Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like, putative

Species:

Leishmania braziliensis

UniProt:

A4HHG2_LEIBR

TriTrypDb:

LbrM.29.1590 , LBRM2903_290022900

Length:

676

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 75
NetGPI	no	yes: 0, no: 75

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	69
GO:0110165	cellular anatomical entity	1	69
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4HHG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHG2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	35
GO:0022857	transmembrane transporter activity	2	35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.861
CLV_C14_Caspase3-7	345	349	PF00656	0.792
CLV_C14_Caspase3-7	412	416	PF00656	0.750
CLV_NRD_NRD_1	212	214	PF00675	0.397
CLV_NRD_NRD_1	239	241	PF00675	0.360
CLV_NRD_NRD_1	364	366	PF00675	0.456
CLV_NRD_NRD_1	403	405	PF00675	0.582
CLV_NRD_NRD_1	507	509	PF00675	0.437
CLV_NRD_NRD_1	646	648	PF00675	0.417
CLV_PCSK_FUR_1	212	216	PF00082	0.323
CLV_PCSK_FUR_1	644	648	PF00082	0.492
CLV_PCSK_KEX2_1	212	214	PF00082	0.395
CLV_PCSK_KEX2_1	239	241	PF00082	0.366
CLV_PCSK_KEX2_1	304	306	PF00082	0.473
CLV_PCSK_KEX2_1	364	366	PF00082	0.463
CLV_PCSK_KEX2_1	507	509	PF00082	0.405
CLV_PCSK_KEX2_1	646	648	PF00082	0.402
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.329
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.466
CLV_PCSK_SKI1_1	214	218	PF00082	0.462
CLV_PCSK_SKI1_1	224	228	PF00082	0.453
CLV_PCSK_SKI1_1	435	439	PF00082	0.450
CLV_PCSK_SKI1_1	479	483	PF00082	0.529
CLV_PCSK_SKI1_1	594	598	PF00082	0.360
CLV_PCSK_SKI1_1	607	611	PF00082	0.643
CLV_PCSK_SKI1_1	75	79	PF00082	0.317
DEG_Nend_UBRbox_1	1	4	PF02207	0.492
DEG_SPOP_SBC_1	23	27	PF00917	0.468
DOC_CYCLIN_RxL_1	432	441	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	544	550	PF00134	0.326
DOC_MAPK_gen_1	103	112	PF00069	0.427
DOC_MAPK_gen_1	268	275	PF00069	0.411
DOC_MAPK_MEF2A_6	268	277	PF00069	0.404
DOC_MAPK_MEF2A_6	435	444	PF00069	0.637
DOC_MAPK_MEF2A_6	479	486	PF00069	0.316
DOC_MAPK_MEF2A_6	621	628	PF00069	0.333
DOC_MAPK_RevD_3	255	269	PF00069	0.547
DOC_MAPK_RevD_3	291	305	PF00069	0.357
DOC_PP1_RVXF_1	73	79	PF00149	0.444
DOC_PP2B_LxvP_1	544	547	PF13499	0.338
DOC_PP4_FxxP_1	121	124	PF00568	0.468
DOC_USP7_MATH_1	23	27	PF00917	0.358
DOC_USP7_MATH_1	256	260	PF00917	0.436
DOC_USP7_MATH_1	344	348	PF00917	0.756
DOC_USP7_UBL2_3	214	218	PF12436	0.515
DOC_WW_Pin1_4	399	404	PF00397	0.802
LIG_14-3-3_CanoR_1	224	229	PF00244	0.621
LIG_14-3-3_CanoR_1	38	44	PF00244	0.420
LIG_14-3-3_CanoR_1	495	503	PF00244	0.368
LIG_14-3-3_CanoR_1	508	517	PF00244	0.631
LIG_14-3-3_CanoR_1	607	612	PF00244	0.341
LIG_APCC_ABBA_1	30	35	PF00400	0.467
LIG_BIR_III_2	202	206	PF00653	0.422
LIG_BRCT_BRCA1_1	468	472	PF00533	0.425
LIG_BRCT_BRCA1_1	582	586	PF00533	0.410
LIG_Clathr_ClatBox_1	437	441	PF01394	0.612
LIG_deltaCOP1_diTrp_1	441	450	PF00928	0.412
LIG_eIF4E_1	242	248	PF01652	0.344
LIG_eIF4E_1	9	15	PF01652	0.596
LIG_FHA_1	155	161	PF00498	0.410
LIG_FHA_1	225	231	PF00498	0.610
LIG_FHA_1	260	266	PF00498	0.477
LIG_FHA_1	32	38	PF00498	0.347
LIG_FHA_1	437	443	PF00498	0.536
LIG_FHA_1	453	459	PF00498	0.423
LIG_FHA_1	491	497	PF00498	0.400
LIG_FHA_1	511	517	PF00498	0.706
LIG_FHA_1	587	593	PF00498	0.354
LIG_FHA_1	658	664	PF00498	0.586
LIG_FHA_2	321	327	PF00498	0.714
LIG_FHA_2	670	676	PF00498	0.744
LIG_FXI_DFP_1	306	310	PF00024	0.401
LIG_IRF3_LxIS_1	18	25	PF10401	0.468
LIG_IRF3_LxIS_1	252	258	PF10401	0.250
LIG_IRF3_LxIS_1	527	532	PF10401	0.230
LIG_LIR_Apic_2	70	74	PF02991	0.517
LIG_LIR_Gen_1	141	152	PF02991	0.549
LIG_LIR_Gen_1	180	190	PF02991	0.352
LIG_LIR_Gen_1	27	37	PF02991	0.431
LIG_LIR_Gen_1	270	280	PF02991	0.352
LIG_LIR_Gen_1	532	541	PF02991	0.480
LIG_LIR_Nem_3	141	147	PF02991	0.533
LIG_LIR_Nem_3	151	155	PF02991	0.414
LIG_LIR_Nem_3	177	182	PF02991	0.350
LIG_LIR_Nem_3	27	33	PF02991	0.441
LIG_LIR_Nem_3	270	275	PF02991	0.365
LIG_LIR_Nem_3	308	312	PF02991	0.601
LIG_LIR_Nem_3	432	437	PF02991	0.569
LIG_LIR_Nem_3	469	475	PF02991	0.380
LIG_LIR_Nem_3	518	524	PF02991	0.341
LIG_LIR_Nem_3	532	536	PF02991	0.342
LIG_LIR_Nem_3	83	89	PF02991	0.356
LIG_LYPXL_yS_3	299	302	PF13949	0.649
LIG_NRBOX	86	92	PF00104	0.415
LIG_PALB2_WD40_1	163	171	PF16756	0.254
LIG_Pex14_1	446	450	PF04695	0.373
LIG_Pex14_2	164	168	PF04695	0.341
LIG_Pex14_2	445	449	PF04695	0.326
LIG_Pex14_2	597	601	PF04695	0.392
LIG_Pex14_2	92	96	PF04695	0.307
LIG_PTB_Apo_2	162	169	PF02174	0.374
LIG_PTB_Apo_2	619	626	PF02174	0.222
LIG_SH2_CRK	144	148	PF00017	0.570
LIG_SH2_CRK	71	75	PF00017	0.529
LIG_SH2_GRB2like	163	166	PF00017	0.412
LIG_SH2_PTP2	19	22	PF00017	0.459
LIG_SH2_PTP2	272	275	PF00017	0.317
LIG_SH2_PTP2	483	486	PF00017	0.301
LIG_SH2_STAP1	182	186	PF00017	0.335
LIG_SH2_STAP1	314	318	PF00017	0.558
LIG_SH2_STAP1	570	574	PF00017	0.559
LIG_SH2_STAT3	231	234	PF00017	0.604
LIG_SH2_STAT3	467	470	PF00017	0.251
LIG_SH2_STAT5	120	123	PF00017	0.391
LIG_SH2_STAT5	163	166	PF00017	0.359
LIG_SH2_STAT5	184	187	PF00017	0.383
LIG_SH2_STAT5	19	22	PF00017	0.421
LIG_SH2_STAT5	199	202	PF00017	0.373
LIG_SH2_STAT5	242	245	PF00017	0.372
LIG_SH2_STAT5	264	267	PF00017	0.437
LIG_SH2_STAT5	272	275	PF00017	0.332
LIG_SH2_STAT5	483	486	PF00017	0.335
LIG_SH2_STAT5	533	536	PF00017	0.351
LIG_SH2_STAT5	60	63	PF00017	0.365
LIG_SH2_STAT5	89	92	PF00017	0.415
LIG_SH3_1	304	310	PF00018	0.714
LIG_SH3_2	400	405	PF14604	0.740
LIG_SH3_3	133	139	PF00018	0.585
LIG_SH3_3	202	208	PF00018	0.515
LIG_SH3_3	304	310	PF00018	0.672
LIG_SH3_3	397	403	PF00018	0.816
LIG_SH3_3	411	417	PF00018	0.708
LIG_SH3_3	73	79	PF00018	0.598
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.290
LIG_SUMO_SIM_par_1	281	287	PF11976	0.439
LIG_SUMO_SIM_par_1	436	441	PF11976	0.595
LIG_SUMO_SIM_par_1	658	664	PF11976	0.729
LIG_UBA3_1	596	603	PF00899	0.494
LIG_WRC_WIRS_1	430	435	PF05994	0.636
MOD_CDC14_SPxK_1	402	405	PF00782	0.810
MOD_CDK_SPK_2	399	404	PF00069	0.679
MOD_CDK_SPxK_1	399	405	PF00069	0.808
MOD_CK1_1	177	183	PF00069	0.383
MOD_CK1_1	259	265	PF00069	0.491
MOD_CK1_1	31	37	PF00069	0.324
MOD_CK1_1	552	558	PF00069	0.506
MOD_CK1_1	634	640	PF00069	0.377
MOD_CK1_1	669	675	PF00069	0.743
MOD_CK2_1	368	374	PF00069	0.822
MOD_CK2_1	391	397	PF00069	0.853
MOD_CK2_1	509	515	PF00069	0.663
MOD_CMANNOS	443	446	PF00535	0.412
MOD_GlcNHglycan	152	155	PF01048	0.421
MOD_GlcNHglycan	179	182	PF01048	0.522
MOD_GlcNHglycan	269	272	PF01048	0.674
MOD_GlcNHglycan	490	493	PF01048	0.391
MOD_GlcNHglycan	497	500	PF01048	0.390
MOD_GlcNHglycan	583	586	PF01048	0.432
MOD_GlcNHglycan	636	639	PF01048	0.423
MOD_GSK3_1	150	157	PF00069	0.412
MOD_GSK3_1	24	31	PF00069	0.417
MOD_GSK3_1	255	262	PF00069	0.386
MOD_GSK3_1	308	315	PF00069	0.671
MOD_GSK3_1	322	329	PF00069	0.752
MOD_GSK3_1	344	351	PF00069	0.792
MOD_GSK3_1	378	385	PF00069	0.796
MOD_GSK3_1	387	394	PF00069	0.835
MOD_GSK3_1	46	53	PF00069	0.342
MOD_GSK3_1	490	497	PF00069	0.441
MOD_GSK3_1	581	588	PF00069	0.401
MOD_GSK3_1	603	610	PF00069	0.414
MOD_GSK3_1	666	673	PF00069	0.702
MOD_N-GLC_1	174	179	PF02516	0.529
MOD_N-GLC_1	377	382	PF02516	0.539
MOD_N-GLC_1	421	426	PF02516	0.394
MOD_N-GLC_1	666	671	PF02516	0.499
MOD_N-GLC_2	56	58	PF02516	0.468
MOD_NEK2_1	155	160	PF00069	0.404
MOD_NEK2_1	191	196	PF00069	0.381
MOD_NEK2_1	22	27	PF00069	0.383
MOD_NEK2_1	255	260	PF00069	0.413
MOD_NEK2_1	445	450	PF00069	0.396
MOD_NEK2_1	452	457	PF00069	0.340
MOD_NEK2_1	517	522	PF00069	0.391
MOD_NEK2_1	529	534	PF00069	0.350
MOD_NEK2_1	549	554	PF00069	0.500
MOD_NEK2_1	580	585	PF00069	0.408
MOD_NEK2_1	586	591	PF00069	0.396
MOD_NEK2_1	8	13	PF00069	0.572
MOD_NEK2_2	226	231	PF00069	0.617
MOD_NEK2_2	28	33	PF00069	0.409
MOD_NEK2_2	562	567	PF00069	0.484
MOD_OFUCOSY	614	619	PF10250	0.588
MOD_PIKK_1	466	472	PF00454	0.326
MOD_PKA_1	214	220	PF00069	0.671
MOD_PKA_2	214	220	PF00069	0.646
MOD_PKA_2	494	500	PF00069	0.395
MOD_Plk_1	377	383	PF00069	0.749
MOD_Plk_1	46	52	PF00069	0.337
MOD_Plk_1	475	481	PF00069	0.387
MOD_Plk_1	603	609	PF00069	0.314
MOD_Plk_1	657	663	PF00069	0.679
MOD_Plk_2-3	320	326	PF00069	0.803
MOD_Plk_4	127	133	PF00069	0.406
MOD_Plk_4	155	161	PF00069	0.387
MOD_Plk_4	191	197	PF00069	0.347
MOD_Plk_4	226	232	PF00069	0.616
MOD_Plk_4	256	262	PF00069	0.397
MOD_Plk_4	429	435	PF00069	0.592
MOD_Plk_4	454	460	PF00069	0.399
MOD_Plk_4	517	523	PF00069	0.370
MOD_Plk_4	586	592	PF00069	0.431
MOD_ProDKin_1	399	405	PF00069	0.803
TRG_ENDOCYTIC_2	144	147	PF00928	0.526
TRG_ENDOCYTIC_2	182	185	PF00928	0.363
TRG_ENDOCYTIC_2	19	22	PF00928	0.422
TRG_ENDOCYTIC_2	272	275	PF00928	0.318
TRG_ENDOCYTIC_2	299	302	PF00928	0.593
TRG_ENDOCYTIC_2	430	433	PF00928	0.600
TRG_ENDOCYTIC_2	483	486	PF00928	0.370
TRG_ENDOCYTIC_2	533	536	PF00928	0.361
TRG_ENDOCYTIC_2	578	581	PF00928	0.370
TRG_ENDOCYTIC_2	60	63	PF00928	0.345
TRG_ENDOCYTIC_2	89	92	PF00928	0.432
TRG_ER_diArg_1	211	213	PF00400	0.625
TRG_ER_diArg_1	239	241	PF00400	0.563
TRG_ER_diArg_1	363	365	PF00400	0.655
TRG_ER_diArg_1	506	508	PF00400	0.609
TRG_ER_diArg_1	645	647	PF00400	0.642
TRG_ER_diArg_1	9	12	PF00400	0.532
TRG_NLS_MonoExtC_3	302	307	PF00514	0.520
TRG_NLS_MonoExtN_4	212	217	PF00514	0.532
TRG_NLS_MonoExtN_4	300	307	PF00514	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	27%	100%
A0A0N1HZC2	Leptomonas seymouri	28%	100%
A0A0N1IKC5	Leptomonas seymouri	27%	100%
A0A0N1PB63	Leptomonas seymouri	26%	100%
A0A0N1PD04	Leptomonas seymouri	24%	100%
A0A0N1PFR4	Leptomonas seymouri	65%	100%
A0A1X0NKK0	Trypanosomatidae	29%	100%
A0A1X0NM09	Trypanosomatidae	29%	100%
A0A1X0NVF9	Trypanosomatidae	22%	100%
A0A1X0NVM7	Trypanosomatidae	28%	100%
A0A1X0NWQ1	Trypanosomatidae	27%	100%
A0A1X0NZE6	Trypanosomatidae	25%	100%
A0A1X0NZT1	Trypanosomatidae	23%	81%
A0A1X0NZU2	Trypanosomatidae	31%	100%
A0A1X0P0M7	Trypanosomatidae	25%	100%
A0A381MMW5	Leishmania infantum	30%	100%
A0A3Q8IEC4	Leishmania donovani	30%	100%
A0A3Q8IF95	Leishmania donovani	24%	100%
A0A3Q8IIT5	Leishmania donovani	83%	100%
A0A3Q8ISY9	Leishmania donovani	27%	100%
A0A3R7KKN8	Trypanosoma rangeli	52%	100%
A0A3R7N3S6	Trypanosoma rangeli	24%	100%
A0A3R7N921	Trypanosoma rangeli	25%	100%
A0A3S7WRJ4	Leishmania donovani	25%	100%
A0A3S7WRJ5	Leishmania donovani	26%	97%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WWU1	Leishmania donovani	26%	100%
A0A3S7X2G0	Leishmania donovani	30%	100%
A0A3S7X2K5	Leishmania donovani	30%	100%
A0A3S7XB11	Leishmania donovani	27%	100%
A0A422MSP6	Trypanosoma rangeli	31%	100%
A0A422MU68	Trypanosoma rangeli	25%	100%
A0A422NL17	Trypanosoma rangeli	23%	84%
A4H6J0	Leishmania braziliensis	25%	98%
A4H6J1	Leishmania braziliensis	27%	96%
A4H6Q5	Leishmania braziliensis	24%	97%
A4HC19	Leishmania braziliensis	26%	99%
A4HHG3	Leishmania braziliensis	30%	100%
A4HHG4	Leishmania braziliensis	29%	100%
A4HJW3	Leishmania braziliensis	28%	100%
A4HPE2	Leishmania braziliensis	28%	100%
A4HUX5	Leishmania infantum	25%	100%
A4HUX6	Leishmania infantum	27%	97%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	24%	100%
A4HZJ4	Leishmania infantum	26%	100%
A4I4L2	Leishmania infantum	82%	100%
A4I7C5	Leishmania infantum	27%	100%
A4ICI3	Leishmania infantum	27%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AE01	Leishmania major	30%	97%
E9AE09	Leishmania major	82%	100%
E9AE10	Leishmania major	82%	100%
E9AE11	Leishmania major	31%	94%
E9AHJ0	Leishmania infantum	30%	100%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	92%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q1E4	Leishmania major	27%	92%
Q4Q5T8	Leishmania major	26%	97%
Q4QC27	Leishmania major	25%	96%
Q4QGU8	Leishmania major	25%	100%
Q4QH14	Leishmania major	27%	98%
Q4QH15	Leishmania major	26%	98%
V5BFV8	Trypanosoma cruzi	27%	100%
V5DT25	Trypanosoma cruzi	28%	100%