ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHF9_LEIBR

TriTrypDb:

LbrM.29.1560 , LBRM2903_290022400

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.593
CLV_C14_Caspase3-7	330	334	PF00656	0.700
CLV_C14_Caspase3-7	446	450	PF00656	0.587
CLV_C14_Caspase3-7	606	610	PF00656	0.672
CLV_NRD_NRD_1	474	476	PF00675	0.450
CLV_NRD_NRD_1	569	571	PF00675	0.588
CLV_NRD_NRD_1	596	598	PF00675	0.571
CLV_NRD_NRD_1	601	603	PF00675	0.652
CLV_NRD_NRD_1	67	69	PF00675	0.782
CLV_NRD_NRD_1	685	687	PF00675	0.650
CLV_PCSK_KEX2_1	474	476	PF00082	0.435
CLV_PCSK_KEX2_1	569	571	PF00082	0.588
CLV_PCSK_KEX2_1	598	600	PF00082	0.524
CLV_PCSK_KEX2_1	67	69	PF00082	0.758
CLV_PCSK_KEX2_1	685	687	PF00082	0.650
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.385
CLV_PCSK_SKI1_1	11	15	PF00082	0.594
CLV_PCSK_SKI1_1	169	173	PF00082	0.530
CLV_PCSK_SKI1_1	191	195	PF00082	0.540
CLV_PCSK_SKI1_1	199	203	PF00082	0.462
CLV_PCSK_SKI1_1	215	219	PF00082	0.534
CLV_PCSK_SKI1_1	230	234	PF00082	0.464
CLV_PCSK_SKI1_1	356	360	PF00082	0.650
CLV_PCSK_SKI1_1	474	478	PF00082	0.475
CLV_PCSK_SKI1_1	647	651	PF00082	0.502
DEG_MDM2_SWIB_1	186	193	PF02201	0.548
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SPOP_SBC_1	323	327	PF00917	0.618
DOC_CKS1_1	231	236	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.602
DOC_MAPK_MEF2A_6	230	239	PF00069	0.523
DOC_MAPK_MEF2A_6	424	432	PF00069	0.392
DOC_MIT_MIM_1	12	22	PF04212	0.485
DOC_PP2B_LxvP_1	221	224	PF13499	0.605
DOC_PP2B_LxvP_1	649	652	PF13499	0.481
DOC_PP2B_LxvP_1	699	702	PF13499	0.502
DOC_USP7_MATH_1	123	127	PF00917	0.784
DOC_USP7_MATH_1	258	262	PF00917	0.630
DOC_USP7_MATH_1	394	398	PF00917	0.590
DOC_USP7_MATH_1	547	551	PF00917	0.362
DOC_USP7_MATH_1	586	590	PF00917	0.545
DOC_USP7_UBL2_3	296	300	PF12436	0.776
DOC_WW_Pin1_4	230	235	PF00397	0.466
LIG_14-3-3_CanoR_1	215	224	PF00244	0.541
LIG_14-3-3_CanoR_1	336	346	PF00244	0.667
LIG_14-3-3_CanoR_1	38	47	PF00244	0.788
LIG_14-3-3_CanoR_1	569	573	PF00244	0.579
LIG_Actin_WH2_2	554	571	PF00022	0.395
LIG_AP2alpha_1	105	109	PF02296	0.786
LIG_BH_BH3_1	162	178	PF00452	0.678
LIG_BRCT_BRCA1_1	611	615	PF00533	0.599
LIG_CtBP_PxDLS_1	513	517	PF00389	0.475
LIG_eIF4E_1	498	504	PF01652	0.573
LIG_EVH1_2	288	292	PF00568	0.693
LIG_FHA_1	157	163	PF00498	0.724
LIG_FHA_1	216	222	PF00498	0.529
LIG_FHA_1	293	299	PF00498	0.552
LIG_FHA_1	383	389	PF00498	0.544
LIG_FHA_1	408	414	PF00498	0.613
LIG_FHA_1	42	48	PF00498	0.804
LIG_FHA_1	589	595	PF00498	0.448
LIG_FHA_1	628	634	PF00498	0.515
LIG_FHA_2	190	196	PF00498	0.650
LIG_FHA_2	231	237	PF00498	0.499
LIG_FHA_2	269	275	PF00498	0.651
LIG_FHA_2	330	336	PF00498	0.712
LIG_FHA_2	531	537	PF00498	0.499
LIG_FHA_2	604	610	PF00498	0.515
LIG_FHA_2	623	629	PF00498	0.542
LIG_FHA_2	656	662	PF00498	0.516
LIG_FHA_2	682	688	PF00498	0.571
LIG_GBD_Chelix_1	428	436	PF00786	0.542
LIG_LIR_Apic_2	353	357	PF02991	0.539
LIG_LIR_Gen_1	106	114	PF02991	0.718
LIG_LIR_Gen_1	164	173	PF02991	0.526
LIG_LIR_Gen_1	248	258	PF02991	0.622
LIG_LIR_Gen_1	486	496	PF02991	0.616
LIG_LIR_Gen_1	526	532	PF02991	0.527
LIG_LIR_Gen_1	618	627	PF02991	0.498
LIG_LIR_Gen_1	665	672	PF02991	0.493
LIG_LIR_Nem_3	106	112	PF02991	0.792
LIG_LIR_Nem_3	164	168	PF02991	0.535
LIG_LIR_Nem_3	248	254	PF02991	0.625
LIG_LIR_Nem_3	486	492	PF02991	0.511
LIG_LIR_Nem_3	494	498	PF02991	0.484
LIG_LIR_Nem_3	526	530	PF02991	0.491
LIG_LIR_Nem_3	618	624	PF02991	0.475
LIG_LIR_Nem_3	665	670	PF02991	0.479
LIG_NRBOX	212	218	PF00104	0.349
LIG_PCNA_yPIPBox_3	583	594	PF02747	0.585
LIG_PDZ_Class_2	701	706	PF00595	0.477
LIG_Pex14_2	105	109	PF04695	0.760
LIG_Pex14_2	182	186	PF04695	0.571
LIG_SH2_CRK	251	255	PF00017	0.619
LIG_SH2_SRC	498	501	PF00017	0.463
LIG_SH2_SRC	676	679	PF00017	0.451
LIG_SH2_STAP1	204	208	PF00017	0.561
LIG_SH2_STAP1	251	255	PF00017	0.619
LIG_SH2_STAP1	498	502	PF00017	0.568
LIG_SH2_STAP1	678	682	PF00017	0.312
LIG_SH2_STAP1	86	90	PF00017	0.747
LIG_SH2_STAT5	225	228	PF00017	0.528
LIG_SH2_STAT5	481	484	PF00017	0.611
LIG_SH2_STAT5	572	575	PF00017	0.522
LIG_SH2_STAT5	581	584	PF00017	0.497
LIG_SH2_STAT5	676	679	PF00017	0.432
LIG_SH3_3	284	290	PF00018	0.639
LIG_SH3_3	49	55	PF00018	0.777
LIG_SH3_3	74	80	PF00018	0.827
LIG_SH3_4	296	303	PF00018	0.774
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.527
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.426
LIG_SUMO_SIM_par_1	499	505	PF11976	0.426
LIG_SUMO_SIM_par_1	647	653	PF11976	0.526
LIG_UBA3_1	636	642	PF00899	0.566
LIG_WRC_WIRS_1	541	546	PF05994	0.551
LIG_WRC_WIRS_1	624	629	PF05994	0.365
MOD_CK1_1	244	250	PF00069	0.559
MOD_CK1_1	312	318	PF00069	0.697
MOD_CK1_1	322	328	PF00069	0.425
MOD_CK1_1	407	413	PF00069	0.614
MOD_CK1_1	551	557	PF00069	0.646
MOD_CK1_1	607	613	PF00069	0.754
MOD_CK1_1	681	687	PF00069	0.580
MOD_CK2_1	122	128	PF00069	0.784
MOD_CK2_1	329	335	PF00069	0.652
MOD_CK2_1	530	536	PF00069	0.540
MOD_CK2_1	547	553	PF00069	0.538
MOD_CK2_1	681	687	PF00069	0.540
MOD_GlcNHglycan	137	140	PF01048	0.729
MOD_GlcNHglycan	209	212	PF01048	0.489
MOD_GlcNHglycan	243	246	PF01048	0.677
MOD_GlcNHglycan	260	263	PF01048	0.527
MOD_GlcNHglycan	30	33	PF01048	0.698
MOD_GlcNHglycan	326	329	PF01048	0.637
MOD_GlcNHglycan	34	37	PF01048	0.711
MOD_GlcNHglycan	406	409	PF01048	0.571
MOD_GlcNHglycan	41	44	PF01048	0.802
MOD_GlcNHglycan	425	428	PF01048	0.543
MOD_GlcNHglycan	445	448	PF01048	0.568
MOD_GlcNHglycan	550	553	PF01048	0.672
MOD_GlcNHglycan	606	609	PF01048	0.757
MOD_GlcNHglycan	611	614	PF01048	0.681
MOD_GlcNHglycan	644	647	PF01048	0.593
MOD_GlcNHglycan	72	75	PF01048	0.881
MOD_GlcNHglycan	99	102	PF01048	0.823
MOD_GSK3_1	28	35	PF00069	0.737
MOD_GSK3_1	306	313	PF00069	0.597
MOD_GSK3_1	315	322	PF00069	0.626
MOD_GSK3_1	378	385	PF00069	0.653
MOD_GSK3_1	547	554	PF00069	0.474
MOD_GSK3_1	577	584	PF00069	0.548
MOD_GSK3_1	603	610	PF00069	0.694
MOD_GSK3_1	623	630	PF00069	0.461
MOD_GSK3_1	638	645	PF00069	0.411
MOD_N-GLC_1	266	271	PF02516	0.609
MOD_N-GLC_1	394	399	PF02516	0.435
MOD_NEK2_1	268	273	PF00069	0.590
MOD_NEK2_1	292	297	PF00069	0.661
MOD_NEK2_1	310	315	PF00069	0.592
MOD_NEK2_1	443	448	PF00069	0.594
MOD_NEK2_1	540	545	PF00069	0.501
MOD_NEK2_1	568	573	PF00069	0.521
MOD_NEK2_1	627	632	PF00069	0.514
MOD_NEK2_1	638	643	PF00069	0.449
MOD_NEK2_1	662	667	PF00069	0.442
MOD_NEK2_2	394	399	PF00069	0.474
MOD_NEK2_2	466	471	PF00069	0.539
MOD_PIKK_1	359	365	PF00454	0.611
MOD_PIKK_1	455	461	PF00454	0.666
MOD_PKA_1	598	604	PF00069	0.419
MOD_PKA_2	277	283	PF00069	0.715
MOD_PKA_2	359	365	PF00069	0.571
MOD_PKA_2	423	429	PF00069	0.571
MOD_PKA_2	568	574	PF00069	0.581
MOD_PKA_2	598	604	PF00069	0.600
MOD_Plk_1	266	272	PF00069	0.476
MOD_Plk_1	394	400	PF00069	0.593
MOD_Plk_2-3	175	181	PF00069	0.537
MOD_Plk_2-3	531	537	PF00069	0.589
MOD_Plk_4	130	136	PF00069	0.511
MOD_Plk_4	277	283	PF00069	0.673
MOD_Plk_4	512	518	PF00069	0.583
MOD_Plk_4	540	546	PF00069	0.557
MOD_Plk_4	650	656	PF00069	0.479
MOD_Plk_4	678	684	PF00069	0.448
MOD_ProDKin_1	230	236	PF00069	0.463
MOD_SUMO_rev_2	269	277	PF00179	0.581
TRG_DiLeu_BaEn_1	108	113	PF01217	0.780
TRG_DiLeu_BaEn_1	536	541	PF01217	0.530
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.350
TRG_ENDOCYTIC_2	251	254	PF00928	0.611
TRG_ENDOCYTIC_2	489	492	PF00928	0.542
TRG_ENDOCYTIC_2	498	501	PF00928	0.509
TRG_ENDOCYTIC_2	621	624	PF00928	0.433
TRG_ER_diArg_1	436	439	PF00400	0.557
TRG_ER_diArg_1	473	475	PF00400	0.450
TRG_ER_diArg_1	568	570	PF00400	0.578
TRG_ER_diArg_1	596	599	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICE2	Leptomonas seymouri	56%	100%
A0A0S4KH65	Bodo saltans	29%	96%
A0A1X0P032	Trypanosomatidae	32%	100%
A0A3Q8IF68	Leishmania donovani	78%	99%
A0A3R7NCZ3	Trypanosoma rangeli	32%	100%
A4I4K9	Leishmania infantum	78%	99%
C9ZL94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE06	Leishmania major	77%	99%
E9ALS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
V5BH81	Trypanosoma cruzi	32%	100%