HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHJ1_LEIBR

TriTrypDb:

LbrM.29.1880 , LBRM2903_310007500

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.469
CLV_NRD_NRD_1	392	394	PF00675	0.439
CLV_NRD_NRD_1	451	453	PF00675	0.570
CLV_NRD_NRD_1	70	72	PF00675	0.559
CLV_PCSK_FUR_1	390	394	PF00082	0.501
CLV_PCSK_KEX2_1	226	228	PF00082	0.535
CLV_PCSK_KEX2_1	339	341	PF00082	0.757
CLV_PCSK_KEX2_1	392	394	PF00082	0.436
CLV_PCSK_KEX2_1	70	72	PF00082	0.522
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.535
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.757
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.538
CLV_PCSK_PC7_1	390	396	PF00082	0.508
CLV_PCSK_PC7_1	66	72	PF00082	0.550
CLV_PCSK_SKI1_1	227	231	PF00082	0.540
CLV_PCSK_SKI1_1	375	379	PF00082	0.518
CLV_PCSK_SKI1_1	386	390	PF00082	0.428
CLV_PCSK_SKI1_1	417	421	PF00082	0.536
CLV_PCSK_SKI1_1	70	74	PF00082	0.498
CLV_Separin_Metazoa	387	391	PF03568	0.535
DEG_Nend_UBRbox_4	1	3	PF02207	0.430
DEG_SCF_TRCP1_1	329	334	PF00400	0.550
DEG_SPOP_SBC_1	140	144	PF00917	0.343
DEG_SPOP_SBC_1	286	290	PF00917	0.733
DOC_CYCLIN_RxL_1	10	24	PF00134	0.382
DOC_MAPK_gen_1	305	312	PF00069	0.437
DOC_PP1_RVXF_1	14	21	PF00149	0.376
DOC_PP4_FxxP_1	273	276	PF00568	0.534
DOC_PP4_FxxP_1	41	44	PF00568	0.523
DOC_USP7_MATH_1	128	132	PF00917	0.543
DOC_USP7_MATH_1	193	197	PF00917	0.620
DOC_USP7_MATH_1	284	288	PF00917	0.679
DOC_USP7_MATH_1	49	53	PF00917	0.321
DOC_USP7_MATH_2	93	99	PF00917	0.635
DOC_USP7_UBL2_3	416	420	PF12436	0.591
DOC_WW_Pin1_4	199	204	PF00397	0.546
DOC_WW_Pin1_4	280	285	PF00397	0.649
LIG_14-3-3_CanoR_1	340	348	PF00244	0.789
LIG_14-3-3_CanoR_1	393	401	PF00244	0.502
LIG_BIR_III_4	36	40	PF00653	0.329
LIG_deltaCOP1_diTrp_1	297	303	PF00928	0.566
LIG_FHA_1	287	293	PF00498	0.491
LIG_FHA_1	57	63	PF00498	0.425
LIG_FHA_2	235	241	PF00498	0.363
LIG_FHA_2	257	263	PF00498	0.633
LIG_FHA_2	288	294	PF00498	0.630
LIG_FHA_2	400	406	PF00498	0.437
LIG_FHA_2	409	415	PF00498	0.418
LIG_FHA_2	425	431	PF00498	0.470
LIG_GBD_Chelix_1	54	62	PF00786	0.257
LIG_HCF-1_HBM_1	407	410	PF13415	0.539
LIG_IRF3_LxIS_1	136	142	PF10401	0.383
LIG_IRF3_LxIS_1	174	181	PF10401	0.312
LIG_LIR_Apic_2	270	276	PF02991	0.519
LIG_LIR_Apic_2	38	44	PF02991	0.517
LIG_LIR_Gen_1	297	303	PF02991	0.495
LIG_LIR_Nem_3	297	301	PF02991	0.498
LIG_LIR_Nem_3	358	362	PF02991	0.492
LIG_LIR_Nem_3	432	437	PF02991	0.353
LIG_PDZ_Class_1	469	474	PF00595	0.410
LIG_Pex14_1	239	243	PF04695	0.368
LIG_PTB_Apo_2	9	16	PF02174	0.310
LIG_SH2_NCK_1	410	414	PF00017	0.561
LIG_SH2_STAP1	158	162	PF00017	0.531
LIG_SH2_STAT5	198	201	PF00017	0.383
LIG_SH2_STAT5	376	379	PF00017	0.534
LIG_SH2_STAT5	410	413	PF00017	0.463
LIG_SH3_2	91	96	PF14604	0.469
LIG_SH3_3	146	152	PF00018	0.425
LIG_SH3_3	268	274	PF00018	0.405
LIG_SH3_3	88	94	PF00018	0.511
LIG_SUMO_SIM_par_1	108	113	PF11976	0.480
LIG_SUMO_SIM_par_1	116	123	PF11976	0.465
LIG_SxIP_EBH_1	96	110	PF03271	0.493
LIG_WRC_WIRS_1	300	305	PF05994	0.570
MOD_CK1_1	122	128	PF00069	0.687
MOD_CK1_1	132	138	PF00069	0.370
MOD_CK1_1	241	247	PF00069	0.654
MOD_CK1_1	287	293	PF00069	0.742
MOD_CK1_1	324	330	PF00069	0.726
MOD_CK2_1	141	147	PF00069	0.505
MOD_CK2_1	234	240	PF00069	0.504
MOD_CK2_1	287	293	PF00069	0.491
MOD_CK2_1	316	322	PF00069	0.671
MOD_CK2_1	331	337	PF00069	0.727
MOD_CK2_1	399	405	PF00069	0.441
MOD_CK2_1	408	414	PF00069	0.403
MOD_CK2_1	424	430	PF00069	0.445
MOD_GlcNHglycan	132	135	PF01048	0.655
MOD_GlcNHglycan	180	183	PF01048	0.457
MOD_GlcNHglycan	256	259	PF01048	0.553
MOD_GlcNHglycan	318	321	PF01048	0.729
MOD_GlcNHglycan	322	326	PF01048	0.711
MOD_GlcNHglycan	328	332	PF01048	0.676
MOD_GlcNHglycan	348	351	PF01048	0.677
MOD_GlcNHglycan	51	54	PF01048	0.337
MOD_GSK3_1	128	135	PF00069	0.698
MOD_GSK3_1	139	146	PF00069	0.545
MOD_GSK3_1	193	200	PF00069	0.475
MOD_GSK3_1	234	241	PF00069	0.552
MOD_GSK3_1	280	287	PF00069	0.744
MOD_GSK3_1	327	334	PF00069	0.713
MOD_GSK3_1	342	349	PF00069	0.587
MOD_GSK3_1	43	50	PF00069	0.469
MOD_GSK3_1	95	102	PF00069	0.661
MOD_N-GLC_1	284	289	PF02516	0.759
MOD_N-GLC_1	316	321	PF02516	0.772
MOD_NEK2_1	178	183	PF00069	0.398
MOD_NEK2_1	21	26	PF00069	0.477
MOD_NEK2_1	469	474	PF00069	0.529
MOD_NEK2_1	99	104	PF00069	0.758
MOD_NEK2_2	459	464	PF00069	0.523
MOD_PIKK_1	241	247	PF00454	0.528
MOD_PIKK_1	331	337	PF00454	0.811
MOD_PKA_1	394	400	PF00069	0.490
MOD_PKA_2	341	347	PF00069	0.775
MOD_PKA_2	394	400	PF00069	0.526
MOD_PKA_2	448	454	PF00069	0.567
MOD_PKB_1	340	348	PF00069	0.764
MOD_Plk_1	122	128	PF00069	0.550
MOD_Plk_1	239	245	PF00069	0.641
MOD_Plk_4	234	240	PF00069	0.542
MOD_Plk_4	43	49	PF00069	0.508
MOD_ProDKin_1	199	205	PF00069	0.535
MOD_ProDKin_1	280	286	PF00069	0.649
MOD_SUMO_rev_2	223	228	PF00179	0.561
MOD_SUMO_rev_2	334	341	PF00179	0.768
TRG_DiLeu_BaEn_1	414	419	PF01217	0.554
TRG_DiLeu_BaEn_1	78	83	PF01217	0.425
TRG_DiLeu_BaEn_2	429	435	PF01217	0.604
TRG_ER_diArg_1	393	396	PF00400	0.441
TRG_ER_diArg_1	69	71	PF00400	0.542
TRG_NLS_MonoCore_2	391	396	PF00514	0.350
TRG_NLS_MonoExtC_3	392	398	PF00514	0.496
TRG_NLS_MonoExtN_4	338	343	PF00514	0.791
TRG_NLS_MonoExtN_4	390	397	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB34	Leptomonas seymouri	49%	91%
A0A0S4JH57	Bodo saltans	29%	89%
A0A1X0P158	Trypanosomatidae	30%	100%
A0A3R7MJJ2	Trypanosoma rangeli	30%	100%
A0A3S7X2K3	Leishmania donovani	75%	100%
A4I4P9	Leishmania infantum	75%	100%
C9ZLD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AE52	Leishmania major	73%	97%
E9ALN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
V5BGH3	Trypanosoma cruzi	29%	100%