Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHG7_LEIBR

TriTrypDb:

LbrM.29.1640 , LBRM2903_290023400

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.526
CLV_C14_Caspase3-7	258	262	PF00656	0.522
CLV_C14_Caspase3-7	270	274	PF00656	0.463
CLV_NRD_NRD_1	112	114	PF00675	0.550
CLV_NRD_NRD_1	311	313	PF00675	0.608
CLV_NRD_NRD_1	396	398	PF00675	0.554
CLV_PCSK_KEX2_1	112	114	PF00082	0.537
CLV_PCSK_KEX2_1	158	160	PF00082	0.509
CLV_PCSK_KEX2_1	311	313	PF00082	0.586
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.408
CLV_PCSK_SKI1_1	112	116	PF00082	0.403
CLV_PCSK_SKI1_1	74	78	PF00082	0.555
DEG_Nend_UBRbox_4	1	3	PF02207	0.457
DEG_SPOP_SBC_1	142	146	PF00917	0.452
DOC_CKS1_1	169	174	PF01111	0.451
DOC_CYCLIN_yClb5_NLxxxL_5	170	179	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.404
DOC_PP4_FxxP_1	169	172	PF00568	0.444
DOC_PP4_FxxP_1	180	183	PF00568	0.491
DOC_USP7_MATH_1	141	145	PF00917	0.531
DOC_USP7_MATH_1	16	20	PF00917	0.469
DOC_USP7_MATH_1	242	246	PF00917	0.488
DOC_USP7_MATH_1	260	264	PF00917	0.706
DOC_USP7_MATH_1	386	390	PF00917	0.644
DOC_USP7_MATH_1	88	92	PF00917	0.568
DOC_WW_Pin1_4	168	173	PF00397	0.455
DOC_WW_Pin1_4	343	348	PF00397	0.508
LIG_14-3-3_CanoR_1	159	164	PF00244	0.438
LIG_14-3-3_CanoR_1	94	102	PF00244	0.489
LIG_Actin_WH2_2	211	226	PF00022	0.395
LIG_FHA_1	152	158	PF00498	0.434
LIG_FHA_1	27	33	PF00498	0.416
LIG_FHA_1	294	300	PF00498	0.460
LIG_FHA_1	374	380	PF00498	0.594
LIG_FHA_1	391	397	PF00498	0.419
LIG_FHA_1	94	100	PF00498	0.674
LIG_FHA_2	143	149	PF00498	0.489
LIG_FHA_2	360	366	PF00498	0.484
LIG_FHA_2	70	76	PF00498	0.421
LIG_LIR_Apic_2	166	172	PF02991	0.469
LIG_LIR_Apic_2	178	183	PF02991	0.518
LIG_LIR_Gen_1	328	337	PF02991	0.458
LIG_LIR_Nem_3	328	334	PF02991	0.460
LIG_LIR_Nem_3	81	87	PF02991	0.553
LIG_MYND_1	285	289	PF01753	0.514
LIG_NRBOX	110	116	PF00104	0.382
LIG_SH2_CRK	121	125	PF00017	0.407
LIG_SH2_CRK	356	360	PF00017	0.428
LIG_SH2_STAP1	164	168	PF00017	0.425
LIG_SH2_STAT3	164	167	PF00017	0.433
LIG_SH2_STAT5	100	103	PF00017	0.410
LIG_SH2_STAT5	225	228	PF00017	0.389
LIG_SH2_STAT5	302	305	PF00017	0.535
LIG_SH2_STAT5	404	407	PF00017	0.430
LIG_SH3_3	286	292	PF00018	0.534
LIG_SH3_3	324	330	PF00018	0.482
LIG_SH3_3	396	402	PF00018	0.455
LIG_Sin3_3	205	212	PF02671	0.456
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.522
LIG_SUMO_SIM_par_1	356	362	PF11976	0.648
LIG_SUMO_SIM_par_1	42	48	PF11976	0.445
LIG_TRAF2_1	362	365	PF00917	0.488
LIG_TRAF2_1	60	63	PF00917	0.412
LIG_TRFH_1	168	172	PF08558	0.433
LIG_TYR_ITIM	354	359	PF00017	0.427
LIG_WW_3	290	294	PF00397	0.481
MOD_CK2_1	316	322	PF00069	0.589
MOD_CK2_1	359	365	PF00069	0.474
MOD_CK2_1	74	80	PF00069	0.432
MOD_GlcNHglycan	319	322	PF01048	0.654
MOD_GlcNHglycan	340	343	PF01048	0.435
MOD_GlcNHglycan	388	391	PF01048	0.563
MOD_GlcNHglycan	392	396	PF01048	0.531
MOD_GSK3_1	194	201	PF00069	0.383
MOD_GSK3_1	22	29	PF00069	0.438
MOD_GSK3_1	240	247	PF00069	0.484
MOD_GSK3_1	260	267	PF00069	0.457
MOD_GSK3_1	274	281	PF00069	0.471
MOD_GSK3_1	317	324	PF00069	0.631
MOD_GSK3_1	325	332	PF00069	0.573
MOD_GSK3_1	386	393	PF00069	0.562
MOD_GSK3_1	74	81	PF00069	0.475
MOD_GSK3_1	89	96	PF00069	0.471
MOD_NEK2_1	126	131	PF00069	0.435
MOD_NEK2_1	133	138	PF00069	0.434
MOD_NEK2_1	198	203	PF00069	0.388
MOD_NEK2_1	45	50	PF00069	0.416
MOD_NEK2_1	69	74	PF00069	0.411
MOD_PKA_2	93	99	PF00069	0.477
MOD_Plk_1	260	266	PF00069	0.712
MOD_Plk_1	391	397	PF00069	0.582
MOD_Plk_1	74	80	PF00069	0.585
MOD_Plk_2-3	365	371	PF00069	0.458
MOD_Plk_2-3	75	81	PF00069	0.400
MOD_Plk_4	159	165	PF00069	0.542
MOD_Plk_4	214	220	PF00069	0.435
MOD_Plk_4	260	266	PF00069	0.484
MOD_Plk_4	45	51	PF00069	0.453
MOD_ProDKin_1	168	174	PF00069	0.457
MOD_ProDKin_1	343	349	PF00069	0.503
MOD_SUMO_for_1	234	237	PF00179	0.589
MOD_SUMO_for_1	249	252	PF00179	0.474
TRG_DiLeu_BaEn_1	214	219	PF01217	0.432
TRG_DiLeu_BaEn_4	193	199	PF01217	0.418
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.505
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.398
TRG_ENDOCYTIC_2	351	354	PF00928	0.416
TRG_ENDOCYTIC_2	356	359	PF00928	0.405
TRG_ER_diArg_1	111	113	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P119	Trypanosomatidae	26%	69%
A0A3R7MDJ5	Trypanosoma rangeli	30%	74%
C9ZLA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	74%
E9AE14	Leishmania major	74%	100%
V5D9T6	Trypanosoma cruzi	31%	74%