Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HHG4_LEIBR

TriTrypDb:

LbrM.29.1610 , LBRM2903_290023100

Length:

655

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 107
NetGPI	no	yes: 0, no: 107

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	101
GO:0110165	cellular anatomical entity	1	101
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4HHG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHG4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	51
GO:0022857	transmembrane transporter activity	2	51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.730
CLV_NRD_NRD_1	216	218	PF00675	0.260
CLV_NRD_NRD_1	614	616	PF00675	0.349
CLV_NRD_NRD_1	620	622	PF00675	0.345
CLV_PCSK_FUR_1	612	616	PF00082	0.435
CLV_PCSK_KEX2_1	215	217	PF00082	0.253
CLV_PCSK_KEX2_1	316	318	PF00082	0.582
CLV_PCSK_KEX2_1	614	616	PF00082	0.345
CLV_PCSK_KEX2_1	619	621	PF00082	0.339
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.394
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.326
CLV_PCSK_PC7_1	615	621	PF00082	0.412
CLV_PCSK_SKI1_1	149	153	PF00082	0.366
CLV_PCSK_SKI1_1	216	220	PF00082	0.326
CLV_PCSK_SKI1_1	316	320	PF00082	0.407
CLV_PCSK_SKI1_1	561	565	PF00082	0.573
CLV_PCSK_SKI1_1	615	619	PF00082	0.359
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DOC_MAPK_gen_1	619	628	PF00069	0.461
DOC_MAPK_MEF2A_6	264	273	PF00069	0.298
DOC_PP2B_LxvP_1	493	496	PF13499	0.417
DOC_PP2B_PxIxI_1	471	477	PF00149	0.391
DOC_SPAK_OSR1_1	14	18	PF12202	0.519
DOC_USP7_MATH_1	257	261	PF00917	0.310
DOC_USP7_MATH_1	347	351	PF00917	0.707
DOC_USP7_MATH_1	418	422	PF00917	0.516
DOC_USP7_MATH_1	479	483	PF00917	0.382
DOC_USP7_MATH_1	496	500	PF00917	0.386
DOC_USP7_UBL2_3	293	297	PF12436	0.688
DOC_USP7_UBL2_3	316	320	PF12436	0.708
DOC_USP7_UBL2_3	530	534	PF12436	0.492
DOC_WW_Pin1_4	329	334	PF00397	0.714
DOC_WW_Pin1_4	573	578	PF00397	0.451
LIG_14-3-3_CanoR_1	168	176	PF00244	0.358
LIG_14-3-3_CanoR_1	215	224	PF00244	0.491
LIG_14-3-3_CanoR_1	264	270	PF00244	0.342
LIG_14-3-3_CanoR_1	357	365	PF00244	0.697
LIG_14-3-3_CanoR_1	453	457	PF00244	0.287
LIG_BRCT_BRCA1_1	605	609	PF00533	0.270
LIG_deltaCOP1_diTrp_1	399	405	PF00928	0.369
LIG_EH1_1	175	183	PF00400	0.441
LIG_FHA_1	108	114	PF00498	0.324
LIG_FHA_1	125	131	PF00498	0.324
LIG_FHA_1	266	272	PF00498	0.356
LIG_FHA_1	453	459	PF00498	0.388
LIG_FHA_1	599	605	PF00498	0.399
LIG_FHA_1	623	629	PF00498	0.533
LIG_FHA_1	88	94	PF00498	0.296
LIG_FHA_2	325	331	PF00498	0.764
LIG_GBD_Chelix_1	272	280	PF00786	0.356
LIG_LIR_Apic_2	253	259	PF02991	0.352
LIG_LIR_Apic_2	74	78	PF02991	0.466
LIG_LIR_Gen_1	13	22	PF02991	0.483
LIG_LIR_Gen_1	171	182	PF02991	0.296
LIG_LIR_Gen_1	389	400	PF02991	0.508
LIG_LIR_Gen_1	439	448	PF02991	0.319
LIG_LIR_LC3C_4	242	245	PF02991	0.393
LIG_LIR_Nem_3	13	18	PF02991	0.506
LIG_LIR_Nem_3	150	154	PF02991	0.349
LIG_LIR_Nem_3	171	177	PF02991	0.266
LIG_LIR_Nem_3	231	237	PF02991	0.511
LIG_LIR_Nem_3	296	302	PF02991	0.629
LIG_LIR_Nem_3	389	395	PF02991	0.518
LIG_LIR_Nem_3	439	444	PF02991	0.347
LIG_LIR_Nem_3	606	611	PF02991	0.370
LIG_LYPXL_yS_3	227	230	PF13949	0.391
LIG_MAD2	368	376	PF02301	0.503
LIG_NRBOX	488	494	PF00104	0.395
LIG_NRBOX	90	96	PF00104	0.295
LIG_Pex14_2	233	237	PF04695	0.334
LIG_Pex14_2	507	511	PF04695	0.349
LIG_PTB_Apo_2	160	167	PF02174	0.310
LIG_PTB_Apo_2	427	434	PF02174	0.329
LIG_PTB_Phospho_1	427	433	PF10480	0.385
LIG_REV1ctd_RIR_1	164	172	PF16727	0.282
LIG_SH2_CRK	256	260	PF00017	0.330
LIG_SH2_CRK	425	429	PF00017	0.295
LIG_SH2_CRK	441	445	PF00017	0.359
LIG_SH2_CRK	75	79	PF00017	0.452
LIG_SH2_GRB2like	256	259	PF00017	0.352
LIG_SH2_NCK_1	256	260	PF00017	0.330
LIG_SH2_NCK_1	96	100	PF00017	0.448
LIG_SH2_SRC	256	259	PF00017	0.361
LIG_SH2_STAP1	433	437	PF00017	0.339
LIG_SH2_STAP1	441	445	PF00017	0.374
LIG_SH2_STAP1	559	563	PF00017	0.311
LIG_SH2_STAP1	96	100	PF00017	0.418
LIG_SH2_STAT3	223	226	PF00017	0.450
LIG_SH2_STAT3	337	340	PF00017	0.578
LIG_SH2_STAT3	380	383	PF00017	0.692
LIG_SH2_STAT3	559	562	PF00017	0.366
LIG_SH2_STAT5	223	226	PF00017	0.463
LIG_SH2_STAT5	234	237	PF00017	0.324
LIG_SH2_STAT5	246	249	PF00017	0.312
LIG_SH2_STAT5	540	543	PF00017	0.376
LIG_SH2_STAT5	7	10	PF00017	0.507
LIG_SH3_1	297	303	PF00018	0.633
LIG_SH3_3	297	303	PF00018	0.620
LIG_SH3_3	574	580	PF00018	0.373
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.435
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.311
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.493
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.408
LIG_SUMO_SIM_par_1	271	277	PF11976	0.365
LIG_SUMO_SIM_par_1	360	367	PF11976	0.651
LIG_SUMO_SIM_par_1	442	449	PF11976	0.339
LIG_SUMO_SIM_par_1	623	629	PF11976	0.571
LIG_TYR_ITSM	437	444	PF00017	0.352
LIG_UBA3_1	492	500	PF00899	0.410
LIG_Vh1_VBS_1	444	462	PF01044	0.162
LIG_WRC_WIRS_1	148	153	PF05994	0.382
LIG_WRC_WIRS_1	508	513	PF05994	0.390
MOD_CK1_1	10	16	PF00069	0.441
MOD_CK1_1	107	113	PF00069	0.334
MOD_CK1_1	124	130	PF00069	0.350
MOD_CK1_1	446	452	PF00069	0.349
MOD_CK1_1	50	56	PF00069	0.338
MOD_CK2_1	324	330	PF00069	0.761
MOD_CK2_1	347	353	PF00069	0.651
MOD_Cter_Amidation	583	586	PF01082	0.477
MOD_GlcNHglycan	261	264	PF01048	0.383
MOD_GlcNHglycan	420	423	PF01048	0.392
MOD_GlcNHglycan	441	444	PF01048	0.329
MOD_GlcNHglycan	448	451	PF01048	0.318
MOD_GSK3_1	120	127	PF00069	0.350
MOD_GSK3_1	133	140	PF00069	0.324
MOD_GSK3_1	22	29	PF00069	0.342
MOD_GSK3_1	387	394	PF00069	0.439
MOD_GSK3_1	432	439	PF00069	0.426
MOD_GSK3_1	46	53	PF00069	0.322
MOD_GSK3_1	461	468	PF00069	0.376
MOD_GSK3_1	513	520	PF00069	0.349
MOD_GSK3_1	83	90	PF00069	0.390
MOD_N-GLC_1	162	167	PF02516	0.352
MOD_N-GLC_1	311	316	PF02516	0.657
MOD_N-GLC_1	324	329	PF02516	0.651
MOD_N-GLC_1	45	50	PF02516	0.381
MOD_N-GLC_1	598	603	PF02516	0.301
MOD_N-GLC_2	6	8	PF02516	0.232
MOD_N-GLC_2	649	651	PF02516	0.401
MOD_NEK2_1	120	125	PF00069	0.340
MOD_NEK2_1	154	159	PF00069	0.378
MOD_NEK2_1	22	27	PF00069	0.308
MOD_NEK2_1	265	270	PF00069	0.281
MOD_NEK2_1	274	279	PF00069	0.331
MOD_NEK2_1	391	396	PF00069	0.384
MOD_NEK2_1	45	50	PF00069	0.344
MOD_NEK2_1	461	466	PF00069	0.335
MOD_NEK2_1	506	511	PF00069	0.348
MOD_NEK2_1	84	89	PF00069	0.273
MOD_NEK2_2	27	32	PF00069	0.331
MOD_PIKK_1	222	228	PF00454	0.353
MOD_PIKK_1	324	330	PF00454	0.672
MOD_PIKK_1	336	342	PF00454	0.650
MOD_PIKK_1	357	363	PF00454	0.489
MOD_PKA_1	216	222	PF00069	0.429
MOD_PKA_2	167	173	PF00069	0.424
MOD_PKA_2	216	222	PF00069	0.325
MOD_PKA_2	452	458	PF00069	0.318
MOD_Plk_1	10	16	PF00069	0.527
MOD_Plk_1	162	168	PF00069	0.382
MOD_Plk_1	203	209	PF00069	0.440
MOD_Plk_1	50	56	PF00069	0.315
MOD_Plk_1	598	604	PF00069	0.323
MOD_Plk_1	622	628	PF00069	0.436
MOD_Plk_4	126	132	PF00069	0.326
MOD_Plk_4	154	160	PF00069	0.369
MOD_Plk_4	162	168	PF00069	0.375
MOD_Plk_4	239	245	PF00069	0.321
MOD_Plk_4	27	33	PF00069	0.319
MOD_Plk_4	387	393	PF00069	0.409
MOD_Plk_4	436	442	PF00069	0.288
MOD_Plk_4	523	529	PF00069	0.341
MOD_Plk_4	57	63	PF00069	0.348
MOD_Plk_4	588	594	PF00069	0.316
MOD_Plk_4	604	610	PF00069	0.280
MOD_ProDKin_1	329	335	PF00069	0.660
MOD_ProDKin_1	573	579	PF00069	0.570
MOD_SUMO_rev_2	367	376	PF00179	0.648
MOD_SUMO_rev_2	431	437	PF00179	0.465
TRG_DiLeu_BaEn_2	10	16	PF01217	0.462
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.437
TRG_ENDOCYTIC_2	164	167	PF00928	0.344
TRG_ENDOCYTIC_2	174	177	PF00928	0.280
TRG_ENDOCYTIC_2	198	201	PF00928	0.350
TRG_ENDOCYTIC_2	227	230	PF00928	0.398
TRG_ENDOCYTIC_2	234	237	PF00928	0.361
TRG_ENDOCYTIC_2	425	428	PF00928	0.357
TRG_ENDOCYTIC_2	441	444	PF00928	0.313
TRG_ENDOCYTIC_2	536	539	PF00928	0.323
TRG_ENDOCYTIC_2	613	616	PF00928	0.398
TRG_ER_diArg_1	215	217	PF00400	0.333
TRG_ER_diArg_1	613	615	PF00400	0.433
TRG_ER_diArg_1	620	622	PF00400	0.437
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	426	431	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	28%	100%
A0A0N1HZC2	Leptomonas seymouri	30%	100%
A0A0N1IKC5	Leptomonas seymouri	32%	100%
A0A0N1PB63	Leptomonas seymouri	27%	99%
A0A0N1PD04	Leptomonas seymouri	25%	100%
A0A0N1PFR4	Leptomonas seymouri	31%	99%
A0A1X0NKK0	Trypanosomatidae	31%	100%
A0A1X0NM09	Trypanosomatidae	30%	100%
A0A1X0NV13	Trypanosomatidae	32%	100%
A0A1X0NV19	Trypanosomatidae	34%	100%
A0A1X0NV27	Trypanosomatidae	33%	100%
A0A1X0NVF9	Trypanosomatidae	25%	98%
A0A1X0NVM7	Trypanosomatidae	30%	100%
A0A1X0NWQ1	Trypanosomatidae	32%	100%
A0A1X0NZE6	Trypanosomatidae	30%	100%
A0A1X0NZU2	Trypanosomatidae	32%	100%
A0A1X0NZU5	Trypanosomatidae	52%	100%
A0A1X0NZW1	Trypanosomatidae	31%	100%
A0A1X0P0M7	Trypanosomatidae	30%	100%
A0A381MMW5	Leishmania infantum	74%	100%
A0A3Q8IEC4	Leishmania donovani	74%	100%
A0A3Q8IF95	Leishmania donovani	27%	100%
A0A3Q8IIT5	Leishmania donovani	29%	97%
A0A3Q8ISY9	Leishmania donovani	26%	100%
A0A3R7KKN8	Trypanosoma rangeli	31%	100%
A0A3R7MAQ7	Trypanosoma rangeli	27%	93%
A0A3R7N3S6	Trypanosoma rangeli	25%	100%
A0A3R7N415	Trypanosoma rangeli	31%	100%
A0A3R7N921	Trypanosoma rangeli	31%	100%
A0A3R7R443	Trypanosoma rangeli	30%	100%
A0A3S7WRJ4	Leishmania donovani	32%	100%
A0A3S7WRJ5	Leishmania donovani	33%	94%
A0A3S7WRS3	Leishmania donovani	26%	100%
A0A3S7WSR4	Leishmania donovani	30%	100%
A0A3S7WWU1	Leishmania donovani	27%	99%
A0A3S7X2G0	Leishmania donovani	74%	100%
A0A3S7X2K5	Leishmania donovani	76%	100%
A0A3S7XB11	Leishmania donovani	30%	100%
A0A422MSE4	Trypanosoma rangeli	35%	100%
A0A422MSP6	Trypanosoma rangeli	48%	100%
A0A422MST9	Trypanosoma rangeli	30%	100%
A0A422MU68	Trypanosoma rangeli	30%	100%
A4H6J0	Leishmania braziliensis	32%	100%
A4H6J1	Leishmania braziliensis	31%	99%
A4H6Q5	Leishmania braziliensis	26%	100%
A4HC19	Leishmania braziliensis	28%	100%
A4HHG2	Leishmania braziliensis	29%	97%
A4HHG3	Leishmania braziliensis	83%	100%
A4HJW3	Leishmania braziliensis	26%	100%
A4HPE2	Leishmania braziliensis	30%	100%
A4HUX5	Leishmania infantum	31%	100%
A4HUX6	Leishmania infantum	33%	94%
A4HV40	Leishmania infantum	26%	100%
A4HZF5	Leishmania infantum	27%	100%
A4HZJ4	Leishmania infantum	27%	99%
A4I4L2	Leishmania infantum	29%	97%
A4I7C5	Leishmania infantum	26%	100%
A4ICI3	Leishmania infantum	30%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AE01	Leishmania major	71%	100%
E9AE09	Leishmania major	31%	100%
E9AE10	Leishmania major	31%	100%
E9AE11	Leishmania major	74%	100%
E9AGK5	Leishmania infantum	30%	100%
E9AHJ0	Leishmania infantum	74%	100%
E9AHJ1	Leishmania infantum	76%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	99%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q1E4	Leishmania major	29%	98%
Q4Q5T8	Leishmania major	27%	97%
Q4QC27	Leishmania major	28%	100%
Q4QC28	Leishmania major	28%	94%
Q4QFY5	Leishmania major	31%	100%
Q4QGU8	Leishmania major	26%	100%
Q4QH14	Leishmania major	32%	100%
Q4QH15	Leishmania major	31%	100%
V5B647	Trypanosoma cruzi	30%	100%
V5B983	Trypanosoma cruzi	47%	100%
V5BBB1	Trypanosoma cruzi	32%	100%
V5BFV8	Trypanosoma cruzi	31%	98%
V5BQY6	Trypanosoma cruzi	28%	93%
V5BVP0	Trypanosoma cruzi	30%	100%
V5DT25	Trypanosoma cruzi	31%	100%