LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HHH2_LEIBR
TriTrypDb:
LbrM.29.1690 , LBRM2903_290023900 *
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHH2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.516
CLV_PCSK_SKI1_1 19 23 PF00082 0.537
DEG_Nend_UBRbox_3 1 3 PF02207 0.619
DOC_WW_Pin1_4 4 9 PF00397 0.693
LIG_14-3-3_CanoR_1 17 26 PF00244 0.492
LIG_FHA_1 13 19 PF00498 0.571
LIG_LIR_Apic_2 100 105 PF02991 0.571
LIG_LIR_Nem_3 55 60 PF02991 0.553
LIG_SH2_NCK_1 29 33 PF00017 0.400
LIG_SH2_STAT5 33 36 PF00017 0.410
LIG_SH3_3 98 104 PF00018 0.518
LIG_TRAF2_1 42 45 PF00917 0.646
LIG_TRAF2_1 78 81 PF00917 0.481
MOD_CDK_SPxK_1 4 10 PF00069 0.494
MOD_CK1_1 35 41 PF00069 0.443
MOD_CK1_1 50 56 PF00069 0.462
MOD_GlcNHglycan 87 90 PF01048 0.655
MOD_GSK3_1 46 53 PF00069 0.489
MOD_NEK2_1 22 27 PF00069 0.541
MOD_NEK2_1 47 52 PF00069 0.665
MOD_PKA_2 9 15 PF00069 0.649
MOD_ProDKin_1 4 10 PF00069 0.693
TRG_DiLeu_BaEn_4 80 86 PF01217 0.537
TRG_ER_diArg_1 16 19 PF00400 0.667
TRG_Pf-PMV_PEXEL_1 63 67 PF00026 0.586

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PED8 Leptomonas seymouri 51% 100%
A0A3S7X2H6 Leishmania donovani 80% 100%
A0A422NEF5 Trypanosoma rangeli 38% 89%
A4I4M1 Leishmania infantum 80% 100%
E9AE19 Leishmania major 80% 100%
E9ALR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS