C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHJ0_LEIBR

TriTrypDb:

LbrM.29.1870 , LBRM2903_310007400

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.445
CLV_NRD_NRD_1	432	434	PF00675	0.652
CLV_NRD_NRD_1	6	8	PF00675	0.558
CLV_PCSK_KEX2_1	216	218	PF00082	0.445
CLV_PCSK_KEX2_1	405	407	PF00082	0.656
CLV_PCSK_KEX2_1	432	434	PF00082	0.725
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.701
CLV_PCSK_SKI1_1	194	198	PF00082	0.453
CLV_PCSK_SKI1_1	334	338	PF00082	0.677
CLV_PCSK_SKI1_1	377	381	PF00082	0.720
DEG_APCC_DBOX_1	333	341	PF00400	0.719
DEG_Nend_UBRbox_2	1	3	PF02207	0.624
DEG_SPOP_SBC_1	100	104	PF00917	0.653
DEG_SPOP_SBC_1	246	250	PF00917	0.717
DOC_CKS1_1	23	28	PF01111	0.497
DOC_CKS1_1	323	328	PF01111	0.644
DOC_MAPK_gen_1	7	15	PF00069	0.546
DOC_MAPK_HePTP_8	30	42	PF00069	0.426
DOC_MAPK_MEF2A_6	33	42	PF00069	0.481
DOC_MAPK_MEF2A_6	8	17	PF00069	0.485
DOC_PP2B_LxvP_1	42	45	PF13499	0.375
DOC_PP2B_LxvP_1	434	437	PF13499	0.729
DOC_PP4_FxxP_1	379	382	PF00568	0.679
DOC_USP7_MATH_1	101	105	PF00917	0.533
DOC_USP7_MATH_1	110	114	PF00917	0.398
DOC_USP7_MATH_1	117	121	PF00917	0.578
DOC_USP7_MATH_1	180	184	PF00917	0.520
DOC_USP7_MATH_1	246	250	PF00917	0.678
DOC_USP7_MATH_1	278	282	PF00917	0.576
DOC_USP7_MATH_1	29	33	PF00917	0.504
DOC_USP7_MATH_1	307	311	PF00917	0.704
DOC_USP7_MATH_1	315	319	PF00917	0.723
DOC_USP7_MATH_1	438	442	PF00917	0.763
DOC_USP7_MATH_1	96	100	PF00917	0.521
DOC_USP7_UBL2_3	381	385	PF12436	0.668
DOC_WW_Pin1_4	22	27	PF00397	0.508
DOC_WW_Pin1_4	322	327	PF00397	0.675
DOC_WW_Pin1_4	343	348	PF00397	0.687
LIG_14-3-3_CanoR_1	124	129	PF00244	0.471
LIG_14-3-3_CanoR_1	279	285	PF00244	0.631
LIG_14-3-3_CanoR_1	331	337	PF00244	0.617
LIG_14-3-3_CanoR_1	82	90	PF00244	0.388
LIG_BIR_III_4	154	158	PF00653	0.378
LIG_BIR_III_4	161	165	PF00653	0.245
LIG_BIR_III_4	264	268	PF00653	0.391
LIG_BRCT_BRCA1_1	13	17	PF00533	0.587
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.547
LIG_deltaCOP1_diTrp_1	63	69	PF00928	0.291
LIG_deltaCOP1_diTrp_1	9	18	PF00928	0.445
LIG_eIF4E_1	195	201	PF01652	0.312
LIG_FHA_1	106	112	PF00498	0.692
LIG_FHA_1	275	281	PF00498	0.577
LIG_FHA_1	285	291	PF00498	0.677
LIG_FHA_1	399	405	PF00498	0.648
LIG_FHA_1	409	415	PF00498	0.583
LIG_FHA_1	426	432	PF00498	0.519
LIG_FHA_1	45	51	PF00498	0.472
LIG_LIR_Gen_1	136	146	PF02991	0.375
LIG_LIR_Gen_1	66	76	PF02991	0.404
LIG_LIR_Gen_1	81	91	PF02991	0.377
LIG_LIR_Nem_3	136	141	PF02991	0.367
LIG_LIR_Nem_3	191	196	PF02991	0.490
LIG_LIR_Nem_3	66	72	PF02991	0.411
LIG_LIR_Nem_3	81	86	PF02991	0.379
LIG_PTB_Apo_2	335	342	PF02174	0.688
LIG_SH2_CRK	193	197	PF00017	0.383
LIG_SH2_NCK_1	28	32	PF00017	0.551
LIG_SH2_PTP2	174	177	PF00017	0.524
LIG_SH2_SRC	174	177	PF00017	0.524
LIG_SH2_SRC	221	224	PF00017	0.365
LIG_SH2_STAP1	375	379	PF00017	0.644
LIG_SH2_STAT5	138	141	PF00017	0.359
LIG_SH2_STAT5	174	177	PF00017	0.477
LIG_SH2_STAT5	195	198	PF00017	0.419
LIG_SH2_STAT5	221	224	PF00017	0.505
LIG_SH2_STAT5	409	412	PF00017	0.553
LIG_SH3_3	174	180	PF00018	0.540
LIG_SH3_3	320	326	PF00018	0.678
LIG_SH3_4	381	388	PF00018	0.692
LIG_SUMO_SIM_anti_2	413	419	PF11976	0.663
LIG_SUMO_SIM_par_1	411	419	PF11976	0.663
LIG_WRC_WIRS_1	316	321	PF05994	0.746
LIG_WRC_WIRS_1	333	338	PF05994	0.472
MOD_CDK_SPxxK_3	343	350	PF00069	0.682
MOD_CK1_1	250	256	PF00069	0.638
MOD_CK1_1	343	349	PF00069	0.501
MOD_CK1_1	99	105	PF00069	0.636
MOD_CK2_1	245	251	PF00069	0.700
MOD_GlcNHglycan	119	122	PF01048	0.541
MOD_GlcNHglycan	257	260	PF01048	0.724
MOD_GlcNHglycan	280	283	PF01048	0.553
MOD_GlcNHglycan	295	298	PF01048	0.646
MOD_GlcNHglycan	309	312	PF01048	0.534
MOD_GlcNHglycan	366	369	PF01048	0.458
MOD_GlcNHglycan	392	395	PF01048	0.709
MOD_GlcNHglycan	66	69	PF01048	0.504
MOD_GlcNHglycan	98	101	PF01048	0.615
MOD_GSK3_1	105	112	PF00069	0.611
MOD_GSK3_1	18	25	PF00069	0.480
MOD_GSK3_1	205	212	PF00069	0.483
MOD_GSK3_1	246	253	PF00069	0.519
MOD_GSK3_1	274	281	PF00069	0.505
MOD_GSK3_1	284	291	PF00069	0.598
MOD_GSK3_1	325	332	PF00069	0.630
MOD_GSK3_1	336	343	PF00069	0.628
MOD_GSK3_1	438	445	PF00069	0.783
MOD_GSK3_1	64	71	PF00069	0.482
MOD_GSK3_1	96	103	PF00069	0.571
MOD_N-GLC_1	253	258	PF02516	0.668
MOD_N-GLC_1	291	296	PF02516	0.560
MOD_NEK2_1	18	23	PF00069	0.493
MOD_NEK2_1	200	205	PF00069	0.424
MOD_NEK2_1	293	298	PF00069	0.723
MOD_NEK2_1	336	341	PF00069	0.693
MOD_NEK2_2	425	430	PF00069	0.509
MOD_PIKK_1	2	8	PF00454	0.574
MOD_PIKK_1	44	50	PF00454	0.475
MOD_PKA_2	117	123	PF00069	0.561
MOD_PKA_2	278	284	PF00069	0.629
MOD_PKA_2	425	431	PF00069	0.614
MOD_PKA_2	81	87	PF00069	0.439
MOD_PKA_2	91	97	PF00069	0.513
MOD_PKB_1	22	30	PF00069	0.499
MOD_Plk_1	329	335	PF00069	0.686
MOD_Plk_4	110	116	PF00069	0.659
MOD_Plk_4	180	186	PF00069	0.525
MOD_Plk_4	200	206	PF00069	0.505
MOD_Plk_4	336	342	PF00069	0.640
MOD_ProDKin_1	22	28	PF00069	0.505
MOD_ProDKin_1	322	328	PF00069	0.670
MOD_ProDKin_1	343	349	PF00069	0.682
MOD_SUMO_for_1	380	383	PF00179	0.706
MOD_SUMO_for_1	404	407	PF00179	0.720
TRG_DiLeu_BaEn_1	166	171	PF01217	0.371
TRG_DiLeu_BaEn_1	235	240	PF01217	0.398
TRG_ENDOCYTIC_2	138	141	PF00928	0.360
TRG_ENDOCYTIC_2	174	177	PF00928	0.497
TRG_ENDOCYTIC_2	193	196	PF00928	0.507
TRG_ER_diArg_1	216	218	PF00400	0.446
TRG_ER_diArg_1	431	433	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q6	Leptomonas seymouri	65%	95%
A0A0S4KK06	Bodo saltans	26%	92%
A0A1X0NJ10	Trypanosomatidae	34%	100%
A0A3Q8IRG7	Leishmania donovani	87%	100%
A0A3R7NSU2	Trypanosoma rangeli	35%	100%
A4I4P8	Leishmania infantum	87%	100%
C9ZN48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE51	Leishmania major	88%	100%
E9ALN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BIJ5	Trypanosoma cruzi	34%	100%