DUF4378 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHI0_LEIBR

TriTrypDb:

LbrM.29.1770 , LBRM2903_290024800

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.359
CLV_NRD_NRD_1	17	19	PF00675	0.558
CLV_NRD_NRD_1	186	188	PF00675	0.356
CLV_PCSK_KEX2_1	186	188	PF00082	0.355
CLV_PCSK_KEX2_1	19	21	PF00082	0.526
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.462
CLV_PCSK_SKI1_1	187	191	PF00082	0.335
CLV_PCSK_SKI1_1	22	26	PF00082	0.406
CLV_PCSK_SKI1_1	258	262	PF00082	0.395
DEG_APCC_DBOX_1	186	194	PF00400	0.316
DOC_MAPK_gen_1	186	193	PF00069	0.360
DOC_MAPK_gen_1	46	54	PF00069	0.475
DOC_MAPK_MEF2A_6	186	195	PF00069	0.316
DOC_MAPK_MEF2A_6	48	56	PF00069	0.473
LIG_14-3-3_CanoR_1	142	148	PF00244	0.534
LIG_14-3-3_CanoR_1	53	57	PF00244	0.308
LIG_APCC_ABBA_1	109	114	PF00400	0.561
LIG_deltaCOP1_diTrp_1	252	260	PF00928	0.367
LIG_eIF4E_1	206	212	PF01652	0.264
LIG_FHA_1	195	201	PF00498	0.228
LIG_FHA_1	23	29	PF00498	0.457
LIG_FHA_2	132	138	PF00498	0.483
LIG_FHA_2	244	250	PF00498	0.407
LIG_FHA_2	27	33	PF00498	0.572
LIG_FHA_2	3	9	PF00498	0.492
LIG_FHA_2	45	51	PF00498	0.518
LIG_LIR_Gen_1	115	124	PF02991	0.412
LIG_LIR_Gen_1	231	242	PF02991	0.356
LIG_LIR_Gen_1	47	56	PF02991	0.295
LIG_LIR_Gen_1	69	78	PF02991	0.519
LIG_LIR_Gen_1	79	90	PF02991	0.472
LIG_LIR_Nem_3	115	121	PF02991	0.393
LIG_LIR_Nem_3	204	209	PF02991	0.431
LIG_LIR_Nem_3	231	237	PF02991	0.352
LIG_LIR_Nem_3	252	256	PF02991	0.347
LIG_LIR_Nem_3	47	52	PF02991	0.502
LIG_LIR_Nem_3	55	61	PF02991	0.459
LIG_LIR_Nem_3	69	75	PF02991	0.456
LIG_LIR_Nem_3	79	85	PF02991	0.454
LIG_NRBOX	189	195	PF00104	0.397
LIG_Pex14_1	234	238	PF04695	0.419
LIG_SH2_NCK_1	239	243	PF00017	0.312
LIG_SH2_NCK_1	265	269	PF00017	0.456
LIG_SH2_NCK_1	72	76	PF00017	0.469
LIG_SH2_STAT5	206	209	PF00017	0.420
LIG_SH2_STAT5	95	98	PF00017	0.642
LIG_SH3_3	165	171	PF00018	0.609
LIG_SUMO_SIM_anti_2	172	177	PF11976	0.376
LIG_SUMO_SIM_par_1	192	197	PF11976	0.306
LIG_TRAF2_1	104	107	PF00917	0.635
LIG_TRAF2_1	13	16	PF00917	0.335
LIG_TRAF2_1	246	249	PF00917	0.487
MOD_CK1_1	146	152	PF00069	0.634
MOD_CK1_1	158	164	PF00069	0.622
MOD_CK1_1	213	219	PF00069	0.582
MOD_CK2_1	119	125	PF00069	0.413
MOD_CK2_1	131	137	PF00069	0.386
MOD_CK2_1	154	160	PF00069	0.485
MOD_CK2_1	2	8	PF00069	0.606
MOD_CK2_1	218	224	PF00069	0.523
MOD_CK2_1	243	249	PF00069	0.414
MOD_CK2_1	26	32	PF00069	0.582
MOD_CK2_1	44	50	PF00069	0.511
MOD_CK2_1	85	91	PF00069	0.475
MOD_CK2_1	9	15	PF00069	0.477
MOD_GlcNHglycan	11	14	PF01048	0.599
MOD_GlcNHglycan	163	166	PF01048	0.743
MOD_GSK3_1	119	126	PF00069	0.482
MOD_GSK3_1	143	150	PF00069	0.594
MOD_GSK3_1	154	161	PF00069	0.656
MOD_GSK3_1	22	29	PF00069	0.390
MOD_N-GLC_1	153	158	PF02516	0.572
MOD_NEK2_1	131	136	PF00069	0.417
MOD_NEK2_1	194	199	PF00069	0.322
MOD_NEK2_1	261	266	PF00069	0.517
MOD_NEK2_1	52	57	PF00069	0.425
MOD_NEK2_1	85	90	PF00069	0.384
MOD_PIKK_1	22	28	PF00454	0.519
MOD_PKA_2	52	58	PF00069	0.385
MOD_PKA_2	76	82	PF00069	0.400
MOD_PKA_2	85	91	PF00069	0.450
MOD_PKB_1	20	28	PF00069	0.527
MOD_Plk_1	159	165	PF00069	0.468
MOD_Plk_4	123	129	PF00069	0.475
MOD_Plk_4	229	235	PF00069	0.370
MOD_Plk_4	85	91	PF00069	0.521
MOD_SUMO_rev_2	12	21	PF00179	0.458
MOD_SUMO_rev_2	248	256	PF00179	0.417
TRG_DiLeu_BaEn_4	16	22	PF01217	0.467
TRG_ENDOCYTIC_2	118	121	PF00928	0.398
TRG_ENDOCYTIC_2	206	209	PF00928	0.420
TRG_ENDOCYTIC_2	72	75	PF00928	0.472
TRG_ER_diArg_1	18	21	PF00400	0.562
TRG_ER_diArg_1	46	49	PF00400	0.398
TRG_NES_CRM1_1	188	204	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM1	Leptomonas seymouri	52%	100%
A0A0S4ING2	Bodo saltans	26%	100%
A0A1X0NZY4	Trypanosomatidae	31%	100%
A0A3Q8IIV0	Leishmania donovani	73%	100%
A0A3R7KCM5	Trypanosoma rangeli	36%	100%
A4I4K6	Leishmania infantum	72%	100%
C9ZLB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AE28	Leishmania major	73%	100%
E9ALQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
V5B997	Trypanosoma cruzi	32%	100%