LeishMANIAdb
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Putative GTPase activator protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GTPase activator protein
Gene product:
GTPase activator protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HHG8_LEIBR
TriTrypDb:
LbrM.29.1650 , LBRM2903_290023500
Length:
586

Annotations

LeishMANIAdb annotations

Related to animal TBC proteins. Likely cytosolic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHG8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHG8

Function

Biological processes
Term Name Level Count
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043087 regulation of GTPase activity 5 1
GO:0043547 positive regulation of GTPase activity 6 1
GO:0044093 positive regulation of molecular function 3 1
GO:0050790 regulation of catalytic activity 3 1
GO:0051336 regulation of hydrolase activity 4 1
GO:0051345 positive regulation of hydrolase activity 5 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0090630 activation of GTPase activity 7 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0003924 GTPase activity 7 5
GO:0003925 G protein activity 2 5
GO:0016462 pyrophosphatase activity 5 5
GO:0016787 hydrolase activity 2 5
GO:0016817 hydrolase activity, acting on acid anhydrides 3 5
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 5
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 5
GO:0098772 molecular function regulator activity 1 5
GO:0005096 GTPase activator activity 4 1
GO:0008047 enzyme activator activity 3 1
GO:0030234 enzyme regulator activity 2 1
GO:0030695 GTPase regulator activity 4 1
GO:0060589 nucleoside-triphosphatase regulator activity 3 1
GO:0140677 molecular function activator activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 321 325 PF00656 0.434
CLV_NRD_NRD_1 242 244 PF00675 0.505
CLV_NRD_NRD_1 245 247 PF00675 0.513
CLV_NRD_NRD_1 254 256 PF00675 0.400
CLV_NRD_NRD_1 28 30 PF00675 0.470
CLV_NRD_NRD_1 313 315 PF00675 0.294
CLV_NRD_NRD_1 511 513 PF00675 0.399
CLV_NRD_NRD_1 542 544 PF00675 0.417
CLV_NRD_NRD_1 566 568 PF00675 0.441
CLV_PCSK_KEX2_1 247 249 PF00082 0.490
CLV_PCSK_KEX2_1 254 256 PF00082 0.420
CLV_PCSK_KEX2_1 28 30 PF00082 0.470
CLV_PCSK_KEX2_1 313 315 PF00082 0.294
CLV_PCSK_KEX2_1 542 544 PF00082 0.417
CLV_PCSK_KEX2_1 566 568 PF00082 0.441
CLV_PCSK_PC1ET2_1 247 249 PF00082 0.438
CLV_PCSK_PC7_1 243 249 PF00082 0.333
CLV_PCSK_SKI1_1 29 33 PF00082 0.469
CLV_PCSK_SKI1_1 578 582 PF00082 0.336
DEG_Nend_UBRbox_3 1 3 PF02207 0.671
DEG_SPOP_SBC_1 185 189 PF00917 0.676
DOC_MAPK_gen_1 251 261 PF00069 0.640
DOC_MAPK_gen_1 28 35 PF00069 0.669
DOC_MAPK_gen_1 432 440 PF00069 0.346
DOC_MAPK_MEF2A_6 28 35 PF00069 0.669
DOC_MAPK_MEF2A_6 287 294 PF00069 0.567
DOC_MAPK_MEF2A_6 386 394 PF00069 0.346
DOC_MAPK_MEF2A_6 434 442 PF00069 0.234
DOC_MAPK_MEF2A_6 478 487 PF00069 0.615
DOC_MAPK_NFAT4_5 287 295 PF00069 0.546
DOC_PP1_RVXF_1 217 223 PF00149 0.620
DOC_PP1_RVXF_1 285 292 PF00149 0.546
DOC_PP4_FxxP_1 222 225 PF00568 0.626
DOC_USP7_MATH_1 121 125 PF00917 0.706
DOC_USP7_MATH_1 183 187 PF00917 0.714
DOC_USP7_MATH_1 204 208 PF00917 0.772
DOC_USP7_MATH_1 22 26 PF00917 0.625
DOC_USP7_MATH_1 27 31 PF00917 0.626
DOC_USP7_MATH_1 39 43 PF00917 0.659
DOC_USP7_MATH_1 579 583 PF00917 0.634
DOC_USP7_MATH_1 8 12 PF00917 0.690
DOC_USP7_UBL2_3 247 251 PF12436 0.640
DOC_WW_Pin1_4 11 16 PF00397 0.666
DOC_WW_Pin1_4 129 134 PF00397 0.742
DOC_WW_Pin1_4 150 155 PF00397 0.850
DOC_WW_Pin1_4 263 268 PF00397 0.637
DOC_WW_Pin1_4 469 474 PF00397 0.586
DOC_WW_Pin1_4 476 481 PF00397 0.514
LIG_14-3-3_CanoR_1 10 15 PF00244 0.686
LIG_14-3-3_CanoR_1 160 170 PF00244 0.652
LIG_14-3-3_CanoR_1 257 262 PF00244 0.674
LIG_14-3-3_CanoR_1 28 34 PF00244 0.620
LIG_14-3-3_CanoR_1 512 519 PF00244 0.600
LIG_14-3-3_CanoR_1 526 532 PF00244 0.652
LIG_APCC_ABBA_1 392 397 PF00400 0.303
LIG_BRCT_BRCA1_1 368 372 PF00533 0.405
LIG_CaM_IQ_9 559 575 PF13499 0.530
LIG_Clathr_ClatBox_1 378 382 PF01394 0.405
LIG_eIF4E_1 306 312 PF01652 0.546
LIG_FHA_1 133 139 PF00498 0.661
LIG_FHA_1 18 24 PF00498 0.666
LIG_FHA_1 30 36 PF00498 0.648
LIG_FHA_1 345 351 PF00498 0.524
LIG_FHA_1 459 465 PF00498 0.247
LIG_FHA_1 513 519 PF00498 0.620
LIG_FHA_1 77 83 PF00498 0.665
LIG_FHA_1 86 92 PF00498 0.675
LIG_FHA_2 1 7 PF00498 0.669
LIG_FHA_2 331 337 PF00498 0.446
LIG_FHA_2 62 68 PF00498 0.749
LIG_GBD_Chelix_1 373 381 PF00786 0.405
LIG_HCF-1_HBM_1 336 339 PF13415 0.434
LIG_LIR_Apic_2 279 283 PF02991 0.468
LIG_LIR_Gen_1 213 222 PF02991 0.698
LIG_LIR_Gen_1 288 299 PF02991 0.450
LIG_LIR_Gen_1 369 378 PF02991 0.422
LIG_LIR_Gen_1 450 458 PF02991 0.347
LIG_LIR_Nem_3 213 217 PF02991 0.688
LIG_LIR_Nem_3 288 294 PF02991 0.460
LIG_LIR_Nem_3 369 373 PF02991 0.338
LIG_LIR_Nem_3 385 391 PF02991 0.374
LIG_LIR_Nem_3 450 455 PF02991 0.362
LIG_Pex14_1 465 469 PF04695 0.604
LIG_Pex14_2 372 376 PF04695 0.405
LIG_Pex14_2 452 456 PF04695 0.501
LIG_PTB_Apo_2 398 405 PF02174 0.415
LIG_PTB_Phospho_1 398 404 PF10480 0.415
LIG_SH2_CRK 280 284 PF00017 0.462
LIG_SH2_STAT5 306 309 PF00017 0.546
LIG_SH2_STAT5 317 320 PF00017 0.451
LIG_SH2_STAT5 339 342 PF00017 0.546
LIG_SH2_STAT5 366 369 PF00017 0.525
LIG_SH2_STAT5 420 423 PF00017 0.326
LIG_SH2_STAT5 467 470 PF00017 0.546
LIG_SH2_STAT5 492 495 PF00017 0.518
LIG_SH3_1 332 338 PF00018 0.546
LIG_SH3_3 167 173 PF00018 0.640
LIG_SH3_3 222 228 PF00018 0.635
LIG_SH3_3 332 338 PF00018 0.434
LIG_Sin3_3 521 528 PF02671 0.577
LIG_SUMO_SIM_par_1 153 158 PF11976 0.652
LIG_SUMO_SIM_par_1 30 36 PF11976 0.685
LIG_SUMO_SIM_par_1 376 385 PF11976 0.405
LIG_TRAF2_1 64 67 PF00917 0.664
LIG_TRAF2_1 95 98 PF00917 0.730
LIG_UBA3_1 507 513 PF00899 0.571
MOD_CDK_SPxxK_3 129 136 PF00069 0.649
MOD_CDK_SPxxK_3 471 478 PF00069 0.434
MOD_CK1_1 11 17 PF00069 0.681
MOD_CK1_1 186 192 PF00069 0.706
MOD_CK1_1 207 213 PF00069 0.662
MOD_CK1_1 42 48 PF00069 0.683
MOD_CK1_1 497 503 PF00069 0.578
MOD_CK1_1 61 67 PF00069 0.651
MOD_CK2_1 189 195 PF00069 0.656
MOD_CK2_1 471 477 PF00069 0.434
MOD_CK2_1 61 67 PF00069 0.682
MOD_Cter_Amidation 241 244 PF01082 0.330
MOD_GlcNHglycan 106 109 PF01048 0.525
MOD_GlcNHglycan 163 166 PF01048 0.429
MOD_GlcNHglycan 20 23 PF01048 0.439
MOD_GlcNHglycan 206 209 PF01048 0.541
MOD_GlcNHglycan 24 27 PF01048 0.418
MOD_GlcNHglycan 263 266 PF01048 0.452
MOD_GlcNHglycan 41 44 PF01048 0.444
MOD_GlcNHglycan 500 503 PF01048 0.354
MOD_GlcNHglycan 581 584 PF01048 0.417
MOD_GlcNHglycan 61 64 PF01048 0.448
MOD_GlcNHglycan 9 13 PF01048 0.488
MOD_GSK3_1 10 17 PF00069 0.683
MOD_GSK3_1 18 25 PF00069 0.661
MOD_GSK3_1 181 188 PF00069 0.735
MOD_GSK3_1 203 210 PF00069 0.692
MOD_GSK3_1 257 264 PF00069 0.689
MOD_GSK3_1 344 351 PF00069 0.440
MOD_GSK3_1 362 369 PF00069 0.359
MOD_GSK3_1 494 501 PF00069 0.494
MOD_GSK3_1 58 65 PF00069 0.730
MOD_GSK3_1 85 92 PF00069 0.647
MOD_N-GLC_1 175 180 PF02516 0.442
MOD_NEK2_1 137 142 PF00069 0.668
MOD_NEK2_1 261 266 PF00069 0.712
MOD_NEK2_1 290 295 PF00069 0.636
MOD_NEK2_1 483 488 PF00069 0.546
MOD_NEK2_1 498 503 PF00069 0.593
MOD_NEK2_1 507 512 PF00069 0.544
MOD_NEK2_1 527 532 PF00069 0.559
MOD_NEK2_2 447 452 PF00069 0.525
MOD_PIKK_1 139 145 PF00454 0.759
MOD_PIKK_1 234 240 PF00454 0.643
MOD_PKA_1 512 518 PF00069 0.568
MOD_PKA_2 126 132 PF00069 0.668
MOD_PKA_2 27 33 PF00069 0.668
MOD_PKB_1 255 263 PF00069 0.556
MOD_Plk_1 175 181 PF00069 0.641
MOD_Plk_1 212 218 PF00069 0.631
MOD_Plk_1 458 464 PF00069 0.247
MOD_Plk_1 483 489 PF00069 0.546
MOD_Plk_1 494 500 PF00069 0.523
MOD_Plk_1 69 75 PF00069 0.657
MOD_Plk_2-3 66 72 PF00069 0.660
MOD_Plk_4 121 127 PF00069 0.662
MOD_Plk_4 257 263 PF00069 0.663
MOD_Plk_4 404 410 PF00069 0.295
MOD_Plk_4 42 48 PF00069 0.656
MOD_Plk_4 447 453 PF00069 0.342
MOD_Plk_4 494 500 PF00069 0.492
MOD_ProDKin_1 11 17 PF00069 0.665
MOD_ProDKin_1 129 135 PF00069 0.744
MOD_ProDKin_1 150 156 PF00069 0.850
MOD_ProDKin_1 263 269 PF00069 0.630
MOD_ProDKin_1 469 475 PF00069 0.586
MOD_ProDKin_1 476 482 PF00069 0.514
MOD_SUMO_rev_2 92 102 PF00179 0.722
TRG_DiLeu_BaEn_1 97 102 PF01217 0.638
TRG_DiLeu_BaLyEn_6 359 364 PF01217 0.563
TRG_ER_diArg_1 240 243 PF00400 0.534
TRG_ER_diArg_1 254 257 PF00400 0.521
TRG_ER_diArg_1 312 314 PF00400 0.494
TRG_ER_diArg_1 541 543 PF00400 0.602
TRG_ER_diArg_1 566 568 PF00400 0.641
TRG_NES_CRM1_1 522 537 PF08389 0.482

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IEG1 Leishmania donovani 75% 100%
A4I4L7 Leishmania infantum 75% 100%
E9AE15 Leishmania major 75% 100%
E9ALR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 82%
E9AU43 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS