Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein 70, putative

Species:

Leishmania braziliensis

UniProt:

A4HHH4_LEIBR

TriTrypDb:

LbrM.29.1710 , LBRM2903_290024100

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 1
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HHH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH4

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.408
CLV_NRD_NRD_1	231	233	PF00675	0.506
CLV_NRD_NRD_1	412	414	PF00675	0.437
CLV_NRD_NRD_1	669	671	PF00675	0.265
CLV_PCSK_KEX2_1	412	414	PF00082	0.437
CLV_PCSK_SKI1_1	138	142	PF00082	0.460
CLV_PCSK_SKI1_1	20	24	PF00082	0.604
CLV_PCSK_SKI1_1	298	302	PF00082	0.519
CLV_PCSK_SKI1_1	413	417	PF00082	0.451
CLV_PCSK_SKI1_1	448	452	PF00082	0.227
DEG_APCC_KENBOX_2	291	295	PF00400	0.231
DEG_ODPH_VHL_1	610	622	PF01847	0.172
DOC_CDC14_PxL_1	22	30	PF14671	0.326
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.556
DOC_MAPK_DCC_7	20	30	PF00069	0.334
DOC_MAPK_gen_1	149	157	PF00069	0.269
DOC_MAPK_gen_1	232	239	PF00069	0.324
DOC_MAPK_gen_1	670	678	PF00069	0.495
DOC_MAPK_MEF2A_6	20	29	PF00069	0.473
DOC_MAPK_MEF2A_6	232	241	PF00069	0.293
DOC_PP1_RVXF_1	242	249	PF00149	0.320
DOC_PP1_RVXF_1	272	279	PF00149	0.278
DOC_PP1_RVXF_1	294	300	PF00149	0.321
DOC_PP2B_LxvP_1	193	196	PF13499	0.292
DOC_PP2B_LxvP_1	23	26	PF13499	0.339
DOC_PP2B_LxvP_1	455	458	PF13499	0.239
DOC_PP4_FxxP_1	373	376	PF00568	0.417
DOC_PP4_FxxP_1	407	410	PF00568	0.217
DOC_PP4_FxxP_1	44	47	PF00568	0.356
DOC_PP4_FxxP_1	83	86	PF00568	0.226
DOC_USP7_MATH_1	50	54	PF00917	0.408
DOC_USP7_MATH_1	528	532	PF00917	0.477
DOC_USP7_UBL2_3	174	178	PF12436	0.266
DOC_USP7_UBL2_3	292	296	PF12436	0.157
DOC_WW_Pin1_4	224	229	PF00397	0.233
DOC_WW_Pin1_4	36	41	PF00397	0.512
DOC_WW_Pin1_4	406	411	PF00397	0.217
LIG_14-3-3_CanoR_1	104	110	PF00244	0.270
LIG_14-3-3_CanoR_1	203	207	PF00244	0.330
LIG_14-3-3_CanoR_1	350	359	PF00244	0.492
LIG_14-3-3_CanoR_1	670	678	PF00244	0.426
LIG_14-3-3_CanoR_1	68	76	PF00244	0.322
LIG_APCC_ABBA_1	235	240	PF00400	0.277
LIG_BRCT_BRCA1_1	505	509	PF00533	0.268
LIG_BRCT_BRCA1_1	569	573	PF00533	0.324
LIG_BRCT_BRCA1_1	622	626	PF00533	0.328
LIG_BRCT_BRCA1_1	664	668	PF00533	0.354
LIG_BRCT_BRCA1_1	70	74	PF00533	0.393
LIG_CaM_NSCaTE_8	303	310	PF13499	0.324
LIG_EH1_1	320	328	PF00400	0.388
LIG_eIF4E_1	433	439	PF01652	0.284
LIG_FHA_1	266	272	PF00498	0.249
LIG_FHA_1	284	290	PF00498	0.275
LIG_FHA_1	3	9	PF00498	0.628
LIG_FHA_1	393	399	PF00498	0.295
LIG_FHA_1	416	422	PF00498	0.312
LIG_FHA_1	425	431	PF00498	0.257
LIG_FHA_1	450	456	PF00498	0.302
LIG_FHA_1	476	482	PF00498	0.264
LIG_FHA_1	543	549	PF00498	0.217
LIG_FHA_1	575	581	PF00498	0.321
LIG_FHA_2	163	169	PF00498	0.277
LIG_FHA_2	224	230	PF00498	0.277
LIG_FHA_2	299	305	PF00498	0.224
LIG_FHA_2	483	489	PF00498	0.277
LIG_GBD_Chelix_1	336	344	PF00786	0.200
LIG_GBD_Chelix_1	396	404	PF00786	0.172
LIG_GBD_Chelix_1	490	498	PF00786	0.172
LIG_LIR_Apic_2	371	376	PF02991	0.417
LIG_LIR_Gen_1	231	241	PF02991	0.251
LIG_LIR_Gen_1	423	434	PF02991	0.361
LIG_LIR_Gen_1	570	580	PF02991	0.298
LIG_LIR_Gen_1	77	86	PF02991	0.324
LIG_LIR_Nem_3	17	22	PF02991	0.508
LIG_LIR_Nem_3	231	237	PF02991	0.237
LIG_LIR_Nem_3	281	287	PF02991	0.293
LIG_LIR_Nem_3	301	306	PF02991	0.217
LIG_LIR_Nem_3	347	351	PF02991	0.422
LIG_LIR_Nem_3	362	368	PF02991	0.417
LIG_LIR_Nem_3	423	429	PF02991	0.361
LIG_LIR_Nem_3	570	576	PF02991	0.295
LIG_LIR_Nem_3	579	584	PF02991	0.276
LIG_LIR_Nem_3	591	597	PF02991	0.289
LIG_NRBOX	416	422	PF00104	0.344
LIG_Pex14_1	150	154	PF04695	0.277
LIG_Pex14_1	381	385	PF04695	0.524
LIG_Pex14_1	447	451	PF04695	0.417
LIG_Pex14_1	605	609	PF04695	0.417
LIG_Pex14_2	538	542	PF04695	0.343
LIG_PTB_Apo_2	104	111	PF02174	0.251
LIG_PTB_Apo_2	145	152	PF02174	0.292
LIG_PTB_Phospho_1	104	110	PF10480	0.251
LIG_PTB_Phospho_1	145	151	PF10480	0.292
LIG_SH2_CRK	673	677	PF00017	0.490
LIG_SH2_GRB2like	154	157	PF00017	0.324
LIG_SH2_GRB2like	441	444	PF00017	0.451
LIG_SH2_GRB2like	599	602	PF00017	0.451
LIG_SH2_PTP2	234	237	PF00017	0.324
LIG_SH2_SRC	45	48	PF00017	0.354
LIG_SH2_SRC	599	602	PF00017	0.451
LIG_SH2_STAP1	110	114	PF00017	0.251
LIG_SH2_STAP1	287	291	PF00017	0.238
LIG_SH2_STAT3	557	560	PF00017	0.405
LIG_SH2_STAT5	234	237	PF00017	0.300
LIG_SH2_STAT5	306	309	PF00017	0.217
LIG_SH2_STAT5	433	436	PF00017	0.266
LIG_SH2_STAT5	441	444	PF00017	0.417
LIG_SH2_STAT5	45	48	PF00017	0.334
LIG_SH2_STAT5	465	468	PF00017	0.284
LIG_SH2_STAT5	540	543	PF00017	0.210
LIG_SH2_STAT5	557	560	PF00017	0.302
LIG_SH2_STAT5	595	598	PF00017	0.426
LIG_SH2_STAT5	609	612	PF00017	0.271
LIG_SH2_STAT5	642	645	PF00017	0.233
LIG_SH3_3	369	375	PF00018	0.459
LIG_SH3_3	493	499	PF00018	0.400
LIG_SH3_3	538	544	PF00018	0.309
LIG_Sin3_3	637	644	PF02671	0.181
LIG_SUMO_SIM_anti_2	325	330	PF11976	0.261
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.172
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.201
LIG_SUMO_SIM_par_1	418	423	PF11976	0.263
LIG_SUMO_SIM_par_1	548	554	PF11976	0.281
LIG_SUMO_SIM_par_1	586	591	PF11976	0.367
LIG_SxIP_EBH_1	473	487	PF03271	0.277
LIG_TRAF2_1	250	253	PF00917	0.157
LIG_TYR_ITIM	463	468	PF00017	0.405
LIG_UBA3_1	105	113	PF00899	0.176
LIG_UBA3_1	340	346	PF00899	0.270
LIG_UBA3_1	467	473	PF00899	0.332
LIG_UBA3_1	73	80	PF00899	0.277
LIG_WRC_WIRS_1	568	573	PF05994	0.288
LIG_WRC_WIRS_1	633	638	PF05994	0.237
MOD_CDC14_SPxK_1	409	412	PF00782	0.237
MOD_CDK_SPxK_1	406	412	PF00069	0.237
MOD_CDK_SPxxK_3	406	413	PF00069	0.217
MOD_CK1_1	221	227	PF00069	0.313
MOD_CK1_1	267	273	PF00069	0.189
MOD_CK1_1	428	434	PF00069	0.372
MOD_CK1_1	629	635	PF00069	0.267
MOD_CK2_1	162	168	PF00069	0.277
MOD_CK2_1	223	229	PF00069	0.277
MOD_CK2_1	482	488	PF00069	0.277
MOD_CK2_1	66	72	PF00069	0.344
MOD_CK2_1	92	98	PF00069	0.257
MOD_GlcNHglycan	13	16	PF01048	0.676
MOD_GlcNHglycan	200	203	PF01048	0.492
MOD_GlcNHglycan	333	336	PF01048	0.366
MOD_GlcNHglycan	430	433	PF01048	0.422
MOD_GlcNHglycan	622	625	PF01048	0.312
MOD_GlcNHglycan	637	640	PF01048	0.534
MOD_GSK3_1	198	205	PF00069	0.309
MOD_GSK3_1	216	223	PF00069	0.334
MOD_GSK3_1	248	255	PF00069	0.263
MOD_GSK3_1	416	423	PF00069	0.428
MOD_GSK3_1	424	431	PF00069	0.445
MOD_GSK3_1	449	456	PF00069	0.505
MOD_GSK3_1	471	478	PF00069	0.215
MOD_GSK3_1	494	501	PF00069	0.339
MOD_GSK3_1	63	70	PF00069	0.382
MOD_GSK3_1	631	638	PF00069	0.239
MOD_GSK3_1	7	14	PF00069	0.647
MOD_LATS_1	9	15	PF00433	0.432
MOD_N-GLC_1	248	253	PF02516	0.457
MOD_N-GLC_1	278	283	PF02516	0.522
MOD_N-GLC_1	471	476	PF02516	0.298
MOD_NEK2_1	105	110	PF00069	0.309
MOD_NEK2_1	211	216	PF00069	0.307
MOD_NEK2_1	265	270	PF00069	0.274
MOD_NEK2_1	278	283	PF00069	0.124
MOD_NEK2_1	305	310	PF00069	0.261
MOD_NEK2_1	331	336	PF00069	0.285
MOD_NEK2_1	416	421	PF00069	0.369
MOD_NEK2_1	451	456	PF00069	0.370
MOD_NEK2_1	503	508	PF00069	0.288
MOD_NEK2_1	574	579	PF00069	0.369
MOD_NEK2_1	620	625	PF00069	0.287
MOD_NEK2_1	626	631	PF00069	0.262
MOD_NEK2_1	63	68	PF00069	0.310
MOD_NEK2_2	285	290	PF00069	0.213
MOD_OFUCOSY	585	592	PF10250	0.405
MOD_PIKK_1	167	173	PF00454	0.357
MOD_PIKK_1	2	8	PF00454	0.596
MOD_PK_1	242	248	PF00069	0.277
MOD_PK_1	92	98	PF00069	0.324
MOD_PKA_2	202	208	PF00069	0.363
MOD_PKA_2	67	73	PF00069	0.379
MOD_Plk_1	167	173	PF00069	0.362
MOD_Plk_1	211	217	PF00069	0.368
MOD_Plk_1	278	284	PF00069	0.303
MOD_Plk_1	50	56	PF00069	0.372
MOD_Plk_1	92	98	PF00069	0.324
MOD_Plk_4	105	111	PF00069	0.226
MOD_Plk_4	202	208	PF00069	0.160
MOD_Plk_4	278	284	PF00069	0.278
MOD_Plk_4	322	328	PF00069	0.294
MOD_Plk_4	416	422	PF00069	0.355
MOD_Plk_4	425	431	PF00069	0.258
MOD_Plk_4	482	488	PF00069	0.249
MOD_Plk_4	498	504	PF00069	0.180
MOD_Plk_4	528	534	PF00069	0.461
MOD_Plk_4	576	582	PF00069	0.215
MOD_Plk_4	647	653	PF00069	0.318
MOD_Plk_4	662	668	PF00069	0.396
MOD_ProDKin_1	224	230	PF00069	0.233
MOD_ProDKin_1	36	42	PF00069	0.518
MOD_ProDKin_1	406	412	PF00069	0.217
MOD_SUMO_for_1	91	94	PF00179	0.332
MOD_SUMO_rev_2	116	121	PF00179	0.261
MOD_SUMO_rev_2	133	143	PF00179	0.152
MOD_SUMO_rev_2	229	235	PF00179	0.209
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.517
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.239
TRG_ENDOCYTIC_2	154	157	PF00928	0.245
TRG_ENDOCYTIC_2	234	237	PF00928	0.292
TRG_ENDOCYTIC_2	465	468	PF00928	0.361
TRG_ENDOCYTIC_2	556	559	PF00928	0.340
TRG_ENDOCYTIC_2	568	571	PF00928	0.174
TRG_ENDOCYTIC_2	594	597	PF00928	0.417
TRG_ENDOCYTIC_2	645	648	PF00928	0.237
TRG_ENDOCYTIC_2	673	676	PF00928	0.477
TRG_ENDOCYTIC_2	78	81	PF00928	0.226
TRG_NES_CRM1_1	103	117	PF08389	0.272
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.217

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	61%	100%
A0A0N1I2B1	Leptomonas seymouri	29%	100%
A0A0N1I6Y7	Leptomonas seymouri	30%	100%
A0A0S4IV41	Bodo saltans	31%	100%
A0A0S4J9X2	Bodo saltans	40%	100%
A0A0S4JBB1	Bodo saltans	34%	100%
A0A0S4JCH7	Bodo saltans	33%	99%
A0A0S4JEU5	Bodo saltans	26%	100%
A0A0S4JIF4	Bodo saltans	36%	100%
A0A0S4JWZ9	Bodo saltans	22%	100%
A0A0S4JZ31	Bodo saltans	26%	100%
A0A1X0NJN3	Trypanosomatidae	23%	100%
A0A1X0NK64	Trypanosomatidae	28%	100%
A0A1X0NLM6	Trypanosomatidae	21%	100%
A0A1X0NZX5	Trypanosomatidae	48%	100%
A0A1X0P2G3	Trypanosomatidae	31%	100%
A0A1X0P6M4	Trypanosomatidae	28%	89%
A0A1X0PA12	Trypanosomatidae	32%	100%
A0A3Q8IBT4	Leishmania donovani	25%	100%
A0A3Q8IFM1	Leishmania donovani	29%	100%
A0A3Q8IHT3	Leishmania donovani	29%	100%
A0A3R7MBZ3	Trypanosoma rangeli	31%	100%
A0A3S7X2L7	Leishmania donovani	81%	100%
A0A422NED2	Trypanosoma rangeli	48%	100%
A0A422NMS9	Trypanosoma rangeli	31%	100%
A0A422P482	Trypanosoma rangeli	23%	100%
A4H7C1	Leishmania braziliensis	24%	100%
A4HB85	Leishmania braziliensis	29%	98%
A4HHY3	Leishmania braziliensis	29%	100%
A4HVR6	Leishmania infantum	25%	100%
A4I4M3	Leishmania infantum	81%	100%
A4I563	Leishmania infantum	30%	100%
A4IAD3	Leishmania infantum	29%	100%
A4IFE9	Bos taurus	27%	100%
A5D7E2	Bos taurus	33%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	93%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AE21	Leishmania major	82%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
F4HW17	Arabidopsis thaliana	26%	100%
F4JRE0	Arabidopsis thaliana	30%	100%
F4KIB2	Arabidopsis thaliana	32%	100%
O15321	Homo sapiens	27%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P58021	Mus musculus	30%	100%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4KLL4	Rattus norvegicus	33%	100%
Q4Q2H8	Leishmania major	29%	99%
Q4Q7S3	Leishmania major	29%	97%
Q4QG16	Leishmania major	22%	90%
Q54ZW0	Dictyostelium discoideum	25%	100%
Q55FP0	Dictyostelium discoideum	30%	100%
Q5R8F1	Pongo abelii	27%	100%
Q5R8Y6	Pongo abelii	30%	100%
Q5RDY2	Pongo abelii	33%	100%
Q66HF2	Rattus norvegicus	27%	100%
Q66HG5	Rattus norvegicus	29%	100%
Q7YTA6	Dictyostelium discoideum	21%	100%
Q8BH24	Mus musculus	33%	100%
Q8RWW1	Arabidopsis thaliana	33%	100%
Q92544	Homo sapiens	33%	100%
Q940G0	Arabidopsis thaliana	27%	100%
Q940S0	Arabidopsis thaliana	27%	100%
Q99805	Homo sapiens	30%	100%
Q9C5N2	Arabidopsis thaliana	34%	100%
Q9C720	Arabidopsis thaliana	32%	100%
Q9DBU0	Mus musculus	27%	100%
Q9FHT4	Arabidopsis thaliana	28%	100%
Q9FYQ8	Arabidopsis thaliana	31%	100%
Q9LIC2	Arabidopsis thaliana	32%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9ZPS7	Arabidopsis thaliana	27%	100%
V5BCD5	Trypanosoma cruzi	31%	100%
V5BHS7	Trypanosoma cruzi	28%	100%
V5D9U0	Trypanosoma cruzi	48%	100%