Protein geranylgeranyltransferase type II

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein farnesyltransferase alpha subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HHJ5_LEIBR

TriTrypDb:

LbrM.29.1920 , LBRM2903_290025500

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005953	CAAX-protein geranylgeranyltransferase complex	3	1
GO:0005965	protein farnesyltransferase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HHJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018342	protein prenylation	4	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0097354	prenylation	3	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0018343	protein farnesylation	5	1
GO:0018344	protein geranylgeranylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0008318	protein prenyltransferase activity	3	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004660	protein farnesyltransferase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	727	731	PF00656	0.433
CLV_C14_Caspase3-7	775	779	PF00656	0.514
CLV_C14_Caspase3-7	94	98	PF00656	0.413
CLV_NRD_NRD_1	208	210	PF00675	0.374
CLV_NRD_NRD_1	249	251	PF00675	0.526
CLV_NRD_NRD_1	309	311	PF00675	0.281
CLV_NRD_NRD_1	365	367	PF00675	0.582
CLV_NRD_NRD_1	497	499	PF00675	0.275
CLV_NRD_NRD_1	735	737	PF00675	0.508
CLV_PCSK_KEX2_1	208	210	PF00082	0.374
CLV_PCSK_KEX2_1	309	311	PF00082	0.226
CLV_PCSK_KEX2_1	365	367	PF00082	0.582
CLV_PCSK_KEX2_1	497	499	PF00082	0.275
CLV_PCSK_KEX2_1	734	736	PF00082	0.513
CLV_PCSK_KEX2_1	810	812	PF00082	0.408
CLV_PCSK_PC1ET2_1	810	812	PF00082	0.510
CLV_PCSK_SKI1_1	186	190	PF00082	0.377
CLV_PCSK_SKI1_1	209	213	PF00082	0.472
CLV_PCSK_SKI1_1	223	227	PF00082	0.461
CLV_PCSK_SKI1_1	310	314	PF00082	0.293
CLV_PCSK_SKI1_1	382	386	PF00082	0.521
CLV_PCSK_SKI1_1	415	419	PF00082	0.535
CLV_PCSK_SKI1_1	487	491	PF00082	0.389
CLV_PCSK_SKI1_1	492	496	PF00082	0.422
CLV_PCSK_SKI1_1	796	800	PF00082	0.517
CLV_PCSK_SKI1_1	811	815	PF00082	0.293
DEG_APCC_DBOX_1	377	385	PF00400	0.546
DEG_APCC_DBOX_1	810	818	PF00400	0.292
DEG_MDM2_SWIB_1	496	503	PF02201	0.281
DEG_Nend_UBRbox_1	1	4	PF02207	0.524
DEG_SCF_FBW7_2	117	122	PF00400	0.569
DOC_CDC14_PxL_1	587	595	PF14671	0.573
DOC_CKS1_1	28	33	PF01111	0.454
DOC_CKS1_1	318	323	PF01111	0.323
DOC_CKS1_1	409	414	PF01111	0.503
DOC_CKS1_1	435	440	PF01111	0.371
DOC_CKS1_1	592	597	PF01111	0.490
DOC_CYCLIN_RxL_1	251	263	PF00134	0.347
DOC_CYCLIN_RxL_1	307	314	PF00134	0.475
DOC_CYCLIN_RxL_1	662	673	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.559
DOC_MAPK_gen_1	365	372	PF00069	0.557
DOC_MAPK_gen_1	774	782	PF00069	0.356
DOC_MAPK_gen_1	807	816	PF00069	0.410
DOC_MAPK_MEF2A_6	186	193	PF00069	0.457
DOC_MAPK_MEF2A_6	776	784	PF00069	0.434
DOC_MAPK_NFAT4_5	186	194	PF00069	0.457
DOC_PP1_RVXF_1	281	288	PF00149	0.377
DOC_PP2B_LxvP_1	29	32	PF13499	0.455
DOC_PP2B_LxvP_1	3	6	PF13499	0.508
DOC_PP2B_LxvP_1	410	413	PF13499	0.497
DOC_PP4_FxxP_1	229	232	PF00568	0.570
DOC_USP7_MATH_1	120	124	PF00917	0.651
DOC_USP7_MATH_1	344	348	PF00917	0.612
DOC_USP7_MATH_1	353	357	PF00917	0.451
DOC_USP7_MATH_1	445	449	PF00917	0.516
DOC_USP7_MATH_1	577	581	PF00917	0.493
DOC_USP7_MATH_1	670	674	PF00917	0.631
DOC_USP7_MATH_1	763	767	PF00917	0.703
DOC_WW_Pin1_4	115	120	PF00397	0.550
DOC_WW_Pin1_4	135	140	PF00397	0.243
DOC_WW_Pin1_4	155	160	PF00397	0.513
DOC_WW_Pin1_4	211	216	PF00397	0.557
DOC_WW_Pin1_4	27	32	PF00397	0.483
DOC_WW_Pin1_4	277	282	PF00397	0.482
DOC_WW_Pin1_4	317	322	PF00397	0.475
DOC_WW_Pin1_4	345	350	PF00397	0.711
DOC_WW_Pin1_4	38	43	PF00397	0.396
DOC_WW_Pin1_4	408	413	PF00397	0.451
DOC_WW_Pin1_4	434	439	PF00397	0.623
DOC_WW_Pin1_4	452	457	PF00397	0.523
DOC_WW_Pin1_4	458	463	PF00397	0.561
DOC_WW_Pin1_4	591	596	PF00397	0.488
DOC_WW_Pin1_4	675	680	PF00397	0.596
LIG_14-3-3_CanoR_1	196	205	PF00244	0.442
LIG_14-3-3_CanoR_1	260	268	PF00244	0.552
LIG_14-3-3_CanoR_1	479	484	PF00244	0.553
LIG_14-3-3_CanoR_1	507	513	PF00244	0.517
LIG_14-3-3_CanoR_1	646	652	PF00244	0.534
LIG_14-3-3_CanoR_1	697	703	PF00244	0.526
LIG_14-3-3_CanoR_1	72	81	PF00244	0.663
LIG_Actin_WH2_2	245	262	PF00022	0.605
LIG_Actin_WH2_2	368	384	PF00022	0.548
LIG_Actin_WH2_2	652	670	PF00022	0.492
LIG_BIR_III_2	224	228	PF00653	0.589
LIG_BRCT_BRCA1_1	137	141	PF00533	0.291
LIG_deltaCOP1_diTrp_1	272	282	PF00928	0.564
LIG_deltaCOP1_diTrp_1	753	760	PF00928	0.565
LIG_FHA_1	156	162	PF00498	0.611
LIG_FHA_1	312	318	PF00498	0.547
LIG_FHA_1	424	430	PF00498	0.530
LIG_FHA_1	462	468	PF00498	0.382
LIG_FHA_1	507	513	PF00498	0.642
LIG_FHA_1	522	528	PF00498	0.304
LIG_FHA_1	551	557	PF00498	0.357
LIG_FHA_1	614	620	PF00498	0.518
LIG_FHA_2	116	122	PF00498	0.526
LIG_FHA_2	12	18	PF00498	0.476
LIG_FHA_2	237	243	PF00498	0.581
LIG_FHA_2	357	363	PF00498	0.541
LIG_FHA_2	442	448	PF00498	0.621
LIG_FHA_2	597	603	PF00498	0.616
LIG_FHA_2	631	637	PF00498	0.424
LIG_FHA_2	655	661	PF00498	0.576
LIG_FHA_2	725	731	PF00498	0.350
LIG_FHA_2	797	803	PF00498	0.565
LIG_KLC1_Yacidic_2	632	636	PF13176	0.335
LIG_LIR_Apic_2	433	438	PF02991	0.386
LIG_LIR_Apic_2	46	51	PF02991	0.456
LIG_LIR_Apic_2	752	757	PF02991	0.600
LIG_LIR_Gen_1	138	148	PF02991	0.304
LIG_LIR_Gen_1	371	379	PF02991	0.548
LIG_LIR_Gen_1	536	544	PF02991	0.490
LIG_LIR_Gen_1	704	714	PF02991	0.481
LIG_LIR_Nem_3	108	113	PF02991	0.441
LIG_LIR_Nem_3	138	144	PF02991	0.367
LIG_LIR_Nem_3	156	160	PF02991	0.456
LIG_LIR_Nem_3	280	285	PF02991	0.376
LIG_LIR_Nem_3	371	375	PF02991	0.454
LIG_LIR_Nem_3	493	499	PF02991	0.262
LIG_LIR_Nem_3	536	542	PF02991	0.455
LIG_LIR_Nem_3	636	641	PF02991	0.353
LIG_LIR_Nem_3	704	709	PF02991	0.448
LIG_LIR_Nem_3	722	728	PF02991	0.248
LIG_MYND_1	456	460	PF01753	0.548
LIG_MYND_1	591	595	PF01753	0.577
LIG_NRBOX	617	623	PF00104	0.328
LIG_PALB2_WD40_1	183	191	PF16756	0.495
LIG_PCNA_yPIPBox_3	642	652	PF02747	0.488
LIG_PDZ_Class_1	820	825	PF00595	0.392
LIG_Pex14_1	484	488	PF04695	0.482
LIG_Pex14_2	496	500	PF04695	0.265
LIG_Rb_LxCxE_1	99	122	PF01857	0.522
LIG_SH2_CRK	148	152	PF00017	0.418
LIG_SH2_CRK	157	161	PF00017	0.536
LIG_SH2_NCK_1	787	791	PF00017	0.470
LIG_SH2_PTP2	541	544	PF00017	0.509
LIG_SH2_SRC	541	544	PF00017	0.509
LIG_SH2_SRC	634	637	PF00017	0.496
LIG_SH2_STAP1	508	512	PF00017	0.438
LIG_SH2_STAP1	535	539	PF00017	0.390
LIG_SH2_STAP1	787	791	PF00017	0.470
LIG_SH2_STAT3	315	318	PF00017	0.510
LIG_SH2_STAT3	535	538	PF00017	0.402
LIG_SH2_STAT5	157	160	PF00017	0.560
LIG_SH2_STAT5	202	205	PF00017	0.406
LIG_SH2_STAT5	323	326	PF00017	0.336
LIG_SH2_STAT5	363	366	PF00017	0.424
LIG_SH2_STAT5	402	405	PF00017	0.456
LIG_SH2_STAT5	435	438	PF00017	0.363
LIG_SH2_STAT5	48	51	PF00017	0.461
LIG_SH2_STAT5	508	511	PF00017	0.533
LIG_SH2_STAT5	541	544	PF00017	0.496
LIG_SH2_STAT5	550	553	PF00017	0.485
LIG_SH2_STAT5	586	589	PF00017	0.466
LIG_SH2_STAT5	634	637	PF00017	0.500
LIG_SH2_STAT5	714	717	PF00017	0.411
LIG_SH3_3	125	131	PF00018	0.666
LIG_SH3_3	156	162	PF00018	0.579
LIG_SH3_3	224	230	PF00018	0.554
LIG_SH3_3	3	9	PF00018	0.498
LIG_SH3_3	346	352	PF00018	0.671
LIG_SH3_3	453	459	PF00018	0.436
LIG_SH3_4	339	346	PF00018	0.521
LIG_SUMO_SIM_anti_2	555	560	PF11976	0.450
LIG_SUMO_SIM_par_1	594	599	PF11976	0.359
LIG_TRAF2_1	417	420	PF00917	0.325
LIG_TRAF2_1	679	682	PF00917	0.732
LIG_TRFH_1	408	412	PF08558	0.489
LIG_TYR_ITIM	155	160	PF00017	0.356
LIG_WRC_WIRS_1	37	42	PF05994	0.420
LIG_WRC_WIRS_1	635	640	PF05994	0.396
LIG_WRC_WIRS_1	703	708	PF05994	0.547
LIG_WW_2	6	9	PF00397	0.486
MOD_CDC14_SPxK_1	280	283	PF00782	0.447
MOD_CDK_SPxK_1	277	283	PF00069	0.552
MOD_CDK_SPxxK_3	408	415	PF00069	0.496
MOD_CK1_1	200	206	PF00069	0.435
MOD_CK1_1	27	33	PF00069	0.735
MOD_CK1_1	356	362	PF00069	0.488
MOD_CK1_1	434	440	PF00069	0.527
MOD_CK1_1	461	467	PF00069	0.447
MOD_CK1_1	601	607	PF00069	0.613
MOD_CK1_1	70	76	PF00069	0.646
MOD_CK1_1	77	83	PF00069	0.605
MOD_CK1_1	86	92	PF00069	0.400
MOD_CK2_1	11	17	PF00069	0.477
MOD_CK2_1	236	242	PF00069	0.560
MOD_CK2_1	441	447	PF00069	0.571
MOD_CK2_1	596	602	PF00069	0.596
MOD_CK2_1	630	636	PF00069	0.434
MOD_CK2_1	654	660	PF00069	0.515
MOD_GlcNHglycan	169	172	PF01048	0.727
MOD_GlcNHglycan	182	185	PF01048	0.428
MOD_GlcNHglycan	326	329	PF01048	0.397
MOD_GlcNHglycan	371	375	PF01048	0.391
MOD_GlcNHglycan	447	450	PF01048	0.592
MOD_GlcNHglycan	602	606	PF01048	0.592
MOD_GlcNHglycan	652	655	PF01048	0.399
MOD_GlcNHglycan	710	713	PF01048	0.522
MOD_GlcNHglycan	764	768	PF01048	0.645
MOD_GlcNHglycan	85	88	PF01048	0.625
MOD_GSK3_1	135	142	PF00069	0.475
MOD_GSK3_1	196	203	PF00069	0.461
MOD_GSK3_1	234	241	PF00069	0.609
MOD_GSK3_1	32	39	PF00069	0.439
MOD_GSK3_1	404	411	PF00069	0.477
MOD_GSK3_1	441	448	PF00069	0.509
MOD_GSK3_1	454	461	PF00069	0.547
MOD_GSK3_1	502	509	PF00069	0.582
MOD_GSK3_1	548	555	PF00069	0.453
MOD_GSK3_1	608	615	PF00069	0.591
MOD_GSK3_1	630	637	PF00069	0.498
MOD_GSK3_1	650	657	PF00069	0.403
MOD_GSK3_1	67	74	PF00069	0.649
MOD_GSK3_1	670	677	PF00069	0.646
MOD_GSK3_1	75	82	PF00069	0.612
MOD_GSK3_1	85	92	PF00069	0.612
MOD_N-GLC_1	139	144	PF02516	0.520
MOD_N-GLC_1	200	205	PF02516	0.467
MOD_N-GLC_1	479	484	PF02516	0.282
MOD_N-GLC_1	533	538	PF02516	0.430
MOD_N-GLC_1	70	75	PF02516	0.732
MOD_NEK2_1	236	241	PF00069	0.605
MOD_NEK2_1	259	264	PF00069	0.553
MOD_NEK2_1	36	41	PF00069	0.597
MOD_NEK2_1	370	375	PF00069	0.384
MOD_NEK2_1	397	402	PF00069	0.385
MOD_NEK2_1	467	472	PF00069	0.492
MOD_NEK2_1	533	538	PF00069	0.482
MOD_NEK2_1	67	72	PF00069	0.735
MOD_NEK2_1	702	707	PF00069	0.474
MOD_NEK2_1	724	729	PF00069	0.500
MOD_PIKK_1	260	266	PF00454	0.535
MOD_PIKK_1	696	702	PF00454	0.466
MOD_PIKK_1	89	95	PF00454	0.621
MOD_PK_1	16	22	PF00069	0.470
MOD_PK_1	479	485	PF00069	0.405
MOD_PKA_2	259	265	PF00069	0.573
MOD_PKA_2	324	330	PF00069	0.497
MOD_PKA_2	377	383	PF00069	0.517
MOD_PKA_2	506	512	PF00069	0.501
MOD_PKA_2	654	660	PF00069	0.501
MOD_PKA_2	696	702	PF00069	0.505
MOD_PKA_2	71	77	PF00069	0.710
MOD_PKA_2	740	746	PF00069	0.587
MOD_Plk_1	139	145	PF00069	0.539
MOD_Plk_1	16	22	PF00069	0.470
MOD_Plk_1	200	206	PF00069	0.469
MOD_Plk_1	356	362	PF00069	0.518
MOD_Plk_1	370	376	PF00069	0.392
MOD_Plk_1	479	485	PF00069	0.490
MOD_Plk_1	533	539	PF00069	0.451
MOD_Plk_2-3	11	17	PF00069	0.477
MOD_Plk_4	16	22	PF00069	0.483
MOD_Plk_4	200	206	PF00069	0.434
MOD_Plk_4	24	30	PF00069	0.470
MOD_Plk_4	319	325	PF00069	0.411
MOD_Plk_4	32	38	PF00069	0.626
MOD_Plk_4	397	403	PF00069	0.468
MOD_Plk_4	431	437	PF00069	0.418
MOD_Plk_4	479	485	PF00069	0.449
MOD_Plk_4	630	636	PF00069	0.445
MOD_Plk_4	647	653	PF00069	0.347
MOD_Plk_4	724	730	PF00069	0.489
MOD_Plk_4	80	86	PF00069	0.478
MOD_ProDKin_1	115	121	PF00069	0.557
MOD_ProDKin_1	135	141	PF00069	0.234
MOD_ProDKin_1	155	161	PF00069	0.518
MOD_ProDKin_1	211	217	PF00069	0.553
MOD_ProDKin_1	27	33	PF00069	0.481
MOD_ProDKin_1	277	283	PF00069	0.478
MOD_ProDKin_1	317	323	PF00069	0.480
MOD_ProDKin_1	345	351	PF00069	0.692
MOD_ProDKin_1	38	44	PF00069	0.398
MOD_ProDKin_1	408	414	PF00069	0.460
MOD_ProDKin_1	434	440	PF00069	0.628
MOD_ProDKin_1	452	458	PF00069	0.516
MOD_ProDKin_1	591	597	PF00069	0.493
MOD_ProDKin_1	675	681	PF00069	0.598
MOD_SUMO_rev_2	678	685	PF00179	0.611
TRG_DiLeu_BaEn_1	617	622	PF01217	0.511
TRG_DiLeu_BaEn_1	636	641	PF01217	0.484
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.569
TRG_ENDOCYTIC_2	148	151	PF00928	0.366
TRG_ENDOCYTIC_2	157	160	PF00928	0.492
TRG_ER_diArg_1	364	366	PF00400	0.555
TRG_ER_diArg_1	496	498	PF00400	0.269
TRG_ER_diArg_1	57	60	PF00400	0.518
TRG_ER_diArg_1	734	736	PF00400	0.529
TRG_NES_CRM1_1	103	116	PF08389	0.503
TRG_NES_CRM1_1	532	543	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH9	Leptomonas seymouri	50%	100%
A0A1X0P015	Trypanosomatidae	32%	100%
A0A3S5H7L6	Leishmania donovani	76%	100%
A0A422NNG1	Trypanosoma rangeli	32%	100%
A4I4Q3	Leishmania infantum	77%	100%
C9ZLE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AE56	Leishmania major	78%	100%
E9ALM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
V5DCL7	Trypanosoma cruzi	33%	100%