UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XPC-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHH1_LEIBR

TriTrypDb:

LbrM.29.1680 , LBRM2903_290023800

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HHH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006289	nucleotide-excision repair	6	8
GO:0006508	proteolysis	4	8
GO:0006511	ubiquitin-dependent protein catabolic process	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009057	macromolecule catabolic process	4	8
GO:0009987	cellular process	1	8
GO:0010498	proteasomal protein catabolic process	5	8
GO:0019538	protein metabolic process	3	8
GO:0019941	modification-dependent protein catabolic process	6	8
GO:0030163	protein catabolic process	4	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043632	modification-dependent macromolecule catabolic process	5	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044248	cellular catabolic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044265	obsolete cellular macromolecule catabolic process	4	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051603	proteolysis involved in protein catabolic process	5	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901565	organonitrogen compound catabolic process	4	8
GO:1901575	organic substance catabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0005515	protein binding	2	2
GO:0031593	polyubiquitin modification-dependent protein binding	4	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140030	modification-dependent protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.676
CLV_NRD_NRD_1	299	301	PF00675	0.483
CLV_PCSK_KEX2_1	135	137	PF00082	0.722
CLV_PCSK_KEX2_1	299	301	PF00082	0.483
CLV_PCSK_KEX2_1	89	91	PF00082	0.431
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.722
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.431
CLV_PCSK_SKI1_1	25	29	PF00082	0.553
CLV_PCSK_SKI1_1	377	381	PF00082	0.312
CLV_PCSK_SKI1_1	89	93	PF00082	0.478
DEG_Nend_UBRbox_1	1	4	PF02207	0.410
DOC_CKS1_1	145	150	PF01111	0.531
DOC_MAPK_MEF2A_6	40	47	PF00069	0.410
DOC_PP1_RVXF_1	375	381	PF00149	0.312
DOC_PP4_FxxP_1	129	132	PF00568	0.532
DOC_PP4_FxxP_1	395	398	PF00568	0.510
DOC_WW_Pin1_4	144	149	PF00397	0.622
DOC_WW_Pin1_4	72	77	PF00397	0.707
LIG_14-3-3_CanoR_1	40	44	PF00244	0.505
LIG_14-3-3_CanoR_1	90	97	PF00244	0.413
LIG_BIR_III_4	330	334	PF00653	0.524
LIG_EH1_1	2	10	PF00400	0.455
LIG_FHA_1	22	28	PF00498	0.362
LIG_FHA_1	4	10	PF00498	0.446
LIG_FHA_1	40	46	PF00498	0.413
LIG_Integrin_RGD_1	300	302	PF01839	0.491
LIG_LIR_Gen_1	185	195	PF02991	0.539
LIG_LIR_Gen_1	221	227	PF02991	0.507
LIG_LIR_Gen_1	231	237	PF02991	0.377
LIG_LIR_Nem_3	185	190	PF02991	0.531
LIG_LIR_Nem_3	221	226	PF02991	0.462
LIG_LIR_Nem_3	231	236	PF02991	0.412
LIG_LIR_Nem_3	288	293	PF02991	0.571
LIG_PAM2_1	47	59	PF00658	0.347
LIG_Pex14_2	54	58	PF04695	0.480
LIG_SH2_STAT5	110	113	PF00017	0.481
LIG_SH2_STAT5	293	296	PF00017	0.552
LIG_SH3_3	142	148	PF00018	0.794
LIG_SH3_3	26	32	PF00018	0.539
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.434
LIG_SUMO_SIM_anti_2	196	201	PF11976	0.506
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.512
LIG_TRAF2_1	152	155	PF00917	0.670
LIG_TRAF2_1	164	167	PF00917	0.658
LIG_TRAF2_1	189	192	PF00917	0.420
LIG_TRAF2_1	355	358	PF00917	0.477
MOD_CK1_1	11	17	PF00069	0.529
MOD_CK1_1	329	335	PF00069	0.541
MOD_CK1_1	74	80	PF00069	0.694
MOD_CK2_1	149	155	PF00069	0.664
MOD_CK2_1	160	166	PF00069	0.592
MOD_CK2_1	267	273	PF00069	0.749
MOD_GlcNHglycan	151	154	PF01048	0.612
MOD_GlcNHglycan	159	165	PF01048	0.599
MOD_GlcNHglycan	295	298	PF01048	0.538
MOD_GlcNHglycan	315	319	PF01048	0.579
MOD_GlcNHglycan	330	334	PF01048	0.698
MOD_GlcNHglycan	66	71	PF01048	0.741
MOD_GSK3_1	17	24	PF00069	0.544
MOD_GSK3_1	263	270	PF00069	0.682
MOD_GSK3_1	3	10	PF00069	0.451
MOD_GSK3_1	349	356	PF00069	0.551
MOD_GSK3_1	62	69	PF00069	0.693
MOD_GSK3_1	74	81	PF00069	0.597
MOD_N-GLC_1	108	113	PF02516	0.630
MOD_N-GLC_1	12	17	PF02516	0.485
MOD_NEK2_1	267	272	PF00069	0.748
MOD_NEK2_1	3	8	PF00069	0.480
MOD_NEK2_1	314	319	PF00069	0.626
MOD_NEK2_1	349	354	PF00069	0.538
MOD_NEK2_1	39	44	PF00069	0.461
MOD_NEK2_1	78	83	PF00069	0.600
MOD_PKA_2	388	394	PF00069	0.373
MOD_PKA_2	39	45	PF00069	0.479
MOD_Plk_1	108	114	PF00069	0.636
MOD_Plk_1	12	18	PF00069	0.488
MOD_Plk_1	160	166	PF00069	0.564
MOD_Plk_1	195	201	PF00069	0.517
MOD_Plk_1	25	31	PF00069	0.550
MOD_Plk_1	267	273	PF00069	0.609
MOD_Plk_2-3	171	177	PF00069	0.754
MOD_Plk_2-3	263	269	PF00069	0.653
MOD_Plk_4	101	107	PF00069	0.493
MOD_Plk_4	12	18	PF00069	0.532
MOD_Plk_4	195	201	PF00069	0.517
MOD_Plk_4	218	224	PF00069	0.522
MOD_Plk_4	229	235	PF00069	0.506
MOD_Plk_4	78	84	PF00069	0.519
MOD_ProDKin_1	144	150	PF00069	0.627
MOD_ProDKin_1	72	78	PF00069	0.706
MOD_SUMO_rev_2	356	363	PF00179	0.312
TRG_DiLeu_BaEn_2	145	151	PF01217	0.560
TRG_DiLeu_BaEn_4	160	166	PF01217	0.667
TRG_DiLeu_BaEn_4	262	268	PF01217	0.629
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.422
TRG_ER_diArg_1	136	139	PF00400	0.722
TRG_NLS_MonoExtC_3	134	140	PF00514	0.681
TRG_NLS_MonoExtN_4	132	139	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I958	Leptomonas seymouri	61%	100%
A0A3Q8IFF1	Leishmania donovani	77%	100%
A4I4M0	Leishmania infantum	77%	100%
E9AE18	Leishmania major	75%	98%
E9ALR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5B988	Trypanosoma cruzi	28%	100%