Integral membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein S linking to the trans Golgi network, putative

Species:

Leishmania braziliensis

UniProt:

A4HHH5_LEIBR

TriTrypDb:

LbrM.29.1720 , LBRM2903_290024200

Length:

378

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, involved in protein trafficking.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	7
GO:0005802	trans-Golgi network	4	1
GO:0005829	cytosol	2	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A4HHH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0006895	Golgi to endosome transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.668
CLV_NRD_NRD_1	163	165	PF00675	0.402
CLV_NRD_NRD_1	195	197	PF00675	0.345
CLV_NRD_NRD_1	218	220	PF00675	0.346
CLV_NRD_NRD_1	242	244	PF00675	0.545
CLV_NRD_NRD_1	271	273	PF00675	0.418
CLV_PCSK_FUR_1	161	165	PF00082	0.401
CLV_PCSK_KEX2_1	163	165	PF00082	0.402
CLV_PCSK_KEX2_1	195	197	PF00082	0.345
CLV_PCSK_KEX2_1	218	220	PF00082	0.346
CLV_PCSK_KEX2_1	242	244	PF00082	0.545
CLV_PCSK_KEX2_1	271	273	PF00082	0.345
CLV_PCSK_SKI1_1	220	224	PF00082	0.346
CLV_PCSK_SKI1_1	242	246	PF00082	0.524
CLV_PCSK_SKI1_1	34	38	PF00082	0.417
DEG_APCC_DBOX_1	195	203	PF00400	0.546
DEG_APCC_DBOX_1	271	279	PF00400	0.618
DEG_SCF_FBW7_1	103	110	PF00400	0.636
DEG_SCF_FBW7_1	70	77	PF00400	0.637
DEG_SPOP_SBC_1	107	111	PF00917	0.646
DEG_SPOP_SBC_1	293	297	PF00917	0.776
DOC_ANK_TNKS_1	343	350	PF00023	0.632
DOC_CKS1_1	71	76	PF01111	0.718
DOC_CYCLIN_RxL_1	216	224	PF00134	0.618
DOC_CYCLIN_RxL_1	31	41	PF00134	0.612
DOC_MAPK_gen_1	218	225	PF00069	0.546
DOC_MAPK_gen_1	271	280	PF00069	0.545
DOC_MAPK_MEF2A_6	218	225	PF00069	0.618
DOC_MAPK_MEF2A_6	95	103	PF00069	0.605
DOC_MAPK_NFAT4_5	218	226	PF00069	0.618
DOC_PP2B_LxvP_1	345	348	PF13499	0.631
DOC_PP2B_LxvP_1	64	67	PF13499	0.647
DOC_PP4_FxxP_1	135	138	PF00568	0.675
DOC_PP4_FxxP_1	143	146	PF00568	0.644
DOC_PP4_MxPP_1	57	60	PF00568	0.638
DOC_USP7_MATH_1	121	125	PF00917	0.785
DOC_USP7_MATH_1	138	142	PF00917	0.602
DOC_USP7_MATH_1	351	355	PF00917	0.735
DOC_USP7_MATH_1	74	78	PF00917	0.645
DOC_WW_Pin1_4	103	108	PF00397	0.631
DOC_WW_Pin1_4	113	118	PF00397	0.630
DOC_WW_Pin1_4	142	147	PF00397	0.582
DOC_WW_Pin1_4	165	170	PF00397	0.608
DOC_WW_Pin1_4	284	289	PF00397	0.706
DOC_WW_Pin1_4	51	56	PF00397	0.752
DOC_WW_Pin1_4	70	75	PF00397	0.711
LIG_14-3-3_CanoR_1	335	340	PF00244	0.650
LIG_Actin_WH2_2	174	192	PF00022	0.589
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	123	127	PF00533	0.718
LIG_BRCT_BRCA1_1	131	135	PF00533	0.647
LIG_BRCT_BRCA1_1	23	27	PF00533	0.385
LIG_BRCT_BRCA1_1	337	341	PF00533	0.635
LIG_DLG_GKlike_1	335	342	PF00625	0.636
LIG_eIF4E_1	210	216	PF01652	0.546
LIG_eIF4E_1	230	236	PF01652	0.183
LIG_FHA_1	110	116	PF00498	0.773
LIG_FHA_1	166	172	PF00498	0.662
LIG_FHA_1	226	232	PF00498	0.411
LIG_FHA_1	264	270	PF00498	0.411
LIG_FHA_1	284	290	PF00498	0.580
LIG_FHA_1	295	301	PF00498	0.760
LIG_FHA_1	31	37	PF00498	0.608
LIG_FHA_1	44	50	PF00498	0.652
LIG_LIR_Apic_2	132	138	PF02991	0.672
LIG_LIR_Apic_2	141	146	PF02991	0.642
LIG_LIR_Apic_2	68	74	PF02991	0.683
LIG_LIR_Gen_1	24	35	PF02991	0.348
LIG_LIR_Gen_1	336	347	PF02991	0.634
LIG_LIR_Nem_3	228	233	PF02991	0.352
LIG_LIR_Nem_3	24	30	PF02991	0.385
LIG_LIR_Nem_3	336	342	PF02991	0.781
LIG_LIR_Nem_3	77	82	PF02991	0.693
LIG_MLH1_MIPbox_1	23	27	PF16413	0.387
LIG_PTB_Apo_2	8	15	PF02174	0.343
LIG_SH2_CRK	339	343	PF00017	0.632
LIG_SH2_CRK	71	75	PF00017	0.720
LIG_SH2_NCK_1	71	75	PF00017	0.682
LIG_SH2_STAT5	133	136	PF00017	0.675
LIG_SH2_STAT5	198	201	PF00017	0.546
LIG_SH2_STAT5	230	233	PF00017	0.411
LIG_SH3_3	112	118	PF00018	0.811
LIG_SH3_3	287	293	PF00018	0.636
LIG_SH3_3	64	70	PF00018	0.682
LIG_SUMO_SIM_par_1	145	150	PF11976	0.596
LIG_SUMO_SIM_par_1	97	102	PF11976	0.606
LIG_TYR_ITIM	231	236	PF00017	0.411
MOD_CDK_SPxK_1	70	76	PF00069	0.637
MOD_CK1_1	108	114	PF00069	0.832
MOD_CK1_1	150	156	PF00069	0.590
MOD_CK1_1	43	49	PF00069	0.759
MOD_CK2_1	123	129	PF00069	0.737
MOD_GlcNHglycan	148	152	PF01048	0.369
MOD_GlcNHglycan	280	283	PF01048	0.534
MOD_GlcNHglycan	327	330	PF01048	0.578
MOD_GlcNHglycan	76	79	PF01048	0.447
MOD_GSK3_1	107	114	PF00069	0.770
MOD_GSK3_1	138	145	PF00069	0.696
MOD_GSK3_1	225	232	PF00069	0.265
MOD_GSK3_1	278	285	PF00069	0.716
MOD_GSK3_1	70	77	PF00069	0.679
MOD_GSK3_1	99	106	PF00069	0.720
MOD_LATS_1	333	339	PF00433	0.642
MOD_N-GLC_1	324	329	PF02516	0.518
MOD_NEK2_1	206	211	PF00069	0.620
MOD_NEK2_1	225	230	PF00069	0.198
MOD_NEK2_1	30	35	PF00069	0.466
MOD_NEK2_1	5	10	PF00069	0.436
MOD_NEK2_1	99	104	PF00069	0.709
MOD_NEK2_2	138	143	PF00069	0.625
MOD_PIKK_1	318	324	PF00454	0.795
MOD_PKA_2	278	284	PF00069	0.801
MOD_PKA_2	318	324	PF00069	0.795
MOD_PKB_1	188	196	PF00069	0.442
MOD_Plk_1	181	187	PF00069	0.585
MOD_Plk_1	40	46	PF00069	0.724
MOD_Plk_1	99	105	PF00069	0.772
MOD_Plk_4	123	129	PF00069	0.720
MOD_Plk_4	138	144	PF00069	0.535
MOD_Plk_4	21	27	PF00069	0.404
MOD_Plk_4	211	217	PF00069	0.572
MOD_Plk_4	225	231	PF00069	0.260
MOD_Plk_4	294	300	PF00069	0.726
MOD_Plk_4	60	66	PF00069	0.678
MOD_ProDKin_1	103	109	PF00069	0.633
MOD_ProDKin_1	113	119	PF00069	0.628
MOD_ProDKin_1	142	148	PF00069	0.583
MOD_ProDKin_1	165	171	PF00069	0.609
MOD_ProDKin_1	284	290	PF00069	0.708
MOD_ProDKin_1	51	57	PF00069	0.753
MOD_ProDKin_1	70	76	PF00069	0.714
TRG_ENDOCYTIC_2	233	236	PF00928	0.411
TRG_ENDOCYTIC_2	339	342	PF00928	0.632
TRG_ER_diArg_1	161	164	PF00400	0.698
TRG_ER_diArg_1	195	197	PF00400	0.545
TRG_ER_diArg_1	241	243	PF00400	0.345
TRG_ER_diLys_1	374	378	PF00400	0.763
TRG_Pf-PMV_PEXEL_1	219	224	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAN0	Leptomonas seymouri	43%	100%
A0A3Q8IDS8	Leishmania donovani	69%	100%
A4I4M5	Leishmania infantum	69%	100%
E9AE23	Leishmania major	66%	93%
E9ALR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%