Mitochondrial import receptor subunit TOM22 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHG0_LEIBR

TriTrypDb:

LbrM.29.1570 , LBRM2903_290022500

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HHG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	140	144	PF00082	0.456
CLV_PCSK_SKI1_1	226	230	PF00082	0.441
DEG_Nend_Nbox_1	1	3	PF02207	0.419
DEG_SCF_FBW7_1	228	235	PF00400	0.660
DOC_AGCK_PIF_1	37	42	PF00069	0.571
DOC_ANK_TNKS_1	81	88	PF00023	0.614
DOC_CKS1_1	229	234	PF01111	0.661
DOC_CYCLIN_RxL_1	223	231	PF00134	0.640
DOC_MAPK_DCC_7	103	113	PF00069	0.612
DOC_MAPK_gen_1	286	294	PF00069	0.797
DOC_PP4_FxxP_1	136	139	PF00568	0.687
DOC_PP4_FxxP_1	42	45	PF00568	0.564
DOC_USP7_MATH_1	109	113	PF00917	0.595
DOC_USP7_MATH_1	208	212	PF00917	0.675
DOC_USP7_MATH_1	232	236	PF00917	0.766
DOC_USP7_MATH_1	363	367	PF00917	0.421
DOC_USP7_MATH_1	80	84	PF00917	0.593
DOC_WW_Pin1_4	101	106	PF00397	0.641
DOC_WW_Pin1_4	162	167	PF00397	0.706
DOC_WW_Pin1_4	204	209	PF00397	0.824
DOC_WW_Pin1_4	213	218	PF00397	0.713
DOC_WW_Pin1_4	228	233	PF00397	0.626
DOC_WW_Pin1_4	346	351	PF00397	0.554
LIG_14-3-3_CanoR_1	124	133	PF00244	0.664
LIG_14-3-3_CanoR_1	140	145	PF00244	0.634
LIG_14-3-3_CanoR_1	233	239	PF00244	0.680
LIG_14-3-3_CanoR_1	321	327	PF00244	0.449
LIG_14-3-3_CanoR_1	39	45	PF00244	0.567
LIG_14-3-3_CanoR_1	99	107	PF00244	0.660
LIG_Actin_WH2_2	25	41	PF00022	0.269
LIG_APCC_ABBA_1	114	119	PF00400	0.586
LIG_BRCT_BRCA1_1	103	107	PF00533	0.633
LIG_EVH1_2	45	49	PF00568	0.553
LIG_FHA_1	180	186	PF00498	0.731
LIG_FHA_1	196	202	PF00498	0.617
LIG_FHA_1	216	222	PF00498	0.584
LIG_FHA_1	296	302	PF00498	0.579
LIG_FHA_1	328	334	PF00498	0.339
LIG_FHA_1	354	360	PF00498	0.549
LIG_LIR_Apic_2	41	45	PF02991	0.560
LIG_LIR_Gen_1	10	20	PF02991	0.250
LIG_LIR_Gen_1	56	65	PF02991	0.615
LIG_LIR_Nem_3	10	16	PF02991	0.250
LIG_LIR_Nem_3	130	136	PF02991	0.653
LIG_LIR_Nem_3	318	323	PF02991	0.719
LIG_LIR_Nem_3	349	355	PF02991	0.558
LIG_LIR_Nem_3	47	51	PF02991	0.547
LIG_LIR_Nem_3	56	60	PF02991	0.605
LIG_Pex14_1	320	324	PF04695	0.633
LIG_SH2_CRK	74	78	PF00017	0.640
LIG_SH2_NCK_1	252	256	PF00017	0.615
LIG_SH2_STAP1	324	328	PF00017	0.269
LIG_SH2_STAP1	355	359	PF00017	0.553
LIG_SH2_STAP1	74	78	PF00017	0.590
LIG_SH2_STAT5	115	118	PF00017	0.588
LIG_SH2_STAT5	352	355	PF00017	0.561
LIG_SH2_STAT5	48	51	PF00017	0.605
LIG_SH3_1	103	109	PF00018	0.622
LIG_SH3_3	102	108	PF00018	0.631
LIG_SH3_3	131	137	PF00018	0.683
LIG_SH3_3	155	161	PF00018	0.727
LIG_SH3_3	340	346	PF00018	0.269
LIG_SH3_3	357	363	PF00018	0.440
LIG_SUMO_SIM_anti_2	329	336	PF11976	0.336
LIG_SUMO_SIM_par_1	339	345	PF11976	0.269
LIG_TRAF2_1	192	195	PF00917	0.665
LIG_TRFH_1	42	46	PF08558	0.565
LIG_WW_1	45	48	PF00397	0.556
MOD_CDK_SPK_2	228	233	PF00069	0.663
MOD_CK1_1	127	133	PF00069	0.642
MOD_CK1_1	146	152	PF00069	0.682
MOD_CK1_1	207	213	PF00069	0.640
MOD_CK1_1	227	233	PF00069	0.639
MOD_CK1_1	237	243	PF00069	0.711
MOD_CK1_1	358	364	PF00069	0.548
MOD_CK1_1	366	372	PF00069	0.554
MOD_CK1_1	97	103	PF00069	0.654
MOD_CK2_1	161	167	PF00069	0.622
MOD_CK2_1	244	250	PF00069	0.606
MOD_CK2_1	80	86	PF00069	0.611
MOD_GlcNHglycan	221	224	PF01048	0.531
MOD_GlcNHglycan	32	35	PF01048	0.307
MOD_GlcNHglycan	360	363	PF01048	0.612
MOD_GlcNHglycan	89	92	PF01048	0.452
MOD_GSK3_1	146	153	PF00069	0.707
MOD_GSK3_1	180	187	PF00069	0.824
MOD_GSK3_1	204	211	PF00069	0.805
MOD_GSK3_1	215	222	PF00069	0.671
MOD_GSK3_1	224	231	PF00069	0.707
MOD_GSK3_1	232	239	PF00069	0.752
MOD_GSK3_1	250	257	PF00069	0.615
MOD_GSK3_1	322	329	PF00069	0.269
MOD_GSK3_1	363	370	PF00069	0.589
MOD_GSK3_1	40	47	PF00069	0.563
MOD_GSK3_1	94	101	PF00069	0.768
MOD_NEK2_1	125	130	PF00069	0.689
MOD_NEK2_1	150	155	PF00069	0.718
MOD_NEK2_1	185	190	PF00069	0.769
MOD_NEK2_1	224	229	PF00069	0.643
MOD_NEK2_1	238	243	PF00069	0.575
MOD_NEK2_1	38	43	PF00069	0.572
MOD_NEK2_1	53	58	PF00069	0.545
MOD_NEK2_2	295	300	PF00069	0.631
MOD_PIKK_1	195	201	PF00454	0.681
MOD_PIKK_1	58	64	PF00454	0.568
MOD_PK_1	244	250	PF00069	0.606
MOD_PKA_2	232	238	PF00069	0.647
MOD_PKA_2	38	44	PF00069	0.569
MOD_PKA_2	94	100	PF00069	0.657
MOD_PKB_1	177	185	PF00069	0.694
MOD_Plk_4	109	115	PF00069	0.712
MOD_Plk_4	208	214	PF00069	0.638
MOD_Plk_4	224	230	PF00069	0.601
MOD_Plk_4	238	244	PF00069	0.574
MOD_Plk_4	355	361	PF00069	0.489
MOD_Plk_4	44	50	PF00069	0.552
MOD_Plk_4	72	78	PF00069	0.589
MOD_ProDKin_1	101	107	PF00069	0.639
MOD_ProDKin_1	162	168	PF00069	0.706
MOD_ProDKin_1	204	210	PF00069	0.824
MOD_ProDKin_1	213	219	PF00069	0.713
MOD_ProDKin_1	228	234	PF00069	0.625
MOD_ProDKin_1	346	352	PF00069	0.555
MOD_SUMO_rev_2	183	188	PF00179	0.658
TRG_ENDOCYTIC_2	48	51	PF00928	0.605
TRG_ENDOCYTIC_2	74	77	PF00928	0.641
TRG_ER_diArg_1	176	179	PF00400	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7L3	Leishmania donovani	61%	100%
A4I4L0	Leishmania infantum	60%	100%
E9AE07	Leishmania major	53%	100%
E9ALS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%