Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHF5_LEIBR

TriTrypDb:

LbrM.29.1520 , LBRM2903_290022100

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.537
CLV_NRD_NRD_1	187	189	PF00675	0.396
CLV_NRD_NRD_1	478	480	PF00675	0.579
CLV_NRD_NRD_1	486	488	PF00675	0.541
CLV_NRD_NRD_1	64	66	PF00675	0.678
CLV_NRD_NRD_1	7	9	PF00675	0.755
CLV_PCSK_KEX2_1	104	106	PF00082	0.411
CLV_PCSK_KEX2_1	142	144	PF00082	0.578
CLV_PCSK_KEX2_1	187	189	PF00082	0.414
CLV_PCSK_KEX2_1	367	369	PF00082	0.557
CLV_PCSK_KEX2_1	486	488	PF00082	0.574
CLV_PCSK_KEX2_1	7	9	PF00082	0.755
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.408
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.708
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.557
CLV_PCSK_PC7_1	3	9	PF00082	0.656
CLV_PCSK_PC7_1	482	488	PF00082	0.550
CLV_PCSK_SKI1_1	157	161	PF00082	0.605
CLV_PCSK_SKI1_1	341	345	PF00082	0.349
CLV_PCSK_SKI1_1	348	352	PF00082	0.419
DEG_APCC_DBOX_1	187	195	PF00400	0.455
DEG_APCC_DBOX_1	340	348	PF00400	0.408
DEG_APCC_DBOX_1	7	15	PF00400	0.502
DEG_SCF_FBW7_1	148	154	PF00400	0.443
DEG_SCF_FBW7_1	440	445	PF00400	0.564
DOC_ANK_TNKS_1	231	238	PF00023	0.417
DOC_CKS1_1	148	153	PF01111	0.678
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.261
DOC_MAPK_gen_1	104	110	PF00069	0.440
DOC_MAPK_gen_1	157	165	PF00069	0.624
DOC_MAPK_gen_1	187	195	PF00069	0.485
DOC_MAPK_gen_1	65	73	PF00069	0.752
DOC_MAPK_gen_1	7	13	PF00069	0.536
DOC_MAPK_MEF2A_6	104	112	PF00069	0.383
DOC_MAPK_MEF2A_6	187	195	PF00069	0.485
DOC_MAPK_MEF2A_6	66	75	PF00069	0.484
DOC_MAPK_NFAT4_5	105	113	PF00069	0.391
DOC_MAPK_NFAT4_5	188	196	PF00069	0.485
DOC_PP1_RVXF_1	396	402	PF00149	0.308
DOC_PP2B_LxvP_1	163	166	PF13499	0.572
DOC_PP2B_LxvP_1	210	213	PF13499	0.271
DOC_USP7_MATH_1	285	289	PF00917	0.557
DOC_USP7_MATH_1	331	335	PF00917	0.614
DOC_USP7_MATH_1	424	428	PF00917	0.615
DOC_USP7_MATH_1	61	65	PF00917	0.716
DOC_USP7_MATH_1	94	98	PF00917	0.502
DOC_WW_Pin1_4	147	152	PF00397	0.642
DOC_WW_Pin1_4	164	169	PF00397	0.618
DOC_WW_Pin1_4	2	7	PF00397	0.529
DOC_WW_Pin1_4	204	209	PF00397	0.477
DOC_WW_Pin1_4	319	324	PF00397	0.492
DOC_WW_Pin1_4	354	359	PF00397	0.518
DOC_WW_Pin1_4	428	433	PF00397	0.723
DOC_WW_Pin1_4	438	443	PF00397	0.536
DOC_WW_Pin1_4	493	498	PF00397	0.727
DOC_WW_Pin1_4	50	55	PF00397	0.629
LIG_14-3-3_CanoR_1	19	25	PF00244	0.688
LIG_14-3-3_CanoR_1	240	249	PF00244	0.358
LIG_14-3-3_CanoR_1	32	39	PF00244	0.558
LIG_14-3-3_CanoR_1	333	340	PF00244	0.545
LIG_14-3-3_CanoR_1	381	389	PF00244	0.526
LIG_14-3-3_CanoR_1	391	399	PF00244	0.378
LIG_14-3-3_CanoR_1	433	442	PF00244	0.516
LIG_14-3-3_CanoR_1	65	69	PF00244	0.768
LIG_14-3-3_CterR_2	500	505	PF00244	0.481
LIG_Actin_WH2_2	332	350	PF00022	0.490
LIG_AP2alpha_1	175	179	PF02296	0.447
LIG_APCC_ABBA_1	172	177	PF00400	0.580
LIG_APCC_ABBA_1	220	225	PF00400	0.495
LIG_BIR_III_2	355	359	PF00653	0.354
LIG_BIR_III_4	300	304	PF00653	0.557
LIG_deltaCOP1_diTrp_1	127	136	PF00928	0.606
LIG_deltaCOP1_diTrp_1	78	87	PF00928	0.483
LIG_eIF4E_1	452	458	PF01652	0.447
LIG_EVH1_2	212	216	PF00568	0.346
LIG_EVH1_2	359	363	PF00568	0.485
LIG_FHA_1	19	25	PF00498	0.723
LIG_FHA_1	205	211	PF00498	0.337
LIG_FHA_1	250	256	PF00498	0.342
LIG_FHA_1	300	306	PF00498	0.587
LIG_FHA_1	435	441	PF00498	0.673
LIG_Integrin_RGD_1	181	183	PF01839	0.466
LIG_LIR_Gen_1	127	136	PF02991	0.594
LIG_LIR_Gen_1	173	184	PF02991	0.544
LIG_LIR_Gen_1	290	297	PF02991	0.391
LIG_LIR_Gen_1	386	396	PF02991	0.444
LIG_LIR_Gen_1	78	85	PF02991	0.476
LIG_LIR_Nem_3	127	133	PF02991	0.610
LIG_LIR_Nem_3	173	179	PF02991	0.534
LIG_LIR_Nem_3	290	295	PF02991	0.471
LIG_LIR_Nem_3	386	392	PF02991	0.474
LIG_LIR_Nem_3	78	84	PF02991	0.476
LIG_MYND_1	208	212	PF01753	0.292
LIG_NRBOX	190	196	PF00104	0.485
LIG_Pex14_2	175	179	PF04695	0.579
LIG_SH2_GRB2like	197	200	PF00017	0.512
LIG_SH2_GRB2like	452	455	PF00017	0.519
LIG_SH2_SRC	164	167	PF00017	0.579
LIG_SH2_STAT5	140	143	PF00017	0.680
LIG_SH2_STAT5	164	167	PF00017	0.521
LIG_SH2_STAT5	197	200	PF00017	0.450
LIG_SH2_STAT5	371	374	PF00017	0.430
LIG_SH2_STAT5	395	398	PF00017	0.376
LIG_SH2_STAT5	452	455	PF00017	0.636
LIG_SH3_1	145	151	PF00018	0.546
LIG_SH3_1	487	493	PF00018	0.536
LIG_SH3_1	57	63	PF00018	0.528
LIG_SH3_2	60	65	PF14604	0.521
LIG_SH3_3	145	151	PF00018	0.696
LIG_SH3_3	162	168	PF00018	0.407
LIG_SH3_3	487	493	PF00018	0.784
LIG_SH3_3	57	63	PF00018	0.825
LIG_TRAF2_1	288	291	PF00917	0.596
LIG_UBA3_1	113	121	PF00899	0.313
LIG_WRC_WIRS_1	292	297	PF05994	0.397
MOD_CDK_SPK_2	2	7	PF00069	0.487
MOD_CDK_SPK_2	428	433	PF00069	0.457
MOD_CDK_SPK_2	52	57	PF00069	0.616
MOD_CDK_SPxK_1	2	8	PF00069	0.526
MOD_CDK_SPxxK_3	493	500	PF00069	0.568
MOD_CDK_SPxxK_3	50	57	PF00069	0.617
MOD_CK1_1	28	34	PF00069	0.621
MOD_CK1_1	284	290	PF00069	0.530
MOD_CK1_1	322	328	PF00069	0.571
MOD_CK1_1	468	474	PF00069	0.613
MOD_CK1_1	49	55	PF00069	0.680
MOD_CK1_1	64	70	PF00069	0.558
MOD_CK1_1	76	82	PF00069	0.516
MOD_CK1_1	97	103	PF00069	0.609
MOD_CK2_1	284	290	PF00069	0.518
MOD_CK2_1	76	82	PF00069	0.632
MOD_Cter_Amidation	102	105	PF01082	0.429
MOD_Cter_Amidation	484	487	PF01082	0.519
MOD_DYRK1A_RPxSP_1	428	432	PF00069	0.691
MOD_GlcNHglycan	242	245	PF01048	0.389
MOD_GlcNHglycan	27	30	PF01048	0.670
MOD_GlcNHglycan	283	286	PF01048	0.501
MOD_GlcNHglycan	313	316	PF01048	0.596
MOD_GlcNHglycan	335	338	PF01048	0.484
MOD_GlcNHglycan	75	78	PF01048	0.705
MOD_GSK3_1	113	120	PF00069	0.496
MOD_GSK3_1	147	154	PF00069	0.565
MOD_GSK3_1	18	25	PF00069	0.778
MOD_GSK3_1	28	35	PF00069	0.652
MOD_GSK3_1	281	288	PF00069	0.583
MOD_GSK3_1	291	298	PF00069	0.587
MOD_GSK3_1	319	326	PF00069	0.659
MOD_GSK3_1	38	45	PF00069	0.624
MOD_GSK3_1	424	431	PF00069	0.748
MOD_GSK3_1	434	441	PF00069	0.565
MOD_GSK3_1	46	53	PF00069	0.577
MOD_GSK3_1	67	74	PF00069	0.710
MOD_GSK3_1	76	83	PF00069	0.573
MOD_N-GLC_1	462	467	PF02516	0.701
MOD_N-GLC_2	199	201	PF02516	0.278
MOD_NEK2_1	117	122	PF00069	0.515
MOD_NEK2_1	462	467	PF00069	0.679
MOD_NEK2_1	498	503	PF00069	0.668
MOD_NEK2_1	71	76	PF00069	0.551
MOD_PIKK_1	434	440	PF00454	0.762
MOD_PKA_2	18	24	PF00069	0.746
MOD_PKA_2	390	396	PF00069	0.363
MOD_PKA_2	49	55	PF00069	0.688
MOD_PKA_2	64	70	PF00069	0.670
MOD_Plk_1	326	332	PF00069	0.484
MOD_Plk_1	468	474	PF00069	0.568
MOD_Plk_2-3	316	322	PF00069	0.485
MOD_Plk_4	113	119	PF00069	0.501
MOD_Plk_4	170	176	PF00069	0.440
MOD_Plk_4	268	274	PF00069	0.520
MOD_Plk_4	76	82	PF00069	0.569
MOD_ProDKin_1	147	153	PF00069	0.640
MOD_ProDKin_1	164	170	PF00069	0.617
MOD_ProDKin_1	2	8	PF00069	0.531
MOD_ProDKin_1	204	210	PF00069	0.481
MOD_ProDKin_1	319	325	PF00069	0.481
MOD_ProDKin_1	354	360	PF00069	0.527
MOD_ProDKin_1	428	434	PF00069	0.722
MOD_ProDKin_1	438	444	PF00069	0.538
MOD_ProDKin_1	493	499	PF00069	0.727
MOD_ProDKin_1	50	56	PF00069	0.628
TRG_DiLeu_BaEn_1	189	194	PF01217	0.493
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.626
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.476
TRG_ENDOCYTIC_2	176	179	PF00928	0.543
TRG_ER_diArg_1	6	8	PF00400	0.708
TRG_NES_CRM1_1	260	274	PF08389	0.407
TRG_NLS_MonoCore_2	141	146	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	381	386	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	433	438	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	43%	90%
A0A0N1ILX4	Leptomonas seymouri	24%	100%
A0A1X0NZT5	Trypanosomatidae	30%	100%
A0A3Q8IAB6	Leishmania donovani	25%	93%
A0A3R7KFA4	Trypanosoma rangeli	30%	100%
A0A3S5IRP3	Trypanosoma rangeli	24%	100%
A0A3S7X2J5	Leishmania donovani	81%	94%
A4H889	Leishmania braziliensis	26%	100%
A4HWL2	Leishmania infantum	25%	93%
A4I4K3	Leishmania infantum	81%	94%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AE02	Leishmania major	81%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QF55	Leishmania major	26%	100%
V5D9T1	Trypanosoma cruzi	31%	100%