EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHJ3_LEIBR

TriTrypDb:

LbrM.29.1900 , LBRM2903_310007700

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HHJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ3

Function

Biological processes
Term	Name	Level	Count
GO:0019220	regulation of phosphate metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0035303	regulation of dephosphorylation	7	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051174	regulation of phosphorus metabolic process	5	7
GO:0065007	biological regulation	1	7
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030865	cortical cytoskeleton organization	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005509	calcium ion binding	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.436
CLV_NRD_NRD_1	17	19	PF00675	0.431
CLV_NRD_NRD_1	171	173	PF00675	0.726
CLV_NRD_NRD_1	384	386	PF00675	0.334
CLV_NRD_NRD_1	499	501	PF00675	0.362
CLV_NRD_NRD_1	60	62	PF00675	0.665
CLV_PCSK_KEX2_1	17	19	PF00082	0.431
CLV_PCSK_KEX2_1	171	173	PF00082	0.725
CLV_PCSK_KEX2_1	241	243	PF00082	0.697
CLV_PCSK_KEX2_1	384	386	PF00082	0.372
CLV_PCSK_KEX2_1	60	62	PF00082	0.495
CLV_PCSK_KEX2_1	607	609	PF00082	0.347
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.697
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.347
CLV_PCSK_SKI1_1	238	242	PF00082	0.466
CLV_PCSK_SKI1_1	30	34	PF00082	0.451
CLV_PCSK_SKI1_1	372	376	PF00082	0.488
CLV_PCSK_SKI1_1	384	388	PF00082	0.348
CLV_PCSK_SKI1_1	395	399	PF00082	0.396
CLV_PCSK_SKI1_1	438	442	PF00082	0.442
CLV_Separin_Metazoa	574	578	PF03568	0.305
DEG_SPOP_SBC_1	4	8	PF00917	0.543
DOC_CKS1_1	532	537	PF01111	0.360
DOC_CYCLIN_RxL_1	242	256	PF00134	0.476
DOC_CYCLIN_RxL_1	381	391	PF00134	0.340
DOC_MAPK_MEF2A_6	298	305	PF00069	0.417
DOC_MAPK_MEF2A_6	93	101	PF00069	0.382
DOC_PP1_RVXF_1	324	331	PF00149	0.272
DOC_PP1_RVXF_1	382	389	PF00149	0.337
DOC_PP1_RVXF_1	499	506	PF00149	0.341
DOC_PP2B_LxvP_1	150	153	PF13499	0.565
DOC_PP2B_LxvP_1	554	557	PF13499	0.399
DOC_USP7_MATH_1	209	213	PF00917	0.749
DOC_USP7_MATH_1	223	227	PF00917	0.684
DOC_USP7_MATH_1	261	265	PF00917	0.574
DOC_USP7_MATH_1	476	480	PF00917	0.420
DOC_USP7_MATH_1	513	517	PF00917	0.385
DOC_USP7_UBL2_3	102	106	PF12436	0.427
DOC_USP7_UBL2_3	177	181	PF12436	0.551
DOC_WW_Pin1_4	185	190	PF00397	0.746
DOC_WW_Pin1_4	196	201	PF00397	0.602
DOC_WW_Pin1_4	205	210	PF00397	0.751
DOC_WW_Pin1_4	255	260	PF00397	0.574
DOC_WW_Pin1_4	472	477	PF00397	0.387
DOC_WW_Pin1_4	531	536	PF00397	0.366
DOC_WW_Pin1_4	583	588	PF00397	0.376
DOC_WW_Pin1_4	7	12	PF00397	0.524
LIG_14-3-3_CanoR_1	123	129	PF00244	0.441
LIG_14-3-3_CanoR_1	229	234	PF00244	0.641
LIG_14-3-3_CanoR_1	30	38	PF00244	0.508
LIG_14-3-3_CanoR_1	347	353	PF00244	0.399
LIG_14-3-3_CanoR_1	399	404	PF00244	0.375
LIG_14-3-3_CanoR_1	60	68	PF00244	0.472
LIG_Actin_RPEL_3	578	597	PF02755	0.352
LIG_Actin_WH2_2	562	579	PF00022	0.288
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BIR_III_4	221	225	PF00653	0.623
LIG_BRCT_BRCA1_1	64	68	PF00533	0.517
LIG_deltaCOP1_diTrp_1	39	46	PF00928	0.573
LIG_eIF4E_1	436	442	PF01652	0.447
LIG_EVH1_1	150	154	PF00568	0.537
LIG_FHA_1	206	212	PF00498	0.716
LIG_FHA_1	430	436	PF00498	0.358
LIG_FHA_1	442	448	PF00498	0.391
LIG_FHA_1	48	54	PF00498	0.484
LIG_FHA_1	486	492	PF00498	0.517
LIG_FHA_1	528	534	PF00498	0.378
LIG_FHA_1	7	13	PF00498	0.520
LIG_FHA_1	82	88	PF00498	0.492
LIG_FHA_2	154	160	PF00498	0.613
LIG_FHA_2	417	423	PF00498	0.490
LIG_FHA_2	462	468	PF00498	0.475
LIG_FHA_2	491	497	PF00498	0.445
LIG_FHA_2	577	583	PF00498	0.370
LIG_LIR_Gen_1	129	138	PF02991	0.414
LIG_LIR_Gen_1	232	240	PF02991	0.547
LIG_LIR_Gen_1	268	276	PF02991	0.462
LIG_LIR_Gen_1	410	418	PF02991	0.382
LIG_LIR_Gen_1	565	575	PF02991	0.381
LIG_LIR_Nem_3	129	134	PF02991	0.420
LIG_LIR_Nem_3	232	236	PF02991	0.564
LIG_LIR_Nem_3	268	272	PF02991	0.471
LIG_LIR_Nem_3	410	415	PF02991	0.373
LIG_LIR_Nem_3	496	502	PF02991	0.357
LIG_LIR_Nem_3	565	570	PF02991	0.358
LIG_LIR_Nem_3	601	605	PF02991	0.364
LIG_LIR_Nem_3	67	72	PF02991	0.437
LIG_LIR_Nem_3	98	104	PF02991	0.422
LIG_NRBOX	113	119	PF00104	0.405
LIG_NRP_CendR_1	608	611	PF00754	0.476
LIG_PALB2_WD40_1	422	430	PF16756	0.459
LIG_PCNA_yPIPBox_3	277	289	PF02747	0.600
LIG_PTB_Apo_2	284	291	PF02174	0.583
LIG_PTB_Apo_2	536	543	PF02174	0.361
LIG_PTB_Phospho_1	284	290	PF10480	0.583
LIG_REV1ctd_RIR_1	539	547	PF16727	0.360
LIG_SH2_STAP1	131	135	PF00017	0.403
LIG_SH2_STAT3	146	149	PF00017	0.518
LIG_SH2_STAT5	290	293	PF00017	0.469
LIG_SH2_STAT5	356	359	PF00017	0.374
LIG_SH2_STAT5	378	381	PF00017	0.324
LIG_SH2_STAT5	485	488	PF00017	0.367
LIG_SH2_STAT5	519	522	PF00017	0.422
LIG_SH3_3	148	154	PF00018	0.534
LIG_SH3_3	197	203	PF00018	0.598
LIG_SH3_3	291	297	PF00018	0.445
LIG_SH3_3	529	535	PF00018	0.370
LIG_SH3_3	581	587	PF00018	0.377
LIG_SUMO_SIM_par_1	504	510	PF11976	0.335
LIG_SUMO_SIM_par_1	523	528	PF11976	0.363
LIG_TRAF2_1	23	26	PF00917	0.513
LIG_TRAF2_1	37	40	PF00917	0.480
LIG_TRAF2_1	579	582	PF00917	0.296
LIG_TRAF2_1	80	83	PF00917	0.403
LIG_WRC_WIRS_1	321	326	PF05994	0.373
LIG_WW_3	295	299	PF00397	0.409
MOD_CK1_1	193	199	PF00069	0.672
MOD_CK1_1	2	8	PF00069	0.627
MOD_CK1_1	205	211	PF00069	0.773
MOD_CK1_1	212	218	PF00069	0.629
MOD_CK1_1	265	271	PF00069	0.580
MOD_CK1_1	601	607	PF00069	0.372
MOD_CK1_1	62	68	PF00069	0.486
MOD_CK2_1	158	164	PF00069	0.633
MOD_CK2_1	346	352	PF00069	0.404
MOD_CK2_1	490	496	PF00069	0.452
MOD_CK2_1	576	582	PF00069	0.381
MOD_GlcNHglycan	118	121	PF01048	0.502
MOD_GlcNHglycan	185	188	PF01048	0.667
MOD_GlcNHglycan	204	207	PF01048	0.691
MOD_GlcNHglycan	211	214	PF01048	0.732
MOD_GlcNHglycan	225	228	PF01048	0.570
MOD_GlcNHglycan	34	37	PF01048	0.433
MOD_GlcNHglycan	64	67	PF01048	0.524
MOD_GSK3_1	190	197	PF00069	0.676
MOD_GSK3_1	2	9	PF00069	0.531
MOD_GSK3_1	205	212	PF00069	0.674
MOD_GSK3_1	225	232	PF00069	0.595
MOD_GSK3_1	261	268	PF00069	0.627
MOD_GSK3_1	399	406	PF00069	0.375
MOD_GSK3_1	472	479	PF00069	0.453
MOD_GSK3_1	527	534	PF00069	0.377
MOD_N-GLC_1	262	267	PF02516	0.514
MOD_NEK2_1	190	195	PF00069	0.566
MOD_NEK2_1	3	8	PF00069	0.611
MOD_NEK2_1	303	308	PF00069	0.447
MOD_NEK2_1	32	37	PF00069	0.523
MOD_NEK2_1	339	344	PF00069	0.414
MOD_NEK2_1	403	408	PF00069	0.365
MOD_NEK2_1	441	446	PF00069	0.465
MOD_NEK2_1	542	547	PF00069	0.407
MOD_NEK2_1	558	563	PF00069	0.378
MOD_NEK2_1	88	93	PF00069	0.442
MOD_NEK2_2	262	267	PF00069	0.503
MOD_NEK2_2	476	481	PF00069	0.417
MOD_NEK2_2	64	69	PF00069	0.433
MOD_PIKK_1	40	46	PF00454	0.546
MOD_PIKK_1	429	435	PF00454	0.346
MOD_PIKK_1	59	65	PF00454	0.376
MOD_PKA_2	122	128	PF00069	0.441
MOD_PKA_2	346	352	PF00069	0.404
MOD_PKA_2	542	548	PF00069	0.361
MOD_PKA_2	558	564	PF00069	0.380
MOD_PKA_2	576	582	PF00069	0.381
MOD_PKA_2	59	65	PF00069	0.487
MOD_Plk_1	262	268	PF00069	0.510
MOD_Plk_1	82	88	PF00069	0.488
MOD_Plk_4	153	159	PF00069	0.609
MOD_Plk_4	326	332	PF00069	0.361
MOD_Plk_4	399	405	PF00069	0.380
MOD_Plk_4	461	467	PF00069	0.550
MOD_Plk_4	476	482	PF00069	0.296
MOD_Plk_4	487	493	PF00069	0.383
MOD_Plk_4	558	564	PF00069	0.380
MOD_Plk_4	598	604	PF00069	0.354
MOD_Plk_4	64	70	PF00069	0.514
MOD_ProDKin_1	185	191	PF00069	0.746
MOD_ProDKin_1	196	202	PF00069	0.605
MOD_ProDKin_1	205	211	PF00069	0.751
MOD_ProDKin_1	255	261	PF00069	0.574
MOD_ProDKin_1	472	478	PF00069	0.379
MOD_ProDKin_1	531	537	PF00069	0.362
MOD_ProDKin_1	583	589	PF00069	0.369
MOD_ProDKin_1	7	13	PF00069	0.520
MOD_SUMO_for_1	331	334	PF00179	0.353
TRG_DiLeu_BaEn_1	245	250	PF01217	0.460
TRG_DiLeu_BaEn_1	487	492	PF01217	0.429
TRG_DiLeu_BaEn_1	565	570	PF01217	0.358
TRG_DiLeu_BaEn_1	83	88	PF01217	0.487
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.538
TRG_DiLeu_LyEn_5	245	250	PF01217	0.460
TRG_DiLeu_LyEn_5	83	88	PF01217	0.487
TRG_ENDOCYTIC_2	131	134	PF00928	0.409
TRG_ENDOCYTIC_2	269	272	PF00928	0.470
TRG_ENDOCYTIC_2	321	324	PF00928	0.381
TRG_ENDOCYTIC_2	436	439	PF00928	0.361
TRG_ENDOCYTIC_2	499	502	PF00928	0.353
TRG_ER_diArg_1	16	18	PF00400	0.431
TRG_ER_diArg_1	384	386	PF00400	0.334
TRG_ER_diArg_1	74	77	PF00400	0.636
TRG_NES_CRM1_1	359	373	PF08389	0.307
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC66	Leptomonas seymouri	69%	97%
A0A3Q8IFG2	Leishmania donovani	86%	100%
A4I4Q1	Leishmania infantum	86%	100%
E9AE54	Leishmania major	87%	100%
E9ALN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%