LeishMANIAdb
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Putative phosphatidylinositol 4-kinase alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phosphatidylinositol 4-kinase alpha
Gene product:
phosphatidylinositol 4-kinase alpha, putative
Species:
Leishmania braziliensis
UniProt:
A4HHF7_LEIBR
TriTrypDb:
LbrM.29.1540 , LBRM2903_290022200 *
Length:
2615

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 1
GO:0020016 ciliary pocket 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4HHF7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0006629 lipid metabolic process 3 2
GO:0006644 phospholipid metabolic process 4 2
GO:0006650 glycerophospholipid metabolic process 5 2
GO:0006661 phosphatidylinositol biosynthetic process 6 2
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0007165 signal transduction 2 8
GO:0008152 metabolic process 1 8
GO:0008610 lipid biosynthetic process 4 2
GO:0008654 phospholipid biosynthetic process 5 2
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 8
GO:0004430 1-phosphatidylinositol 4-kinase activity 6 7
GO:0016301 kinase activity 4 8
GO:0016740 transferase activity 2 8
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 8
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0052742 phosphatidylinositol kinase activity 5 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1648 1652 PF00656 0.562
CLV_C14_Caspase3-7 2384 2388 PF00656 0.249
CLV_C14_Caspase3-7 266 270 PF00656 0.763
CLV_C14_Caspase3-7 388 392 PF00656 0.628
CLV_C14_Caspase3-7 71 75 PF00656 0.559
CLV_C14_Caspase3-7 786 790 PF00656 0.567
CLV_C14_Caspase3-7 818 822 PF00656 0.435
CLV_C14_Caspase3-7 847 851 PF00656 0.454
CLV_C14_Caspase3-7 85 89 PF00656 0.440
CLV_C14_Caspase3-7 939 943 PF00656 0.504
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3S7X2L6 Leishmania donovani 77% 98%
A0A422N5T9 Trypanosoma rangeli 37% 100%
A4I4K7 Leishmania infantum 77% 98%
C9ZL90 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AE04 Leishmania major 77% 100%
E9ALS8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 98%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS