Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHJ2_LEIBR

TriTrypDb:

LbrM.29.1890 , LBRM2903_310007600

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.720
CLV_NRD_NRD_1	124	126	PF00675	0.534
CLV_NRD_NRD_1	152	154	PF00675	0.719
CLV_NRD_NRD_1	157	159	PF00675	0.726
CLV_NRD_NRD_1	247	249	PF00675	0.669
CLV_NRD_NRD_1	68	70	PF00675	0.524
CLV_PCSK_FUR_1	245	249	PF00082	0.780
CLV_PCSK_FUR_1	66	70	PF00082	0.520
CLV_PCSK_KEX2_1	124	126	PF00082	0.534
CLV_PCSK_KEX2_1	152	154	PF00082	0.728
CLV_PCSK_KEX2_1	157	159	PF00082	0.753
CLV_PCSK_KEX2_1	247	249	PF00082	0.667
CLV_PCSK_KEX2_1	269	271	PF00082	0.580
CLV_PCSK_KEX2_1	68	70	PF00082	0.524
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.580
CLV_PCSK_PC7_1	153	159	PF00082	0.625
CLV_PCSK_SKI1_1	174	178	PF00082	0.703
CLV_PCSK_SKI1_1	248	252	PF00082	0.752
CLV_PCSK_SKI1_1	54	58	PF00082	0.596
DEG_Nend_UBRbox_3	1	3	PF02207	0.574
DEG_SPOP_SBC_1	211	215	PF00917	0.629
DOC_CYCLIN_RxL_1	168	179	PF00134	0.681
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	251	254	PF00134	0.756
DOC_MAPK_gen_1	168	178	PF00069	0.718
DOC_MAPK_gen_1	245	252	PF00069	0.670
DOC_MAPK_MEF2A_6	130	137	PF00069	0.465
DOC_MAPK_MEF2A_6	171	180	PF00069	0.738
DOC_MAPK_MEF2A_6	259	268	PF00069	0.672
DOC_MAPK_NFAT4_5	130	138	PF00069	0.466
DOC_PP1_RVXF_1	172	178	PF00149	0.637
DOC_PP2B_LxvP_1	112	115	PF13499	0.462
DOC_PP2B_LxvP_1	251	254	PF13499	0.756
DOC_USP7_MATH_1	119	123	PF00917	0.558
DOC_USP7_MATH_1	187	191	PF00917	0.647
DOC_USP7_MATH_1	211	215	PF00917	0.676
DOC_WW_Pin1_4	181	186	PF00397	0.630
DOC_WW_Pin1_4	7	12	PF00397	0.661
LIG_14-3-3_CanoR_1	104	112	PF00244	0.552
LIG_14-3-3_CanoR_1	157	165	PF00244	0.684
LIG_14-3-3_CanoR_1	188	192	PF00244	0.660
LIG_14-3-3_CanoR_1	54	59	PF00244	0.550
LIG_Actin_WH2_2	176	194	PF00022	0.710
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.534
LIG_FHA_1	171	177	PF00498	0.639
LIG_FHA_1	194	200	PF00498	0.591
LIG_FHA_1	258	264	PF00498	0.610
LIG_FHA_1	51	57	PF00498	0.707
LIG_FHA_1	77	83	PF00498	0.628
LIG_IRF3_LxIS_1	13	19	PF10401	0.528
LIG_LIR_Apic_2	122	126	PF02991	0.674
LIG_LIR_Gen_1	19	27	PF02991	0.502
LIG_LIR_Gen_1	260	268	PF02991	0.611
LIG_LIR_Nem_3	19	23	PF02991	0.501
LIG_LIR_Nem_3	260	264	PF02991	0.611
LIG_SH2_CRK	123	127	PF00017	0.696
LIG_SH2_STAP1	94	98	PF00017	0.571
LIG_SH2_STAT5	117	120	PF00017	0.481
LIG_SH2_STAT5	206	209	PF00017	0.672
LIG_SH3_3	247	253	PF00018	0.533
LIG_SH3_3	85	91	PF00018	0.747
LIG_SUMO_SIM_par_1	262	267	PF11976	0.460
LIG_TRAF2_1	44	47	PF00917	0.555
MOD_CDK_SPxxK_3	181	188	PF00069	0.616
MOD_CK1_1	145	151	PF00069	0.618
MOD_CK1_1	213	219	PF00069	0.663
MOD_CK1_1	97	103	PF00069	0.800
MOD_CK2_1	192	198	PF00069	0.644
MOD_CK2_1	41	47	PF00069	0.614
MOD_Cter_Amidation	155	158	PF01082	0.594
MOD_GlcNHglycan	161	164	PF01048	0.707
MOD_GlcNHglycan	198	202	PF01048	0.623
MOD_GlcNHglycan	218	221	PF01048	0.689
MOD_GlcNHglycan	88	91	PF01048	0.695
MOD_GSK3_1	12	19	PF00069	0.530
MOD_GSK3_1	138	145	PF00069	0.716
MOD_GSK3_1	187	194	PF00069	0.685
MOD_GSK3_1	210	217	PF00069	0.660
MOD_GSK3_1	218	225	PF00069	0.718
MOD_GSK3_1	33	40	PF00069	0.641
MOD_GSK3_1	46	53	PF00069	0.678
MOD_GSK3_1	93	100	PF00069	0.774
MOD_N-GLC_1	1	6	PF02516	0.682
MOD_NEK2_1	1	6	PF00069	0.817
MOD_NEK2_1	16	21	PF00069	0.524
MOD_NEK2_1	191	196	PF00069	0.700
MOD_NEK2_1	50	55	PF00069	0.550
MOD_NEK2_2	187	192	PF00069	0.685
MOD_PIKK_1	138	144	PF00454	0.686
MOD_PIKK_1	239	245	PF00454	0.826
MOD_PIKK_1	37	43	PF00454	0.550
MOD_PKA_1	157	163	PF00069	0.744
MOD_PKA_2	103	109	PF00069	0.566
MOD_PKA_2	157	163	PF00069	0.820
MOD_PKA_2	187	193	PF00069	0.652
MOD_Plk_1	1	7	PF00069	0.648
MOD_Plk_1	46	52	PF00069	0.797
MOD_Plk_1	94	100	PF00069	0.565
MOD_ProDKin_1	181	187	PF00069	0.621
MOD_ProDKin_1	7	13	PF00069	0.661
TRG_ER_diArg_1	123	125	PF00400	0.503
TRG_ER_diArg_1	245	248	PF00400	0.690
TRG_ER_diArg_1	66	69	PF00400	0.724
TRG_NES_CRM1_1	14	28	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ42	Leptomonas seymouri	38%	100%
A0A3Q8IBJ9	Leishmania donovani	68%	100%
A4I4Q0	Leishmania infantum	68%	100%
E9AE53	Leishmania major	68%	100%
E9ALN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%