Putative ABC transporter domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHH8_LEIBR

TriTrypDb:

LbrM.29.1750 , LBRM2903_290024600

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.351
CLV_NRD_NRD_1	110	112	PF00675	0.268
CLV_NRD_NRD_1	272	274	PF00675	0.424
CLV_PCSK_KEX2_1	110	112	PF00082	0.268
CLV_PCSK_KEX2_1	272	274	PF00082	0.424
CLV_PCSK_SKI1_1	206	210	PF00082	0.320
CLV_PCSK_SKI1_1	301	305	PF00082	0.414
CLV_PCSK_SKI1_1	328	332	PF00082	0.548
CLV_PCSK_SKI1_1	72	76	PF00082	0.459
DEG_APCC_DBOX_1	205	213	PF00400	0.258
DEG_COP1_1	411	420	PF00400	0.466
DOC_CYCLIN_RxL_1	162	173	PF00134	0.241
DOC_CYCLIN_RxL_1	202	210	PF00134	0.328
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.472
DOC_MAPK_gen_1	110	117	PF00069	0.268
DOC_MAPK_gen_1	202	211	PF00069	0.264
DOC_MAPK_gen_1	272	281	PF00069	0.341
DOC_MAPK_MEF2A_6	99	106	PF00069	0.410
DOC_MAPK_NFAT4_5	99	107	PF00069	0.369
DOC_PP1_RVXF_1	163	170	PF00149	0.281
DOC_PP2B_LxvP_1	102	105	PF13499	0.532
DOC_PP2B_LxvP_1	5	8	PF13499	0.477
DOC_USP7_MATH_1	35	39	PF00917	0.411
DOC_USP7_MATH_1	390	394	PF00917	0.640
DOC_USP7_MATH_1	416	420	PF00917	0.599
DOC_USP7_MATH_1	42	46	PF00917	0.437
DOC_USP7_MATH_1	79	83	PF00917	0.624
DOC_WW_Pin1_4	194	199	PF00397	0.169
DOC_WW_Pin1_4	30	35	PF00397	0.503
DOC_WW_Pin1_4	400	405	PF00397	0.557
DOC_WW_Pin1_4	406	411	PF00397	0.548
LIG_14-3-3_CanoR_1	163	168	PF00244	0.252
LIG_14-3-3_CanoR_1	206	212	PF00244	0.371
LIG_14-3-3_CanoR_1	27	34	PF00244	0.476
LIG_14-3-3_CanoR_1	272	281	PF00244	0.338
LIG_14-3-3_CanoR_1	372	378	PF00244	0.479
LIG_14-3-3_CanoR_1	389	395	PF00244	0.460
LIG_APCC_ABBA_1	424	429	PF00400	0.479
LIG_BIR_III_2	31	35	PF00653	0.431
LIG_BRCT_BRCA1_1	165	169	PF00533	0.214
LIG_Clathr_ClatBox_1	245	249	PF01394	0.180
LIG_FHA_1	124	130	PF00498	0.237
LIG_FHA_1	140	146	PF00498	0.281
LIG_FHA_1	171	177	PF00498	0.237
LIG_FHA_1	250	256	PF00498	0.383
LIG_FHA_1	258	264	PF00498	0.362
LIG_FHA_1	274	280	PF00498	0.353
LIG_FHA_1	318	324	PF00498	0.433
LIG_FHA_2	15	21	PF00498	0.638
LIG_FHA_2	179	185	PF00498	0.237
LIG_FHA_2	375	381	PF00498	0.466
LIG_FHA_2	73	79	PF00498	0.443
LIG_Integrin_isoDGR_2	146	148	PF01839	0.261
LIG_LIR_Gen_1	113	120	PF02991	0.277
LIG_LIR_Gen_1	173	182	PF02991	0.281
LIG_LIR_Gen_1	305	314	PF02991	0.425
LIG_LIR_Gen_1	360	369	PF02991	0.532
LIG_LIR_Nem_3	113	117	PF02991	0.293
LIG_LIR_Nem_3	173	177	PF02991	0.281
LIG_LIR_Nem_3	305	310	PF02991	0.443
LIG_LIR_Nem_3	317	322	PF02991	0.484
LIG_LIR_Nem_3	360	366	PF02991	0.527
LIG_SH2_GRB2like	363	366	PF00017	0.476
LIG_SH2_STAP1	290	294	PF00017	0.314
LIG_SH2_STAP1	319	323	PF00017	0.355
LIG_SH2_STAT5	296	299	PF00017	0.339
LIG_SH2_STAT5	319	322	PF00017	0.320
LIG_SH3_2	105	110	PF14604	0.405
LIG_SH3_3	102	108	PF00018	0.477
LIG_SH3_3	183	189	PF00018	0.281
LIG_SH3_3	398	404	PF00018	0.594
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.268
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.383
LIG_SUMO_SIM_par_1	244	250	PF11976	0.237
LIG_SUMO_SIM_par_1	256	265	PF11976	0.445
LIG_SUMO_SIM_par_1	63	73	PF11976	0.465
LIG_TRAF2_1	34	37	PF00917	0.482
LIG_UBA3_1	192	199	PF00899	0.268
LIG_UBA3_1	266	275	PF00899	0.343
LIG_WRC_WIRS_1	171	176	PF05994	0.281
MOD_CDK_SPK_2	194	199	PF00069	0.169
MOD_CK1_1	151	157	PF00069	0.210
MOD_CK1_1	223	229	PF00069	0.281
MOD_CK1_1	30	36	PF00069	0.513
MOD_CK1_1	371	377	PF00069	0.545
MOD_CK1_1	419	425	PF00069	0.532
MOD_CK2_1	134	140	PF00069	0.357
MOD_CK2_1	14	20	PF00069	0.521
MOD_CK2_1	178	184	PF00069	0.238
MOD_CK2_1	223	229	PF00069	0.304
MOD_CK2_1	30	36	PF00069	0.427
MOD_CK2_1	333	339	PF00069	0.660
MOD_CK2_1	374	380	PF00069	0.540
MOD_CK2_1	6	12	PF00069	0.511
MOD_CK2_1	79	85	PF00069	0.569
MOD_GlcNHglycan	120	123	PF01048	0.285
MOD_GlcNHglycan	224	228	PF01048	0.291
MOD_GlcNHglycan	335	338	PF01048	0.467
MOD_GlcNHglycan	394	397	PF01048	0.600
MOD_GlcNHglycan	413	416	PF01048	0.433
MOD_GSK3_1	231	238	PF00069	0.251
MOD_GSK3_1	339	346	PF00069	0.488
MOD_GSK3_1	367	374	PF00069	0.541
MOD_GSK3_1	390	397	PF00069	0.668
MOD_GSK3_1	416	423	PF00069	0.548
MOD_N-GLC_1	194	199	PF02516	0.223
MOD_N-GLC_1	333	338	PF02516	0.459
MOD_N-GLC_1	80	85	PF02516	0.476
MOD_NEK2_1	14	19	PF00069	0.429
MOD_NEK2_1	176	181	PF00069	0.237
MOD_NEK2_1	255	260	PF00069	0.338
MOD_NEK2_1	333	338	PF00069	0.490
MOD_NEK2_1	392	397	PF00069	0.616
MOD_NEK2_2	384	389	PF00069	0.449
MOD_PK_1	90	96	PF00069	0.423
MOD_PKA_2	231	237	PF00069	0.295
MOD_PKA_2	271	277	PF00069	0.314
MOD_PKA_2	371	377	PF00069	0.539
MOD_Plk_1	72	78	PF00069	0.434
MOD_Plk_2-3	339	345	PF00069	0.435
MOD_Plk_4	124	130	PF00069	0.298
MOD_Plk_4	188	194	PF00069	0.273
MOD_Plk_4	207	213	PF00069	0.340
MOD_Plk_4	241	247	PF00069	0.268
MOD_Plk_4	343	349	PF00069	0.399
MOD_ProDKin_1	194	200	PF00069	0.169
MOD_ProDKin_1	30	36	PF00069	0.495
MOD_ProDKin_1	400	406	PF00069	0.557
TRG_DiLeu_BaEn_1	262	267	PF01217	0.393
TRG_ENDOCYTIC_2	363	366	PF00928	0.476
TRG_ER_diArg_1	109	111	PF00400	0.268
TRG_ER_diArg_1	201	204	PF00400	0.237
TRG_ER_diArg_1	214	217	PF00400	0.237
TRG_ER_KDEL_1	434	437	PF00810	0.491
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICD4	Leptomonas seymouri	59%	93%
A0A0S4J9X9	Bodo saltans	57%	100%
A0A3S7X2I8	Leishmania donovani	68%	94%
A4H4H6	Leishmania braziliensis	30%	66%
A4I4M8	Leishmania infantum	68%	94%
E9AE26	Leishmania major	68%	100%
E9ALQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	94%
E9ANF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
Q134N9	Rhodopseudomonas palustris (strain BisB5)	34%	100%
Q21BU8	Rhodopseudomonas palustris (strain BisB18)	31%	100%
Q6N9W0	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	31%	100%
Q8G5P8	Bifidobacterium longum (strain NCC 2705)	30%	100%
V5D9U5	Trypanosoma cruzi	63%	100%