Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHH3_LEIBR

TriTrypDb:

LbrM.29.1700 , LBRM2903_290024000

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.566
CLV_C14_Caspase3-7	349	353	PF00656	0.558
CLV_C14_Caspase3-7	473	477	PF00656	0.558
CLV_C14_Caspase3-7	547	551	PF00656	0.558
CLV_MEL_PAP_1	533	539	PF00089	0.557
CLV_NRD_NRD_1	211	213	PF00675	0.828
CLV_NRD_NRD_1	330	332	PF00675	0.781
CLV_NRD_NRD_1	361	363	PF00675	0.765
CLV_NRD_NRD_1	426	428	PF00675	0.592
CLV_NRD_NRD_1	437	439	PF00675	0.642
CLV_NRD_NRD_1	440	442	PF00675	0.666
CLV_NRD_NRD_1	56	58	PF00675	0.553
CLV_NRD_NRD_1	616	618	PF00675	0.740
CLV_NRD_NRD_1	641	643	PF00675	0.614
CLV_NRD_NRD_1	702	704	PF00675	0.572
CLV_PCSK_FUR_1	438	442	PF00082	0.513
CLV_PCSK_KEX2_1	211	213	PF00082	0.743
CLV_PCSK_KEX2_1	329	331	PF00082	0.793
CLV_PCSK_KEX2_1	361	363	PF00082	0.765
CLV_PCSK_KEX2_1	426	428	PF00082	0.592
CLV_PCSK_KEX2_1	439	441	PF00082	0.659
CLV_PCSK_KEX2_1	56	58	PF00082	0.553
CLV_PCSK_KEX2_1	616	618	PF00082	0.579
CLV_PCSK_KEX2_1	641	643	PF00082	0.837
CLV_PCSK_KEX2_1	701	703	PF00082	0.584
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.513
CLV_PCSK_PC7_1	207	213	PF00082	0.572
CLV_PCSK_PC7_1	326	332	PF00082	0.545
CLV_PCSK_SKI1_1	417	421	PF00082	0.687
CLV_PCSK_SKI1_1	426	430	PF00082	0.581
CLV_PCSK_SKI1_1	59	63	PF00082	0.775
CLV_PCSK_SKI1_1	644	648	PF00082	0.632
DEG_APCC_DBOX_1	425	433	PF00400	0.594
DEG_SCF_FBW7_1	24	30	PF00400	0.560
DEG_SCF_FBW7_1	684	691	PF00400	0.553
DEG_SPOP_SBC_1	156	160	PF00917	0.556
DEG_SPOP_SBC_1	193	197	PF00917	0.538
DEG_SPOP_SBC_1	460	464	PF00917	0.605
DEG_SPOP_SBC_1	585	589	PF00917	0.622
DEG_SPOP_SBC_1	599	603	PF00917	0.669
DEG_SPOP_SBC_1	7	11	PF00917	0.740
DOC_CKS1_1	142	147	PF01111	0.522
DOC_CKS1_1	24	29	PF01111	0.560
DOC_CKS1_1	333	338	PF01111	0.619
DOC_CKS1_1	685	690	PF01111	0.764
DOC_CYCLIN_yCln2_LP_2	396	399	PF00134	0.563
DOC_MAPK_gen_1	514	522	PF00069	0.553
DOC_MAPK_gen_1	56	63	PF00069	0.538
DOC_MAPK_MEF2A_6	361	370	PF00069	0.696
DOC_PP1_RVXF_1	57	64	PF00149	0.677
DOC_PP2B_LxvP_1	318	321	PF13499	0.503
DOC_PP2B_LxvP_1	396	399	PF13499	0.660
DOC_PP4_FxxP_1	449	452	PF00568	0.562
DOC_USP7_MATH_1	157	161	PF00917	0.756
DOC_USP7_MATH_1	163	167	PF00917	0.651
DOC_USP7_MATH_1	170	174	PF00917	0.564
DOC_USP7_MATH_1	18	22	PF00917	0.667
DOC_USP7_MATH_1	193	197	PF00917	0.685
DOC_USP7_MATH_1	206	210	PF00917	0.513
DOC_USP7_MATH_1	255	259	PF00917	0.752
DOC_USP7_MATH_1	264	268	PF00917	0.691
DOC_USP7_MATH_1	346	350	PF00917	0.714
DOC_USP7_MATH_1	354	358	PF00917	0.814
DOC_USP7_MATH_1	36	40	PF00917	0.653
DOC_USP7_MATH_1	366	370	PF00917	0.554
DOC_USP7_MATH_1	51	55	PF00917	0.653
DOC_USP7_MATH_1	529	533	PF00917	0.572
DOC_USP7_MATH_1	549	553	PF00917	0.615
DOC_USP7_MATH_1	600	604	PF00917	0.594
DOC_USP7_MATH_1	631	635	PF00917	0.815
DOC_USP7_MATH_1	688	692	PF00917	0.763
DOC_USP7_MATH_1	8	12	PF00917	0.674
DOC_WW_Pin1_4	141	146	PF00397	0.623
DOC_WW_Pin1_4	23	28	PF00397	0.765
DOC_WW_Pin1_4	260	265	PF00397	0.715
DOC_WW_Pin1_4	283	288	PF00397	0.686
DOC_WW_Pin1_4	310	315	PF00397	0.680
DOC_WW_Pin1_4	329	334	PF00397	0.700
DOC_WW_Pin1_4	362	367	PF00397	0.692
DOC_WW_Pin1_4	410	415	PF00397	0.823
DOC_WW_Pin1_4	456	461	PF00397	0.774
DOC_WW_Pin1_4	463	468	PF00397	0.803
DOC_WW_Pin1_4	525	530	PF00397	0.542
DOC_WW_Pin1_4	604	609	PF00397	0.740
DOC_WW_Pin1_4	644	649	PF00397	0.592
DOC_WW_Pin1_4	684	689	PF00397	0.760
LIG_14-3-3_CanoR_1	182	192	PF00244	0.578
LIG_14-3-3_CanoR_1	239	244	PF00244	0.774
LIG_14-3-3_CanoR_1	283	287	PF00244	0.688
LIG_14-3-3_CanoR_1	361	366	PF00244	0.684
LIG_14-3-3_CanoR_1	400	405	PF00244	0.607
LIG_14-3-3_CanoR_1	453	461	PF00244	0.694
LIG_14-3-3_CanoR_1	536	543	PF00244	0.651
LIG_14-3-3_CanoR_1	565	571	PF00244	0.753
LIG_14-3-3_CanoR_1	586	591	PF00244	0.655
LIG_14-3-3_CanoR_1	59	64	PF00244	0.663
LIG_14-3-3_CanoR_1	6	14	PF00244	0.715
LIG_14-3-3_CanoR_1	649	657	PF00244	0.592
LIG_14-3-3_CanoR_1	689	697	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BIR_III_4	474	478	PF00653	0.555
LIG_BRCT_BRCA1_1	131	135	PF00533	0.626
LIG_BRCT_BRCA1_1	239	243	PF00533	0.577
LIG_BRCT_BRCA1_1	366	370	PF00533	0.545
LIG_CtBP_PxDLS_1	336	340	PF00389	0.556
LIG_deltaCOP1_diTrp_1	126	135	PF00928	0.669
LIG_EVH1_1	318	322	PF00568	0.504
LIG_FHA_1	156	162	PF00498	0.561
LIG_FHA_1	173	179	PF00498	0.560
LIG_FHA_1	2	8	PF00498	0.746
LIG_FHA_1	385	391	PF00498	0.581
LIG_FHA_1	399	405	PF00498	0.746
LIG_FHA_1	432	438	PF00498	0.489
LIG_FHA_1	528	534	PF00498	0.548
LIG_FHA_1	56	62	PF00498	0.664
LIG_FHA_1	94	100	PF00498	0.792
LIG_FHA_2	195	201	PF00498	0.548
LIG_FHA_2	60	66	PF00498	0.762
LIG_LIR_Apic_2	694	700	PF02991	0.574
LIG_LIR_Gen_1	132	143	PF02991	0.481
LIG_LIR_Gen_1	226	236	PF02991	0.533
LIG_LIR_Gen_1	367	378	PF02991	0.549
LIG_LIR_Nem_3	132	138	PF02991	0.474
LIG_LIR_Nem_3	226	231	PF02991	0.641
LIG_LIR_Nem_3	367	373	PF02991	0.582
LIG_NRP_CendR_1	707	708	PF00754	0.676
LIG_Pex14_2	135	139	PF04695	0.616
LIG_SH2_CRK	284	288	PF00017	0.537
LIG_SH2_STAT5	223	226	PF00017	0.535
LIG_SH2_STAT5	70	73	PF00017	0.638
LIG_SH3_1	330	336	PF00018	0.543
LIG_SH3_3	11	17	PF00018	0.536
LIG_SH3_3	166	172	PF00018	0.716
LIG_SH3_3	304	310	PF00018	0.676
LIG_SH3_3	316	322	PF00018	0.600
LIG_SH3_3	330	336	PF00018	0.666
LIG_SH3_3	519	525	PF00018	0.544
LIG_SH3_3	680	686	PF00018	0.760
LIG_SH3_3	82	88	PF00018	0.570
LIG_SH3_CIN85_PxpxPR_1	684	689	PF14604	0.797
LIG_SUMO_SIM_par_1	321	327	PF11976	0.764
LIG_TRAF2_1	44	47	PF00917	0.739
LIG_WRC_WIRS_1	185	190	PF05994	0.539
LIG_WRC_WIRS_1	228	233	PF05994	0.538
LIG_WW_2	169	172	PF00397	0.729
LIG_WW_3	397	401	PF00397	0.610
MOD_CDK_SPK_2	27	32	PF00069	0.559
MOD_CDK_SPK_2	644	649	PF00069	0.592
MOD_CDK_SPK_2	684	689	PF00069	0.550
MOD_CDK_SPxxK_3	410	417	PF00069	0.575
MOD_CDK_SPxxK_3	463	470	PF00069	0.597
MOD_CDK_SPxxK_3	604	611	PF00069	0.572
MOD_CK1_1	10	16	PF00069	0.697
MOD_CK1_1	181	187	PF00069	0.753
MOD_CK1_1	191	197	PF00069	0.664
MOD_CK1_1	227	233	PF00069	0.723
MOD_CK1_1	267	273	PF00069	0.757
MOD_CK1_1	275	281	PF00069	0.604
MOD_CK1_1	332	338	PF00069	0.660
MOD_CK1_1	364	370	PF00069	0.642
MOD_CK1_1	39	45	PF00069	0.726
MOD_CK1_1	459	465	PF00069	0.626
MOD_CK1_1	469	475	PF00069	0.753
MOD_CK1_1	527	533	PF00069	0.729
MOD_CK1_1	535	541	PF00069	0.607
MOD_CK1_1	548	554	PF00069	0.551
MOD_CK1_1	564	570	PF00069	0.629
MOD_CK1_1	576	582	PF00069	0.660
MOD_CK1_1	592	598	PF00069	0.635
MOD_CK1_1	620	626	PF00069	0.798
MOD_CK1_1	691	697	PF00069	0.794
MOD_CK2_1	194	200	PF00069	0.546
MOD_CK2_1	267	273	PF00069	0.833
MOD_CK2_1	373	379	PF00069	0.739
MOD_CK2_1	419	425	PF00069	0.615
MOD_CK2_1	459	465	PF00069	0.599
MOD_CK2_1	59	65	PF00069	0.528
MOD_DYRK1A_RPxSP_1	644	648	PF00069	0.591
MOD_GlcNHglycan	151	154	PF01048	0.805
MOD_GlcNHglycan	188	191	PF01048	0.751
MOD_GlcNHglycan	208	211	PF01048	0.489
MOD_GlcNHglycan	233	236	PF01048	0.677
MOD_GlcNHglycan	257	260	PF01048	0.822
MOD_GlcNHglycan	27	30	PF01048	0.587
MOD_GlcNHglycan	314	317	PF01048	0.613
MOD_GlcNHglycan	348	351	PF01048	0.726
MOD_GlcNHglycan	37	41	PF01048	0.621
MOD_GlcNHglycan	382	385	PF01048	0.786
MOD_GlcNHglycan	456	459	PF01048	0.814
MOD_GlcNHglycan	488	491	PF01048	0.643
MOD_GlcNHglycan	53	56	PF01048	0.685
MOD_GlcNHglycan	539	542	PF01048	0.607
MOD_GlcNHglycan	544	550	PF01048	0.638
MOD_GlcNHglycan	558	561	PF01048	0.553
MOD_GlcNHglycan	575	578	PF01048	0.684
MOD_GlcNHglycan	591	594	PF01048	0.594
MOD_GlcNHglycan	597	600	PF01048	0.555
MOD_GlcNHglycan	612	615	PF01048	0.554
MOD_GlcNHglycan	617	620	PF01048	0.511
MOD_GlcNHglycan	633	636	PF01048	0.756
MOD_GlcNHglycan	657	660	PF01048	0.651
MOD_GlcNHglycan	690	693	PF01048	0.664
MOD_GlcNHglycan	703	706	PF01048	0.537
MOD_GSK3_1	151	158	PF00069	0.587
MOD_GSK3_1	184	191	PF00069	0.750
MOD_GSK3_1	192	199	PF00069	0.737
MOD_GSK3_1	223	230	PF00069	0.755
MOD_GSK3_1	23	30	PF00069	0.612
MOD_GSK3_1	231	238	PF00069	0.677
MOD_GSK3_1	239	246	PF00069	0.693
MOD_GSK3_1	260	267	PF00069	0.696
MOD_GSK3_1	272	279	PF00069	0.712
MOD_GSK3_1	283	290	PF00069	0.585
MOD_GSK3_1	308	315	PF00069	0.773
MOD_GSK3_1	35	42	PF00069	0.769
MOD_GSK3_1	362	369	PF00069	0.755
MOD_GSK3_1	380	387	PF00069	0.715
MOD_GSK3_1	456	463	PF00069	0.704
MOD_GSK3_1	466	473	PF00069	0.658
MOD_GSK3_1	51	58	PF00069	0.790
MOD_GSK3_1	525	532	PF00069	0.740
MOD_GSK3_1	544	551	PF00069	0.563
MOD_GSK3_1	552	559	PF00069	0.623
MOD_GSK3_1	560	567	PF00069	0.579
MOD_GSK3_1	571	578	PF00069	0.662
MOD_GSK3_1	585	592	PF00069	0.609
MOD_GSK3_1	594	601	PF00069	0.783
MOD_GSK3_1	6	13	PF00069	0.664
MOD_GSK3_1	615	622	PF00069	0.663
MOD_GSK3_1	627	634	PF00069	0.755
MOD_GSK3_1	684	691	PF00069	0.615
MOD_GSK3_1	93	100	PF00069	0.636
MOD_LATS_1	508	514	PF00433	0.569
MOD_N-GLC_1	267	272	PF02516	0.620
MOD_N-GLC_1	303	308	PF02516	0.691
MOD_N-GLC_1	454	459	PF02516	0.586
MOD_NEK2_1	1	6	PF00069	0.783
MOD_NEK2_1	113	118	PF00069	0.625
MOD_NEK2_1	188	193	PF00069	0.729
MOD_NEK2_1	201	206	PF00069	0.508
MOD_NEK2_1	231	236	PF00069	0.613
MOD_NEK2_1	243	248	PF00069	0.549
MOD_NEK2_1	295	300	PF00069	0.681
MOD_NEK2_1	419	424	PF00069	0.721
MOD_NEK2_1	485	490	PF00069	0.730
MOD_NEK2_1	497	502	PF00069	0.691
MOD_NEK2_1	637	642	PF00069	0.583
MOD_NEK2_1	657	662	PF00069	0.495
MOD_NEK2_1	98	103	PF00069	0.597
MOD_NEK2_2	18	23	PF00069	0.531
MOD_NEK2_2	386	391	PF00069	0.572
MOD_NEK2_2	549	554	PF00069	0.554
MOD_NEK2_2	600	605	PF00069	0.553
MOD_OFUCOSY	665	670	PF10250	0.536
MOD_PIKK_1	272	278	PF00454	0.574
MOD_PIKK_1	398	404	PF00454	0.622
MOD_PIKK_1	617	623	PF00454	0.817
MOD_PIKK_1	657	663	PF00454	0.781
MOD_PKA_1	361	367	PF00069	0.576
MOD_PKA_1	701	707	PF00069	0.573
MOD_PKA_2	178	184	PF00069	0.749
MOD_PKA_2	206	212	PF00069	0.688
MOD_PKA_2	255	261	PF00069	0.655
MOD_PKA_2	282	288	PF00069	0.689
MOD_PKA_2	361	367	PF00069	0.723
MOD_PKA_2	497	503	PF00069	0.720
MOD_PKA_2	516	522	PF00069	0.696
MOD_PKA_2	535	541	PF00069	0.621
MOD_PKA_2	55	61	PF00069	0.718
MOD_PKA_2	564	570	PF00069	0.754
MOD_PKA_2	585	591	PF00069	0.578
MOD_PKA_2	610	616	PF00069	0.649
MOD_PKA_2	655	661	PF00069	0.641
MOD_PKA_2	688	694	PF00069	0.566
MOD_PKA_2	701	707	PF00069	0.520
MOD_PKB_1	57	65	PF00069	0.538
MOD_Plk_1	267	273	PF00069	0.586
MOD_Plk_1	303	309	PF00069	0.690
MOD_Plk_1	392	398	PF00069	0.578
MOD_Plk_1	549	555	PF00069	0.554
MOD_Plk_1	625	631	PF00069	0.812
MOD_Plk_1	64	70	PF00069	0.514
MOD_Plk_4	172	178	PF00069	0.600
MOD_Plk_4	303	309	PF00069	0.607
MOD_Plk_4	392	398	PF00069	0.578
MOD_ProDKin_1	141	147	PF00069	0.627
MOD_ProDKin_1	23	29	PF00069	0.768
MOD_ProDKin_1	260	266	PF00069	0.717
MOD_ProDKin_1	283	289	PF00069	0.684
MOD_ProDKin_1	310	316	PF00069	0.678
MOD_ProDKin_1	329	335	PF00069	0.699
MOD_ProDKin_1	362	368	PF00069	0.692
MOD_ProDKin_1	410	416	PF00069	0.822
MOD_ProDKin_1	456	462	PF00069	0.776
MOD_ProDKin_1	463	469	PF00069	0.803
MOD_ProDKin_1	525	531	PF00069	0.542
MOD_ProDKin_1	604	610	PF00069	0.742
MOD_ProDKin_1	644	650	PF00069	0.592
MOD_ProDKin_1	684	690	PF00069	0.762
MOD_SUMO_for_1	390	393	PF00179	0.585
TRG_DiLeu_BaEn_2	444	450	PF01217	0.553
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.586
TRG_ENDOCYTIC_2	228	231	PF00928	0.638
TRG_ER_diArg_1	211	213	PF00400	0.571
TRG_ER_diArg_1	328	331	PF00400	0.697
TRG_ER_diArg_1	361	363	PF00400	0.739
TRG_ER_diArg_1	426	428	PF00400	0.592
TRG_ER_diArg_1	437	440	PF00400	0.648
TRG_ER_diArg_1	56	59	PF00400	0.552
TRG_ER_diArg_1	615	617	PF00400	0.578
TRG_ER_diArg_1	641	644	PF00400	0.632
TRG_ER_diArg_1	654	657	PF00400	0.554
TRG_ER_diArg_1	700	703	PF00400	0.765
TRG_ER_diArg_1	84	87	PF00400	0.576
TRG_NLS_Bipartite_1	426	443	PF00514	0.478
TRG_NLS_MonoCore_2	437	442	PF00514	0.508
TRG_NLS_MonoExtN_4	438	443	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I428	Leptomonas seymouri	30%	80%
A0A3Q8IF77	Leishmania donovani	51%	70%
A4I4M2	Leishmania infantum	52%	70%
E9AE20	Leishmania major	49%	100%
E9ALR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	70%