470	PF00899	0.462
LIG_WW_3	43	47	PF00397	0.546
MOD_CK1_1	10	16	PF00069	0.508
MOD_CK1_1	101	107	PF00069	0.642
MOD_CK1_1	172	178	PF00069	0.490
MOD_CK1_1	365	371	PF00069	0.635
MOD_CK1_1	408	414	PF00069	0.676
MOD_CK1_1	53	59	PF00069	0.692
MOD_CK2_1	349	355	PF00069	0.585
MOD_CK2_1	413	419	PF00069	0.757
MOD_CK2_1	427	433	PF00069	0.579
MOD_CK2_1	493	499	PF00069	0.490
MOD_CK2_1	59	65	PF00069	0.542
MOD_GlcNHglycan	1	4	PF01048	0.560
MOD_GlcNHglycan	202	205	PF01048	0.640
MOD_GlcNHglycan	219	222	PF01048	0.521
MOD_GlcNHglycan	295	298	PF01048	0.525
MOD_GlcNHglycan	33	36	PF01048	0.589
MOD_GlcNHglycan	345	348	PF01048	0.720
MOD_GlcNHglycan	349	352	PF01048	0.770
MOD_GlcNHglycan	412	415	PF01048	0.761
MOD_GlcNHglycan	55	58	PF01048	0.781
MOD_GlcNHglycan	77	80	PF01048	0.635
MOD_GlcNHglycan	86	90	PF01048	0.473
MOD_GSK3_1	123	130	PF00069	0.808
MOD_GSK3_1	194	201	PF00069	0.626
MOD_GSK3_1	334	341	PF00069	0.660
MOD_GSK3_1	343	350	PF00069	0.583
MOD_GSK3_1	365	372	PF00069	0.760
MOD_GSK3_1	398	405	PF00069	0.619
MOD_GSK3_1	409	416	PF00069	0.677
MOD_GSK3_1	434	441	PF00069	0.689
MOD_GSK3_1	52	59	PF00069	0.721
MOD_GSK3_1	71	78	PF00069	0.510
MOD_N-GLC_1	217	222	PF02516	0.454
MOD_NEK2_1	137	142	PF00069	0.578
MOD_NEK2_1	171	176	PF00069	0.541
MOD_NEK2_1	189	194	PF00069	0.459
MOD_NEK2_1	217	222	PF00069	0.614
MOD_NEK2_1	248	253	PF00069	0.521
MOD_NEK2_1	349	354	PF00069	0.601
MOD_NEK2_1	380	385	PF00069	0.706
MOD_PIKK_1	101	107	PF00454	0.609
MOD_PIKK_1	33	39	PF00454	0.622
MOD_PIKK_1	356	362	PF00454	0.528
MOD_PIKK_1	413	419	PF00454	0.652
MOD_PK_1	280	286	PF00069	0.622
MOD_PK_1	50	56	PF00069	0.544
MOD_PKA_2	189	195	PF00069	0.472
MOD_PKA_2	333	339	PF00069	0.666
MOD_PKA_2	369	375	PF00069	0.609
MOD_PKA_2	63	69	PF00069	0.663
MOD_Plk_1	280	286	PF00069	0.622
MOD_Plk_1	334	340	PF00069	0.680
MOD_Plk_1	354	360	PF00069	0.482
MOD_Plk_1	427	433	PF00069	0.537
MOD_Plk_1	85	91	PF00069	0.622
MOD_Plk_4	380	386	PF00069	0.605
MOD_Plk_4	387	393	PF00069	0.534
MOD_Plk_4	77	83	PF00069	0.580
MOD_ProDKin_1	172	178	PF00069	0.601
MOD_ProDKin_1	255	261	PF00069	0.548
MOD_ProDKin_1	405	411	PF00069	0.556
MOD_ProDKin_1	434	440	PF00069	0.679
MOD_ProDKin_1	5	11	PF00069	0.755
MOD_ProDKin_1	517	523	PF00069	0.493
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.705
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.533
TRG_ENDOCYTIC_2	128	131	PF00928	0.607
TRG_ENDOCYTIC_2	134	137	PF00928	0.605
TRG_ENDOCYTIC_2	270	273	PF00928	0.493
TRG_ENDOCYTIC_2	523	526	PF00928	0.554
TRG_ENDOCYTIC_2	93	96	PF00928	0.573
TRG_ER_diArg_1	121	123	PF00400	0.643
TRG_ER_diArg_1	96	98	PF00400	0.591
TRG_NES_CRM1_1	456	469	PF08389	0.559
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXW3	Leptomonas seymouri	26%	92%
A0A3Q8IDU7	Leishmania donovani	68%	100%
A4I4Q7	Leishmania infantum	68%	100%
E9AE60	Leishmania major	68%	100%
E9ALM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%