Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HHH9_LEIBR

TriTrypDb:

LbrM.29.1760 , LBRM2903_290024700

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.533
CLV_C14_Caspase3-7	323	327	PF00656	0.554
CLV_NRD_NRD_1	133	135	PF00675	0.425
CLV_NRD_NRD_1	62	64	PF00675	0.612
CLV_PCSK_FUR_1	131	135	PF00082	0.422
CLV_PCSK_KEX2_1	133	135	PF00082	0.425
CLV_PCSK_KEX2_1	165	167	PF00082	0.582
CLV_PCSK_KEX2_1	62	64	PF00082	0.612
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.582
CLV_PCSK_SKI1_1	233	237	PF00082	0.372
CLV_PCSK_SKI1_1	311	315	PF00082	0.567
CLV_Separin_Metazoa	77	81	PF03568	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SCF_TRCP1_1	285	291	PF00400	0.538
DEG_SPOP_SBC_1	203	207	PF00917	0.522
DEG_SPOP_SBC_1	275	279	PF00917	0.620
DOC_CKS1_1	38	43	PF01111	0.589
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.537
DOC_MAPK_gen_1	233	241	PF00069	0.381
DOC_MAPK_MEF2A_6	233	241	PF00069	0.305
DOC_MAPK_MEF2A_6	80	88	PF00069	0.510
DOC_PP1_RVXF_1	234	241	PF00149	0.381
DOC_PP1_RVXF_1	88	94	PF00149	0.506
DOC_PP2B_LxvP_1	295	298	PF13499	0.526
DOC_USP7_MATH_1	203	207	PF00917	0.522
DOC_USP7_MATH_1	251	255	PF00917	0.353
DOC_WW_Pin1_4	165	170	PF00397	0.638
DOC_WW_Pin1_4	191	196	PF00397	0.596
DOC_WW_Pin1_4	271	276	PF00397	0.666
DOC_WW_Pin1_4	289	294	PF00397	0.599
DOC_WW_Pin1_4	37	42	PF00397	0.590
DOC_WW_Pin1_4	420	425	PF00397	0.641
DOC_WW_Pin1_4	440	445	PF00397	0.634
LIG_14-3-3_CanoR_1	131	141	PF00244	0.428
LIG_14-3-3_CanoR_1	217	222	PF00244	0.392
LIG_14-3-3_CanoR_1	25	31	PF00244	0.616
LIG_14-3-3_CanoR_1	311	317	PF00244	0.544
LIG_BRCT_BRCA1_1	277	281	PF00533	0.554
LIG_BRCT_BRCA1_1	5	9	PF00533	0.458
LIG_Clathr_ClatBox_1	365	369	PF01394	0.363
LIG_EH1_1	360	368	PF00400	0.347
LIG_FHA_1	140	146	PF00498	0.454
LIG_FHA_1	205	211	PF00498	0.599
LIG_FHA_1	275	281	PF00498	0.553
LIG_FHA_1	308	314	PF00498	0.566
LIG_FHA_1	334	340	PF00498	0.522
LIG_FHA_2	336	342	PF00498	0.478
LIG_FHA_2	424	430	PF00498	0.627
LIG_FHA_2	70	76	PF00498	0.539
LIG_LIR_Nem_3	387	391	PF02991	0.375
LIG_NRBOX	410	416	PF00104	0.463
LIG_REV1ctd_RIR_1	238	247	PF16727	0.387
LIG_SH2_CRK	2	6	PF00017	0.493
LIG_SH2_GRB2like	302	305	PF00017	0.547
LIG_SH2_NCK_1	2	6	PF00017	0.465
LIG_SH2_STAT5	2	5	PF00017	0.509
LIG_SH2_STAT5	39	42	PF00017	0.526
LIG_SH3_3	150	156	PF00018	0.536
LIG_SH3_3	208	214	PF00018	0.533
LIG_SH3_3	352	358	PF00018	0.405
LIG_SH3_3	92	98	PF00018	0.505
LIG_SUMO_SIM_anti_2	362	370	PF11976	0.414
LIG_SUMO_SIM_par_1	364	370	PF11976	0.421
LIG_SUMO_SIM_par_1	409	416	PF11976	0.380
LIG_SUMO_SIM_par_1	67	72	PF11976	0.522
LIG_TRAF2_1	338	341	PF00917	0.394
LIG_WRC_WIRS_1	218	223	PF05994	0.465
LIG_WRC_WIRS_1	385	390	PF05994	0.382
MOD_CK1_1	180	186	PF00069	0.559
MOD_CK1_1	191	197	PF00069	0.497
MOD_CK1_1	206	212	PF00069	0.468
MOD_CK1_1	37	43	PF00069	0.506
MOD_CK1_1	384	390	PF00069	0.388
MOD_CK1_1	423	429	PF00069	0.681
MOD_CK1_1	443	449	PF00069	0.478
MOD_CK2_1	202	208	PF00069	0.604
MOD_CK2_1	335	341	PF00069	0.407
MOD_CK2_1	423	429	PF00069	0.617
MOD_CK2_1	71	77	PF00069	0.562
MOD_GlcNHglycan	134	137	PF01048	0.421
MOD_GlcNHglycan	190	193	PF01048	0.559
MOD_GlcNHglycan	200	203	PF01048	0.551
MOD_GlcNHglycan	284	288	PF01048	0.553
MOD_GlcNHglycan	295	298	PF01048	0.603
MOD_GlcNHglycan	42	45	PF01048	0.510
MOD_GlcNHglycan	445	448	PF01048	0.735
MOD_GlcNHglycan	49	52	PF01048	0.498
MOD_GlcNHglycan	6	9	PF01048	0.476
MOD_GSK3_1	110	117	PF00069	0.535
MOD_GSK3_1	161	168	PF00069	0.605
MOD_GSK3_1	187	194	PF00069	0.552
MOD_GSK3_1	198	205	PF00069	0.522
MOD_GSK3_1	247	254	PF00069	0.337
MOD_GSK3_1	26	33	PF00069	0.529
MOD_GSK3_1	271	278	PF00069	0.574
MOD_GSK3_1	289	296	PF00069	0.613
MOD_GSK3_1	307	314	PF00069	0.487
MOD_GSK3_1	331	338	PF00069	0.526
MOD_GSK3_1	40	47	PF00069	0.468
MOD_GSK3_1	413	420	PF00069	0.505
MOD_GSK3_1	439	446	PF00069	0.745
MOD_N-GLC_2	393	395	PF02516	0.444
MOD_NEK2_1	1	6	PF00069	0.465
MOD_NEK2_1	132	137	PF00069	0.427
MOD_NEK2_1	148	153	PF00069	0.471
MOD_NEK2_1	188	193	PF00069	0.562
MOD_NEK2_1	241	246	PF00069	0.308
MOD_NEK2_1	367	372	PF00069	0.389
MOD_NEK2_1	69	74	PF00069	0.564
MOD_NEK2_1	84	89	PF00069	0.471
MOD_NEK2_2	276	281	PF00069	0.554
MOD_NEK2_2	44	49	PF00069	0.519
MOD_PIKK_1	30	36	PF00454	0.526
MOD_PIKK_1	413	419	PF00454	0.424
MOD_PIKK_1	429	435	PF00454	0.512
MOD_PKA_2	132	138	PF00069	0.426
MOD_PKA_2	307	313	PF00069	0.563
MOD_PKA_2	53	59	PF00069	0.607
MOD_Plk_1	374	380	PF00069	0.448
MOD_Plk_1	69	75	PF00069	0.509
MOD_Plk_4	115	121	PF00069	0.482
MOD_Plk_4	206	212	PF00069	0.510
MOD_Plk_4	26	32	PF00069	0.614
MOD_Plk_4	276	282	PF00069	0.599
MOD_Plk_4	34	40	PF00069	0.540
MOD_Plk_4	359	365	PF00069	0.480
MOD_Plk_4	384	390	PF00069	0.388
MOD_ProDKin_1	165	171	PF00069	0.638
MOD_ProDKin_1	191	197	PF00069	0.595
MOD_ProDKin_1	271	277	PF00069	0.670
MOD_ProDKin_1	289	295	PF00069	0.600
MOD_ProDKin_1	37	43	PF00069	0.590
MOD_ProDKin_1	420	426	PF00069	0.643
MOD_ProDKin_1	440	446	PF00069	0.632
MOD_SUMO_rev_2	340	344	PF00179	0.464
TRG_DiLeu_BaEn_1	407	412	PF01217	0.451
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.593
TRG_ENDOCYTIC_2	2	5	PF00928	0.495
TRG_ER_diArg_1	131	134	PF00400	0.467
TRG_ER_diArg_1	22	25	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2I2	Leishmania donovani	62%	100%