WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHH0_LEIBR

TriTrypDb:

LbrM.29.1670 , LBRM2903_290023700

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0019898	extrinsic component of membrane	2	1
GO:0034045	phagophore assembly site membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHH0

Function

Biological processes
Term	Name	Level	Count
GO:0000422	autophagy of mitochondrion	4	1
GO:0006497	protein lipidation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1
GO:0022411	cellular component disassembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0034497	protein localization to phagophore assembly site	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044804	autophagy of nucleus	4	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0061726	mitochondrion disassembly	6	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903008	organelle disassembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032266	phosphatidylinositol-3-phosphate binding	6	1
GO:0035091	phosphatidylinositol binding	4	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1
GO:1902936	phosphatidylinositol bisphosphate binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.789
CLV_NRD_NRD_1	254	256	PF00675	0.799
CLV_PCSK_KEX2_1	253	255	PF00082	0.814
CLV_PCSK_SKI1_1	329	333	PF00082	0.760
CLV_PCSK_SKI1_1	8	12	PF00082	0.750
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	90	94	PF00917	0.586
DOC_ANK_TNKS_1	118	125	PF00023	0.650
DOC_MAPK_gen_1	153	163	PF00069	0.645
DOC_MAPK_gen_1	37	45	PF00069	0.540
DOC_MAPK_MEF2A_6	156	165	PF00069	0.643
DOC_PP4_FxxP_1	345	348	PF00568	0.758
DOC_USP7_MATH_1	128	132	PF00917	0.620
DOC_USP7_MATH_1	16	20	PF00917	0.769
DOC_USP7_MATH_1	192	196	PF00917	0.491
DOC_USP7_MATH_1	206	210	PF00917	0.646
DOC_USP7_MATH_1	220	224	PF00917	0.732
DOC_USP7_MATH_1	239	243	PF00917	0.482
DOC_USP7_MATH_1	263	267	PF00917	0.810
DOC_USP7_MATH_1	276	280	PF00917	0.610
DOC_USP7_MATH_1	327	331	PF00917	0.701
DOC_USP7_MATH_1	71	75	PF00917	0.604
DOC_WW_Pin1_4	200	205	PF00397	0.542
DOC_WW_Pin1_4	209	214	PF00397	0.811
DOC_WW_Pin1_4	279	284	PF00397	0.580
DOC_WW_Pin1_4	331	336	PF00397	0.741
DOC_WW_Pin1_4	346	351	PF00397	0.487
DOC_WW_Pin1_4	97	102	PF00397	0.807
LIG_14-3-3_CanoR_1	125	133	PF00244	0.631
LIG_14-3-3_CanoR_1	197	202	PF00244	0.634
LIG_14-3-3_CanoR_1	238	247	PF00244	0.561
LIG_14-3-3_CanoR_1	254	260	PF00244	0.512
LIG_14-3-3_CanoR_1	268	275	PF00244	0.523
LIG_14-3-3_CanoR_1	66	71	PF00244	0.610
LIG_BRCT_BRCA1_1	92	96	PF00533	0.731
LIG_deltaCOP1_diTrp_1	291	300	PF00928	0.663
LIG_FHA_1	134	140	PF00498	0.598
LIG_FHA_1	142	148	PF00498	0.505
LIG_FHA_1	178	184	PF00498	0.442
LIG_FHA_1	280	286	PF00498	0.575
LIG_FHA_1	304	310	PF00498	0.583
LIG_FHA_2	127	133	PF00498	0.627
LIG_Integrin_RGD_1	40	42	PF01839	0.528
LIG_LIR_Gen_1	366	374	PF02991	0.522
LIG_LIR_Nem_3	366	372	PF02991	0.516
LIG_PDZ_Class_2	369	374	PF00595	0.756
LIG_SH2_CRK	2	6	PF00017	0.765
LIG_SH2_CRK	369	373	PF00017	0.518
LIG_SH2_NCK_1	275	279	PF00017	0.594
LIG_SH2_NCK_1	28	32	PF00017	0.701
LIG_SH2_PTP2	371	374	PF00017	0.767
LIG_SH2_SRC	275	278	PF00017	0.828
LIG_SH2_STAP1	28	32	PF00017	0.701
LIG_SH2_STAT5	371	374	PF00017	0.767
LIG_SH3_3	1	7	PF00018	0.823
LIG_SH3_3	198	204	PF00018	0.517
LIG_SH3_3	27	33	PF00018	0.708
LIG_SUMO_SIM_anti_2	42	47	PF11976	0.688
LIG_SUMO_SIM_par_1	44	50	PF11976	0.487
LIG_SUMO_SIM_par_1	66	72	PF11976	0.596
LIG_SUMO_SIM_par_1	9	14	PF11976	0.746
MOD_CDC14_SPxK_1	349	352	PF00782	0.760
MOD_CDK_SPK_2	331	336	PF00069	0.764
MOD_CDK_SPxK_1	346	352	PF00069	0.756
MOD_CK1_1	200	206	PF00069	0.686
MOD_CK1_1	209	215	PF00069	0.561
MOD_CK1_1	279	285	PF00069	0.580
MOD_CK1_1	69	75	PF00069	0.701
MOD_CK1_1	81	87	PF00069	0.593
MOD_CK2_1	126	132	PF00069	0.507
MOD_CK2_1	271	277	PF00069	0.824
MOD_GlcNHglycan	12	16	PF01048	0.747
MOD_GlcNHglycan	175	178	PF01048	0.620
MOD_GlcNHglycan	194	197	PF01048	0.335
MOD_GlcNHglycan	208	211	PF01048	0.592
MOD_GlcNHglycan	241	244	PF01048	0.786
MOD_GlcNHglycan	277	281	PF01048	0.784
MOD_GlcNHglycan	329	332	PF01048	0.760
MOD_GlcNHglycan	34	37	PF01048	0.768
MOD_GlcNHglycan	355	358	PF01048	0.793
MOD_GlcNHglycan	71	74	PF01048	0.677
MOD_GlcNHglycan	93	96	PF01048	0.813
MOD_GSK3_1	100	107	PF00069	0.501
MOD_GSK3_1	128	135	PF00069	0.629
MOD_GSK3_1	173	180	PF00069	0.610
MOD_GSK3_1	192	199	PF00069	0.354
MOD_GSK3_1	239	246	PF00069	0.691
MOD_GSK3_1	264	271	PF00069	0.694
MOD_GSK3_1	321	328	PF00069	0.741
MOD_GSK3_1	47	54	PF00069	0.541
MOD_GSK3_1	77	84	PF00069	0.720
MOD_GSK3_1	91	98	PF00069	0.505
MOD_N-GLC_1	177	182	PF02516	0.606
MOD_N-GLC_2	351	353	PF02516	0.534
MOD_NEK2_1	11	16	PF00069	0.751
MOD_NEK2_1	126	131	PF00069	0.606
MOD_NEK2_1	133	138	PF00069	0.506
MOD_NEK2_1	247	252	PF00069	0.583
MOD_NEK2_2	177	182	PF00069	0.606
MOD_PIKK_1	329	335	PF00454	0.526
MOD_PK_1	197	203	PF00069	0.494
MOD_PK_1	66	72	PF00069	0.596
MOD_PKA_2	196	202	PF00069	0.625
MOD_PKA_2	353	359	PF00069	0.567
MOD_PKA_2	78	84	PF00069	0.765
MOD_PKB_1	253	261	PF00069	0.583
MOD_Plk_1	24	30	PF00069	0.512
MOD_Plk_1	41	47	PF00069	0.611
MOD_Plk_4	211	217	PF00069	0.814
MOD_Plk_4	231	237	PF00069	0.394
MOD_Plk_4	255	261	PF00069	0.584
MOD_Plk_4	303	309	PF00069	0.440
MOD_Plk_4	41	47	PF00069	0.685
MOD_ProDKin_1	200	206	PF00069	0.546
MOD_ProDKin_1	209	215	PF00069	0.811
MOD_ProDKin_1	279	285	PF00069	0.580
MOD_ProDKin_1	331	337	PF00069	0.743
MOD_ProDKin_1	346	352	PF00069	0.492
MOD_ProDKin_1	97	103	PF00069	0.803
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.650
TRG_ENDOCYTIC_2	2	5	PF00928	0.769
TRG_ENDOCYTIC_2	369	372	PF00928	0.722
TRG_ER_diArg_1	253	255	PF00400	0.803
TRG_ER_diArg_1	352	355	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2H0	Leishmania donovani	79%	83%
A4I4L9	Leishmania infantum	79%	83%
E9AE17	Leishmania major	78%	100%