HotDog ACOT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl-coenzyme A thioesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHI1_LEIBR

TriTrypDb:

LbrM.29.1780 , LBRM2903_290024900

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHI1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035383	thioester metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016790	thiolester hydrolase activity	4	13
GO:0000062	fatty-acyl-CoA binding	4	1
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0008289	lipid binding	2	1
GO:0016289	CoA hydrolase activity	5	1
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0033218	amide binding	2	1
GO:0036042	long-chain fatty acyl-CoA binding	5	1
GO:0036094	small molecule binding	2	4
GO:0047617	acyl-CoA hydrolase activity	6	1
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:0120227	acyl-CoA binding	3	1
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4
GO:1901567	fatty acid derivative binding	3	1
GO:1901681	sulfur compound binding	2	1
GO:0005524	ATP binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.607
CLV_NRD_NRD_1	272	274	PF00675	0.553
CLV_PCSK_FUR_1	134	138	PF00082	0.621
CLV_PCSK_KEX2_1	136	138	PF00082	0.581
CLV_PCSK_KEX2_1	336	338	PF00082	0.526
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.607
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.526
CLV_PCSK_SKI1_1	136	140	PF00082	0.499
CLV_PCSK_SKI1_1	167	171	PF00082	0.478
CLV_PCSK_SKI1_1	198	202	PF00082	0.398
CLV_PCSK_SKI1_1	204	208	PF00082	0.349
CLV_PCSK_SKI1_1	24	28	PF00082	0.492
CLV_PCSK_SKI1_1	308	312	PF00082	0.506
CLV_PCSK_SKI1_1	95	99	PF00082	0.486
DEG_MDM2_SWIB_1	221	228	PF02201	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.272
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.543
DOC_MAPK_DCC_7	95	105	PF00069	0.444
DOC_MAPK_gen_1	273	281	PF00069	0.492
DOC_MAPK_gen_1	95	105	PF00069	0.491
DOC_MAPK_HePTP_8	271	283	PF00069	0.527
DOC_MAPK_MEF2A_6	236	244	PF00069	0.336
DOC_MAPK_MEF2A_6	273	281	PF00069	0.481
DOC_MAPK_MEF2A_6	98	105	PF00069	0.429
DOC_PP1_RVXF_1	165	171	PF00149	0.547
DOC_PP4_FxxP_1	216	219	PF00568	0.323
DOC_PP4_FxxP_1	37	40	PF00568	0.446
DOC_USP7_MATH_1	144	148	PF00917	0.527
DOC_USP7_MATH_1	7	11	PF00917	0.516
DOC_USP7_MATH_1	80	84	PF00917	0.477
DOC_USP7_UBL2_3	247	251	PF12436	0.472
DOC_USP7_UBL2_3	328	332	PF12436	0.789
DOC_WD40_RPTOR_TOS_1	109	115	PF00400	0.296
DOC_WW_Pin1_4	36	41	PF00397	0.496
DOC_WW_Pin1_4	68	73	PF00397	0.464
DOC_WW_Pin1_4	75	80	PF00397	0.459
DOC_WW_Pin1_4	88	93	PF00397	0.217
LIG_14-3-3_CanoR_1	236	241	PF00244	0.343
LIG_14-3-3_CanoR_1	24	32	PF00244	0.475
LIG_14-3-3_CanoR_1	260	264	PF00244	0.388
LIG_14-3-3_CanoR_1	300	306	PF00244	0.493
LIG_14-3-3_CanoR_1	8	14	PF00244	0.501
LIG_Actin_WH2_2	80	97	PF00022	0.432
LIG_AP2alpha_2	107	109	PF02296	0.545
LIG_BRCT_BRCA1_1	212	216	PF00533	0.391
LIG_CaM_IQ_9	320	335	PF13499	0.521
LIG_DCNL_PONY_1	1	4	PF03556	0.279
LIG_FHA_1	116	122	PF00498	0.453
LIG_FHA_1	221	227	PF00498	0.351
LIG_FHA_1	237	243	PF00498	0.250
LIG_FHA_1	25	31	PF00498	0.421
LIG_FHA_1	251	257	PF00498	0.465
LIG_FHA_1	318	324	PF00498	0.508
LIG_FHA_1	89	95	PF00498	0.499
LIG_FHA_2	138	144	PF00498	0.478
LIG_FHA_2	159	165	PF00498	0.484
LIG_FHA_2	236	242	PF00498	0.362
LIG_FHA_2	285	291	PF00498	0.471
LIG_FHA_2	72	78	PF00498	0.510
LIG_LIR_Apic_2	213	219	PF02991	0.338
LIG_LIR_Apic_2	35	40	PF02991	0.486
LIG_LIR_Gen_1	115	125	PF02991	0.371
LIG_LIR_Gen_1	223	233	PF02991	0.370
LIG_LIR_Gen_1	262	271	PF02991	0.378
LIG_LIR_Gen_1	82	92	PF02991	0.403
LIG_LIR_Nem_3	115	120	PF02991	0.339
LIG_LIR_Nem_3	223	228	PF02991	0.370
LIG_LIR_Nem_3	262	266	PF02991	0.375
LIG_LIR_Nem_3	82	88	PF02991	0.435
LIG_PCNA_yPIPBox_3	288	302	PF02747	0.519
LIG_Pex14_2	221	225	PF04695	0.370
LIG_PTB_Apo_2	31	38	PF02174	0.461
LIG_SH2_CRK	117	121	PF00017	0.388
LIG_SH2_STAP1	117	121	PF00017	0.301
LIG_SH2_STAT5	117	120	PF00017	0.460
LIG_SH2_STAT5	234	237	PF00017	0.363
LIG_SH2_STAT5	25	28	PF00017	0.524
LIG_SH2_STAT5	64	67	PF00017	0.449
LIG_SH3_3	211	217	PF00018	0.415
LIG_SUMO_SIM_anti_2	241	246	PF11976	0.421
LIG_SUMO_SIM_par_1	86	91	PF11976	0.443
LIG_TRAF2_1	140	143	PF00917	0.570
LIG_TRAF2_1	286	289	PF00917	0.494
MOD_CDK_SPxxK_3	68	75	PF00069	0.564
MOD_CDK_SPxxK_3	88	95	PF00069	0.224
MOD_CK1_1	71	77	PF00069	0.481
MOD_CK1_1	83	89	PF00069	0.362
MOD_CK2_1	137	143	PF00069	0.534
MOD_CK2_1	144	150	PF00069	0.501
MOD_CK2_1	158	164	PF00069	0.476
MOD_CK2_1	235	241	PF00069	0.362
MOD_CK2_1	284	290	PF00069	0.472
MOD_CK2_1	71	77	PF00069	0.520
MOD_Cter_Amidation	271	274	PF01082	0.558
MOD_Cter_Amidation	330	333	PF01082	0.524
MOD_Cter_Amidation	334	337	PF01082	0.510
MOD_GSK3_1	220	227	PF00069	0.352
MOD_GSK3_1	251	258	PF00069	0.476
MOD_GSK3_1	26	33	PF00069	0.411
MOD_GSK3_1	313	320	PF00069	0.697
MOD_GSK3_1	71	78	PF00069	0.470
MOD_LATS_1	155	161	PF00433	0.570
MOD_LATS_1	22	28	PF00433	0.558
MOD_N-GLC_1	158	163	PF02516	0.534
MOD_N-GLC_1	176	181	PF02516	0.187
MOD_N-GLC_1	236	241	PF02516	0.370
MOD_N-GLC_2	301	303	PF02516	0.402
MOD_NEK2_1	169	174	PF00069	0.522
MOD_NEK2_1	228	233	PF00069	0.450
MOD_NEK2_1	26	31	PF00069	0.429
MOD_NEK2_2	80	85	PF00069	0.488
MOD_PIKK_1	284	290	PF00454	0.499
MOD_PIKK_1	7	13	PF00454	0.495
MOD_PK_1	273	279	PF00069	0.301
MOD_PKA_1	250	256	PF00069	0.596
MOD_PKA_1	273	279	PF00069	0.457
MOD_PKA_2	115	121	PF00069	0.395
MOD_PKA_2	235	241	PF00069	0.343
MOD_PKA_2	259	265	PF00069	0.386
MOD_PKA_2	301	307	PF00069	0.518
MOD_PKA_2	7	13	PF00069	0.498
MOD_Plk_1	176	182	PF00069	0.315
MOD_Plk_1	228	234	PF00069	0.375
MOD_Plk_1	236	242	PF00069	0.328
MOD_Plk_1	251	257	PF00069	0.512
MOD_Plk_2-3	224	230	PF00069	0.391
MOD_Plk_4	176	182	PF00069	0.383
MOD_Plk_4	228	234	PF00069	0.406
MOD_Plk_4	252	258	PF00069	0.483
MOD_Plk_4	259	265	PF00069	0.341
MOD_Plk_4	32	38	PF00069	0.443
MOD_Plk_4	80	86	PF00069	0.408
MOD_ProDKin_1	36	42	PF00069	0.499
MOD_ProDKin_1	68	74	PF00069	0.468
MOD_ProDKin_1	75	81	PF00069	0.453
MOD_ProDKin_1	88	94	PF00069	0.219
MOD_SUMO_for_1	246	249	PF00179	0.472
MOD_SUMO_rev_2	147	154	PF00179	0.538
MOD_SUMO_rev_2	243	253	PF00179	0.424
MOD_SUMO_rev_2	326	334	PF00179	0.679
TRG_DiLeu_BaEn_3	289	295	PF01217	0.550
TRG_ENDOCYTIC_2	117	120	PF00928	0.417
TRG_ENDOCYTIC_2	64	67	PF00928	0.464
TRG_ER_diArg_1	299	302	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C1	Leptomonas seymouri	32%	75%
A0A0N1PDQ1	Leptomonas seymouri	75%	86%
A0A0S4JR10	Bodo saltans	43%	77%
A0A1X0NZW0	Trypanosomatidae	59%	92%
A0A1X0P0I5	Trypanosomatidae	40%	87%
A0A3S7X2I7	Leishmania donovani	88%	96%
A0A422NEB6	Trypanosoma rangeli	37%	85%
A4I4M9	Leishmania infantum	88%	96%
C9ZLB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	92%
E9AE30	Leishmania major	88%	100%
E9ALQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	85%